Location: Hodgkin & Huxley (1952) model @ dcbfc81ad776 / experiments / periodic-IStim-protocol.cellml

Author:
WeiweiAi <wai484@aucklanduni.ac.nz>
Date:
2021-05-04 19:15:45+12:00
Desc:
(1) Add component gate_initials and gate_steady to compute initial values of m, n, and h gates (2) Add figures, and data derived from the original paper using Engauge Digitizer; (3) Add sedml files for experimental setup (4) Add python simulation and plot scripts to reproduce the figures
Permanent Source URI:
https://staging.physiomeproject.org/workspace/64f/rawfile/dcbfc81ad776bc96927e9ebd084619ae2560cdb3/experiments/periodic-IStim-protocol.cellml

<?xml version='1.0' encoding='UTF-8'?>
<model name="periodic_IStim" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
    <import xlink:href="../components/units.cellml">
        <units name="ms" units_ref="ms"/>
        <units name="uA_per_cmsq" units_ref="uA_per_cmsq"/>
    </import>
    <component name="stimulus_protocol">
        <variable name="IStim" public_interface="out" units="uA_per_cmsq"/>
        <variable name="time" public_interface="in" units="ms"/>
        <variable name="stimPeriod" public_interface="in" units="ms"/>
        <variable name="stimDuration" public_interface="in" units="ms"/>
        <variable name="stimCurrent" public_interface="in" units="uA_per_cmsq"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply id="stimulus_calculation">
                <eq/>
                <ci>IStim</ci>
                <piecewise>
                    <piece>
                        <ci>stimCurrent</ci>
                        <apply>
                            <lt/>
                            <apply>
                                <rem/>
                                <ci>time</ci>
                                <ci>stimPeriod</ci>
                            </apply>
                            <ci>stimDuration</ci>
                        </apply>
                    </piece>
                    <otherwise>
                        <cn cellml:units="uA_per_cmsq">0.0</cn>
                    </otherwise>
                </piecewise>
            </apply>
        </math>
    </component>
</model>