Location: BG_GPCR_M2_reduced @ f4ab4b068efe / BG_GPCR_M2_reduced_Exported_flat.cellml

Author:
Shelley Fong <sfon036@UoA.auckland.ac.nz>
Date:
2025-04-15 11:41:47+12:00
Desc:
Fixing loc of hyd reaction
Permanent Source URI:
https://staging.physiomeproject.org/workspace/7dd/rawfile/f4ab4b068efe81f542710098cf47dced6ac0705c/BG_GPCR_M2_reduced_Exported_flat.cellml

<?xml version="1.0" encoding="utf-8"?>
<!--
This CellML file was generated on 18/02/2022 at 10:09:40 at AM using:

COR (0.9.31.1409)
Copyright 2002-2022 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk

CellML 1.0 was used to generate this model
http://www.cellml.org/
-->
<model name="individual_GPCR_M2_reduced" cmeta:id="individual_GPCR_M2_reduced" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
   <units xmlns="http://www.cellml.org/cellml/1.0#" name="per_sec">
      <unit units="second" exponent="-1"/>
   </units>
   <units xmlns="http://www.cellml.org/cellml/1.0#" name="J_per_K_per_mol">
      <unit units="joule"/>
      <unit units="kelvin" exponent="-1"/>
      <unit units="mole" exponent="-1"/>
   </units>
   <units xmlns="http://www.cellml.org/cellml/1.0#" name="C_per_mol">
      <unit units="coulomb"/>
      <unit units="mole" exponent="-1"/>
   </units>
   <units xmlns="http://www.cellml.org/cellml/1.0#" name="fmol">
      <unit units="mole" prefix="femto"/>
   </units>
   <units xmlns="http://www.cellml.org/cellml/1.0#" name="fmol_per_L">
      <unit units="mole" prefix="femto"/>
      <unit units="litre" exponent="-1"/>
   </units>
   <units xmlns="http://www.cellml.org/cellml/1.0#" name="fmol_per_L_per_sec">
      <unit units="fmol_per_L"/>
      <unit units="second" exponent="-1"/>
   </units>
   <units xmlns="http://www.cellml.org/cellml/1.0#" name="per_sec_per_fmol_per_L">
      <unit units="second" exponent="-1"/>
      <unit units="fmol_per_L" exponent="-1"/>
   </units>
   <units xmlns="http://www.cellml.org/cellml/1.0#" name="per_fmol">
      <unit units="fmol" exponent="-1"/>
   </units>
   <units xmlns="http://www.cellml.org/cellml/1.0#" name="fmol_per_sec">
      <unit units="fmol"/>
      <unit units="second" exponent="-1"/>
   </units>
   <units xmlns="http://www.cellml.org/cellml/1.0#" name="J_per_mol">
      <unit units="joule"/>
      <unit units="mole" exponent="-1"/>
   </units>
   <units xmlns="http://www.cellml.org/cellml/1.0#" name="mM">
      <unit units="mole" prefix="milli"/>
      <unit units="litre" exponent="-1"/>
   </units>
   <units xmlns="http://www.cellml.org/cellml/1.0#" name="uM">
      <unit units="mole" prefix="micro"/>
      <unit units="litre" exponent="-1"/>
   </units>
   <units xmlns="http://www.cellml.org/cellml/1.0#" name="mM_per_sec">
      <unit units="mM"/>
      <unit units="second" exponent="-1"/>
   </units>
   <units xmlns="http://www.cellml.org/cellml/1.0#" name="uM_per_sec">
      <unit units="uM"/>
      <unit units="second" exponent="-1"/>
   </units>
   <units xmlns="http://www.cellml.org/cellml/1.0#" name="pL">
      <unit units="litre" prefix="pico"/>
   </units>
   <units xmlns="http://www.cellml.org/cellml/1.0#" name="m_to_u">
      <unit units="second" prefix="micro"/>
      <unit units="second" prefix="milli"/>
   </units>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="environment">
      <variable name="time" units="second" public_interface="out"/>
      <variable name="q_RM2_inactive" units="fmol" initial_value="0.00072162" public_interface="out"/>
      <variable name="q_L_RM2_inactive" units="fmol" initial_value="1e-18" public_interface="out"/>
      <variable name="q_LM2" units="fmol" public_interface="out"/>
      <variable name="q_LM2_stim" units="fmol"/>
      <variable name="q_LM2_ode" units="fmol" initial_value="0"/>
      <variable name="q_RM2" units="fmol" initial_value="1e-18" public_interface="out"/>
      <variable name="q_Gi" units="fmol" initial_value="0.00836" public_interface="out"/>
      <variable name="q_RM2_Gi" units="fmol" initial_value="1e-18" public_interface="out"/>
      <variable name="q_L_RM2" units="fmol" initial_value="1e-18" public_interface="out"/>
      <variable name="q_L_RM2_Gi" units="fmol" initial_value="1e-18" public_interface="out"/>
      <variable name="q_Gia_GTP" units="fmol" initial_value="1e-18" public_interface="out"/>
      <variable name="q_Gibetagamma" units="fmol" initial_value="1e-18" public_interface="out"/>
      <variable name="q_Gia_GDP" units="fmol" initial_value="1e-18" public_interface="out"/>
      <variable name="q_GTP" units="fmol" initial_value="2.2" public_interface="out"/>
      <variable name="q_GDP" units="fmol" initial_value="1.1" public_interface="out"/>
      <variable name="q_Pi" units="fmol" initial_value="570" public_interface="out"/>
      <variable name="q_RM2_tag" units="fmol" initial_value="1e-18" public_interface="out"/>
      <variable name="q_L_RM2_tag" units="fmol" initial_value="1e-18" public_interface="out"/>
      <variable name="q_RM2_GRKArr" units="fmol" initial_value="1e-18" public_interface="out"/>
      <variable name="q_L_RM2_GRKArr" units="fmol" initial_value="1e-18" public_interface="out"/>
      <variable name="q_GRKArr" units="fmol" initial_value="1e-18" public_interface="out"/>
      <variable name="stimSt" units="second" initial_value="7e1"/>
      <variable name="stimDur" units="second" initial_value="5e1"/>
      <variable name="tR" units="second" initial_value="5e1"/>
      <variable name="stimMag" units="fmol" initial_value="0e2"/>
      <variable name="stimHolding" units="fmol" initial_value="1e-8"/>
      <variable name="m" units="fmol_per_sec"/>
      <variable name="conserv_R_T" units="fmol"/>
      <variable name="conserv_L_T" units="fmol"/>
      <variable name="conserv_G_T" units="fmol"/>
      <variable name="total_R" units="fmol"/>
      <variable name="v_Rswitch_M2" units="fmol_per_sec" public_interface="in"/>
      <variable name="v_LRswitch_M2" units="fmol_per_sec" public_interface="in"/>
      <variable name="v_C_M2" units="fmol_per_sec" public_interface="in"/>
      <variable name="v_R_M2" units="fmol_per_sec" public_interface="in"/>
      <variable name="v_L_M2" units="fmol_per_sec" public_interface="in"/>
      <variable name="v_Act1_Gi" units="fmol_per_sec" public_interface="in"/>
      <variable name="v_Act2_Gi" units="fmol_per_sec" public_interface="in"/>
      <variable name="v_Hyd_Gi" units="fmol_per_sec" public_interface="in"/>
      <variable name="v_Reassoc_Gi" units="fmol_per_sec" public_interface="in"/>
      <variable name="v_InternR_M2" units="fmol_per_sec" public_interface="in"/>
      <variable name="v_InternLR_M2" units="fmol_per_sec" public_interface="in"/>
      <variable name="v_Rsynthesis" units="fmol_per_sec"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>m</ci>
            <apply>
               <divide/>
               <ci>stimMag</ci>
               <ci>tR</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>q_LM2_stim</ci>
            <piecewise>
               <piece>
                  <apply>
                     <plus/>
                     <ci>stimHolding</ci>
                     <apply>
                        <times/>
                        <ci>m</ci>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <ci>time</ci>
                              <ci>stimSt</ci>
                           </apply>
                           <ci>tR</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <and/>
                     <apply>
                        <lt/>
                        <ci>time</ci>
                        <ci>stimSt</ci>
                     </apply>
                     <apply>
                        <gt/>
                        <ci>time</ci>
                        <apply>
                           <minus/>
                           <ci>stimSt</ci>
                           <ci>tR</ci>
                        </apply>
                     </apply>
                  </apply>
               </piece>
               <piece>
                  <apply>
                     <plus/>
                     <ci>stimMag</ci>
                     <ci>stimHolding</ci>
                  </apply>
                  <apply>
                     <and/>
                     <apply>
                        <geq/>
                        <ci>time</ci>
                        <ci>stimSt</ci>
                     </apply>
                     <apply>
                        <lt/>
                        <ci>time</ci>
                        <apply>
                           <plus/>
                           <ci>stimSt</ci>
                           <ci>stimDur</ci>
                        </apply>
                     </apply>
                  </apply>
               </piece>
               <piece>
                  <apply>
                     <plus/>
                     <ci>stimHolding</ci>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <ci>m</ci>
                        </apply>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <ci>time</ci>
                                 <ci>stimSt</ci>
                              </apply>
                              <ci>tR</ci>
                           </apply>
                           <ci>stimDur</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <and/>
                     <apply>
                        <lt/>
                        <ci>time</ci>
                        <apply>
                           <plus/>
                           <ci>stimSt</ci>
                           <ci>tR</ci>
                           <ci>stimDur</ci>
                        </apply>
                     </apply>
                     <apply>
                        <geq/>
                        <ci>time</ci>
                        <apply>
                           <plus/>
                           <ci>stimSt</ci>
                           <ci>stimDur</ci>
                        </apply>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <ci>stimHolding</ci>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>conserv_R_T</ci>
            <apply>
               <plus/>
               <ci>q_RM2_inactive</ci>
               <ci>q_L_RM2_inactive</ci>
               <ci>q_RM2</ci>
               <ci>q_RM2_Gi</ci>
               <ci>q_L_RM2</ci>
               <ci>q_L_RM2_Gi</ci>
               <ci>q_RM2_tag</ci>
               <ci>q_L_RM2_tag</ci>
               <ci>q_RM2_GRKArr</ci>
               <ci>q_L_RM2_GRKArr</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>total_R</ci>
            <apply>
               <plus/>
               <ci>q_RM2_inactive</ci>
               <ci>q_L_RM2_inactive</ci>
               <ci>q_RM2</ci>
               <ci>q_RM2_Gi</ci>
               <ci>q_L_RM2</ci>
               <ci>q_L_RM2_Gi</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>conserv_L_T</ci>
            <apply>
               <plus/>
               <ci>q_L_RM2_inactive</ci>
               <ci>q_LM2</ci>
               <ci>q_L_RM2</ci>
               <ci>q_L_RM2_Gi</ci>
               <ci>q_L_RM2_tag</ci>
               <ci>q_L_RM2_GRKArr</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>conserv_G_T</ci>
            <apply>
               <plus/>
               <ci>q_Gi</ci>
               <ci>q_RM2_Gi</ci>
               <ci>q_L_RM2_Gi</ci>
               <ci>q_Gia_GTP</ci>
               <ci>q_Gia_GDP</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>v_Rsynthesis</ci>
            <apply>
               <plus/>
               <ci>v_C_M2</ci>
               <ci>v_L_M2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>q_RM2_inactive</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <ci>v_Rswitch_M2</ci>
               </apply>
               <ci>v_L_M2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>q_L_RM2_inactive</ci>
            </apply>
            <apply>
               <minus/>
               <ci>v_LRswitch_M2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>q_LM2_stim</ci>
            </apply>
            <apply>
               <minus/>
               <ci>v_L_M2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>q_RM2</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <ci>v_Rswitch_M2</ci>
                  <ci>v_C_M2</ci>
               </apply>
               <apply>
                  <times/>
                  <cn cellml:units="dimensionless">1</cn>
                  <ci>v_Rsynthesis</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>q_Gi</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <ci>v_C_M2</ci>
                  </apply>
                  <ci>v_R_M2</ci>
               </apply>
               <ci>v_Reassoc_Gi</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>q_RM2_Gi</ci>
            </apply>
            <apply>
               <minus/>
               <ci>v_C_M2</ci>
               <ci>v_Act1_Gi</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>q_L_RM2</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <ci>v_LRswitch_M2</ci>
                  <ci>v_R_M2</ci>
               </apply>
               <ci>v_L_M2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>q_L_RM2_Gi</ci>
            </apply>
            <apply>
               <minus/>
               <ci>v_R_M2</ci>
               <ci>v_Act2_Gi</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>q_Gia_GTP</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>v_Act1_Gi</ci>
                  <ci>v_Act2_Gi</ci>
               </apply>
               <ci>v_Hyd_Gi</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>q_Gibetagamma</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>v_Act1_Gi</ci>
                  <ci>v_Act2_Gi</ci>
               </apply>
               <ci>v_Reassoc_Gi</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>q_Gia_GDP</ci>
            </apply>
            <apply>
               <minus/>
               <ci>v_Hyd_Gi</ci>
               <ci>v_Reassoc_Gi</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>q_GTP</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <ci>v_Act1_Gi</ci>
               </apply>
               <ci>v_Act2_Gi</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>q_GDP</ci>
            </apply>
            <apply>
               <plus/>
               <ci>v_Act1_Gi</ci>
               <ci>v_Act2_Gi</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>q_Pi</ci>
            </apply>
            <ci>v_Hyd_Gi</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>q_RM2_tag</ci>
            </apply>
            <apply>
               <minus/>
               <ci>v_Act1_Gi</ci>
               <ci>v_InternR_M2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>q_L_RM2_tag</ci>
            </apply>
            <apply>
               <minus/>
               <ci>v_Act2_Gi</ci>
               <ci>v_InternLR_M2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>q_RM2_GRKArr</ci>
            </apply>
            <ci>v_InternR_M2</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>q_L_RM2_GRKArr</ci>
            </apply>
            <ci>v_InternLR_M2</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>q_GRKArr</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <ci>v_InternR_M2</ci>
               </apply>
               <ci>v_InternLR_M2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>q_LM2</ci>
            <apply>
               <plus/>
               <ci>q_LM2_stim</ci>
               <ci>q_LM2_ode</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="GPCR_M2_reduced_parameters">
      <variable name="kappa_Rswitch_M2" units="fmol_per_sec" initial_value="77.8337" public_interface="out"/>
      <variable name="kappa_LRswitch_M2" units="fmol_per_sec" initial_value="0.00321972" public_interface="out"/>
      <variable name="kappa_C_M2" units="fmol_per_sec" initial_value="4441.42" public_interface="out"/>
      <variable name="kappa_R_M2" units="fmol_per_sec" initial_value="183727" public_interface="out"/>
      <variable name="kappa_L_M2" units="fmol_per_sec" initial_value="0.0354169" public_interface="out"/>
      <variable name="kappa_Act1_Gi" units="fmol_per_sec" initial_value="0.00199813" public_interface="out"/>
      <variable name="kappa_Act2_Gi" units="fmol_per_sec" initial_value="1.08204" public_interface="out"/>
      <variable name="kappa_Hyd_Gi" units="fmol_per_sec" initial_value="0.604042" public_interface="out"/>
      <variable name="kappa_Reassoc_Gi" units="fmol_per_sec" initial_value="0.0057063" public_interface="out"/>
      <variable name="kappa_InternR_M2" units="fmol_per_sec" initial_value="0.00590542" public_interface="out"/>
      <variable name="kappa_InternLR_M2" units="fmol_per_sec" initial_value="3.19794" public_interface="out"/>
      <variable name="K_RM2_inactive" units="per_fmol" initial_value="3.73486" public_interface="out"/>
      <variable name="K_L_RM2_inactive" units="per_fmol" initial_value="90286.7" public_interface="out"/>
      <variable name="K_LM2" units="per_fmol" initial_value="63.8849" public_interface="out"/>
      <variable name="K_RM2" units="per_fmol" initial_value="0.0373486" public_interface="out"/>
      <variable name="K_Gi" units="per_fmol" initial_value="0.0509433" public_interface="out"/>
      <variable name="K_RM2_Gi" units="per_fmol" initial_value="1.96354" public_interface="out"/>
      <variable name="K_L_RM2" units="per_fmol" initial_value="0.000902867" public_interface="out"/>
      <variable name="K_L_RM2_Gi" units="per_fmol" initial_value="0.00362594" public_interface="out"/>
      <variable name="K_Gia_GTP" units="per_fmol" initial_value="0.0385003" public_interface="out"/>
      <variable name="K_Gibetagamma" units="per_fmol" initial_value="19.8214" public_interface="out"/>
      <variable name="K_Gia_GDP" units="per_fmol" initial_value="9.04022" public_interface="out"/>
      <variable name="K_GTP" units="per_fmol" initial_value="0.538466" public_interface="out"/>
      <variable name="K_GDP" units="per_fmol" initial_value="3.39308e-6" public_interface="out"/>
      <variable name="K_Pi" units="per_fmol" initial_value="1.54752e-6" public_interface="out"/>
      <variable name="K_RM2_tag" units="per_fmol" initial_value="1.38022" public_interface="out"/>
      <variable name="K_L_RM2_tag" units="per_fmol" initial_value="0.00254876" public_interface="out"/>
      <variable name="K_RM2_GRKArr" units="per_fmol" initial_value="0.000492256" public_interface="out"/>
      <variable name="K_L_RM2_GRKArr" units="per_fmol" initial_value="9.09015e-7" public_interface="out"/>
      <variable name="K_GRKArr" units="per_fmol" initial_value="1036.77" public_interface="out"/>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="GPCR_M2_reduced">
      <variable name="time" units="second" public_interface="in"/>
      <variable name="R" units="J_per_K_per_mol" public_interface="in"/>
      <variable name="T" units="kelvin" public_interface="in"/>
      <variable name="kappa_Rswitch_M2" units="fmol_per_sec" public_interface="in"/>
      <variable name="kappa_LRswitch_M2" units="fmol_per_sec" public_interface="in"/>
      <variable name="kappa_C_M2" units="fmol_per_sec" public_interface="in"/>
      <variable name="kappa_R_M2" units="fmol_per_sec" public_interface="in"/>
      <variable name="kappa_L_M2" units="fmol_per_sec" public_interface="in"/>
      <variable name="kappa_Act1_Gi" units="fmol_per_sec" public_interface="in"/>
      <variable name="kappa_Act2_Gi" units="fmol_per_sec" public_interface="in"/>
      <variable name="kappa_Hyd_Gi" units="fmol_per_sec" public_interface="in"/>
      <variable name="kappa_Reassoc_Gi" units="fmol_per_sec" public_interface="in"/>
      <variable name="kappa_InternR_M2" units="fmol_per_sec" public_interface="in"/>
      <variable name="kappa_InternLR_M2" units="fmol_per_sec" public_interface="in"/>
      <variable name="K_RM2_inactive" units="per_fmol" public_interface="in"/>
      <variable name="K_L_RM2_inactive" units="per_fmol" public_interface="in"/>
      <variable name="K_LM2" units="per_fmol" public_interface="in"/>
      <variable name="K_RM2" units="per_fmol" public_interface="in"/>
      <variable name="K_Gi" units="per_fmol" public_interface="in"/>
      <variable name="K_RM2_Gi" units="per_fmol" public_interface="in"/>
      <variable name="K_L_RM2" units="per_fmol" public_interface="in"/>
      <variable name="K_L_RM2_Gi" units="per_fmol" public_interface="in"/>
      <variable name="K_Gia_GTP" units="per_fmol" public_interface="in"/>
      <variable name="K_Gibetagamma" units="per_fmol" public_interface="in"/>
      <variable name="K_Gia_GDP" units="per_fmol" public_interface="in"/>
      <variable name="K_GTP" units="per_fmol" public_interface="in"/>
      <variable name="K_GDP" units="per_fmol" public_interface="in"/>
      <variable name="K_Pi" units="per_fmol" public_interface="in"/>
      <variable name="K_RM2_tag" units="per_fmol" public_interface="in"/>
      <variable name="K_L_RM2_tag" units="per_fmol" public_interface="in"/>
      <variable name="K_RM2_GRKArr" units="per_fmol" public_interface="in"/>
      <variable name="K_L_RM2_GRKArr" units="per_fmol" public_interface="in"/>
      <variable name="K_GRKArr" units="per_fmol" public_interface="in"/>
      <variable name="q_RM2_inactive" units="fmol" public_interface="in"/>
      <variable name="q_L_RM2_inactive" units="fmol" public_interface="in"/>
      <variable name="q_LM2" units="fmol" public_interface="in"/>
      <variable name="q_RM2" units="fmol" public_interface="in"/>
      <variable name="q_Gi" units="fmol" public_interface="in"/>
      <variable name="q_RM2_Gi" units="fmol" public_interface="in"/>
      <variable name="q_L_RM2" units="fmol" public_interface="in"/>
      <variable name="q_L_RM2_Gi" units="fmol" public_interface="in"/>
      <variable name="q_Gia_GTP" units="fmol" public_interface="in"/>
      <variable name="q_Gibetagamma" units="fmol" public_interface="in"/>
      <variable name="q_Gia_GDP" units="fmol" public_interface="in"/>
      <variable name="q_GTP" units="fmol" public_interface="in"/>
      <variable name="q_GDP" units="fmol" public_interface="in"/>
      <variable name="q_Pi" units="fmol" public_interface="in"/>
      <variable name="q_RM2_tag" units="fmol" public_interface="in"/>
      <variable name="q_L_RM2_tag" units="fmol" public_interface="in"/>
      <variable name="q_RM2_GRKArr" units="fmol" public_interface="in"/>
      <variable name="q_L_RM2_GRKArr" units="fmol" public_interface="in"/>
      <variable name="q_GRKArr" units="fmol" public_interface="in"/>
      <variable name="mu_RM2_inactive" units="J_per_mol"/>
      <variable name="mu_L_RM2_inactive" units="J_per_mol"/>
      <variable name="mu_LM2" units="J_per_mol"/>
      <variable name="mu_RM2" units="J_per_mol"/>
      <variable name="mu_Gi" units="J_per_mol"/>
      <variable name="mu_RM2_Gi" units="J_per_mol"/>
      <variable name="mu_L_RM2" units="J_per_mol"/>
      <variable name="mu_L_RM2_Gi" units="J_per_mol"/>
      <variable name="mu_Gia_GTP" units="J_per_mol"/>
      <variable name="mu_Gibetagamma" units="J_per_mol"/>
      <variable name="mu_Gia_GDP" units="J_per_mol"/>
      <variable name="mu_GTP" units="J_per_mol"/>
      <variable name="mu_GDP" units="J_per_mol"/>
      <variable name="mu_Pi" units="J_per_mol"/>
      <variable name="mu_RM2_tag" units="J_per_mol"/>
      <variable name="mu_L_RM2_tag" units="J_per_mol"/>
      <variable name="mu_RM2_GRKArr" units="J_per_mol"/>
      <variable name="mu_L_RM2_GRKArr" units="J_per_mol"/>
      <variable name="mu_GRKArr" units="J_per_mol"/>
      <variable name="v_Rswitch_M2" units="fmol_per_sec" public_interface="out"/>
      <variable name="v_LRswitch_M2" units="fmol_per_sec" public_interface="out"/>
      <variable name="v_C_M2" units="fmol_per_sec" public_interface="out"/>
      <variable name="v_R_M2" units="fmol_per_sec" public_interface="out"/>
      <variable name="v_L_M2" units="fmol_per_sec" public_interface="out"/>
      <variable name="v_Act1_Gi" units="fmol_per_sec" public_interface="out"/>
      <variable name="v_Act2_Gi" units="fmol_per_sec" public_interface="out"/>
      <variable name="v_Hyd_Gi" units="fmol_per_sec" public_interface="out"/>
      <variable name="v_Reassoc_Gi" units="fmol_per_sec" public_interface="out"/>
      <variable name="v_InternR_M2" units="fmol_per_sec" public_interface="out"/>
      <variable name="v_InternLR_M2" units="fmol_per_sec" public_interface="out"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>mu_RM2_inactive</ci>
            <apply>
               <times/>
               <ci>R</ci>
               <ci>T</ci>
               <apply>
                  <ln/>
                  <apply>
                     <times/>
                     <ci>K_RM2_inactive</ci>
                     <ci>q_RM2_inactive</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>mu_L_RM2_inactive</ci>
            <apply>
               <times/>
               <ci>R</ci>
               <ci>T</ci>
               <apply>
                  <ln/>
                  <apply>
                     <times/>
                     <ci>K_L_RM2_inactive</ci>
                     <ci>q_L_RM2_inactive</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>mu_LM2</ci>
            <apply>
               <times/>
               <ci>R</ci>
               <ci>T</ci>
               <apply>
                  <ln/>
                  <apply>
                     <times/>
                     <ci>K_LM2</ci>
                     <ci>q_LM2</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>mu_RM2</ci>
            <apply>
               <times/>
               <ci>R</ci>
               <ci>T</ci>
               <apply>
                  <ln/>
                  <apply>
                     <times/>
                     <ci>K_RM2</ci>
                     <ci>q_RM2</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>mu_Gi</ci>
            <apply>
               <times/>
               <ci>R</ci>
               <ci>T</ci>
               <apply>
                  <ln/>
                  <apply>
                     <times/>
                     <ci>K_Gi</ci>
                     <ci>q_Gi</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>mu_RM2_Gi</ci>
            <apply>
               <times/>
               <ci>R</ci>
               <ci>T</ci>
               <apply>
                  <ln/>
                  <apply>
                     <times/>
                     <ci>K_RM2_Gi</ci>
                     <ci>q_RM2_Gi</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>mu_L_RM2</ci>
            <apply>
               <times/>
               <ci>R</ci>
               <ci>T</ci>
               <apply>
                  <ln/>
                  <apply>
                     <times/>
                     <ci>K_L_RM2</ci>
                     <ci>q_L_RM2</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>mu_L_RM2_Gi</ci>
            <apply>
               <times/>
               <ci>R</ci>
               <ci>T</ci>
               <apply>
                  <ln/>
                  <apply>
                     <times/>
                     <ci>K_L_RM2_Gi</ci>
                     <ci>q_L_RM2_Gi</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>mu_Gia_GTP</ci>
            <apply>
               <times/>
               <ci>R</ci>
               <ci>T</ci>
               <apply>
                  <ln/>
                  <apply>
                     <times/>
                     <ci>K_Gia_GTP</ci>
                     <ci>q_Gia_GTP</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>mu_Gibetagamma</ci>
            <apply>
               <times/>
               <ci>R</ci>
               <ci>T</ci>
               <apply>
                  <ln/>
                  <apply>
                     <times/>
                     <ci>K_Gibetagamma</ci>
                     <ci>q_Gibetagamma</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>mu_Gia_GDP</ci>
            <apply>
               <times/>
               <ci>R</ci>
               <ci>T</ci>
               <apply>
                  <ln/>
                  <apply>
                     <times/>
                     <ci>K_Gia_GDP</ci>
                     <ci>q_Gia_GDP</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>mu_GTP</ci>
            <apply>
               <times/>
               <ci>R</ci>
               <ci>T</ci>
               <apply>
                  <ln/>
                  <apply>
                     <times/>
                     <ci>K_GTP</ci>
                     <ci>q_GTP</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>mu_GDP</ci>
            <apply>
               <times/>
               <ci>R</ci>
               <ci>T</ci>
               <apply>
                  <ln/>
                  <apply>
                     <times/>
                     <ci>K_GDP</ci>
                     <ci>q_GDP</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>mu_Pi</ci>
            <apply>
               <times/>
               <ci>R</ci>
               <ci>T</ci>
               <apply>
                  <ln/>
                  <apply>
                     <times/>
                     <ci>K_Pi</ci>
                     <ci>q_Pi</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>mu_RM2_tag</ci>
            <apply>
               <times/>
               <ci>R</ci>
               <ci>T</ci>
               <apply>
                  <ln/>
                  <apply>
                     <times/>
                     <ci>K_RM2_tag</ci>
                     <ci>q_RM2_tag</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>mu_L_RM2_tag</ci>
            <apply>
               <times/>
               <ci>R</ci>
               <ci>T</ci>
               <apply>
                  <ln/>
                  <apply>
                     <times/>
                     <ci>K_L_RM2_tag</ci>
                     <ci>q_L_RM2_tag</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>mu_RM2_GRKArr</ci>
            <apply>
               <times/>
               <ci>R</ci>
               <ci>T</ci>
               <apply>
                  <ln/>
                  <apply>
                     <times/>
                     <ci>K_RM2_GRKArr</ci>
                     <ci>q_RM2_GRKArr</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>mu_L_RM2_GRKArr</ci>
            <apply>
               <times/>
               <ci>R</ci>
               <ci>T</ci>
               <apply>
                  <ln/>
                  <apply>
                     <times/>
                     <ci>K_L_RM2_GRKArr</ci>
                     <ci>q_L_RM2_GRKArr</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>mu_GRKArr</ci>
            <apply>
               <times/>
               <ci>R</ci>
               <ci>T</ci>
               <apply>
                  <ln/>
                  <apply>
                     <times/>
                     <ci>K_GRKArr</ci>
                     <ci>q_GRKArr</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>v_Rswitch_M2</ci>
            <apply>
               <times/>
               <ci>kappa_Rswitch_M2</ci>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <ci>mu_RM2_inactive</ci>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <ci>mu_RM2</ci>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>v_LRswitch_M2</ci>
            <apply>
               <times/>
               <ci>kappa_LRswitch_M2</ci>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <ci>mu_L_RM2_inactive</ci>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <ci>mu_L_RM2</ci>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>v_C_M2</ci>
            <apply>
               <times/>
               <ci>kappa_C_M2</ci>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>mu_RM2</ci>
                           <ci>mu_Gi</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <ci>mu_RM2_Gi</ci>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>v_R_M2</ci>
            <apply>
               <times/>
               <ci>kappa_R_M2</ci>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>mu_L_RM2</ci>
                           <ci>mu_Gi</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <ci>mu_L_RM2_Gi</ci>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>v_L_M2</ci>
            <apply>
               <times/>
               <ci>kappa_L_M2</ci>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>mu_RM2_inactive</ci>
                           <ci>mu_LM2</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <ci>mu_L_RM2_inactive</ci>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>v_Act1_Gi</ci>
            <apply>
               <times/>
               <ci>kappa_Act1_Gi</ci>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>mu_RM2_Gi</ci>
                           <ci>mu_GTP</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>mu_Gia_GTP</ci>
                           <ci>mu_Gibetagamma</ci>
                           <ci>mu_RM2_tag</ci>
                           <ci>mu_GDP</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>v_Act2_Gi</ci>
            <apply>
               <times/>
               <ci>kappa_Act2_Gi</ci>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>mu_L_RM2_Gi</ci>
                           <ci>mu_GTP</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>mu_Gia_GTP</ci>
                           <ci>mu_Gibetagamma</ci>
                           <ci>mu_L_RM2_tag</ci>
                           <ci>mu_GDP</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>v_Hyd_Gi</ci>
            <apply>
               <times/>
               <ci>kappa_Hyd_Gi</ci>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <ci>mu_Gia_GTP</ci>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>mu_Gia_GDP</ci>
                           <ci>mu_Pi</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>v_Reassoc_Gi</ci>
            <apply>
               <times/>
               <ci>kappa_Reassoc_Gi</ci>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>mu_Gia_GDP</ci>
                           <ci>mu_Gibetagamma</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <ci>mu_Gi</ci>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>v_InternR_M2</ci>
            <apply>
               <times/>
               <ci>kappa_InternR_M2</ci>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>mu_RM2_tag</ci>
                           <ci>mu_GRKArr</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <ci>mu_RM2_GRKArr</ci>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>v_InternLR_M2</ci>
            <apply>
               <times/>
               <ci>kappa_InternLR_M2</ci>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>mu_L_RM2_tag</ci>
                           <ci>mu_GRKArr</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <ci>mu_L_RM2_GRKArr</ci>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="constants">
      <variable name="R" units="J_per_K_per_mol" initial_value="8.31" public_interface="out"/>
      <variable name="T" units="kelvin" initial_value="310" public_interface="out"/>
      <variable name="F" units="C_per_mol" initial_value="96485" public_interface="out"/>
   </component>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="environment" component_2="GPCR_M2_reduced"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="q_RM2_inactive" variable_2="q_RM2_inactive"/>
      <map_variables variable_1="q_L_RM2_inactive" variable_2="q_L_RM2_inactive"/>
      <map_variables variable_1="q_LM2" variable_2="q_LM2"/>
      <map_variables variable_1="q_RM2" variable_2="q_RM2"/>
      <map_variables variable_1="q_Gi" variable_2="q_Gi"/>
      <map_variables variable_1="q_RM2_Gi" variable_2="q_RM2_Gi"/>
      <map_variables variable_1="q_L_RM2" variable_2="q_L_RM2"/>
      <map_variables variable_1="q_L_RM2_Gi" variable_2="q_L_RM2_Gi"/>
      <map_variables variable_1="q_Gia_GTP" variable_2="q_Gia_GTP"/>
      <map_variables variable_1="q_Gibetagamma" variable_2="q_Gibetagamma"/>
      <map_variables variable_1="q_Gia_GDP" variable_2="q_Gia_GDP"/>
      <map_variables variable_1="q_GTP" variable_2="q_GTP"/>
      <map_variables variable_1="q_GDP" variable_2="q_GDP"/>
      <map_variables variable_1="q_Pi" variable_2="q_Pi"/>
      <map_variables variable_1="q_RM2_tag" variable_2="q_RM2_tag"/>
      <map_variables variable_1="q_L_RM2_tag" variable_2="q_L_RM2_tag"/>
      <map_variables variable_1="q_RM2_GRKArr" variable_2="q_RM2_GRKArr"/>
      <map_variables variable_1="q_L_RM2_GRKArr" variable_2="q_L_RM2_GRKArr"/>
      <map_variables variable_1="q_GRKArr" variable_2="q_GRKArr"/>
      <map_variables variable_1="v_Rswitch_M2" variable_2="v_Rswitch_M2"/>
      <map_variables variable_1="v_LRswitch_M2" variable_2="v_LRswitch_M2"/>
      <map_variables variable_1="v_C_M2" variable_2="v_C_M2"/>
      <map_variables variable_1="v_R_M2" variable_2="v_R_M2"/>
      <map_variables variable_1="v_L_M2" variable_2="v_L_M2"/>
      <map_variables variable_1="v_Act1_Gi" variable_2="v_Act1_Gi"/>
      <map_variables variable_1="v_Act2_Gi" variable_2="v_Act2_Gi"/>
      <map_variables variable_1="v_Hyd_Gi" variable_2="v_Hyd_Gi"/>
      <map_variables variable_1="v_Reassoc_Gi" variable_2="v_Reassoc_Gi"/>
      <map_variables variable_1="v_InternR_M2" variable_2="v_InternR_M2"/>
      <map_variables variable_1="v_InternLR_M2" variable_2="v_InternLR_M2"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="GPCR_M2_reduced" component_2="GPCR_M2_reduced_parameters"/>
      <map_variables variable_1="kappa_Rswitch_M2" variable_2="kappa_Rswitch_M2"/>
      <map_variables variable_1="kappa_LRswitch_M2" variable_2="kappa_LRswitch_M2"/>
      <map_variables variable_1="kappa_C_M2" variable_2="kappa_C_M2"/>
      <map_variables variable_1="kappa_R_M2" variable_2="kappa_R_M2"/>
      <map_variables variable_1="kappa_L_M2" variable_2="kappa_L_M2"/>
      <map_variables variable_1="kappa_Act1_Gi" variable_2="kappa_Act1_Gi"/>
      <map_variables variable_1="kappa_Act2_Gi" variable_2="kappa_Act2_Gi"/>
      <map_variables variable_1="kappa_Hyd_Gi" variable_2="kappa_Hyd_Gi"/>
      <map_variables variable_1="kappa_Reassoc_Gi" variable_2="kappa_Reassoc_Gi"/>
      <map_variables variable_1="kappa_InternR_M2" variable_2="kappa_InternR_M2"/>
      <map_variables variable_1="kappa_InternLR_M2" variable_2="kappa_InternLR_M2"/>
      <map_variables variable_1="K_RM2_inactive" variable_2="K_RM2_inactive"/>
      <map_variables variable_1="K_L_RM2_inactive" variable_2="K_L_RM2_inactive"/>
      <map_variables variable_1="K_LM2" variable_2="K_LM2"/>
      <map_variables variable_1="K_RM2" variable_2="K_RM2"/>
      <map_variables variable_1="K_Gi" variable_2="K_Gi"/>
      <map_variables variable_1="K_RM2_Gi" variable_2="K_RM2_Gi"/>
      <map_variables variable_1="K_L_RM2" variable_2="K_L_RM2"/>
      <map_variables variable_1="K_L_RM2_Gi" variable_2="K_L_RM2_Gi"/>
      <map_variables variable_1="K_Gia_GTP" variable_2="K_Gia_GTP"/>
      <map_variables variable_1="K_Gibetagamma" variable_2="K_Gibetagamma"/>
      <map_variables variable_1="K_Gia_GDP" variable_2="K_Gia_GDP"/>
      <map_variables variable_1="K_GTP" variable_2="K_GTP"/>
      <map_variables variable_1="K_GDP" variable_2="K_GDP"/>
      <map_variables variable_1="K_Pi" variable_2="K_Pi"/>
      <map_variables variable_1="K_RM2_tag" variable_2="K_RM2_tag"/>
      <map_variables variable_1="K_L_RM2_tag" variable_2="K_L_RM2_tag"/>
      <map_variables variable_1="K_RM2_GRKArr" variable_2="K_RM2_GRKArr"/>
      <map_variables variable_1="K_L_RM2_GRKArr" variable_2="K_L_RM2_GRKArr"/>
      <map_variables variable_1="K_GRKArr" variable_2="K_GRKArr"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="constants" component_2="GPCR_M2_reduced"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
   </connection>
</model>