- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2021-07-06 11:22:35+12:00
- Desc:
- Change the figures size to fit the Physiome paper;
Adjust the solver setting to remove the notch in Fig6.
Minor editting in README.
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/692/rawfile/b98a10f69ee76a70243efdb648c598db5a866a2c/Doc/Periodic_stimulation.rst
Periodic stimulation
--------------------------
In the `periodic stimulation experiment <../Experiments/Periodic_stimulation.cellml>`_, the `Membrane potential component <../Components/Membrane_potential.cellml/view>`_ is configured and parameterised with an applied `periodic stimulus current <../Experiments/Periodic_IStim_protocol.cellml>`_.
You can change the parameters of stimulation in the component ``Istim_parameters``. The following simulation uses 310K for the temperature setting.
You can also bypass the parameters in the component ``model_parameters`` and ``initial_conditions`` and define your own parameters.
The simulation experiment can be obtained by loading the `corresponding SED-ML document <../Simulation/Periodic_stimulation.sedml>`__ into OpenCOR and executing the simulation.
Membrane action potential
-------------------------
Figure [#]_ shows the simulated hJSMC action potential trace and free intracellular calcium concentration after a simulation of 30 minutes of electrical activity (@ 6 cpm).
.. [#]
.. figure:: ../Simulation/simFig8.png
:width: 85%
:align: center
:alt: simFig8
Simulated hJSMC action potentials after a simulation of 30 minutes of electrical activity and free intracellular calcium concentration.
Figure [#]_ shows the simulated hJSMC action potential trace after a simulation of 30 minutes of electrical activity (@ 7.5 cpm). Note: ICC stimulus were modified.
.. [#]
.. figure:: ../Simulation/simFig9.png
:width: 85%
:align: center
:alt: simFig9
Simulated hJSMC action potentials after a simulation of 30 minutes of electrical activity (@ 7.5 cpm).
