- Author:
- agrawal-aditi <aditi.agrawal@dtc.ox.ac.uk>
- Date:
- 2021-09-05 12:13:43+01:00
- Desc:
- correcting tau_yca in the cellml file
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/6fb/rawfile/46ce441dcdeec91467543cf1a78bda8cdf5ef714/iyer_mazhari_winslow_2004.cellml
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<variable name="C2" units="dimensionless" initial_value="5.66632522499999978e-05"/>
<variable name="C2_to_C1" units="mS_per_uF"/>
<variable name="C2_to_C3" units="mS_per_uF"/>
<variable name="C2_to_CCa2" units="mS_per_uF"/>
<variable name="C3" units="dimensionless" initial_value="1.25021356999999990e-07"/>
<variable name="C3_to_C2" units="mS_per_uF"/>
<variable name="C3_to_C4" units="mS_per_uF"/>
<variable name="C3_to_CCa3" units="mS_per_uF"/>
<variable name="C4" units="dimensionless" initial_value="1.03442674800000000e-10"/>
<variable name="C4_to_C3" units="mS_per_uF"/>
<variable name="C4_to_CCa4" units="mS_per_uF"/>
<variable name="CCa0" units="dimensionless" initial_value="1.19854708099999999e-01"/>
<variable name="CCa0_to_C0" units="mS_per_uF"/>
<variable name="CCa0_to_CCa1" units="mS_per_uF"/>
<variable name="CCa1" units="dimensionless" initial_value="6.34679430199999988e-03"/>
<variable name="CCa1_to_C1" units="mS_per_uF"/>
<variable name="CCa1_to_CCa0" units="mS_per_uF"/>
<variable name="CCa1_to_CCa2" units="mS_per_uF"/>
<variable name="CCa2" units="dimensionless" initial_value="1.26032648799999987e-04"/>
<variable name="CCa2_to_C2" units="mS_per_uF"/>
<variable name="CCa2_to_CCa1" units="mS_per_uF"/>
<variable name="CCa2_to_CCa3" units="mS_per_uF"/>
<variable name="CCa3" units="dimensionless" initial_value="1.11231523799999993e-06"/>
<variable name="CCa3_to_C3" units="mS_per_uF"/>
<variable name="CCa3_to_CCa2" units="mS_per_uF"/>
<variable name="CCa3_to_CCa4" units="mS_per_uF"/>
<variable name="CCa4" units="dimensionless" initial_value="3.68131589199999984e-09"/>
<variable name="CCa4_to_C4" units="mS_per_uF"/>
<variable name="CCa4_to_CCa3" units="mS_per_uF"/>
<variable name="CaSS" units="mM" public_interface="in"/>
<variable name="Open" units="dimensionless" public_interface="out" initial_value="7.75798156300000011e-12"/>
<variable name="V" units="mV" public_interface="in"/>
<variable name="a1_C0" units="mS_per_uF"/>
<variable name="a1_C1" units="mS_per_uF"/>
<variable name="a1_C2" units="mS_per_uF"/>
<variable name="a1_C3" units="mS_per_uF"/>
<variable name="a1_C4" units="mS_per_uF"/>
<variable name="a1_Ca0" units="mS_per_uF"/>
<variable name="a1_Ca1" units="mS_per_uF"/>
<variable name="a1_Ca2" units="mS_per_uF"/>
<variable name="a1_Ca3" units="mS_per_uF"/>
<variable name="a1_Ca4" units="mS_per_uF"/>
<variable name="a1_Cainf" units="dimensionless" initial_value="0.82"/>
<variable name="a2_C0" units="mS_per_uF"/>
<variable name="a2_C1" units="mS_per_uF"/>
<variable name="a2_C2" units="mS_per_uF"/>
<variable name="a2_C3" units="mS_per_uF"/>
<variable name="a2_C4" units="mS_per_uF"/>
<variable name="a2_Ca0" units="mS_per_uF"/>
<variable name="a2_Ca1" units="mS_per_uF"/>
<variable name="a2_Ca2" units="mS_per_uF"/>
<variable name="a2_Ca3" units="mS_per_uF"/>
<variable name="a2_Ca4" units="mS_per_uF"/>
<variable name="aL" units="dimensionless" initial_value="2.0"/>
<variable name="alpha" units="mS_per_uF"/>
<variable name="alpha_prime" units="mS_per_uF"/>
<variable name="bL" units="dimensionless" initial_value="2.0"/>
<variable name="beta" units="mS_per_uF"/>
<variable name="beta_prime" units="mS_per_uF"/>
<variable name="fL" units="mS_per_uF" initial_value="0.3"/>
<variable name="gL" units="mS_per_uF" initial_value="4.0"/>
<variable name="gamma" units="mS_per_uF"/>
<variable name="omega" units="mS_per_uF"/>
<variable name="tau_yCa" units="ms"/>
<variable name="time" units="ms" public_interface="in"/>
<variable name="yCa" units="dimensionless" public_interface="out" initial_value="9.99715707400000042e-01"/>
<variable name="yCa_inf" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C0</ci>
</apply>
<apply>
<minus/>
<ci>a2_C0</ci>
<ci>a1_C0</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C0_to_C1</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">4.0</cn>
<ci>alpha</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C0_to_CCa0</ci>
<ci>gamma</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1</ci>
</apply>
<apply>
<minus/>
<ci>a2_C1</ci>
<ci>a1_C1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C1_to_C0</ci>
<ci>beta</ci>
</apply>
<apply>
<eq/>
<ci>C1_to_C2</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3.0</cn>
<ci>alpha</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C1_to_CCa1</ci>
<apply>
<times/>
<ci>aL</ci>
<ci>C0_to_CCa0</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2</ci>
</apply>
<apply>
<minus/>
<ci>a2_C2</ci>
<ci>a1_C2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C2_to_C1</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>beta</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C2_to_C3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>alpha</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C2_to_CCa2</ci>
<apply>
<times/>
<ci>aL</ci>
<ci>C1_to_CCa1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C3</ci>
</apply>
<apply>
<minus/>
<ci>a2_C3</ci>
<ci>a1_C3</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C3_to_C2</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3.0</cn>
<ci>beta</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C3_to_C4</ci>
<ci>alpha</ci>
</apply>
<apply>
<eq/>
<ci>C3_to_CCa3</ci>
<apply>
<times/>
<ci>aL</ci>
<ci>C2_to_CCa2</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C4</ci>
</apply>
<apply>
<minus/>
<ci>a2_C4</ci>
<ci>a1_C4</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C4_to_C3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">4.0</cn>
<ci>beta</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C4_to_CCa4</ci>
<apply>
<times/>
<ci>aL</ci>
<ci>C3_to_CCa3</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CCa0</ci>
</apply>
<apply>
<minus/>
<ci>a2_Ca0</ci>
<ci>a1_Ca0</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa0_to_C0</ci>
<ci>omega</ci>
</apply>
<apply>
<eq/>
<ci>CCa0_to_CCa1</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">4.0</cn>
<ci>alpha_prime</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CCa1</ci>
</apply>
<apply>
<minus/>
<ci>a2_Ca1</ci>
<ci>a1_Ca1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa1_to_C1</ci>
<apply>
<divide/>
<ci>CCa0_to_C0</ci>
<ci>bL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa1_to_CCa0</ci>
<ci>beta_prime</ci>
</apply>
<apply>
<eq/>
<ci>CCa1_to_CCa2</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3.0</cn>
<ci>alpha_prime</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CCa2</ci>
</apply>
<apply>
<minus/>
<ci>a2_Ca2</ci>
<ci>a1_Ca2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa2_to_C2</ci>
<apply>
<divide/>
<ci>CCa1_to_C1</ci>
<ci>bL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa2_to_CCa1</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>beta_prime</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa2_to_CCa3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>alpha_prime</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CCa3</ci>
</apply>
<apply>
<minus/>
<ci>a2_Ca3</ci>
<ci>a1_Ca3</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa3_to_C3</ci>
<apply>
<divide/>
<ci>CCa2_to_C2</ci>
<ci>bL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa3_to_CCa2</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3.0</cn>
<ci>beta_prime</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa3_to_CCa4</ci>
<ci>alpha_prime</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CCa4</ci>
</apply>
<apply>
<minus/>
<ci>a2_Ca4</ci>
<ci>a1_Ca4</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa4_to_C4</ci>
<apply>
<divide/>
<ci>CCa3_to_C3</ci>
<ci>bL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa4_to_CCa3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">4.0</cn>
<ci>beta_prime</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Open</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>fL</ci>
<ci>C4</ci>
</apply>
<apply>
<times/>
<ci>gL</ci>
<ci>Open</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_C0</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>C0_to_C1</ci>
<ci>C0_to_CCa0</ci>
</apply>
<ci>C0</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_C1</ci>
<apply>
<times/>
<apply>
<plus/>
<apply>
<plus/>
<ci>C1_to_C0</ci>
<ci>C1_to_C2</ci>
</apply>
<ci>C1_to_CCa1</ci>
</apply>
<ci>C1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_C2</ci>
<apply>
<times/>
<apply>
<plus/>
<apply>
<plus/>
<ci>C2_to_C1</ci>
<ci>C2_to_C3</ci>
</apply>
<ci>C2_to_CCa2</ci>
</apply>
<ci>C2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_C3</ci>
<apply>
<times/>
<apply>
<plus/>
<apply>
<plus/>
<ci>C3_to_C2</ci>
<ci>C3_to_C4</ci>
</apply>
<ci>C3_to_CCa3</ci>
</apply>
<ci>C3</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_C4</ci>
<apply>
<times/>
<apply>
<plus/>
<apply>
<plus/>
<ci>C4_to_C3</ci>
<ci>fL</ci>
</apply>
<ci>C4_to_CCa4</ci>
</apply>
<ci>C4</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_Ca0</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>CCa0_to_CCa1</ci>
<ci>CCa0_to_C0</ci>
</apply>
<ci>CCa0</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_Ca1</ci>
<apply>
<times/>
<apply>
<plus/>
<apply>
<plus/>
<ci>CCa1_to_CCa0</ci>
<ci>CCa1_to_CCa2</ci>
</apply>
<ci>CCa1_to_C1</ci>
</apply>
<ci>CCa1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_Ca2</ci>
<apply>
<times/>
<apply>
<plus/>
<apply>
<plus/>
<ci>CCa2_to_CCa1</ci>
<ci>CCa2_to_CCa3</ci>
</apply>
<ci>CCa2_to_C2</ci>
</apply>
<ci>CCa2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_Ca3</ci>
<apply>
<times/>
<apply>
<plus/>
<apply>
<plus/>
<ci>CCa3_to_CCa2</ci>
<ci>CCa3_to_CCa4</ci>
</apply>
<ci>CCa3_to_C3</ci>
</apply>
<ci>CCa3</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_Ca4</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>CCa4_to_CCa3</ci>
<ci>CCa4_to_C4</ci>
</apply>
<ci>CCa4</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_C0</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>C1_to_C0</ci>
<ci>C1</ci>
</apply>
<apply>
<times/>
<ci>CCa0_to_C0</ci>
<ci>CCa0</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_C1</ci>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<times/>
<ci>C0_to_C1</ci>
<ci>C0</ci>
</apply>
<apply>
<times/>
<ci>C2_to_C1</ci>
<ci>C2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>CCa1_to_C1</ci>
<ci>CCa1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_C2</ci>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<times/>
<ci>C1_to_C2</ci>
<ci>C1</ci>
</apply>
<apply>
<times/>
<ci>C3_to_C2</ci>
<ci>C3</ci>
</apply>
</apply>
<apply>
<times/>
<ci>CCa2_to_C2</ci>
<ci>CCa2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_C3</ci>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<times/>
<ci>C2_to_C3</ci>
<ci>C2</ci>
</apply>
<apply>
<times/>
<ci>C4_to_C3</ci>
<ci>C4</ci>
</apply>
</apply>
<apply>
<times/>
<ci>CCa3_to_C3</ci>
<ci>CCa3</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_C4</ci>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<times/>
<ci>C3_to_C4</ci>
<ci>C3</ci>
</apply>
<apply>
<times/>
<ci>gL</ci>
<ci>Open</ci>
</apply>
</apply>
<apply>
<times/>
<ci>CCa4_to_C4</ci>
<ci>CCa4</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_Ca0</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>CCa1_to_CCa0</ci>
<ci>CCa1</ci>
</apply>
<apply>
<times/>
<ci>C0_to_CCa0</ci>
<ci>C0</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_Ca1</ci>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<times/>
<ci>CCa0_to_CCa1</ci>
<ci>CCa0</ci>
</apply>
<apply>
<times/>
<ci>CCa2_to_CCa1</ci>
<ci>CCa2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>C1_to_CCa1</ci>
<ci>C1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_Ca2</ci>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<times/>
<ci>CCa1_to_CCa2</ci>
<ci>CCa1</ci>
</apply>
<apply>
<times/>
<ci>CCa3_to_CCa2</ci>
<ci>CCa3</ci>
</apply>
</apply>
<apply>
<times/>
<ci>C2_to_CCa2</ci>
<ci>C2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_Ca3</ci>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<times/>
<ci>CCa2_to_CCa3</ci>
<ci>CCa2</ci>
</apply>
<apply>
<times/>
<ci>CCa4_to_CCa3</ci>
<ci>CCa4</ci>
</apply>
</apply>
<apply>
<times/>
<ci>C3_to_CCa3</ci>
<ci>C3</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_Ca4</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>CCa3_to_CCa4</ci>
<ci>CCa3</ci>
</apply>
<apply>
<times/>
<ci>C4_to_CCa4</ci>
<ci>C4</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="mS_per_uF">4.0</cn>
<cn cellml:units="dimensionless">1.2</cn>
</apply>
<cn cellml:units="dimensionless">0.416</cn>
</apply>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_mV">0.012</cn>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="mV">35.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_prime</ci>
<apply>
<times/>
<ci>aL</ci>
<ci>alpha</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>beta</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="mS_per_uF">4.0</cn>
<cn cellml:units="dimensionless">0.45</cn>
</apply>
<cn cellml:units="dimensionless">0.049</cn>
</apply>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.065</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="mV">22.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_prime</ci>
<apply>
<divide/>
<ci>beta</ci>
<ci>bL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>gamma</ci>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="mS_per_uF">0.6</cn>
<cn cellml:units="m3_per_mol">0.09233</cn>
</apply>
<ci>CaSS</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>omega</ci>
<apply>
<times/>
<cn cellml:units="mS_per_uF">0.25</cn>
<cn cellml:units="dimensionless">0.01</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_yCa</ci>
<apply>
<divide/>
<cn cellml:units="ms">1.0</cn>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.00336</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">0.5</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="mV">5.54</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0079</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="mV">49.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>yCa</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>yCa_inf</ci>
<ci>yCa</ci>
</apply>
<ci>tau_yCa</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>yCa_inf</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<ci>a1_Cainf</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">28.5</cn>
</apply>
<cn cellml:units="mV">7.8</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<ci>a1_Cainf</ci>
</apply>
</apply>
</math>
</component>
<component name="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES">
<variable name="C1_RyR" units="dimensionless" initial_value="4.44803894600000027e-01"/>
<variable name="C2_RyR" units="dimensionless" initial_value="5.54535923999999958e-01"/>
<variable name="CaSS" units="mM" public_interface="in"/>
<variable name="O1_RyR" units="dimensionless" public_interface="out" initial_value="6.60178328700000033e-04"/>
<variable name="O2_RyR" units="dimensionless" public_interface="out" initial_value="3.97392005999999971e-09"/>
<variable name="dC1_RyR" units="mS_per_uF"/>
<variable name="dC2_RyR" units="mS_per_uF"/>
<variable name="dO1_RyR" units="mS_per_uF"/>
<variable name="dO2_RyR" units="mS_per_uF"/>
<variable name="kaminus" units="mS_per_uF" initial_value="0.576"/>
<variable name="kaplus" units="m12_per_s_per_mol4_times_1e15" initial_value="0.01215"/>
<variable name="kbminus" units="mS_per_uF" initial_value="1.93"/>
<variable name="kbplus" units="m9_per_s_per_mol3_times_1e12" initial_value="0.00405"/>
<variable name="kcminus" units="mS_per_uF" initial_value="0.0008"/>
<variable name="kcplus" units="mS_per_uF" initial_value="0.1"/>
<variable name="mcoop" units="dimensionless" initial_value="3.0"/>
<variable name="ncoop" units="dimensionless" initial_value="4.0"/>
<variable name="time" units="ms" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1_RyR</ci>
</apply>
<ci>dC1_RyR</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2_RyR</ci>
</apply>
<ci>dC2_RyR</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O1_RyR</ci>
</apply>
<ci>dO1_RyR</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O2_RyR</ci>
</apply>
<ci>dO2_RyR</ci>
</apply>
<apply>
<eq/>
<ci>dC1_RyR</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<times/>
<apply>
<minus/>
<ci>kaplus</ci>
</apply>
<apply>
<power/>
<apply>
<times/>
<ci>CaSS</ci>
<cn cellml:units="dimensionless_times_1e_minus_3">1000.0</cn>
</apply>
<ci>ncoop</ci>
</apply>
</apply>
<ci>C1_RyR</ci>
</apply>
<apply>
<times/>
<ci>kaminus</ci>
<ci>O1_RyR</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dC2_RyR</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kcplus</ci>
<ci>O1_RyR</ci>
</apply>
<apply>
<times/>
<ci>kcminus</ci>
<ci>C2_RyR</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dO1_RyR</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<plus/>
<ci>dC1_RyR</ci>
<ci>dO2_RyR</ci>
</apply>
<ci>dC2_RyR</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dO2_RyR</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<times/>
<ci>kbplus</ci>
<apply>
<power/>
<apply>
<times/>
<ci>CaSS</ci>
<cn cellml:units="dimensionless_times_1e_minus_3">1000.0</cn>
</apply>
<ci>mcoop</ci>
</apply>
</apply>
<ci>O1_RyR</ci>
</apply>
<apply>
<times/>
<ci>kbminus</ci>
<ci>O2_RyR</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="COMPUTE_ICa_ICaK">
<variable name="Cao" units="mM" public_interface="in"/>
<variable name="Faraday" units="C_per_mmol" public_interface="in"/>
<variable name="ICa" units="A_per_F" public_interface="out"/>
<variable name="ICaK" units="A_per_F" public_interface="out"/>
<variable name="ICahalf" units="A_per_F"/>
<variable name="ICamax" units="A_per_F"/>
<variable name="Icabar" units="A_per_F"/>
<variable name="Ki" units="mM" public_interface="in"/>
<variable name="Ko" units="mM" public_interface="in"/>
<variable name="Open" units="dimensionless" public_interface="in"/>
<variable name="PCa" units="L_per_F_per_ms_times_1e0"/>
<variable name="PCa_max" units="L_per_F_per_ms_times_1e0" initial_value="0.0002469" cmeta:id="PCa_max"/>
<variable name="PK" units="L_per_F_per_ms_times_1e0"/>
<variable name="PKprime" units="L_per_F_per_ms_times_1e0"/>
<variable name="Pscale" units="dimensionless" initial_value="7.0"/>
<variable name="RT_over_F" units="mV" public_interface="in"/>
<variable name="V" units="mV" public_interface="in"/>
<variable name="VF_over_RT" units="dimensionless"/>
<variable name="VFsq_over_RT" units="C_per_mmol"/>
<variable name="a1_Ca" units="mM"/>
<variable name="a1_K" units="mM"/>
<variable name="a2_Ca" units="dimensionless"/>
<variable name="a2_K" units="dimensionless"/>
<variable name="driving_term_ghk" units="s_A_per_m3_times_1e3"/>
<variable name="driving_term_ghk_Ca" units="s_A_per_m3_times_1e3"/>
<variable name="driving_term_ghk_K" units="s_A_per_m3_times_1e3"/>
<variable name="i_cal_total" units="A_per_F" cmeta:id="i_cal_total"/>
<variable name="open_prob" units="dimensionless" cmeta:id="open_prob"/>
<variable name="yCa" units="dimensionless" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ICa</ci>
<apply>
<times/>
<ci>ICamax</ci>
<ci>open_prob</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ICaK</ci>
<apply>
<times/>
<apply>
<times/>
<ci>PKprime</ci>
<ci>open_prob</ci>
</apply>
<ci>driving_term_ghk_K</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ICahalf</ci>
<apply>
<minus/>
<cn cellml:units="A_per_F">0.265</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>ICamax</ci>
<apply>
<times/>
<ci>PCa</ci>
<ci>driving_term_ghk_Ca</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Icabar</ci>
<piecewise>
<piece>
<cn cellml:units="A_per_F">0.0</cn>
<apply>
<geq/>
<ci>ICamax</ci>
<cn cellml:units="A_per_F">0.0</cn>
</apply>
</piece>
<otherwise>
<ci>ICamax</ci>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>PCa</ci>
<apply>
<times/>
<ci>Pscale</ci>
<ci>PCa_max</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>PK</ci>
<apply>
<times/>
<ci>Pscale</ci>
<cn cellml:units="L_per_F_per_ms_times_1e0">4.574e-07</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>PKprime</ci>
<apply>
<divide/>
<ci>PK</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<divide/>
<ci>Icabar</ci>
<ci>ICahalf</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>VF_over_RT</ci>
<apply>
<divide/>
<ci>V</ci>
<ci>RT_over_F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>VFsq_over_RT</ci>
<apply>
<times/>
<ci>Faraday</ci>
<ci>VF_over_RT</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_Ca</ci>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="mM">0.001</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>VF_over_RT</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>Cao</ci>
<cn cellml:units="dimensionless">0.341</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_K</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>Ki</ci>
<apply>
<exp/>
<ci>VF_over_RT</ci>
</apply>
</apply>
<ci>Ko</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_Ca</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>VF_over_RT</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_K</ci>
<apply>
<minus/>
<apply>
<exp/>
<ci>VF_over_RT</ci>
</apply>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>driving_term_ghk</ci>
<apply>
<plus/>
<ci>driving_term_ghk_Ca</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>driving_term_ghk_K</ci>
<ci>PKprime</ci>
</apply>
<ci>PCa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>driving_term_ghk_Ca</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">4.0</cn>
<ci>VFsq_over_RT</ci>
</apply>
<ci>a1_Ca</ci>
</apply>
<ci>a2_Ca</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>driving_term_ghk_K</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>VFsq_over_RT</ci>
<ci>a1_K</ci>
</apply>
<ci>a2_K</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_cal_total</ci>
<apply>
<times/>
<apply>
<times/>
<ci>PCa</ci>
<ci>driving_term_ghk</ci>
</apply>
<ci>open_prob</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>open_prob</ci>
<apply>
<times/>
<ci>yCa</ci>
<ci>Open</ci>
</apply>
</apply>
</math>
</component>
<component name="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES">
<variable name="CaJSR" units="mM" public_interface="in"/>
<variable name="CaNSR" units="mM" public_interface="in"/>
<variable name="CaSS" units="mM" public_interface="in"/>
<variable name="Cai" units="mM" public_interface="in"/>
<variable name="Jrel" units="mM_per_ms" public_interface="out" cmeta:id="Jrel"/>
<variable name="Jtr" units="mM_per_ms" public_interface="out"/>
<variable name="Jup" units="mM_per_ms" public_interface="out" cmeta:id="Jup"/>
<variable name="Jxfer" units="mM_per_ms" public_interface="out"/>
<variable name="KSR" units="mM" initial_value="1.2" cmeta:id="KSR"/>
<variable name="Kfb" units="mM" initial_value="0.000168"/>
<variable name="Krb" units="mM" initial_value="3.29"/>
<variable name="Nfb" units="dimensionless" initial_value="1.2"/>
<variable name="Nrb" units="dimensionless" initial_value="1.0"/>
<variable name="O1_RyR" units="dimensionless" public_interface="in"/>
<variable name="O2_RyR" units="dimensionless" public_interface="in"/>
<variable name="fb" units="dimensionless"/>
<variable name="rb" units="dimensionless"/>
<variable name="tautr" units="ms" initial_value="0.5747"/>
<variable name="tauxfer" units="ms" initial_value="26.7"/>
<variable name="v1" units="mS_per_uF" initial_value="1.8" cmeta:id="v1"/>
<variable name="vmaxf" units="mS_per_uF" initial_value="7.48e-05"/>
<variable name="vmaxr" units="mS_per_uF" initial_value="0.000318"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Jrel</ci>
<apply>
<times/>
<apply>
<times/>
<ci>v1</ci>
<apply>
<plus/>
<ci>O1_RyR</ci>
<ci>O2_RyR</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>CaJSR</ci>
<ci>CaSS</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Jtr</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>CaNSR</ci>
<ci>CaJSR</ci>
</apply>
<ci>tautr</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Jup</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>KSR</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>vmaxf</ci>
<ci>fb</ci>
</apply>
<apply>
<times/>
<ci>vmaxr</ci>
<ci>rb</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>fb</ci>
</apply>
<ci>rb</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Jxfer</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>CaSS</ci>
<ci>Cai</ci>
</apply>
<ci>tauxfer</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>fb</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>Cai</ci>
<ci>Kfb</ci>
</apply>
<ci>Nfb</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>rb</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>CaNSR</ci>
<ci>Krb</ci>
</apply>
<ci>Nrb</ci>
</apply>
</apply>
</math>
</component>
<component name="COMPUTE_INaK_INaCa_ICab_IpCa">
<variable name="Cai" units="mM" public_interface="in"/>
<variable name="Cao" units="mM" public_interface="in"/>
<variable name="ECa" units="mV" public_interface="in"/>
<variable name="GCab" units="mS_per_uF" initial_value="7.684e-05"/>
<variable name="ICab" units="A_per_F" public_interface="out"/>
<variable name="INaCa" units="A_per_F" public_interface="out" cmeta:id="INaCa"/>
<variable name="INaK" units="A_per_F" public_interface="out"/>
<variable name="INaKmax" units="A_per_F" initial_value="2.387" cmeta:id="INaKmax"/>
<variable name="IpCa" units="A_per_F" public_interface="out" cmeta:id="IpCa"/>
<variable name="IpCamax" units="A_per_F" initial_value="0.05"/>
<variable name="KmCa" units="mM" initial_value="1.38"/>
<variable name="KmKo" units="mM" initial_value="1.5"/>
<variable name="KmNa" units="mM" initial_value="87.5"/>
<variable name="KmNai" units="mM" initial_value="20.0"/>
<variable name="KmpCa" units="mM" initial_value="0.0005"/>
<variable name="Ko" units="mM" public_interface="in"/>
<variable name="Nai" units="mM" public_interface="in"/>
<variable name="Nao" units="mM" public_interface="in"/>
<variable name="RT_over_F" units="mV" public_interface="in"/>
<variable name="V" units="mV" public_interface="in"/>
<variable name="VF_over_RT" units="dimensionless"/>
<variable name="a1_K" units="dimensionless"/>
<variable name="a1_Na" units="dimensionless"/>
<variable name="a1_ncx" units="mol4_per_m12"/>
<variable name="a2_K" units="dimensionless"/>
<variable name="a2_Na" units="dimensionless"/>
<variable name="a2_ncx" units="mol4_per_m12"/>
<variable name="a3_ncx" units="dimensionless"/>
<variable name="a4_ncx" units="mM"/>
<variable name="a5_ncx" units="mM3"/>
<variable name="eta" units="dimensionless" initial_value="0.35"/>
<variable name="fNaK" units="dimensionless"/>
<variable name="kNaCa" units="A_per_F" initial_value="0.44" cmeta:id="kNaCa"/>
<variable name="ksat" units="dimensionless" initial_value="0.2"/>
<variable name="sigma" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ICab</ci>
<apply>
<times/>
<ci>GCab</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>ECa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>INaCa</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>kNaCa</ci>
<apply>
<minus/>
<ci>a1_ncx</ci>
<ci>a2_ncx</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<times/>
<ci>a4_ncx</ci>
<ci>a3_ncx</ci>
</apply>
<ci>a5_ncx</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>INaK</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<times/>
<ci>INaKmax</ci>
<ci>fNaK</ci>
</apply>
<ci>a1_K</ci>
</apply>
<ci>a2_K</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>IpCa</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>IpCamax</ci>
<ci>Cai</ci>
</apply>
<apply>
<plus/>
<ci>KmpCa</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>VF_over_RT</ci>
<apply>
<divide/>
<ci>V</ci>
<ci>RT_over_F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_K</ci>
<apply>
<divide/>
<ci>Ko</ci>
<apply>
<plus/>
<ci>Ko</ci>
<ci>KmKo</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_Na</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1245</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.1</cn>
</apply>
<ci>VF_over_RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_ncx</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<times/>
<ci>eta</ci>
<ci>VF_over_RT</ci>
</apply>
</apply>
<apply>
<power/>
<ci>Nai</ci>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
</apply>
<ci>Cao</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_K</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>KmNai</ci>
<ci>Nai</ci>
</apply>
<cn cellml:units="dimensionless">1.5</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_Na</ci>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0365</cn>
<ci>sigma</ci>
</apply>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.33</cn>
</apply>
<ci>VF_over_RT</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_ncx</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<ci>VF_over_RT</ci>
</apply>
</apply>
<apply>
<power/>
<ci>Nao</ci>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
</apply>
<ci>Cai</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a3_ncx</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<times/>
<ci>ksat</ci>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<ci>VF_over_RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a4_ncx</ci>
<apply>
<plus/>
<ci>KmCa</ci>
<ci>Cao</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a5_ncx</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<power/>
<ci>KmNa</ci>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
<apply>
<power/>
<ci>Nao</ci>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">5000.0</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>fNaK</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<ci>a1_Na</ci>
<ci>a2_Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>sigma</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Nao</ci>
<cn cellml:units="mM">67.3</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<cn cellml:units="dimensionless">7.0</cn>
</apply>
</apply>
</math>
</component>
<component name="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp">
<variable name="EK" units="mV" public_interface="in"/>
<variable name="ENa" units="mV" public_interface="in"/>
<variable name="Faraday" units="C_per_mmol" public_interface="in"/>
<variable name="GK1" units="mS_per_uF" initial_value="1.25305126118807980e-01" cmeta:id="GK1"/>
<variable name="GKr" units="mS_per_uF" initial_value="0.0186" cmeta:id="GKr"/>
<variable name="GKr_calc" units="mS_per_uF" cmeta:id="GKr_calc"/>
<variable name="GKs" units="mS_per_uF" initial_value="0.0035" cmeta:id="GKs"/>
<variable name="GKv43" units="mS_per_uF"/>
<variable name="GNa" units="mS_per_uF" initial_value="56.32" cmeta:id="GNa"/>
<variable name="GNab" units="mS_per_uF" initial_value="0.001"/>
<variable name="GtoFfactor" units="mS_per_uF" initial_value="0.0872" cmeta:id="GtoFfactor"/>
<variable name="IK1" units="A_per_F" public_interface="out" cmeta:id="IK1"/>
<variable name="IKr" units="A_per_F" public_interface="out" cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_IKr"/>
<variable name="IKs" units="A_per_F" public_interface="out" cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_IKs"/>
<variable name="IKv14" units="A_per_F"/>
<variable name="IKv14_K" units="A_per_F" public_interface="out"/>
<variable name="IKv14_Na" units="A_per_F" public_interface="out"/>
<variable name="IKv43" units="A_per_F" public_interface="out"/>
<variable name="INa" units="A_per_F" public_interface="out" cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_INa"/>
<variable name="INab" units="A_per_F" public_interface="out"/>
<variable name="Ito1" units="A_per_F" public_interface="out" cmeta:id="Ito1"/>
<variable name="K1_inf" units="dimensionless"/>
<variable name="Ki" units="mM" public_interface="in"/>
<variable name="Ko" units="mM" public_interface="in"/>
<variable name="Kv43Frac" units="dimensionless" initial_value="0.889"/>
<variable name="Nai" units="mM" public_interface="in"/>
<variable name="Nao" units="mM" public_interface="in"/>
<variable name="O1ks" units="dimensionless" public_interface="in"/>
<variable name="O2ks" units="dimensionless" public_interface="in"/>
<variable name="OHerg" units="dimensionless" public_interface="in"/>
<variable name="OKv14" units="dimensionless" public_interface="in"/>
<variable name="OKv43" units="dimensionless" public_interface="in"/>
<variable name="PKv14" units="L_per_F_per_ms_times_1e0"/>
<variable name="PtoSfactor" units="L_per_F_per_ms_times_1e0" initial_value="3.74839999999999987e-07" cmeta:id="PtoSfactor"/>
<variable name="RT_over_F" units="mV" public_interface="in"/>
<variable name="V" units="mV" public_interface="in"/>
<variable name="VF_over_RT" units="dimensionless"/>
<variable name="VFsq_over_RT" units="C_per_mmol"/>
<variable name="a1_K" units="mM"/>
<variable name="a1_Na" units="mM"/>
<variable name="a2" units="dimensionless"/>
<variable name="fKo" units="dimensionless"/>
<variable name="na6" units="dimensionless" public_interface="in"/>
<variable name="na7" units="dimensionless" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>GKr_calc</ci>
<apply>
<times/>
<ci>GKr</ci>
<ci>fKo</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>GKv43</ci>
<apply>
<times/>
<ci>Kv43Frac</ci>
<ci>GtoFfactor</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>IK1</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<ci>GK1</ci>
<apply>
<root/>
<apply>
<divide/>
<ci>Ko</ci>
<cn cellml:units="mM">1.0</cn>
</apply>
</apply>
</apply>
<ci>K1_inf</ci>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>EK</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>IKr</ci>
<apply>
<times/>
<apply>
<times/>
<ci>GKr_calc</ci>
<ci>OHerg</ci>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>EK</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>IKs</ci>
<apply>
<times/>
<apply>
<times/>
<ci>GKs</ci>
<apply>
<plus/>
<ci>O1ks</ci>
<ci>O2ks</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>EK</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>IKv14</ci>
<apply>
<plus/>
<ci>IKv14_K</ci>
<ci>IKv14_Na</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>IKv14_K</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<ci>PKv14</ci>
<ci>OKv14</ci>
</apply>
<ci>VFsq_over_RT</ci>
</apply>
<ci>a1_K</ci>
</apply>
<ci>a2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>IKv14_Na</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.02</cn>
<ci>PKv14</ci>
</apply>
<ci>OKv14</ci>
</apply>
<ci>VFsq_over_RT</ci>
</apply>
<ci>a1_Na</ci>
</apply>
<ci>a2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>IKv43</ci>
<apply>
<times/>
<apply>
<times/>
<ci>GKv43</ci>
<ci>OKv43</ci>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>EK</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>INa</ci>
<apply>
<times/>
<apply>
<times/>
<ci>GNa</ci>
<apply>
<plus/>
<ci>na6</ci>
<ci>na7</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>ENa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>INab</ci>
<apply>
<times/>
<ci>GNab</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>ENa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ito1</ci>
<apply>
<plus/>
<ci>IKv43</ci>
<ci>IKv14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>K1_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">0.94</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.26</cn>
<ci>RT_over_F</ci>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>EK</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>PKv14</ci>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>Kv43Frac</ci>
</apply>
<ci>PtoSfactor</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>VF_over_RT</ci>
<apply>
<divide/>
<ci>V</ci>
<ci>RT_over_F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>VFsq_over_RT</ci>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">1000.0</cn>
<ci>Faraday</ci>
</apply>
<ci>VF_over_RT</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_K</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>Ki</ci>
<apply>
<exp/>
<ci>VF_over_RT</ci>
</apply>
</apply>
<ci>Ko</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_Na</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>Nai</ci>
<apply>
<exp/>
<ci>VF_over_RT</ci>
</apply>
</apply>
<ci>Nao</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2</ci>
<apply>
<minus/>
<apply>
<exp/>
<ci>VF_over_RT</ci>
</apply>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>fKo</ci>
<apply>
<root/>
<apply>
<divide/>
<ci>Ko</ci>
<cn cellml:units="mM">4.0</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS">
<variable name="CMDNtot" units="mM" initial_value="0.05"/>
<variable name="CSQNtot" units="mM" initial_value="15.0"/>
<variable name="CaJSR" units="mM" public_interface="in"/>
<variable name="CaSS" units="mM" public_interface="in"/>
<variable name="Cai" units="mM" public_interface="in"/>
<variable name="EGTAtot" units="mM" initial_value="0.0"/>
<variable name="HTRPNCa" units="dimensionless" initial_value="9.77215248100000045e-01"/>
<variable name="HTRPNtot" units="mM" initial_value="0.14"/>
<variable name="Jtrpn" units="mM_per_ms" public_interface="out"/>
<variable name="KmCMDN" units="mM" initial_value="0.00238"/>
<variable name="KmCSQN" units="mM" initial_value="0.8"/>
<variable name="KmEGTA" units="mM" initial_value="0.00015"/>
<variable name="LTRPNCa" units="dimensionless" initial_value="8.04658497299999970e-02"/>
<variable name="LTRPNtot" units="mM" initial_value="0.07"/>
<variable name="beta_JSR" units="dimensionless" public_interface="out"/>
<variable name="beta_SS" units="dimensionless" public_interface="out" cmeta:id="beta_SS"/>
<variable name="beta_i" units="dimensionless" public_interface="out" cmeta:id="beta_i"/>
<variable name="dHTRPNCa" units="mS_per_uF"/>
<variable name="dLTRPNCa" units="mS_per_uF"/>
<variable name="khtrpn_minus" units="mS_per_uF" initial_value="6.6e-05"/>
<variable name="khtrpn_plus" units="per_mM_per_ms" initial_value="20.0"/>
<variable name="kltrpn_minus" units="mS_per_uF" initial_value="0.04"/>
<variable name="kltrpn_plus" units="per_mM_per_ms" initial_value="40.0"/>
<variable name="time" units="ms" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>HTRPNCa</ci>
</apply>
<ci>dHTRPNCa</ci>
</apply>
<apply>
<eq/>
<ci>Jtrpn</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>LTRPNtot</ci>
<ci>dLTRPNCa</ci>
</apply>
<apply>
<times/>
<ci>HTRPNtot</ci>
<ci>dHTRPNCa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>LTRPNCa</ci>
</apply>
<ci>dLTRPNCa</ci>
</apply>
<apply>
<eq/>
<ci>beta_JSR</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>CSQNtot</ci>
<ci>KmCSQN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>CaJSR</ci>
<ci>KmCSQN</ci>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_SS</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>CMDNtot</ci>
<ci>KmCMDN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>CaSS</ci>
<ci>KmCMDN</ci>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>EGTAtot</ci>
<ci>KmEGTA</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>CaSS</ci>
<ci>KmEGTA</ci>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_i</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>CMDNtot</ci>
<ci>KmCMDN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>Cai</ci>
<ci>KmCMDN</ci>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>EGTAtot</ci>
<ci>KmEGTA</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>Cai</ci>
<ci>KmEGTA</ci>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dHTRPNCa</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<times/>
<ci>khtrpn_plus</ci>
<ci>Cai</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>HTRPNCa</ci>
</apply>
</apply>
<apply>
<times/>
<ci>khtrpn_minus</ci>
<ci>HTRPNCa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dLTRPNCa</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<times/>
<ci>kltrpn_plus</ci>
<ci>Cai</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>LTRPNCa</ci>
</apply>
</apply>
<apply>
<times/>
<ci>kltrpn_minus</ci>
<ci>LTRPNCa</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="COMPUTE_REVERSAL_POTENTIALS">
<variable name="Cai" units="mM" public_interface="in"/>
<variable name="Cao" units="mM" public_interface="in"/>
<variable name="ECa" units="mV" public_interface="out" cmeta:id="ECa"/>
<variable name="EK" units="mV" public_interface="out" cmeta:id="EK"/>
<variable name="EKs" units="mV"/>
<variable name="ENa" units="mV" public_interface="out" cmeta:id="ENa"/>
<variable name="Ki" units="mM" public_interface="in"/>
<variable name="Ko" units="mM" public_interface="in"/>
<variable name="Nai" units="mM" public_interface="in"/>
<variable name="Nao" units="mM" public_interface="in"/>
<variable name="RT_over_F" units="mV" public_interface="in"/>
<variable name="a1" units="mM"/>
<variable name="a2" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ECa</ci>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5</cn>
<ci>RT_over_F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Cao</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>EK</ci>
<apply>
<times/>
<ci>RT_over_F</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>EKs</ci>
<apply>
<times/>
<ci>RT_over_F</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>a1</ci>
<ci>a2</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ENa</ci>
<apply>
<times/>
<ci>RT_over_F</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>Nai</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a1</ci>
<apply>
<plus/>
<ci>Ko</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.01833</cn>
<ci>Nao</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a2</ci>
<apply>
<plus/>
<ci>Ki</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.01833</cn>
<ci>Nai</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="IKr">
<variable name="A0_HERG" units="mS_per_uF" initial_value="1.71476417330859998e-02"/>
<variable name="A1_HERG" units="mS_per_uF" initial_value="3.96932838114099976e-02"/>
<variable name="A2_HERG" units="mS_per_uF" initial_value="2.05744860597700009e-02"/>
<variable name="A3_HERG" units="mS_per_uF" initial_value="1.34366604422999996e-03"/>
<variable name="A4_HERG" units="mS_per_uF" initial_value="1.06663164912879999e-01"/>
<variable name="A5_HERG" units="mS_per_uF" initial_value="6.46393910049000014e-03"/>
<variable name="A6_HERG" units="mS_per_uF" initial_value="8.03937440300000057e-05"/>
<variable name="B0_HERG" units="per_mV" initial_value="3.30460803883500034e-02"/>
<variable name="B1_HERG" units="per_mV"/>
<variable name="B2_HERG" units="per_mV" initial_value="2.61741271511800010e-02"/>
<variable name="B3_HERG" units="per_mV"/>
<variable name="B4_HERG" units="per_mV" initial_value="5.68908859717000021e-03"/>
<variable name="B5_HERG" units="per_mV"/>
<variable name="B6_HERG" units="per_mV" initial_value="6.98089239999999969e-07"/>
<variable name="C1H_to_C2H" units="mS_per_uF"/>
<variable name="C1Herg" units="dimensionless" initial_value="9.96697338000000044e-01"/>
<variable name="C2H_to_C1H" units="mS_per_uF"/>
<variable name="C2H_to_C3H" units="mS_per_uF"/>
<variable name="C2Herg" units="dimensionless" initial_value="4.34087964799999976e-04"/>
<variable name="C3H_to_C2H" units="mS_per_uF"/>
<variable name="C3H_to_IH" units="mS_per_uF"/>
<variable name="C3H_to_OH" units="mS_per_uF"/>
<variable name="C3Herg" units="dimensionless" initial_value="7.63409975500000055e-05"/>
<variable name="IH_to_C3H" units="mS_per_uF"/>
<variable name="IH_to_OH" units="mS_per_uF"/>
<variable name="IHerg" units="dimensionless" initial_value="1.53334700699999995e-06"/>
<variable name="OH_to_C3H" units="mS_per_uF"/>
<variable name="OH_to_IH" units="mS_per_uF"/>
<variable name="OHerg" units="dimensionless" public_interface="out" initial_value="9.51178911299999993e-06"/>
<variable name="T_Const_HERG" units="dimensionless" initial_value="5.32000000100000037e+00"/>
<variable name="V" units="mV" public_interface="in"/>
<variable name="a1_C2" units="mS_per_uF"/>
<variable name="a1_C3" units="mS_per_uF"/>
<variable name="a1_I" units="mS_per_uF"/>
<variable name="a1_O" units="mS_per_uF"/>
<variable name="a2_C2" units="mS_per_uF"/>
<variable name="a2_C3" units="mS_per_uF"/>
<variable name="a2_I" units="mS_per_uF"/>
<variable name="a2_O" units="mS_per_uF"/>
<variable name="time" units="ms" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>B1_HERG</ci>
<apply>
<minus/>
<cn cellml:units="per_mV"> 4.30605416397999985e-02</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>B3_HERG</ci>
<apply>
<minus/>
<cn cellml:units="per_mV"> 2.69138549839900015e-02</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>B5_HERG</ci>
<apply>
<minus/>
<cn cellml:units="per_mV"> 4.53664295954299968e-02</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>C1H_to_C2H</ci>
<apply>
<times/>
<apply>
<times/>
<ci>T_Const_HERG</ci>
<ci>A0_HERG</ci>
</apply>
<apply>
<exp/>
<apply>
<times/>
<ci>B0_HERG</ci>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1Herg</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>C2H_to_C1H</ci>
<ci>C2Herg</ci>
</apply>
<apply>
<times/>
<ci>C1H_to_C2H</ci>
<ci>C1Herg</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>C2H_to_C1H</ci>
<apply>
<times/>
<apply>
<times/>
<ci>T_Const_HERG</ci>
<ci>A1_HERG</ci>
</apply>
<apply>
<exp/>
<apply>
<times/>
<ci>B1_HERG</ci>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>C2H_to_C3H</ci>
<apply>
<times/>
<ci>T_Const_HERG</ci>
<cn cellml:units="mS_per_uF"> 2.60836204333700014e-02</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2Herg</ci>
</apply>
<apply>
<minus/>
<ci>a1_C2</ci>
<ci>a2_C2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C3H_to_C2H</ci>
<apply>
<times/>
<ci>T_Const_HERG</ci>
<cn cellml:units="mS_per_uF"> 1.48329781321449999e-01</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>C3H_to_IH</ci>
<apply>
<times/>
<apply>
<times/>
<ci>T_Const_HERG</ci>
<ci>A6_HERG</ci>
</apply>
<apply>
<exp/>
<apply>
<times/>
<ci>B6_HERG</ci>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>C3H_to_OH</ci>
<apply>
<times/>
<apply>
<times/>
<ci>T_Const_HERG</ci>
<ci>A2_HERG</ci>
</apply>
<apply>
<exp/>
<apply>
<times/>
<ci>B2_HERG</ci>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C3Herg</ci>
</apply>
<apply>
<minus/>
<ci>a1_C3</ci>
<ci>a2_C3</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>IH_to_C3H</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<times/>
<ci>OH_to_C3H</ci>
<ci>IH_to_OH</ci>
</apply>
<ci>C3H_to_IH</ci>
</apply>
<apply>
<times/>
<ci>C3H_to_OH</ci>
<ci>OH_to_IH</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>IH_to_OH</ci>
<apply>
<times/>
<apply>
<times/>
<ci>T_Const_HERG</ci>
<ci>A5_HERG</ci>
</apply>
<apply>
<exp/>
<apply>
<times/>
<ci>B5_HERG</ci>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>IHerg</ci>
</apply>
<apply>
<minus/>
<ci>a1_I</ci>
<ci>a2_I</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>OH_to_C3H</ci>
<apply>
<times/>
<apply>
<times/>
<ci>T_Const_HERG</ci>
<ci>A3_HERG</ci>
</apply>
<apply>
<exp/>
<apply>
<times/>
<ci>B3_HERG</ci>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>OH_to_IH</ci>
<apply>
<times/>
<apply>
<times/>
<ci>T_Const_HERG</ci>
<ci>A4_HERG</ci>
</apply>
<apply>
<exp/>
<apply>
<times/>
<ci>B4_HERG</ci>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>OHerg</ci>
</apply>
<apply>
<minus/>
<ci>a1_O</ci>
<ci>a2_O</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_C2</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>C1H_to_C2H</ci>
<ci>C1Herg</ci>
</apply>
<apply>
<times/>
<ci>C3H_to_C2H</ci>
<ci>C3Herg</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_C3</ci>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<times/>
<ci>C2H_to_C3H</ci>
<ci>C2Herg</ci>
</apply>
<apply>
<times/>
<ci>OH_to_C3H</ci>
<ci>OHerg</ci>
</apply>
</apply>
<apply>
<times/>
<ci>IH_to_C3H</ci>
<ci>IHerg</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_I</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>C3H_to_IH</ci>
<ci>C3Herg</ci>
</apply>
<apply>
<times/>
<ci>OH_to_IH</ci>
<ci>OHerg</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_O</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>C3H_to_OH</ci>
<ci>C3Herg</ci>
</apply>
<apply>
<times/>
<ci>IH_to_OH</ci>
<ci>IHerg</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_C2</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>C2H_to_C1H</ci>
<ci>C2H_to_C3H</ci>
</apply>
<ci>C2Herg</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_C3</ci>
<apply>
<times/>
<apply>
<plus/>
<apply>
<plus/>
<ci>C3H_to_IH</ci>
<ci>C3H_to_OH</ci>
</apply>
<ci>C3H_to_C2H</ci>
</apply>
<ci>C3Herg</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_I</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>IH_to_C3H</ci>
<ci>IH_to_OH</ci>
</apply>
<ci>IHerg</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_O</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>OH_to_C3H</ci>
<ci>OH_to_IH</ci>
</apply>
<ci>OHerg</ci>
</apply>
</apply>
</math>
</component>
<component name="IKs">
<variable name="C0ks" units="dimensionless" initial_value="9.64560629499999989e-01"/>
<variable name="C0ks_C1ks" units="mS_per_uF" initial_value="7.95600798003999986e-03"/>
<variable name="C1ks" units="dimensionless" initial_value="3.54261356799999982e-02"/>
<variable name="C1ks_C0ks" units="mS_per_uF"/>
<variable name="C1ks_O1ks" units="mS_per_uF" initial_value="3.96672067607099985e-02"/>
<variable name="O1ks" units="dimensionless" public_interface="out" initial_value="2.49171069599999984e-07"/>
<variable name="O1ks_C1ks" units="mS_per_uF"/>
<variable name="O1ks_O2ks" units="mS_per_uF"/>
<variable name="O2ks" units="dimensionless" public_interface="out" initial_value="1.29854782200000006e-05"/>
<variable name="O2ks_O1ks" units="mS_per_uF"/>
<variable name="V" units="mV" public_interface="in"/>
<variable name="time" units="ms" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C0ks</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<ci>C0ks_C1ks</ci>
</apply>
<ci>C0ks</ci>
</apply>
<apply>
<times/>
<ci>C1ks_C0ks</ci>
<ci>C1ks</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1ks</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci>C0ks_C1ks</ci>
<ci>C0ks</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>C1ks_C0ks</ci>
<ci>C1ks_O1ks</ci>
</apply>
<ci>C1ks</ci>
</apply>
</apply>
<apply>
<times/>
<ci>O1ks_C1ks</ci>
<ci>O1ks</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>C1ks_C0ks</ci>
<apply>
<times/>
<cn cellml:units="mS_per_uF"> 2.16255758958499994e-01</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV"> 1.88912302100000014e-05</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O1ks</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci>C1ks_O1ks</ci>
<ci>C1ks</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>O1ks_C1ks</ci>
<ci>O1ks_O2ks</ci>
</apply>
<ci>O1ks</ci>
</apply>
</apply>
<apply>
<times/>
<ci>O2ks_O1ks</ci>
<ci>O2ks</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>O1ks_C1ks</ci>
<apply>
<times/>
<cn cellml:units="mS_per_uF"> 7.00806628929000024e-03</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV"> 1.49997547002850007e-01</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>O1ks_O2ks</ci>
<apply>
<times/>
<cn cellml:units="mS_per_uF"> 7.67254363063000003e-03</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_mV"> 8.66294591465500002e-02</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O2ks</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>O1ks_O2ks</ci>
<ci>O1ks</ci>
</apply>
<apply>
<times/>
<ci>O2ks_O1ks</ci>
<ci>O2ks</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>O2ks_O1ks</ci>
<apply>
<times/>
<cn cellml:units="mS_per_uF"> 3.79737998367999990e-03</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV"> 1.42566812688100005e-02</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="INa">
<variable name="Cf" units="mS_per_uF"/>
<variable name="Cn" units="mS_per_uF"/>
<variable name="Delta1" units="mS_per_uF"/>
<variable name="DeltaDelta" units="mS_per_uF"/>
<variable name="Faraday" units="C_per_mmol" public_interface="in"/>
<variable name="FoverRT" units="per_mV"/>
<variable name="GammaGamma" units="mS_per_uF"/>
<variable name="KToverH" units="mS_per_uF"/>
<variable name="Of" units="mS_per_uF"/>
<variable name="On" units="mS_per_uF"/>
<variable name="RTNa" units="g_m2_per_s2_per_mol_times_1e3"/>
<variable name="RTNaF" units="mV"/>
<variable name="RT_over_F" units="mV" public_interface="in"/>
<variable name="Rgas" units="J_per_mol_per_K" public_interface="in"/>
<variable name="TNa" units="kelvin" initial_value="294.16"/>
<variable name="Temp_Scale" units="dimensionless" initial_value="1.38862291252870995e+00"/>
<variable name="V" units="mV" public_interface="in"/>
<variable name="alpha1" units="mS_per_uF"/>
<variable name="beta1" units="mS_per_uF"/>
<variable name="epsilon" units="mS_per_uF"/>
<variable name="gamma1" units="mS_per_uF"/>
<variable name="k1011" units="mS_per_uF"/>
<variable name="k103" units="mS_per_uF"/>
<variable name="k109" units="mS_per_uF"/>
<variable name="k1110" units="mS_per_uF"/>
<variable name="k1112" units="mS_per_uF"/>
<variable name="k114" units="mS_per_uF"/>
<variable name="k12" units="mS_per_uF"/>
<variable name="k1211" units="mS_per_uF"/>
<variable name="k1213" units="mS_per_uF"/>
<variable name="k125" units="mS_per_uF"/>
<variable name="k1312" units="mS_per_uF"/>
<variable name="k136" units="mS_per_uF"/>
<variable name="k18" units="mS_per_uF"/>
<variable name="k21" units="mS_per_uF"/>
<variable name="k23" units="mS_per_uF"/>
<variable name="k29" units="mS_per_uF"/>
<variable name="k310" units="mS_per_uF"/>
<variable name="k32" units="mS_per_uF"/>
<variable name="k34" units="mS_per_uF"/>
<variable name="k411" units="mS_per_uF"/>
<variable name="k43" units="mS_per_uF"/>
<variable name="k45" units="mS_per_uF"/>
<variable name="k512" units="mS_per_uF"/>
<variable name="k54" units="mS_per_uF"/>
<variable name="k56" units="mS_per_uF"/>
<variable name="k57" units="mS_per_uF"/>
<variable name="k613" units="mS_per_uF"/>
<variable name="k65" units="mS_per_uF"/>
<variable name="k67" units="mS_per_uF"/>
<variable name="k75" units="mS_per_uF"/>
<variable name="k76" units="mS_per_uF"/>
<variable name="k81" units="mS_per_uF"/>
<variable name="k89" units="mS_per_uF"/>
<variable name="k910" units="mS_per_uF"/>
<variable name="k92" units="mS_per_uF"/>
<variable name="k98" units="mS_per_uF"/>
<variable name="mu" units="mS_per_uF"/>
<variable name="na1" units="dimensionless" initial_value="1.43757564899999996e-01"/>
<variable name="na10" units="dimensionless" initial_value="5.78612005700000001e-02"/>
<variable name="na11" units="dimensionless" initial_value="5.49629227900000003e-03"/>
<variable name="na12" units="dimensionless" initial_value="1.95787451900000006e-04"/>
<variable name="na13" units="dimensionless" initial_value="4.17679396000000000e-04"/>
<variable name="na2" units="dimensionless" initial_value="4.17776207999999982e-02"/>
<variable name="na3" units="dimensionless" initial_value="4.55289836399999995e-03"/>
<variable name="na4" units="dimensionless" initial_value="2.20520742999999995e-04"/>
<variable name="na5" units="dimensionless" initial_value="4.00526648400000040e-06"/>
<variable name="na6" units="dimensionless" public_interface="out" initial_value="1.57442748999999985e-08"/>
<variable name="na7" units="dimensionless" public_interface="out" initial_value="2.85660717899999982e-09"/>
<variable name="na8" units="dimensionless" initial_value="4.74995000800000011e-01"/>
<variable name="na9" units="dimensionless" initial_value="2.70721409700000026e-01"/>
<variable name="omega_na" units="mS_per_uF"/>
<variable name="parameter_a" units="dimensionless" initial_value="1.40042625477401006e+00"/>
<variable name="rho" units="mS_per_uF"/>
<variable name="time" units="ms" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Cf</ci>
<apply>
<times/>
<apply>
<times/>
<ci>Temp_Scale</ci>
<ci>KToverH</ci>
</apply>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="g_m2_per_s2_per_mol_times_1e3"> 5.95652236284583996e+04</cn>
</apply>
<ci>RTNa</ci>
</apply>
<apply>
<divide/>
<cn cellml:units="J_per_mol_per_K">0.00711</cn>
<ci>Rgas</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Cn</ci>
<apply>
<times/>
<apply>
<times/>
<ci>Temp_Scale</ci>
<ci>KToverH</ci>
</apply>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="g_m2_per_s2_per_mol_times_1e3"> 2.87913446530952991e+05</cn>
</apply>
<ci>RTNa</ci>
</apply>
<apply>
<divide/>
<cn cellml:units="J_per_mol_per_K">786.217</cn>
<ci>Rgas</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Delta1</ci>
<apply>
<times/>
<apply>
<times/>
<ci>Temp_Scale</ci>
<ci>KToverH</ci>
</apply>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="g_m2_per_s2_per_mol_times_1e3"> 1.33689930409099994e+05</cn>
</apply>
<ci>RTNa</ci>
</apply>
<apply>
<divide/>
<cn cellml:units="J_per_mol_per_K">229.205</cn>
<ci>Rgas</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless"> 1.55804214553883003e+00</cn>
</apply>
<ci>V</ci>
</apply>
<ci>RTNaF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>DeltaDelta</ci>
<apply>
<times/>
<apply>
<times/>
<ci>Temp_Scale</ci>
<ci>KToverH</ci>
</apply>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="g_m2_per_s2_per_mol_times_1e3"> 5.57006624658306973e+04</cn>
</apply>
<ci>RTNa</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="J_per_mol_per_K">130.639</cn>
</apply>
<ci>Rgas</ci>
</apply>
</apply>
<apply>
<divide/>
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<bqbiol:is rdf:resource="https://chaste.comlab.ox.ac.uk/cellml/ns/oxford-metadata#membrane_stimulus_current"/>
</rdf:Description>
<rdf:Description rdf:about="#i_cal_total">
<bqbiol:is rdf:resource="https://chaste.comlab.ox.ac.uk/cellml/ns/oxford-metadata#membrane_L_type_calcium_current"/>
</rdf:Description>
<rdf:Description rdf:about="#kNaCa">
<bqbiol:is rdf:resource="https://chaste.comlab.ox.ac.uk/cellml/ns/oxford-metadata#membrane_sodium_calcium_exchanger_current_conductance"/>
</rdf:Description>
<rdf:Description rdf:about="#open_prob">
<bqbiol:is rdf:resource="https://chaste.comlab.ox.ac.uk/cellml/ns/oxford-metadata#membrane_L_type_calcium_current_open_probability"/>
</rdf:Description>
<rdf:Description rdf:about="#stim_amplitude">
<bqbiol:is rdf:resource="https://chaste.comlab.ox.ac.uk/cellml/ns/oxford-metadata#membrane_stimulus_current_amplitude"/>
</rdf:Description>
<rdf:Description rdf:about="#stim_period">
<bqbiol:is rdf:resource="https://chaste.comlab.ox.ac.uk/cellml/ns/oxford-metadata#membrane_stimulus_current_period"/>
</rdf:Description>
<rdf:Description rdf:about="#time">
<bqbiol:is rdf:resource="https://chaste.comlab.ox.ac.uk/cellml/ns/oxford-metadata#time"/>
</rdf:Description>
<rdf:Description rdf:about="#v1">
<bqbiol:is rdf:resource="https://chaste.comlab.ox.ac.uk/cellml/ns/oxford-metadata#SR_release_current_max"/>
</rdf:Description>
</rdf:RDF>
</model>
