- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2022-10-19 10:24:37+13:00
- Desc:
- Add readme to link the documentation on overleaf.
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/701/rawfile/6741283829975cd4f084159e7734dcbece29f7b1/Simulation/src/clampIV_sim.py
# To reproduce the data needed for IV curve in clamping experiments in associated original paper
import clampExp
import imp
imp.reload(clampExp)
sedversions=['0','1','2','3']
for i, sedversion in enumerate(sedversions):
simfile='../Patch_clamp_experiment_%s.sedml' % sedversion
simFign='FigA1F_%s' % sedversion
V_clamp=[-60, 120, 120, -50, 80, 10]
paraKeys=['Clamp_parameters/Cai']
paras=[8.97e-5]
outKeys=['outputs/I_CaL']
clampExp.clampExp(simFign,simfile,V_clamp,paraKeys,paras,outKeys)
simFign='FigA2F_%s' % sedversion
V_clamp=[-80, 100, 100, -70, 80, 10]
paraKeys=['Clamp_parameters/Cai']
paras=[8.97e-5]
outKeys=['outputs/I_CaT']
clampExp.clampExp(simFign,simfile,V_clamp,paraKeys,paras,outKeys)
simFign='FigA3F_%s' % sedversion
V_clamp=[-90, 50, 50, -50, 80, 10]
paraKeys=['Clamp_parameters/Nai']
paras=[4]
outKeys=['outputs/I_Na']
clampExp.clampExp(simFign,simfile,V_clamp,paraKeys,paras,outKeys)
simFign='FigA4F_%s' % sedversion
V_clamp=[-80, 8000, 8000, -60, 80, 10]
paraKeys=['Clamp_parameters/Ki']
paras=[140]
outKeys=['outputs/I_K1']
clampExp.clampExp(simFign,simfile,V_clamp,paraKeys,paras,outKeys)
simFign='FigA5F_%s' % sedversion
V_clamp=[-80, 8000, 8000, -60, 80, 10]
paraKeys=['Clamp_parameters/Ki']
paras=[140]
outKeys=['outputs/I_K2']
clampExp.clampExp(simFign,simfile,V_clamp,paraKeys,paras,outKeys)
simFign='FigA6F_%s' % sedversion
V_clamp=[-80, 150, 150, -80, 80, 10]
paraKeys=['Clamp_parameters/Ki']
paras=[140]
outKeys=['outputs/I_KA']
clampExp.clampExp(simFign, simfile, V_clamp,paraKeys,paras,outKeys)
simFign='FigA7D_%s' % sedversion
V_clamp=[-10, 3000, 3000, -20, -130, -10]
paraKeys=['Clamp_parameters/Nai','Clamp_parameters/Ki']
paras=[4,140]
outKeys=['outputs/I_h']
clampExp.clampExp(simFign,simfile,V_clamp,paraKeys,paras,outKeys)
simFign='FigA8E_%s' % sedversion
V_clamp=[0, 100, 100, -60, 50, 10]
paraKeys=['Clamp_parameters/Cai']
paras=[8.97e-5]
outKeys=['outputs/I_Cl']
clampExp.clampExp(simFign, simfile, V_clamp,paraKeys,paras,outKeys)
