- Author:
- neilstephen2001 <npar276@aucklanduni.ac.nz>
- Date:
- 2021-01-25 22:52:44+13:00
- Desc:
- modifying composite annotations
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/7f1/rawfile/7d5ca2e12d0bc02157edc09f42bdb2415c90c5cc/fridlyand_tamarina_philipson_2003/model/fridlyand_tamarina_philipson_2003.rdf
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:semsim="http://www.bhi.washington.edu/SemSim#"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bqmodel="http://biomodels.net/model-qualifiers/"
xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current.n">
<dcterms:description>gating variable of voltage-dependent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_calcium_exchanger.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#SERCA_pump.Jer_p">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>calcium uptake of the endoplasmic reticulum by SERCA pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#calcium_and_sodium_dynamics.i_CRAN">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>calcium release-activated nonselective cation current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#membrane.Cm">
<dcterms:description>membrane capacitance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#ATP_dependent_potassium_current.Kdd">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#entity_4">
<bqbiol:isPartOf>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#entity_1">
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:85704"/>
</rdf:Description>
</bqbiol:isPartOf>
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:66835"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#ATP_dependent_potassium_current.Ktt">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_4"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_current.i_Na">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>inward sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.f1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_current_p_Na_gate.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.Nao">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#entity_2">
<bqbiol:isPartOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_1"/>
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:70022"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#cell_and_external_parameters.Ko">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_2"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current.Ko">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_2"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_current.Nai">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#entity_0">
<bqbiol:isPartOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_1"/>
<bqbiol:is rdf:resource="http://identifiers.org/go/GO:0005829"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#nonselective_cation_current.CaER">
<bqbiol:isPropertyOf>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#entity_3">
<bqbiol:isPartOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_1"/>
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:63842"/>
</rdf:Description>
</bqbiol:isPropertyOf>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of calcium in endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#SERCA_pump.Cai">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of free intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#nonselective_cation_current.V_CRAN">
<dcterms:description>reversal potential of calcium release-activated nonselective cation current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#nonselective_cation_current.gm_CRAN">
<dcterms:description>maximum conductance coefficient of calcium release-activated nonselective cation current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#CaER_mobilisation.O_infinity">
<dcterms:description>fraction of open IP3-activated calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_current.p_Na">
<dcterms:description>current-voltage relationship of sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current.i_KDr">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>delayed rectifier potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.f2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current_n_gate.n">
<dcterms:description>gating variable of voltage-dependent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.Ko">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_2"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_current_p_Na_gate.p_Na">
<dcterms:description>current-voltage relationship of sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#calcium_and_sodium_dynamics.i_VCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>voltage-dependent calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#whole_cell_calcium_current.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.b5_">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current.gm_KDr">
<dcterms:description>maximum conductance of delayed rectifier potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#whole_cell_calcium_current.Cao">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_2"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of free extracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#PM_calcium_pumps.K_Cap">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>half-maximal pump activity of plasma membrane calcium pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_calcium_exchanger.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#membrane.i_NaCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-calcium exchange current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#ATP_dependent_potassium_current.ATPi">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of cytosolic ATP</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#ATP_homeostasis.ATPi">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of cytosolic ATP</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#cell_and_external_parameters.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_calcium_exchanger.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#PM_calcium_pumps.Cai">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of free intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#nonselective_cation_current.P_CRAN">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>reversal potential of non-selective cation current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#membrane.i_KATP">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>ATP-dependent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#ATP_dependent_potassium_current.ADPi">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of cytosolic ADP</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.F1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#SERCA_pump.K_Carp">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>half maximal pump activity of SERCA pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#membrane.i_Ca_pump">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>plasma membrane calcium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#calcium_dependent_potassium_current_fCa_gate.fCa">
<dcterms:description>voltage-independent component of calcium-dependent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current_n_gate.Sn">
<dcterms:description>slope at half-maximal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.B6">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#calcium_and_sodium_dynamics.fer">
<dcterms:description>fraction of free calcium in endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#calcium_and_sodium_dynamics.Vi">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_4"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
<dcterms:description>intracellular volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#whole_cell_calcium_current_p_VCa_gate.K_Cah">
<dcterms:description>slope of voltage-dependent calcium current at half-maximum potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#calcium_and_sodium_dynamics.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.b5">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#membrane.i_NaK">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-potassium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#IP3_metabolism.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#calcium_and_sodium_dynamics.fi">
<dcterms:description>fraction of free calcium in cytoplasm</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#calcium_dependent_potassium_current.Cai">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of free intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#cell_and_external_parameters.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#ATP_homeostasis.ADPi">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of cytosolic ADP</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#cell_and_external_parameters.Nao">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_2"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.b6">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#calcium_and_sodium_dynamics.Ver">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_3"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
<dcterms:description>volume of endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_current.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#calcium_dependent_potassium_current.V_K">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#environment.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current_n_gate.a">
<dcterms:description>adjustable coefficient</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#CaER_mobilisation.P_IP3">
<dcterms:description>maximum endoplasmic reticulum calcium permeability through open IP3-activated channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#CaER_mobilisation.IP3i">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of cytosolic IP3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.f5_">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_calcium_exchanger.Nao">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_2"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#cell_and_external_parameters.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.B4">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.b3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_calcium_exchanger.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#ATP_dependent_potassium_current.V_K">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#calcium_and_sodium_dynamics.i_NaCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-calcium exchange current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#calcium_dependent_potassium_current.fCa">
<dcterms:description>voltage-independent component of calcium-dependent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#calcium_dependent_potassium_current_fCa_gate.K_KCa">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>affinity constant of voltage-dependent small conductance calcium-activated potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_calcium_exchanger.Cao">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_2"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of free extracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#ATP_dependent_potassium_current.O_KATP">
<dcterms:description>fraction of ATP-sensitive potassium channels open</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current.Ki">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#cell_and_external_parameters.Ki">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_calcium_exchanger.V_NaCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>reversal potential of sodium-calcium exchanger</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#ATP_dependent_potassium_current.i_KATP">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>ATP-dependent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current.V_K">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#nonselective_cation_current.K_Car">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_3"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>half-activation endoplasmic reticulum calcium concentration level of calcium release-activated nonselective cation current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.b4">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#ATP_homeostasis.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#cell_and_external_parameters.Cao">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_2"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of free extracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#whole_cell_calcium_current.Cai">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of free intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#ATP_dependent_potassium_current.Ktd">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_4"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#membrane.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#calcium_and_sodium_dynamics.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.B2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#ATP_homeostasis.i_CRAN">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>calcium release-activated nonselective cation current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#CaER_mobilisation.J_out">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>calcium leak current out of the endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.b1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#ATP_homeostasis.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#CaER_mobilisation.K_IP3">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_4"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>affinity constant of intracellular IP3 to IP3 receptor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#whole_cell_calcium_current.i_VCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>voltage-dependent calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#IP3_metabolism.kdIP">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>IP3 degradation rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#membrane.i_CRAN">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>calcium release-activated nonselective cation current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.b2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.B3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#CaER_mobilisation.K_RCa">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>affinity constant of intracellular calcium to IP3 receptor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_current.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_calcium_exchanger.g_NaCa">
<dcterms:description>maximum conductance of sodium-calcium exchange current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#calcium_and_sodium_dynamics.i_NaK">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-potassium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#whole_cell_calcium_current_p_VCa_gate.p_VCa">
<dcterms:description>current-voltage relationship of voltage-dependent calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#calcium_dependent_potassium_current.i_KCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>voltage-dependent small conductance calcium-activated potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#nonselective_cation_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#IP3_metabolism.K_IPCa">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>half activation intracellular calcium concentration of IP3 metabolism</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#calcium_dependent_potassium_current.gm_KCa">
<dcterms:description>maximum conductance of voltage-dependent small conductance calcium-activated potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_current.gm_Na">
<dcterms:description>maximum conductance of inward sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#nonselective_cation_current.i_CRAN">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>calcium release-activated nonselective cation current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#fridlyand_tamarina_philipson_2003_version01"
bqmodel:isDescribedBy="12644446">
<semsim:modelName>fridlyand_tamarina_philipson_2003_version01</semsim:modelName>
<semsim:unknown>Pancreatic Beta-cell</semsim:unknown>
<semsim:modelName>fridlyand_tamarina_philipson_2003</semsim:modelName>
<semsim:hasCellMLdocumentation><documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Modelling Ca2+ Flux in Pancreatic Beta-cells</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>This is the original unchecked version of the model imported from the previous
CellML model repository, 24-Jan-2006.</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
An increase in the concentration of intracellular free calcium ([Ca
<superscript>2+</superscript>
]
<subscript>i</subscript>
) is an essential signal for the initiation of insulin secretion in pancreatic beta-cells. This increase is primarily due to the opening of Ca
<superscript>2+</superscript>
channels in the plasma membrane in response to glucose. Glucose metabolism leads to an increase in the cytosolic ATP:ADP ratio, which in turn causes the ATP-sensitive potassium channels to close. The beta-cell membrane becomes depolarised, Ca
<superscript>2+</superscript>
channels open, and Ca
<superscript>2+</superscript>
enters the cell. These events underlie the glucose-induced electrical activity, which in pancreatic islets, consists of Ca
<superscript>2+</superscript>
-dependent action potentials.
</para>
<para>
There is an abundance of literature that describes beta-cell electrical activity and its relationship to [Ca
<superscript>2+</superscript>
]
<subscript>i</subscript>
. Complex and cyclic spike-burst activity, and corresponding [Ca
<superscript>2+</superscript>
]
<subscript>i</subscript>
oscillations in pancreatic islets and beta-cell clusters are induced in response to a rise in extracellular glucose concentration. Intermediate glucose concentrations induce both fast and slow oscillations. The authors of this current study: Fridlyand, Tamarina and Philipson, have previously studied slow and fast [Ca
<superscript>2+</superscript>
]
<subscript>i</subscript>
oscillations in islets in response to a variety of conditions. However, the experimental results were complex, and precise understanding was limited by the large number of channels and pumps in the beta-cell plasma membrane that were simultaneously working.
</para>
<para>
In order to better understand the molecular mechanisms underlying this behaviour, in this publication Fridlyand
<emphasis>et al.</emphasis>
have developed a mathematical model of the Ca
<superscript>2+</superscript>
fluxes in pancreatic beta-cells. Several other mathematical models of glucose-induced insulin secretion, with corresponding descriptions of glucose transport, metabolism and ion regulation, have been published. These include:
</para>
<itemizedlist>
<listitem>
<para>
<ulink url="${HTML_EXMPL_CHAY_MODEL97}">Extracellular and Intracellular Calcium Effects on Pancreatic Beta Cells, Chay, 1997</ulink>
;
</para>
</listitem>
<listitem>
<para>
<ulink url="${HTML_EXMPL_GALL_MODEL}">
Na
<superscript>+</superscript>
/Ca
<superscript>2+</superscript>
Exchange in Models for Pancreatic Beta-Cells, Gall and Susa, 1999
</ulink>
; and
</para>
</listitem>
<listitem>
<para>
<ulink url="${HTML_EXMPL_BERTRAM_MODEL}">
The Phantom Burster Model for Pancreatic Beta-Cells, Bertram
<emphasis>et al.</emphasis>
, 2000
</ulink>
.
</para>
</listitem>
</itemizedlist>
<para>
However, most of these models are focused on describing one specific phenomenon. They only include a very limited set of channels and pumps, and therefore it is difficult to apply them to a another situation. In addition, since their publication, new experimental data has become available, and these new findings should be included in a theoretical model. For this reason Fridlyand
<emphasis>et al.</emphasis>
have developed the new mathematical model described here (see the raw CellML description of the Fridlyand
<emphasis>et al.</emphasis>
2003 model in
<xref linkend="sec_download_this_model" />
). They have adopted the more complex style of modelling that has previously been used successfully to describe the electrophysiology of cardiac myocytes and other cell types (for example in
<ulink url="${HTML_EXMPL_NYGREN_ATRIAL_MODEL}">
Human Atrial Cell Model, Nygren
<emphasis>et al.</emphasis>
1998
</ulink>
and in
<ulink url="${HTML_EXMPL_RICE_MODEL2}">
Modelling Interval-Force Relations in Cardiac Muscle, Rice
<emphasis>et al.</emphasis>
, 2000
</ulink>
).
</para>
<para>
Their new model includes a wider range of channels and pumps, as well as endoplasmic reticulum (ER) Ca
<superscript>2+</superscript>
sequestration mechanisms (see
<xref linkend="fig_cell_diagram" />
below). Using this model they were able to simulate whole cell electrical activity and [Ca
<superscript>2+</superscript>
]
<subscript>i</subscript>
, free calcium in the ER ([Ca
<superscript>2+</superscript>
]
<subscript>ER</subscript>
), intracellular Na
<superscript>+</superscript>
([Na
<superscript>+</superscript>
]
<subscript>i</subscript>
), cytosolic ATP ([ATP]
<subscript>i</subscript>
), and inositol triphosphate ([IP
<subscript>3</subscript>
]
<subscript>i</subscript>
) concentrations. However, they acknowledge that this model does not consider metabolic processes or insulin secretion.
</para>
<para>The complete original paper reference is cited below:</para>
<para>
<ulink url="http://ajpendo.physiology.org/cgi/content/abstract/285/1/E138">
Modeling of Ca
<superscript>2+</superscript>
flux in pancreatic beta-cells: role of the plasma membrane and intracellular stores
</ulink>
, Leonid E. Fridlyand, Natalia Tamarina, and Louis H. Philipson, 2003,
<ulink url="http://ajpendo.physiology.org/">
<emphasis>American Journal of Physiology</emphasis>
</ulink>
, 285, E138-E154. (
<ulink url="http://ajpendo.physiology.org/cgi/content/full/285/1/E138">Full text (HTML)</ulink>
and
<ulink url="http://ajpendo.physiology.org/cgi/reprint/285/1/E138.pdf">PDF</ulink>
versions of the article are available on the
<emphasis>American Jounal of Physiology</emphasis>
website.)
<ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=12644446&amp;dopt=Abstract">PubMed ID: 12644446</ulink>
</para>
<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>cell diagram</title>
</objectinfo>
<imagedata fileref="fridlyand_2003.png" />
</imageobject>
</mediaobject>
<caption>Schematic representation of currents and ion fluxes, through the plasma membrane and the endoplasmic reticulum membrane, which have been included in the whole beta-cell mathematical model.</caption>
</informalfigure>
</sect1>
</article>
</documentation></semsim:hasCellMLdocumentation>
<semsim:unknown>Fridlyand et al's 2003 mathematical model of Ca2+ fluxes in pancreatic
beta-cells.</semsim:unknown>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#PM_calcium_pumps.i_Ca_pump">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>plasma membrane calcium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.P">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_calcium_exchanger.K_NaCa">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>calcium affinity constant of sodium-calcium exchange current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#calcium_and_sodium_dynamics.J_out">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>calcium leak current out of the endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#membrane.i_KDr">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>delayed rectifier potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#ATP_homeostasis.Cai">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of free intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.ADPi">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of cytosolic ADP</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#whole_cell_calcium_current_p_VCa_gate.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#ATP_homeostasis.Vi">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_4"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
<dcterms:description>intracellular volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_current.Nao">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_2"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current_n_gate.b">
<dcterms:description>adjustable coefficient</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.ATPi">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of cytosolic ATP</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#SERCA_pump.P_CaER">
<dcterms:description>maximum pumping rate of SERCA pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#ATP_homeostasis.i_NaK">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-potassium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#ATP_dependent_potassium_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current_n_gate.n_infinity">
<dcterms:description>steady-state value of gating variable of voltage-dependent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current_n_gate.tau_n">
<dcterms:description>relaxation time constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#ATP_homeostasis.k_ATP_Ca">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>rate constant of permanent ATP consumption</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#ATP_homeostasis.Ao">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_4"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular nucleotides</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_current.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current_n_gate.c">
<dcterms:description>adjustable coefficient</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#CaER_mobilisation.CaER">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_3"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of calcium in endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#calcium_and_sodium_dynamics.Cai">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of free intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.i_NaK">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-potassium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#cell_and_external_parameters.Vi">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_4"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
<dcterms:description>intracellular volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#whole_cell_calcium_current.gm_VCa">
<dcterms:description>maximum conductance of voltage-dependent calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#calcium_and_sodium_dynamics.i_Na">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>inward sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_calcium_exchanger.Nai">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#whole_cell_calcium_current.V_Ca">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>calcium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#ATP_homeostasis.Jer_p">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>calcium uptake of the endoplasmic reticulum by SERCA pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_calcium_exchanger.Cai">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of free intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_current.V_Na">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>sodium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.f5">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#calcium_and_sodium_dynamics.Jer_p">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>calcium uptake of the endoplasmic reticulum by SERCA pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.P_NaK">
<dcterms:description>current coefficient of sodium-potassium pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#IP3_metabolism.kIP">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>IP3 production rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#whole_cell_calcium_current_p_VCa_gate.V_Cah">
<dcterms:description>half-activation potential of voltage-dependent calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#calcium_and_sodium_dynamics.Nai">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#membrane.i_KCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>voltage-dependent small conductance calcium-activated potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#ATP_dependent_potassium_current.gm_KATP">
<dcterms:description>maximum conductance of ATP-dependent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.f6">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#nonselective_cation_current.f_CRAN">
<dcterms:description>voltage-independent component of non-selective cation current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#nonselective_cation_current.V_Na">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>sodium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#whole_cell_calcium_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#membrane.i_Na">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>inward sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#membrane.i_VCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>voltage-dependent calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current_n_gate.Vtau">
<dcterms:description>adjustable coefficient</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#whole_cell_calcium_current.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#calcium_and_sodium_dynamics.ksg">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>coefficient of calcium sequestration rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#calcium_and_sodium_dynamics.CaER">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_3"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of calcium in endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#CaER_mobilisation.Cai">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of free intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current_n_gate.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current_n_gate.Vn">
<dcterms:description>half-activation potential of voltage-dependent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#PM_calcium_pumps.Pm_Cap">
<dcterms:description>maximum plasma membrane calcium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#IP3_metabolism.IP3i">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of cytosolic IP3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#IP3_metabolism.Cai">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of free intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.F4">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.f3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.Nai">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#calcium_dependent_potassium_current.V">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#whole_cell_calcium_current.p_VCa">
<dcterms:description>current-voltage relationship of voltage-dependent calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#ATP_homeostasis.i_Ca_pump">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>plasma membrane calcium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.K_supi">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#ATP_homeostasis.k_ADP">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>rate constant of ATP production</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#CaER_mobilisation.P_leak">
<dcterms:description>calcium leak permeability out of the endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#calcium_and_sodium_dynamics.i_Ca_pump">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>plasma membrane calcium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#whole_cell_calcium_current.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.F5">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#membrane.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.f4">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#calcium_dependent_potassium_current_fCa_gate.Cai">
<bqbiol:isPropertyOf rdf:resource="./fridlyand_tamarina_philipson_2003.cellml#entity_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>concentration of free intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#ATP_homeostasis.k_ATP">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296"/>
<dcterms:description>rate constant of calcium-dependent ATP consumption</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#sodium_calcium_exchanger.i_NaCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
<dcterms:description>sodium-calcium exchange current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current_n_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023"/>
</rdf:Description>
</rdf:RDF>
