- Author:
- neilstephen2001 <npar276@aucklanduni.ac.nz>
- Date:
- 2021-01-25 19:32:58+13:00
- Desc:
- adding OMEX archives to workspace
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/7f1/rawfile/8a75fa307ab49aa87a6310ec8adf05ab8c95155f/fridlyand_tamarina_philipson_2003/model/fridlyand_tamarina_philipson_2003.cellml
<?xml version="1.0" encoding="UTF-8"?>
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<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Modelling Ca2+ Flux in Pancreatic Beta-cells</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>This is the original unchecked version of the model imported from the previous
CellML model repository, 24-Jan-2006.</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
An increase in the concentration of intracellular free calcium ([Ca
<superscript>2+</superscript>
]
<subscript>i</subscript>
) is an essential signal for the initiation of insulin secretion in pancreatic beta-cells. This increase is primarily due to the opening of Ca
<superscript>2+</superscript>
channels in the plasma membrane in response to glucose. Glucose metabolism leads to an increase in the cytosolic ATP:ADP ratio, which in turn causes the ATP-sensitive potassium channels to close. The beta-cell membrane becomes depolarised, Ca
<superscript>2+</superscript>
channels open, and Ca
<superscript>2+</superscript>
enters the cell. These events underlie the glucose-induced electrical activity, which in pancreatic islets, consists of Ca
<superscript>2+</superscript>
-dependent action potentials.
</para>
<para>
There is an abundance of literature that describes beta-cell electrical activity and its relationship to [Ca
<superscript>2+</superscript>
]
<subscript>i</subscript>
. Complex and cyclic spike-burst activity, and corresponding [Ca
<superscript>2+</superscript>
]
<subscript>i</subscript>
oscillations in pancreatic islets and beta-cell clusters are induced in response to a rise in extracellular glucose concentration. Intermediate glucose concentrations induce both fast and slow oscillations. The authors of this current study: Fridlyand, Tamarina and Philipson, have previously studied slow and fast [Ca
<superscript>2+</superscript>
]
<subscript>i</subscript>
oscillations in islets in response to a variety of conditions. However, the experimental results were complex, and precise understanding was limited by the large number of channels and pumps in the beta-cell plasma membrane that were simultaneously working.
</para>
<para>
In order to better understand the molecular mechanisms underlying this behaviour, in this publication Fridlyand
<emphasis>et al.</emphasis>
have developed a mathematical model of the Ca
<superscript>2+</superscript>
fluxes in pancreatic beta-cells. Several other mathematical models of glucose-induced insulin secretion, with corresponding descriptions of glucose transport, metabolism and ion regulation, have been published. These include:
</para>
<itemizedlist>
<listitem>
<para>
<ulink url="${HTML_EXMPL_CHAY_MODEL97}">Extracellular and Intracellular Calcium Effects on Pancreatic Beta Cells, Chay, 1997</ulink>
;
</para>
</listitem>
<listitem>
<para>
<ulink url="${HTML_EXMPL_GALL_MODEL}">
Na
<superscript>+</superscript>
/Ca
<superscript>2+</superscript>
Exchange in Models for Pancreatic Beta-Cells, Gall and Susa, 1999
</ulink>
; and
</para>
</listitem>
<listitem>
<para>
<ulink url="${HTML_EXMPL_BERTRAM_MODEL}">
The Phantom Burster Model for Pancreatic Beta-Cells, Bertram
<emphasis>et al.</emphasis>
, 2000
</ulink>
.
</para>
</listitem>
</itemizedlist>
<para>
However, most of these models are focused on describing one specific phenomenon. They only include a very limited set of channels and pumps, and therefore it is difficult to apply them to a another situation. In addition, since their publication, new experimental data has become available, and these new findings should be included in a theoretical model. For this reason Fridlyand
<emphasis>et al.</emphasis>
have developed the new mathematical model described here (see the raw CellML description of the Fridlyand
<emphasis>et al.</emphasis>
2003 model in
<xref linkend="sec_download_this_model" />
). They have adopted the more complex style of modelling that has previously been used successfully to describe the electrophysiology of cardiac myocytes and other cell types (for example in
<ulink url="${HTML_EXMPL_NYGREN_ATRIAL_MODEL}">
Human Atrial Cell Model, Nygren
<emphasis>et al.</emphasis>
1998
</ulink>
and in
<ulink url="${HTML_EXMPL_RICE_MODEL2}">
Modelling Interval-Force Relations in Cardiac Muscle, Rice
<emphasis>et al.</emphasis>
, 2000
</ulink>
).
</para>
<para>
Their new model includes a wider range of channels and pumps, as well as endoplasmic reticulum (ER) Ca
<superscript>2+</superscript>
sequestration mechanisms (see
<xref linkend="fig_cell_diagram" />
below). Using this model they were able to simulate whole cell electrical activity and [Ca
<superscript>2+</superscript>
]
<subscript>i</subscript>
, free calcium in the ER ([Ca
<superscript>2+</superscript>
]
<subscript>ER</subscript>
), intracellular Na
<superscript>+</superscript>
([Na
<superscript>+</superscript>
]
<subscript>i</subscript>
), cytosolic ATP ([ATP]
<subscript>i</subscript>
), and inositol triphosphate ([IP
<subscript>3</subscript>
]
<subscript>i</subscript>
) concentrations. However, they acknowledge that this model does not consider metabolic processes or insulin secretion.
</para>
<para>The complete original paper reference is cited below:</para>
<para>
<ulink url="http://ajpendo.physiology.org/cgi/content/abstract/285/1/E138">
Modeling of Ca
<superscript>2+</superscript>
flux in pancreatic beta-cells: role of the plasma membrane and intracellular stores
</ulink>
, Leonid E. Fridlyand, Natalia Tamarina, and Louis H. Philipson, 2003,
<ulink url="http://ajpendo.physiology.org/">
<emphasis>American Journal of Physiology</emphasis>
</ulink>
, 285, E138-E154. (
<ulink url="http://ajpendo.physiology.org/cgi/content/full/285/1/E138">Full text (HTML)</ulink>
and
<ulink url="http://ajpendo.physiology.org/cgi/reprint/285/1/E138.pdf">PDF</ulink>
versions of the article are available on the
<emphasis>American Jounal of Physiology</emphasis>
website.)
<ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12644446&dopt=Abstract">PubMed ID: 12644446</ulink>
</para>
<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>cell diagram</title>
</objectinfo>
<imagedata fileref="fridlyand_2003.png" />
</imageobject>
</mediaobject>
<caption>Schematic representation of currents and ion fluxes, through the plasma membrane and the endoplasmic reticulum membrane, which have been included in the whole beta-cell mathematical model.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
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<unit units="coulomb" />
</units>
<units name="femtoA">
<unit prefix="femto" units="ampere" />
</units>
<units name="millimolar">
<unit exponent="-1.0" units="litre" />
<unit prefix="micro" units="mole" />
</units>
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<unit units="picoS" />
<unit exponent="-1.0" units="millivolt" />
</units>
<units name="picol">
<unit prefix="pico" units="litre" />
</units>
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</units>
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<unit exponent="-1.0" units="millisecond" />
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<units name="millisecond">
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</units>
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<unit units="micromolar" />
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<unit exponent="-1.0" units="millivolt" />
</units>
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<unit units="joule" />
<unit exponent="-1.0" prefix="kilo" units="mole" />
<unit exponent="-1.0" units="kelvin" />
</units>
<component name="environment">
<variable cmeta:id="environment.time" name="time" public_interface="out" units="millisecond" />
</component>
<component name="membrane">
<variable cmeta:id="membrane.V" initial_value="-84.624" name="V" public_interface="out" units="millivolt" />
<variable cmeta:id="membrane.Cm" initial_value="6158.0" name="Cm" units="femtoF" />
<variable cmeta:id="membrane.time" name="time" public_interface="in" units="millisecond" />
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<variable cmeta:id="membrane.i_NaCa" name="i_NaCa" public_interface="in" units="femtoA" />
<variable cmeta:id="membrane.i_CRAN" name="i_CRAN" public_interface="in" units="femtoA" />
<variable cmeta:id="membrane.i_Na" name="i_Na" public_interface="in" units="femtoA" />
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<variable cmeta:id="membrane.i_KDr" name="i_KDr" public_interface="in" units="femtoA" />
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<eq />
<apply>
<diff />
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<ci>V</ci>
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<ci>i_CRAN</ci>
<ci>i_Na</ci>
<ci>i_NaK</ci>
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<ci>i_KATP</ci>
</apply>
<apply>
<minus />
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</apply>
</apply>
</apply>
</math>
</component>
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<variable cmeta:id="whole_cell_calcium_current.i_VCa" name="i_VCa" public_interface="out" units="femtoA" />
<variable cmeta:id="whole_cell_calcium_current.V_Ca" name="V_Ca" units="millivolt" />
<variable cmeta:id="whole_cell_calcium_current.gm_VCa" initial_value="770.0" name="gm_VCa" units="picoS" />
<variable cmeta:id="whole_cell_calcium_current.V" name="V" public_interface="in" private_interface="out" units="millivolt" />
<variable cmeta:id="whole_cell_calcium_current.R" name="R" public_interface="in" units="joule_per_kilomole_kelvin" />
<variable cmeta:id="whole_cell_calcium_current.F" name="F" public_interface="in" units="coulomb_per_mole" />
<variable cmeta:id="whole_cell_calcium_current.T" name="T" public_interface="in" units="kelvin" />
<variable cmeta:id="whole_cell_calcium_current.Cai" name="Cai" public_interface="in" units="micromolar" />
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<apply>
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</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="whole_cell_calcium_current_p_VCa_gate">
<variable cmeta:id="whole_cell_calcium_current_p_VCa_gate.p_VCa" name="p_VCa" public_interface="out" units="dimensionless" />
<variable cmeta:id="whole_cell_calcium_current_p_VCa_gate.V_Cah" initial_value="-19.0" name="V_Cah" units="millivolt" />
<variable cmeta:id="whole_cell_calcium_current_p_VCa_gate.K_Cah" initial_value="9.5" name="K_Cah" units="millivolt" />
<variable cmeta:id="whole_cell_calcium_current_p_VCa_gate.V" name="V" public_interface="in" units="millivolt" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
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</apply>
<ci>K_Cah</ci>
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</apply>
</apply>
</apply>
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</math>
</component>
<component name="PM_calcium_pumps">
<variable cmeta:id="PM_calcium_pumps.i_Ca_pump" name="i_Ca_pump" public_interface="out" units="femtoA" />
<variable cmeta:id="PM_calcium_pumps.Pm_Cap" initial_value="2000.0" name="Pm_Cap" units="femtoA" />
<variable cmeta:id="PM_calcium_pumps.K_Cap" initial_value="0.1" name="K_Cap" units="micromolar" />
<variable cmeta:id="PM_calcium_pumps.Cai" name="Cai" public_interface="in" units="micromolar" />
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</apply>
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<variable cmeta:id="sodium_current.Nao" name="Nao" public_interface="in" units="micromolar" />
<variable cmeta:id="sodium_current.p_Na" name="p_Na" private_interface="in" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="i_Na_calculation">
<eq />
<ci>i_Na</ci>
<apply>
<times />
<ci>gm_Na</ci>
<ci>p_Na</ci>
<apply>
<minus />
<ci>V</ci>
<ci>V_Na</ci>
</apply>
</apply>
</apply>
<apply id="V_Na_calculation">
<eq />
<ci>V_Na</ci>
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln />
<apply>
<divide />
<ci>Nao</ci>
<ci>Nai</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_current_p_Na_gate">
<variable cmeta:id="sodium_current_p_Na_gate.p_Na" name="p_Na" public_interface="out" units="dimensionless" />
<variable cmeta:id="sodium_current_p_Na_gate.V" name="V" public_interface="in" units="millivolt" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="p_Na_calculation">
<eq />
<ci>p_Na</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">104.0</cn>
<ci>V</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">8.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_potassium_active_transport">
<variable cmeta:id="sodium_potassium_active_transport.i_NaK" name="i_NaK" public_interface="out" units="femtoA" />
<variable cmeta:id="sodium_potassium_active_transport.P_NaK" initial_value="600.0" name="P_NaK" units="femtoA" />
<variable cmeta:id="sodium_potassium_active_transport.P" initial_value="4950.0" name="P" units="micromolar" />
<variable cmeta:id="sodium_potassium_active_transport.K_supi" name="K_supi" units="micromolar" />
<variable cmeta:id="sodium_potassium_active_transport.F1" name="F1" units="first_order_rate_constant" />
<variable cmeta:id="sodium_potassium_active_transport.F4" name="F4" units="first_order_rate_constant" />
<variable cmeta:id="sodium_potassium_active_transport.F5" name="F5" units="first_order_rate_constant" />
<variable cmeta:id="sodium_potassium_active_transport.f1" initial_value="2.5E-10" name="f1" units="forth_order_rate_constant" />
<variable cmeta:id="sodium_potassium_active_transport.f2" initial_value="10.0" name="f2" units="first_order_rate_constant" />
<variable cmeta:id="sodium_potassium_active_transport.f3" initial_value="0.172" name="f3" units="first_order_rate_constant" />
<variable cmeta:id="sodium_potassium_active_transport.f4" initial_value="1.5E-8" name="f4" units="third_order_rate_constant" />
<variable cmeta:id="sodium_potassium_active_transport.f5_" initial_value="0.002" name="f5_" units="second_order_rate_constant" />
<variable cmeta:id="sodium_potassium_active_transport.f5" name="f5" units="second_order_rate_constant" />
<variable cmeta:id="sodium_potassium_active_transport.f6" initial_value="11.5" name="f6" units="first_order_rate_constant" />
<variable cmeta:id="sodium_potassium_active_transport.b1" initial_value="100.0" name="b1" units="first_order_rate_constant" />
<variable cmeta:id="sodium_potassium_active_transport.b2" initial_value="0.0001" name="b2" units="second_order_rate_constant" />
<variable cmeta:id="sodium_potassium_active_transport.b3" initial_value="1.72E-17" name="b3" units="forth_order_rate_constant" />
<variable cmeta:id="sodium_potassium_active_transport.b4" initial_value="0.0002" name="b4" units="second_order_rate_constant" />
<variable cmeta:id="sodium_potassium_active_transport.b5_" initial_value="0.03" name="b5_" units="first_order_rate_constant" />
<variable cmeta:id="sodium_potassium_active_transport.b5" name="b5" units="first_order_rate_constant" />
<variable cmeta:id="sodium_potassium_active_transport.b6" initial_value="6.0E-7" name="b6" units="second_order_rate_constant" />
<variable cmeta:id="sodium_potassium_active_transport.B2" name="B2" units="first_order_rate_constant" />
<variable cmeta:id="sodium_potassium_active_transport.B3" name="B3" units="first_order_rate_constant" />
<variable cmeta:id="sodium_potassium_active_transport.B4" name="B4" units="first_order_rate_constant" />
<variable cmeta:id="sodium_potassium_active_transport.B6" name="B6" units="first_order_rate_constant" />
<variable cmeta:id="sodium_potassium_active_transport.D" name="D" units="dimensionless" />
<variable cmeta:id="sodium_potassium_active_transport.V" name="V" public_interface="in" units="millivolt" />
<variable cmeta:id="sodium_potassium_active_transport.R" name="R" public_interface="in" units="joule_per_kilomole_kelvin" />
<variable cmeta:id="sodium_potassium_active_transport.F" name="F" public_interface="in" units="coulomb_per_mole" />
<variable cmeta:id="sodium_potassium_active_transport.T" name="T" public_interface="in" units="kelvin" />
<variable cmeta:id="sodium_potassium_active_transport.Nai" name="Nai" public_interface="in" units="micromolar" />
<variable cmeta:id="sodium_potassium_active_transport.Nao" name="Nao" public_interface="in" units="micromolar" />
<variable cmeta:id="sodium_potassium_active_transport.ATPi" name="ATPi" public_interface="in" units="micromolar" />
<variable cmeta:id="sodium_potassium_active_transport.ADPi" name="ADPi" public_interface="in" units="micromolar" />
<variable cmeta:id="sodium_potassium_active_transport.Ko" name="Ko" public_interface="in" units="micromolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="i_NaK_calculation">
<eq />
<ci>i_NaK</ci>
<apply>
<times />
<ci>P_NaK</ci>
<apply>
<divide />
<apply>
<minus />
<apply>
<times />
<ci>F1</ci>
<ci>f2</ci>
<ci>f3</ci>
<ci>F4</ci>
<ci>F5</ci>
<ci>f6</ci>
</apply>
<apply>
<times />
<ci>b1</ci>
<ci>B2</ci>
<ci>B3</ci>
<ci>B4</ci>
<ci>b5</ci>
<ci>B6</ci>
</apply>
</apply>
<ci>D</ci>
</apply>
</apply>
</apply>
<apply id="D_calculation">
<eq />
<ci>D</ci>
<apply>
<plus />
<apply>
<times />
<ci>f2</ci>
<ci>f3</ci>
<ci>F4</ci>
<ci>F5</ci>
<ci>f6</ci>
</apply>
<apply>
<times />
<ci>b1</ci>
<ci>f3</ci>
<ci>F4</ci>
<ci>F5</ci>
<ci>f6</ci>
</apply>
<apply>
<times />
<ci>b1</ci>
<ci>B2</ci>
<ci>F4</ci>
<ci>F5</ci>
<ci>f6</ci>
</apply>
<apply>
<times />
<ci>b1</ci>
<ci>B2</ci>
<ci>B3</ci>
<ci>F5</ci>
<ci>f6</ci>
</apply>
<apply>
<times />
<ci>b1</ci>
<ci>B2</ci>
<ci>B3</ci>
<ci>B4</ci>
<ci>f6</ci>
</apply>
<apply>
<times />
<ci>b1</ci>
<ci>B2</ci>
<ci>B3</ci>
<ci>B4</ci>
<ci>b5</ci>
</apply>
</apply>
</apply>
<apply id="F1_calculation">
<eq />
<ci>F1</ci>
<apply>
<times />
<ci>f1</ci>
<apply>
<power />
<ci>Nai</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
</apply>
</apply>
</apply>
<apply id="F4_calculation">
<eq />
<ci>F4</ci>
<apply>
<times />
<ci>f4</ci>
<apply>
<power />
<ci>Ko</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
<apply id="F5_calculation">
<eq />
<ci>F5</ci>
<apply>
<times />
<ci>f5</ci>
<ci>ATPi</ci>
</apply>
</apply>
<apply id="f5_calculation">
<eq />
<ci>f5</ci>
<apply>
<times />
<ci>f5_</ci>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply id="B2_calculation">
<eq />
<ci>B2</ci>
<apply>
<times />
<ci>b2</ci>
<ci>ATPi</ci>
</apply>
</apply>
<apply id="B3_calculation">
<eq />
<ci>B3</ci>
<apply>
<times />
<ci>b3</ci>
<apply>
<power />
<ci>Nai</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
</apply>
</apply>
</apply>
<apply id="B4_calculation">
<eq />
<ci>B4</ci>
<apply>
<times />
<ci>b4</ci>
<ci>P</ci>
</apply>
</apply>
<apply id="B6_calculation">
<eq />
<ci>B6</ci>
<apply>
<times />
<ci>b6</ci>
<apply>
<power />
<ci>K_supi</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
<apply id="b5_calculation">
<eq />
<ci>b5</ci>
<apply>
<times />
<ci>b5_</ci>
<apply>
<exp />
<apply>
<divide />
<apply>
<minus />
<apply>
<times />
<ci>V</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="voltage_dependent_potassium_current">
<variable cmeta:id="voltage_dependent_potassium_current.i_KDr" name="i_KDr" public_interface="out" units="femtoA" />
<variable cmeta:id="voltage_dependent_potassium_current.V_K" name="V_K" public_interface="out" units="millivolt" />
<variable cmeta:id="voltage_dependent_potassium_current.gm_KDr" initial_value="3000.0" name="gm_KDr" units="picoS" />
<variable cmeta:id="voltage_dependent_potassium_current.time" name="time" public_interface="in" private_interface="out" units="millisecond" />
<variable cmeta:id="voltage_dependent_potassium_current.V" name="V" public_interface="in" private_interface="out" units="millivolt" />
<variable cmeta:id="voltage_dependent_potassium_current.R" name="R" public_interface="in" units="joule_per_kilomole_kelvin" />
<variable cmeta:id="voltage_dependent_potassium_current.F" name="F" public_interface="in" units="coulomb_per_mole" />
<variable cmeta:id="voltage_dependent_potassium_current.T" name="T" public_interface="in" units="kelvin" />
<variable cmeta:id="voltage_dependent_potassium_current.Ki" name="Ki" public_interface="in" units="micromolar" />
<variable cmeta:id="voltage_dependent_potassium_current.Ko" name="Ko" public_interface="in" units="micromolar" />
<variable cmeta:id="voltage_dependent_potassium_current.n" name="n" private_interface="in" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="i_KDr_calculation">
<eq />
<ci>i_KDr</ci>
<apply>
<times />
<ci>gm_KDr</ci>
<ci>n</ci>
<apply>
<minus />
<ci>V</ci>
<ci>V_K</ci>
</apply>
</apply>
</apply>
<apply id="V_K_calculation">
<eq />
<ci>V_K</ci>
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln />
<apply>
<divide />
<ci>Ko</ci>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="voltage_dependent_potassium_current_n_gate">
<variable cmeta:id="voltage_dependent_potassium_current_n_gate.n" initial_value="0.00123" name="n" public_interface="out" units="dimensionless" />
<variable cmeta:id="voltage_dependent_potassium_current_n_gate.tau_n" name="tau_n" units="dimensionless" />
<variable cmeta:id="voltage_dependent_potassium_current_n_gate.n_infinity" name="n_infinity" units="dimensionless" />
<variable cmeta:id="voltage_dependent_potassium_current_n_gate.Vn" initial_value="-14.0" name="Vn" units="millivolt" />
<variable cmeta:id="voltage_dependent_potassium_current_n_gate.Vtau" initial_value="-75.0" name="Vtau" units="millivolt" />
<variable cmeta:id="voltage_dependent_potassium_current_n_gate.Sn" initial_value="7.0" name="Sn" units="millivolt" />
<variable cmeta:id="voltage_dependent_potassium_current_n_gate.a" initial_value="65.0" name="a" units="millivolt" />
<variable cmeta:id="voltage_dependent_potassium_current_n_gate.b" initial_value="20.0" name="b" units="millivolt" />
<variable cmeta:id="voltage_dependent_potassium_current_n_gate.c" initial_value="20.0" name="c" units="millisecond" />
<variable cmeta:id="voltage_dependent_potassium_current_n_gate.V" name="V" public_interface="in" units="millivolt" />
<variable cmeta:id="voltage_dependent_potassium_current_n_gate.time" name="time" public_interface="in" units="millisecond" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="n_diff_eq">
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>n</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<ci>n_infinity</ci>
<ci>n</ci>
</apply>
<ci>tau_n</ci>
</apply>
</apply>
<apply id="n_infinity_calculation">
<eq />
<ci>n_infinity</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<minus />
<ci>Vn</ci>
<ci>V</ci>
</apply>
<ci>Sn</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply id="tau_n_calculation">
<eq />
<ci>tau_n</ci>
<apply>
<divide />
<ci>c</ci>
<apply>
<plus />
<apply>
<exp />
<apply>
<divide />
<apply>
<minus />
<ci>V</ci>
<ci>Vtau</ci>
</apply>
<ci>a</ci>
</apply>
</apply>
<apply>
<exp />
<apply>
<divide />
<apply>
<minus />
<ci>Vtau</ci>
<ci>V</ci>
</apply>
<ci>b</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calcium_dependent_potassium_current">
<variable cmeta:id="calcium_dependent_potassium_current.i_KCa" name="i_KCa" public_interface="out" units="femtoA" />
<variable cmeta:id="calcium_dependent_potassium_current.gm_KCa" initial_value="130.0" name="gm_KCa" units="picoS" />
<variable cmeta:id="calcium_dependent_potassium_current.V_K" name="V_K" public_interface="in" units="millivolt" />
<variable cmeta:id="calcium_dependent_potassium_current.V" name="V" public_interface="in" units="millivolt" />
<variable cmeta:id="calcium_dependent_potassium_current.Cai" name="Cai" public_interface="in" private_interface="out" units="micromolar" />
<variable cmeta:id="calcium_dependent_potassium_current.fCa" name="fCa" private_interface="in" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="i_KCa_calculation">
<eq />
<ci>i_KCa</ci>
<apply>
<times />
<ci>gm_KCa</ci>
<ci>fCa</ci>
<apply>
<minus />
<ci>V</ci>
<ci>V_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calcium_dependent_potassium_current_fCa_gate">
<variable cmeta:id="calcium_dependent_potassium_current_fCa_gate.fCa" name="fCa" public_interface="out" units="dimensionless" />
<variable cmeta:id="calcium_dependent_potassium_current_fCa_gate.K_KCa" initial_value="0.1" name="K_KCa" units="micromolar" />
<variable cmeta:id="calcium_dependent_potassium_current_fCa_gate.Cai" name="Cai" public_interface="in" units="micromolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="fCa_calculation">
<eq />
<ci>fCa</ci>
<apply>
<divide />
<apply>
<power />
<ci>Cai</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
<apply>
<plus />
<apply>
<power />
<ci>Cai</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
<apply>
<power />
<ci>K_KCa</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.0</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ATP_dependent_potassium_current">
<variable cmeta:id="ATP_dependent_potassium_current.i_KATP" name="i_KATP" public_interface="out" units="femtoA" />
<variable cmeta:id="ATP_dependent_potassium_current.gm_KATP" initial_value="24000.0" name="gm_KATP" units="picoS" />
<variable cmeta:id="ATP_dependent_potassium_current.O_KATP" name="O_KATP" units="dimensionless" />
<variable cmeta:id="ATP_dependent_potassium_current.Kdd" initial_value="17.0" name="Kdd" units="micromolar" />
<variable cmeta:id="ATP_dependent_potassium_current.Ktd" initial_value="26.0" name="Ktd" units="micromolar" />
<variable cmeta:id="ATP_dependent_potassium_current.Ktt" initial_value="1.0" name="Ktt" units="micromolar" />
<variable cmeta:id="ATP_dependent_potassium_current.V" name="V" public_interface="in" units="millivolt" />
<variable cmeta:id="ATP_dependent_potassium_current.V_K" name="V_K" public_interface="in" units="millivolt" />
<variable cmeta:id="ATP_dependent_potassium_current.ADPi" name="ADPi" public_interface="in" units="micromolar" />
<variable cmeta:id="ATP_dependent_potassium_current.ATPi" name="ATPi" public_interface="in" units="micromolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="i_KATP_calculation">
<eq />
<ci>i_KATP</ci>
<apply>
<times />
<ci>gm_KATP</ci>
<ci>O_KATP</ci>
<apply>
<minus />
<ci>V</ci>
<ci>V_K</ci>
</apply>
</apply>
</apply>
<apply id="O_KATP_calculation">
<eq />
<ci>O_KATP</ci>
<apply>
<divide />
<apply>
<plus />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.08</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.33</cn>
<ci>ADPi</ci>
</apply>
<ci>Kdd</ci>
</apply>
</apply>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.89</cn>
<apply>
<power />
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.165</cn>
<apply>
<divide />
<ci>ADPi</ci>
<ci>Kdd</ci>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
<apply>
<times />
<apply>
<power />
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.165</cn>
<apply>
<divide />
<ci>ADPi</ci>
<ci>Kdd</ci>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.135</cn>
<ci>ADPi</ci>
</apply>
<ci>Ktd</ci>
</apply>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.05</cn>
<ci>ATPi</ci>
</apply>
<ci>Ktt</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="SERCA_pump">
<variable cmeta:id="SERCA_pump.Jer_p" name="Jer_p" public_interface="out" units="flux" />
<variable cmeta:id="SERCA_pump.P_CaER" initial_value="0.105" name="P_CaER" units="flux" />
<variable cmeta:id="SERCA_pump.K_Carp" initial_value="0.5" name="K_Carp" units="micromolar" />
<variable cmeta:id="SERCA_pump.Cai" name="Cai" public_interface="in" units="micromolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="Jer_p_calculation">
<eq />
<ci>Jer_p</ci>
<apply>
<times />
<ci>P_CaER</ci>
<apply>
<divide />
<apply>
<power />
<ci>Cai</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
<apply>
<plus />
<apply>
<power />
<ci>Cai</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
<apply>
<power />
<ci>K_Carp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="IP3_metabolism">
<variable cmeta:id="IP3_metabolism.IP3i" initial_value="0.33" name="IP3i" public_interface="out" units="micromolar" />
<variable cmeta:id="IP3_metabolism.kIP" initial_value="0.0003" name="kIP" units="flux" />
<variable cmeta:id="IP3_metabolism.kdIP" initial_value="0.00004" name="kdIP" units="first_order_rate_constant" />
<variable cmeta:id="IP3_metabolism.K_IPCa" initial_value="0.4" name="K_IPCa" units="micromolar" />
<variable cmeta:id="IP3_metabolism.Cai" name="Cai" public_interface="in" units="micromolar" />
<variable cmeta:id="IP3_metabolism.time" name="time" public_interface="in" units="millisecond" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="IP3_diff_eq">
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>IP3i</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>kIP</ci>
<apply>
<divide />
<apply>
<power />
<ci>Cai</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
<apply>
<plus />
<apply>
<power />
<ci>Cai</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
<apply>
<power />
<ci>K_IPCa</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times />
<ci>kdIP</ci>
<ci>IP3i</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="CaER_mobilisation">
<variable cmeta:id="CaER_mobilisation.J_out" name="J_out" public_interface="out" units="flux" />
<variable cmeta:id="CaER_mobilisation.P_leak" initial_value="0.0001" name="P_leak" units="picol_per_ms" />
<variable cmeta:id="CaER_mobilisation.P_IP3" initial_value="0.0012" name="P_IP3" units="picol_per_ms" />
<variable cmeta:id="CaER_mobilisation.O_infinity" name="O_infinity" units="dimensionless" />
<variable cmeta:id="CaER_mobilisation.K_RCa" initial_value="3.2" name="K_RCa" units="micromolar" />
<variable cmeta:id="CaER_mobilisation.K_IP3" initial_value="0.077" name="K_IP3" units="micromolar" />
<variable cmeta:id="CaER_mobilisation.IP3i" name="IP3i" public_interface="in" units="micromolar" />
<variable cmeta:id="CaER_mobilisation.Cai" name="Cai" public_interface="in" units="micromolar" />
<variable cmeta:id="CaER_mobilisation.CaER" name="CaER" public_interface="in" units="micromolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>J_out</ci>
<apply>
<times />
<apply>
<plus />
<ci>P_leak</ci>
<apply>
<times />
<ci>P_IP3</ci>
<ci>O_infinity</ci>
</apply>
</apply>
<apply>
<minus />
<ci>CaER</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>O_infinity</ci>
<apply>
<times />
<apply>
<divide />
<ci>Cai</ci>
<apply>
<plus />
<ci>Cai</ci>
<ci>K_RCa</ci>
</apply>
</apply>
<apply>
<divide />
<apply>
<power />
<ci>IP3i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
</apply>
<apply>
<plus />
<apply>
<power />
<ci>IP3i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
</apply>
<apply>
<power />
<ci>K_IP3</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calcium_and_sodium_dynamics">
<variable cmeta:id="calcium_and_sodium_dynamics.Cai" initial_value="0.085" name="Cai" public_interface="out" units="micromolar" />
<variable cmeta:id="calcium_and_sodium_dynamics.CaER" initial_value="22.8" name="CaER" public_interface="out" units="micromolar" />
<variable cmeta:id="calcium_and_sodium_dynamics.Nai" initial_value="9858.0" name="Nai" public_interface="out" units="micromolar" />
<variable cmeta:id="calcium_and_sodium_dynamics.fi" initial_value="0.01" name="fi" units="dimensionless" />
<variable cmeta:id="calcium_and_sodium_dynamics.fer" initial_value="0.03" name="fer" units="dimensionless" />
<variable cmeta:id="calcium_and_sodium_dynamics.ksg" initial_value="0.0001" name="ksg" units="first_order_rate_constant" />
<variable cmeta:id="calcium_and_sodium_dynamics.Ver" initial_value="0.280" name="Ver" units="picol" />
<variable cmeta:id="calcium_and_sodium_dynamics.Vi" name="Vi" public_interface="in" units="picol" />
<variable cmeta:id="calcium_and_sodium_dynamics.i_VCa" name="i_VCa" public_interface="in" units="femtoA" />
<variable cmeta:id="calcium_and_sodium_dynamics.i_NaCa" name="i_NaCa" public_interface="in" units="femtoA" />
<variable cmeta:id="calcium_and_sodium_dynamics.i_Ca_pump" name="i_Ca_pump" public_interface="in" units="femtoA" />
<variable cmeta:id="calcium_and_sodium_dynamics.i_NaK" name="i_NaK" public_interface="in" units="femtoA" />
<variable cmeta:id="calcium_and_sodium_dynamics.i_Na" name="i_Na" public_interface="in" units="femtoA" />
<variable cmeta:id="calcium_and_sodium_dynamics.i_CRAN" name="i_CRAN" public_interface="in" units="femtoA" />
<variable cmeta:id="calcium_and_sodium_dynamics.F" name="F" public_interface="in" units="coulomb_per_mole" />
<variable cmeta:id="calcium_and_sodium_dynamics.J_out" name="J_out" public_interface="in" units="flux" />
<variable cmeta:id="calcium_and_sodium_dynamics.Jer_p" name="Jer_p" public_interface="in" units="flux" />
<variable cmeta:id="calcium_and_sodium_dynamics.time" name="time" public_interface="in" units="millisecond" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="Cai_diff_eq">
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Cai</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>fi</ci>
<apply>
<plus />
<apply>
<minus />
<apply>
<divide />
<apply>
<minus />
<apply>
<plus />
<apply>
<minus />
<ci>i_VCa</ci>
</apply>
<apply>
<times />
<ci>i_NaCa</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<times />
<ci>i_Ca_pump</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
<ci>F</ci>
<ci>Vi</ci>
</apply>
</apply>
<ci>Jer_p</ci>
</apply>
<apply>
<divide />
<ci>J_out</ci>
<ci>Vi</ci>
</apply>
</apply>
</apply>
<apply>
<times />
<ci>ksg</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
<apply id="CaER_diff_eq">
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>CaER</ci>
</apply>
<apply>
<times />
<apply>
<divide />
<ci>fer</ci>
<ci>Ver</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>Jer_p</ci>
<ci>Vi</ci>
</apply>
<ci>J_out</ci>
</apply>
</apply>
</apply>
<apply id="Nai_diff_eq">
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Nai</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
<ci>i_NaCa</ci>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
<ci>i_NaK</ci>
</apply>
<ci>i_Na</ci>
<ci>i_CRAN</ci>
</apply>
</apply>
<apply>
<times />
<ci>Vi</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ATP_homeostasis">
<variable cmeta:id="ATP_homeostasis.ATPi" initial_value="932.1" name="ATPi" public_interface="out" units="micromolar" />
<variable cmeta:id="ATP_homeostasis.ADPi" name="ADPi" public_interface="out" units="millimolar" />
<variable cmeta:id="ATP_homeostasis.k_ADP" name="k_ADP" units="first_order_rate_constant" />
<variable cmeta:id="ATP_homeostasis.k_ATP" initial_value="0.00005" name="k_ATP" units="first_order_rate_constant" />
<variable cmeta:id="ATP_homeostasis.k_ATP_Ca" initial_value="0.00005" name="k_ATP_Ca" units="second_order_rate_constant" />
<variable cmeta:id="ATP_homeostasis.Ao" initial_value="4000.0" name="Ao" units="micromolar" />
<variable cmeta:id="ATP_homeostasis.Vi" name="Vi" public_interface="in" units="picol" />
<variable cmeta:id="ATP_homeostasis.Cai" name="Cai" public_interface="in" units="micromolar" />
<variable cmeta:id="ATP_homeostasis.i_Ca_pump" name="i_Ca_pump" public_interface="in" units="femtoA" />
<variable cmeta:id="ATP_homeostasis.i_CRAN" name="i_CRAN" public_interface="in" units="femtoA" />
<variable cmeta:id="ATP_homeostasis.i_NaK" name="i_NaK" public_interface="in" units="femtoA" />
<variable cmeta:id="ATP_homeostasis.F" name="F" public_interface="in" units="coulomb_per_mole" />
<variable cmeta:id="ATP_homeostasis.Jer_p" name="Jer_p" public_interface="in" units="flux" />
<variable cmeta:id="ATP_homeostasis.time" name="time" public_interface="in" units="millisecond" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="ATPi_diff_eq">
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>ATPi</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>k_ADP</ci>
<ci>ADPi</ci>
</apply>
<apply>
<plus />
<apply>
<divide />
<apply>
<plus />
<ci>i_NaK</ci>
<ci>i_CRAN</ci>
</apply>
<apply>
<times />
<ci>Vi</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<divide />
<ci>Jer_p</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
<apply>
<times />
<apply>
<plus />
<apply>
<times />
<ci>k_ATP_Ca</ci>
<ci>Cai</ci>
</apply>
<ci>k_ATP</ci>
</apply>
<ci>ATPi</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>ADPi</ci>
<apply>
<minus />
<ci>Ao</ci>
<ci>ATPi</ci>
</apply>
</apply>
</math>
</component>
<component name="cell_and_external_parameters">
<variable cmeta:id="cell_and_external_parameters.Cao" initial_value="2.6" name="Cao" public_interface="out" units="millimolar" />
<variable cmeta:id="cell_and_external_parameters.Nao" initial_value="140.0" name="Nao" public_interface="out" units="millimolar" />
<variable cmeta:id="cell_and_external_parameters.Ko" initial_value="8.0" name="Ko" public_interface="out" units="millimolar" />
<variable cmeta:id="cell_and_external_parameters.Ki" initial_value="132.4" name="Ki" public_interface="out" units="millimolar" />
<variable cmeta:id="cell_and_external_parameters.R" initial_value="8314.0" name="R" public_interface="out" units="joule_per_kilomole_kelvin" />
<variable cmeta:id="cell_and_external_parameters.T" initial_value="310.0" name="T" public_interface="out" units="kelvin" />
<variable cmeta:id="cell_and_external_parameters.F" initial_value="96500.0" name="F" public_interface="out" units="coulomb_per_mole" />
<variable cmeta:id="cell_and_external_parameters.Vi" initial_value="0.764" name="Vi" public_interface="out" units="picol" />
</component>
<group>
<relationship_ref relationship="encapsulation" />
<component_ref component="calcium_dependent_potassium_current">
<component_ref component="calcium_dependent_potassium_current_fCa_gate" />
</component_ref>
<component_ref component="whole_cell_calcium_current">
<component_ref component="whole_cell_calcium_current_p_VCa_gate" />
</component_ref>
<component_ref component="sodium_current">
<component_ref component="sodium_current_p_Na_gate" />
</component_ref>
<component_ref component="voltage_dependent_potassium_current">
<component_ref component="voltage_dependent_potassium_current_n_gate" />
</component_ref>
</group>
<group>
<relationship_ref relationship="containment" />
<component_ref component="membrane">
<component_ref component="ATP_homeostasis" />
<component_ref component="SERCA_pump" />
<component_ref component="IP3_metabolism" />
<component_ref component="sodium_potassium_active_transport" />
<component_ref component="calcium_dependent_potassium_current">
<component_ref component="calcium_dependent_potassium_current_fCa_gate" />
</component_ref>
<component_ref component="ATP_dependent_potassium_current" />
<component_ref component="nonselective_cation_current" />
<component_ref component="cell_and_external_parameters" />
<component_ref component="voltage_dependent_potassium_current">
<component_ref component="voltage_dependent_potassium_current_n_gate" />
</component_ref>
<component_ref component="sodium_calcium_exchanger" />
<component_ref component="CaER_mobilisation" />
<component_ref component="PM_calcium_pumps" />
<component_ref component="whole_cell_calcium_current">
<component_ref component="whole_cell_calcium_current_p_VCa_gate" />
</component_ref>
<component_ref component="calcium_and_sodium_dynamics" />
<component_ref component="sodium_current">
<component_ref component="sodium_current_p_Na_gate" />
</component_ref>
</component_ref>
</group>
<connection>
<map_components component_1="cell_and_external_parameters" component_2="sodium_calcium_exchanger" />
<map_variables variable_1="Cao" variable_2="Cao" />
<map_variables variable_1="R" variable_2="R" />
<map_variables variable_1="Nao" variable_2="Nao" />
<map_variables variable_1="T" variable_2="T" />
<map_variables variable_1="F" variable_2="F" />
</connection>
<connection>
<map_components component_1="sodium_potassium_active_transport" component_2="ATP_homeostasis" />
<map_variables variable_1="i_NaK" variable_2="i_NaK" />
</connection>
<connection>
<map_components component_1="cell_and_external_parameters" component_2="calcium_and_sodium_dynamics" />
<map_variables variable_1="Vi" variable_2="Vi" />
<map_variables variable_1="F" variable_2="F" />
</connection>
<connection>
<map_components component_1="PM_calcium_pumps" component_2="calcium_and_sodium_dynamics" />
<map_variables variable_1="i_Ca_pump" variable_2="i_Ca_pump" />
</connection>
<connection>
<map_components component_1="membrane" component_2="voltage_dependent_potassium_current" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="calcium_and_sodium_dynamics" component_2="PM_calcium_pumps" />
<map_variables variable_1="Cai" variable_2="Cai" />
</connection>
<connection>
<map_components component_1="calcium_and_sodium_dynamics" component_2="IP3_metabolism" />
<map_variables variable_1="Cai" variable_2="Cai" />
</connection>
<connection>
<map_components component_1="environment" component_2="voltage_dependent_potassium_current" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="cell_and_external_parameters" component_2="voltage_dependent_potassium_current" />
<map_variables variable_1="Ko" variable_2="Ko" />
<map_variables variable_1="Ki" variable_2="Ki" />
<map_variables variable_1="R" variable_2="R" />
<map_variables variable_1="T" variable_2="T" />
<map_variables variable_1="F" variable_2="F" />
</connection>
<connection>
<map_components component_1="calcium_and_sodium_dynamics" component_2="calcium_dependent_potassium_current" />
<map_variables variable_1="Cai" variable_2="Cai" />
</connection>
<connection>
<map_components component_1="calcium_and_sodium_dynamics" component_2="sodium_current" />
<map_variables variable_1="Nai" variable_2="Nai" />
</connection>
<connection>
<map_components component_1="voltage_dependent_potassium_current_n_gate" component_2="voltage_dependent_potassium_current" />
<map_variables variable_1="n" variable_2="n" />
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_current" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="nonselective_cation_current" component_2="ATP_homeostasis" />
<map_variables variable_1="i_CRAN" variable_2="i_CRAN" />
</connection>
<connection>
<map_components component_1="voltage_dependent_potassium_current" component_2="calcium_dependent_potassium_current" />
<map_variables variable_1="V_K" variable_2="V_K" />
</connection>
<connection>
<map_components component_1="calcium_and_sodium_dynamics" component_2="CaER_mobilisation" />
<map_variables variable_1="Cai" variable_2="Cai" />
<map_variables variable_1="CaER" variable_2="CaER" />
</connection>
<connection>
<map_components component_1="whole_cell_calcium_current" component_2="calcium_and_sodium_dynamics" />
<map_variables variable_1="i_VCa" variable_2="i_VCa" />
</connection>
<connection>
<map_components component_1="membrane" component_2="calcium_dependent_potassium_current" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="voltage_dependent_potassium_current" component_2="membrane" />
<map_variables variable_1="i_KDr" variable_2="i_KDr" />
</connection>
<connection>
<map_components component_1="cell_and_external_parameters" component_2="whole_cell_calcium_current" />
<map_variables variable_1="Cao" variable_2="Cao" />
<map_variables variable_1="R" variable_2="R" />
<map_variables variable_1="T" variable_2="T" />
<map_variables variable_1="F" variable_2="F" />
</connection>
<connection>
<map_components component_1="environment" component_2="membrane" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="environment" component_2="calcium_and_sodium_dynamics" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="calcium_and_sodium_dynamics" component_2="sodium_potassium_active_transport" />
<map_variables variable_1="Nai" variable_2="Nai" />
</connection>
<connection>
<map_components component_1="SERCA_pump" component_2="calcium_and_sodium_dynamics" />
<map_variables variable_1="Jer_p" variable_2="Jer_p" />
</connection>
<connection>
<map_components component_1="whole_cell_calcium_current_p_VCa_gate" component_2="whole_cell_calcium_current" />
<map_variables variable_1="p_VCa" variable_2="p_VCa" />
</connection>
<connection>
<map_components component_1="calcium_and_sodium_dynamics" component_2="SERCA_pump" />
<map_variables variable_1="Cai" variable_2="Cai" />
</connection>
<connection>
<map_components component_1="whole_cell_calcium_current" component_2="whole_cell_calcium_current_p_VCa_gate" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="sodium_current" component_2="nonselective_cation_current" />
<map_variables variable_1="V_Na" variable_2="V_Na" />
</connection>
<connection>
<map_components component_1="ATP_homeostasis" component_2="ATP_dependent_potassium_current" />
<map_variables variable_1="ADPi" variable_2="ADPi" />
<map_variables variable_1="ATPi" variable_2="ATPi" />
</connection>
<connection>
<map_components component_1="calcium_dependent_potassium_current_fCa_gate" component_2="calcium_dependent_potassium_current" />
<map_variables variable_1="fCa" variable_2="fCa" />
</connection>
<connection>
<map_components component_1="calcium_dependent_potassium_current" component_2="membrane" />
<map_variables variable_1="i_KCa" variable_2="i_KCa" />
</connection>
<connection>
<map_components component_1="PM_calcium_pumps" component_2="ATP_homeostasis" />
<map_variables variable_1="i_Ca_pump" variable_2="i_Ca_pump" />
</connection>
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<connection>
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<connection>
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<connection>
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<connection>
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<connection>
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<connection>
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<connection>
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<connection>
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<connection>
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<connection>
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<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
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<dcterms:description>concentration of free extracellular calcium</dcterms:description>
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<dcterms:description>membrane potential</dcterms:description>
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<rdf:Description rdf:about="#PM_calcium_pumps.Cai">
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<rdf:Description rdf:about="#property_18">
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<dcterms:description>concentration of free intracellular calcium</dcterms:description>
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<dcterms:description>intracellular volume</dcterms:description>
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<dcterms:description>maximum conductance of voltage-dependent small conductance calcium-activated potassium current</dcterms:description>
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<rdf:Description rdf:about="#SERCA_pump.P_CaER">
<dcterms:description>maximum pumping rate of SERCA pumps</dcterms:description>
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<rdf:Description rdf:about="#sodium_potassium_active_transport.Ko">
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<rdf:Description rdf:about="#property_47">
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<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
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<dcterms:description>concentration of extracellular potassium</dcterms:description>
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<dcterms:description>reversal potential of non-selective cation current</dcterms:description>
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<rdf:Description rdf:about="#whole_cell_calcium_current.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#nonselective_cation_current.f_CRAN">
<dcterms:description>voltage-independent component of non-selective cation current</dcterms:description>
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<rdf:Description rdf:about="#property_10">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
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<dcterms:description>voltage-dependent calcium current</dcterms:description>
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<dcterms:description>rate constant of calcium-dependent ATP consumption</dcterms:description>
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.b3">
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<rdf:Description rdf:about="#membrane.i_VCa">
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<rdf:Description rdf:about="#property_1">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
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<dcterms:description>voltage-dependent calcium current</dcterms:description>
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<rdf:Description rdf:about="#voltage_dependent_potassium_current_n_gate.a">
<dcterms:description>adjustable coefficient</dcterms:description>
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<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_0" />
<dcterms:description>concentration of free intracellular calcium</dcterms:description>
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<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
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<dcterms:description>membrane potential</dcterms:description>
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<rdf:Description rdf:about="#SERCA_pump.Cai">
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<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
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<dcterms:description>concentration of free intracellular calcium</dcterms:description>
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_calcium_exchanger.V">
<dcterms:description>membrane potential</dcterms:description>
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<rdf:Description rdf:about="#property_20">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
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</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#membrane.i_Na">
<dcterms:description>inward sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.B2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.b1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="#voltage_dependent_potassium_current_n_gate.Sn">
<dcterms:description>slope at half-maximal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current.i_KDr">
<dcterms:description>delayed rectifier potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#IP3_metabolism.Cai">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_73">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
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</semsim:isComputationalComponentFor>
<dcterms:description>concentration of free intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_current.T">
<dcterms:description>absolute temperature</dcterms:description>
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<rdf:Description rdf:about="#voltage_dependent_potassium_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_calcium_exchanger.T">
<dcterms:description>absolute temperature</dcterms:description>
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#calcium_and_sodium_dynamics.i_Na">
<dcterms:description>inward sodium current</dcterms:description>
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_current_p_Na_gate.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current_n_gate.c">
<dcterms:description>adjustable coefficient</dcterms:description>
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current_n_gate.Vn">
<dcterms:description>half-activation potential of voltage-dependent potassium current</dcterms:description>
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_current.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_calcium_exchanger.g_NaCa">
<dcterms:description>maximum conductance of sodium-calcium exchange current</dcterms:description>
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#ATP_dependent_potassium_current.i_KATP">
<dcterms:description>ATP-dependent potassium current</dcterms:description>
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current_n_gate.tau_n">
<dcterms:description>relaxation time constant</dcterms:description>
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#ATP_homeostasis.Jer_p">
<dcterms:description>calcium uptake of the endoplasmic reticulum by SERCA pumps</dcterms:description>
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<rdf:Description rdf:about="#cell_and_external_parameters.Ko">
<semsim:isComputationalComponentFor>
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</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
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<dcterms:description>adjustable coefficient</dcterms:description>
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<rdf:Description rdf:about="#property_30">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
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<dcterms:description>membrane potential</dcterms:description>
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<dcterms:description>voltage-independent component of calcium-dependent potassium current</dcterms:description>
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<rdf:Description rdf:about="#calcium_dependent_potassium_current.V_K">
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<rdf:Description rdf:about="#property_55">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
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<dcterms:description>potassium reversal potential</dcterms:description>
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<dcterms:description>membrane potential</dcterms:description>
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<rdf:Description rdf:about="#ATP_homeostasis.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
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<rdf:Description rdf:about="#cell_and_external_parameters.T">
<dcterms:description>absolute temperature</dcterms:description>
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<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>rate constant of permanent ATP consumption</dcterms:description>
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<dcterms:description>half-activation potential of voltage-dependent calcium current</dcterms:description>
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#ATP_homeostasis.k_ADP">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>rate constant of ATP production</dcterms:description>
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<dcterms:description>concentration of free intracellular calcium</dcterms:description>
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<dcterms:description>membrane potential</dcterms:description>
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<dcterms:description>concentration of cytosolic ATP</dcterms:description>
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</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#membrane.i_KDr">
<dcterms:description>delayed rectifier potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ATP_homeostasis.Cai">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_97">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of free intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ATP_dependent_potassium_current.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_64">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_calcium_exchanger.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="#membrane.i_KDr">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_7">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>delayed rectifier potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_current.Nai">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_0" />
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#calcium_and_sodium_dynamics.Nai">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_0" />
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_current.gm_Na">
<dcterms:description>maximum conductance of inward sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ATP_dependent_potassium_current.Ktd">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_62">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_current.V_Na">
<dcterms:description>sodium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#cell_and_external_parameters.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#calcium_and_sodium_dynamics.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#calcium_dependent_potassium_current.fCa">
<dcterms:description>voltage-independent component of calcium-dependent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#cell_and_external_parameters.Vi">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_106">
<semsim:physicalPropertyOf rdf:resource="#entity_1" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>intracellular volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current_n_gate.Vtau">
<dcterms:description>adjustable coefficient</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.Ko">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_2" />
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#whole_cell_calcium_current.V_Ca">
<dcterms:description>calcium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ATP_dependent_potassium_current.Kdd">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_61">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#IP3_metabolism.Cai">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_0" />
<dcterms:description>concentration of free intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#PM_calcium_pumps.K_Cap">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_0" />
<dcterms:description>half-maximal pump activity of plasma membrane calcium pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#ATP_dependent_potassium_current.O_KATP">
<dcterms:description>fraction of ATP-sensitive potassium channels open</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.ATPi">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_0" />
<dcterms:description>concentration of cytosolic ATP</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_calcium_exchanger.Nao">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_2" />
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_calcium_exchanger.Cao">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_2" />
<dcterms:description>concentration of free extracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#membrane.Cm">
<dcterms:description>membrane capacitance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_current.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#ATP_dependent_potassium_current.Ktt">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_4" />
<dcterms:description>dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#calcium_dependent_potassium_current.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current.n">
<dcterms:description>gating variable of voltage-dependent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#CaER_mobilisation.IP3i">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_0" />
<dcterms:description>concentration of cytosolic IP3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#whole_cell_calcium_current.p_VCa">
<dcterms:description>current-voltage relationship of voltage-dependent calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#ATP_dependent_potassium_current.V_K">
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#voltage_dependent_potassium_current_n_gate.Vn">
<dcterms:description>half-activation potential of voltage-dependent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#calcium_dependent_potassium_current.gm_KCa">
<dcterms:description>maximum conductance of voltage-dependent small conductance calcium-activated potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_current.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="#ATP_dependent_potassium_current.i_KATP">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_60">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>ATP-dependent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_calcium_exchanger.K_NaCa">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_0" />
<dcterms:description>calcium affinity constant of sodium-calcium exchange current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#CaER_mobilisation.O_infinity">
<dcterms:description>fraction of open IP3-activated calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#whole_cell_calcium_current.gm_VCa">
<dcterms:description>maximum conductance of voltage-dependent calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#whole_cell_calcium_current.i_VCa">
<dcterms:description>voltage-dependent calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#CaER_mobilisation.J_out">
<dcterms:description>calcium leak current out of the endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#nonselective_cation_current.V_CRAN">
<dcterms:description>reversal potential of calcium release-activated nonselective cation current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#IP3_metabolism.kdIP">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>IP3 degradation rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#calcium_and_sodium_dynamics.Cai">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_0" />
<dcterms:description>concentration of free intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ATP_homeostasis.ADPi">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_94">
<semsim:physicalPropertyOf rdf:resource="#entity_11" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of cytosolic ADP</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#calcium_and_sodium_dynamics.i_NaCa">
<dcterms:description>sodium-calcium exchange current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.i_CRAN">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_4">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium release-activated nonselective cation current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#calcium_and_sodium_dynamics.i_Ca_pump">
<dcterms:description>plasma membrane calcium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_calcium_exchanger.i_NaCa">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_19">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium-calcium exchange current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#IP3_metabolism.IP3i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_71">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_14">
<ro:part_of rdf:resource="#entity_1" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:16595" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of cytosolic IP3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#whole_cell_calcium_current.Cai">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_0" />
<dcterms:description>concentration of free intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#cell_and_external_parameters.Nao">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_2" />
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#whole_cell_calcium_current.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#fridlyand_tamarina_philipson_2003_version01" bqmodel:isDescribedBy="12644446">
<semsim:modelName>fridlyand_tamarina_philipson_2003_version01</semsim:modelName>
<semsim:unknown>Pancreatic Beta-cell</semsim:unknown>
<semsim:modelName>fridlyand_tamarina_philipson_2003</semsim:modelName>
<semsim:unknown>Fridlyand et al's 2003 mathematical model of Ca2+ fluxes in pancreatic
beta-cells.</semsim:unknown>
</rdf:Description>
<rdf:Description rdf:about="#calcium_and_sodium_dynamics.i_Na">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_89">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>inward sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.i_NaCa">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_3">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium-calcium exchange current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#ATP_homeostasis.ATPi">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_0" />
<dcterms:description>concentration of cytosolic ATP</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_calcium_exchanger.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#CaER_mobilisation.P_leak">
<dcterms:description>calcium leak permeability out of the endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#ATP_homeostasis.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#CaER_mobilisation.P_leak">
<dcterms:description>calcium leak permeability out of the endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#calcium_dependent_potassium_current_fCa_gate.K_KCa">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_0" />
<dcterms:description>affinity constant of voltage-dependent small conductance calcium-activated potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current_n_gate.n_infinity">
<dcterms:description>steady-state value of gating variable of voltage-dependent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ATP_dependent_potassium_current.O_KATP">
<dcterms:description>fraction of ATP-sensitive potassium channels open</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#calcium_dependent_potassium_current_fCa_gate.Cai">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_0" />
<dcterms:description>concentration of free intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_current.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="#sodium_calcium_exchanger.Cai">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_23">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of free intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current.Ko">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_2" />
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#cell_and_external_parameters.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="#sodium_calcium_exchanger.Nai">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_25">
<semsim:physicalPropertyOf rdf:resource="#entity_4" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#calcium_dependent_potassium_current.i_KCa">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_54">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>voltage-dependent small conductance calcium-activated potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#cell_and_external_parameters.Ko">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_2" />
<dcterms:description>concentration of extracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_current_p_Na_gate.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_38">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#whole_cell_calcium_current.Cao">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_2" />
<dcterms:description>concentration of free extracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#cell_and_external_parameters.Cao">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_2" />
<dcterms:description>concentration of free extracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#membrane.i_NaK">
<dcterms:description>sodium-potassium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#calcium_dependent_potassium_current.Cai">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_0" />
<dcterms:description>concentration of free intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_current.i_Na">
<dcterms:description>inward sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#nonselective_cation_current.V_CRAN">
<dcterms:description>reversal potential of calcium release-activated nonselective cation current</dcterms:description>
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#whole_cell_calcium_current.T">
<dcterms:description>absolute temperature</dcterms:description>
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<rdf:Description rdf:about="#sodium_potassium_active_transport.f1">
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<rdf:Description rdf:about="#ATP_homeostasis.Ao">
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<rdf:Description rdf:about="#property_95">
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<rdf:Description rdf:about="#entity_15">
<ro:part_of rdf:resource="#entity_1" />
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<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
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<dcterms:description>concentration of intracellular nucleotides</dcterms:description>
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.i_NaK">
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<dcterms:description>slope of voltage-dependent calcium current at half-maximum potential</dcterms:description>
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_current.p_Na">
<dcterms:description>current-voltage relationship of sodium current</dcterms:description>
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<rdf:Description rdf:about="#property_21">
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<dcterms:description>calcium affinity constant of sodium-calcium exchange current</dcterms:description>
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<dcterms:description>concentration of intracellular nucleotides</dcterms:description>
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<rdf:Description rdf:about="#IP3_metabolism.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
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<rdf:Description rdf:about="#sodium_potassium_active_transport.Nai">
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<rdf:Description rdf:about="#property_43">
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</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
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<rdf:Description rdf:about="#CaER_mobilisation.IP3i">
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<rdf:Description rdf:about="#property_77">
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<dcterms:description>concentration of cytosolic IP3</dcterms:description>
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<rdf:Description rdf:about="#voltage_dependent_potassium_current.Ko">
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<rdf:Description rdf:about="#property_52">
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</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular potassium</dcterms:description>
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<dcterms:description>potassium reversal potential</dcterms:description>
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<rdf:Description rdf:about="#sodium_current.T">
<dcterms:description>absolute temperature</dcterms:description>
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#whole_cell_calcium_current_p_VCa_gate.V">
<dcterms:description>membrane potential</dcterms:description>
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current_n_gate.Sn">
<dcterms:description>slope at half-maximal potential</dcterms:description>
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#PM_calcium_pumps.Pm_Cap">
<dcterms:description>maximum plasma membrane calcium pump current</dcterms:description>
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<rdf:Description rdf:about="#sodium_potassium_active_transport.F1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#cell_and_external_parameters.T">
<dcterms:description>absolute temperature</dcterms:description>
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<rdf:Description rdf:about="#calcium_and_sodium_dynamics.Cai">
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<rdf:Description rdf:about="#property_80">
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<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
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</semsim:isComputationalComponentFor>
<dcterms:description>concentration of free intracellular calcium</dcterms:description>
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<rdf:Description rdf:about="#calcium_and_sodium_dynamics.Nai">
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<rdf:Description rdf:about="#property_82">
<semsim:physicalPropertyOf rdf:resource="#entity_4" />
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</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular sodium</dcterms:description>
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#calcium_dependent_potassium_current.i_KCa">
<dcterms:description>voltage-dependent small conductance calcium-activated potassium current</dcterms:description>
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<rdf:Description rdf:about="#ATP_homeostasis.i_Ca_pump">
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<rdf:Description rdf:about="#property_98">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
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</semsim:isComputationalComponentFor>
<dcterms:description>plasma membrane calcium pump current</dcterms:description>
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<rdf:Description rdf:about="#PM_calcium_pumps.i_Ca_pump">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_16">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
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</semsim:isComputationalComponentFor>
<dcterms:description>plasma membrane calcium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_potassium_active_transport.f3">
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</rdf:Description>
<rdf:Description rdf:about="#sodium_potassium_active_transport.F4">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#ATP_dependent_potassium_current.ATPi">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_0" />
<dcterms:description>concentration of cytosolic ATP</dcterms:description>
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#membrane.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#whole_cell_calcium_current.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#ATP_dependent_potassium_current.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#nonselective_cation_current.i_CRAN">
<dcterms:description>calcium release-activated nonselective cation current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_potassium_active_transport.Nao">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_44">
<semsim:physicalPropertyOf rdf:resource="#entity_5" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#CaER_mobilisation.K_IP3">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_76">
<semsim:physicalPropertyOf rdf:resource="#entity_14" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>affinity constant of intracellular IP3 to IP3 receptor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#CaER_mobilisation.O_infinity">
<dcterms:description>fraction of open IP3-activated calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#ATP_homeostasis.i_NaK">
<dcterms:description>sodium-potassium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ATP_dependent_potassium_current.ATPi">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_67">
<semsim:physicalPropertyOf rdf:resource="#entity_10" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
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</semsim:isComputationalComponentFor>
<dcterms:description>concentration of cytosolic ATP</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#calcium_and_sodium_dynamics.fer">
<dcterms:description>fraction of free calcium in endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#calcium_and_sodium_dynamics.Ver">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_83">
<semsim:physicalPropertyOf rdf:resource="#entity_9" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00154" />
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</semsim:isComputationalComponentFor>
<dcterms:description>volume of endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_potassium_active_transport.f2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#cell_and_external_parameters.Vi">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_4" />
<dcterms:description>intracellular volume</dcterms:description>
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#ATP_homeostasis.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current_n_gate.n">
<dcterms:description>gating variable of voltage-dependent potassium current</dcterms:description>
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<rdf:Description rdf:about="#nonselective_cation_current.i_CRAN">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_27">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
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</semsim:isComputationalComponentFor>
<dcterms:description>calcium release-activated nonselective cation current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#voltage_dependent_potassium_current_n_gate.n_infinity">
<dcterms:description>steady-state value of gating variable of voltage-dependent potassium current</dcterms:description>
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<rdf:Description rdf:about="#voltage_dependent_potassium_current_n_gate.n">
<dcterms:description>gating variable of voltage-dependent potassium current</dcterms:description>
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.Nao">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_2" />
<dcterms:description>concentration of extracellular sodium</dcterms:description>
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#nonselective_cation_current.gm_CRAN">
<dcterms:description>maximum conductance coefficient of calcium release-activated nonselective cation current</dcterms:description>
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#calcium_and_sodium_dynamics.i_NaK">
<dcterms:description>sodium-potassium pump current</dcterms:description>
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
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<rdf:Description rdf:about="#environment.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
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<rdf:Description rdf:about="#whole_cell_calcium_current.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_12">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
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<dcterms:description>membrane potential</dcterms:description>
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<rdf:Description rdf:about="#voltage_dependent_potassium_current.F">
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<rdf:Description rdf:about="#sodium_potassium_active_transport.f5">
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<rdf:Description rdf:about="#PM_calcium_pumps.Pm_Cap">
<dcterms:description>maximum plasma membrane calcium pump current</dcterms:description>
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#calcium_dependent_potassium_current.V_K">
<dcterms:description>potassium reversal potential</dcterms:description>
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<rdf:Description rdf:about="#IP3_metabolism.K_IPCa">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_72">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_6">
<ro:part_of>
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</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/chebi/CHEBI:29108" />
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<dcterms:description>half activation intracellular calcium concentration of IP3 metabolism</dcterms:description>
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#CaER_mobilisation.P_IP3">
<dcterms:description>maximum endoplasmic reticulum calcium permeability through open IP3-activated channels</dcterms:description>
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<rdf:Description rdf:about="#sodium_potassium_active_transport.f6">
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<rdf:Description rdf:about="#nonselective_cation_current.K_Car">
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<rdf:Description rdf:about="#property_28">
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#PM_calcium_pumps.i_Ca_pump">
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<rdf:Description rdf:about="#SERCA_pump.K_Carp">
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<dcterms:description>half maximal pump activity of SERCA pumps</dcterms:description>
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<rdf:Description rdf:about="#cell_and_external_parameters.Ki">
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</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium uptake of the endoplasmic reticulum by SERCA pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#IP3_metabolism.kdIP">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>IP3 degradation rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#fridlyand_tamarina_philipson_2003_version01" bqmodel:isDescribedBy="12644446" />
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_calcium_exchanger.V_NaCa">
<dcterms:description>reversal potential of sodium-calcium exchanger</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#whole_cell_calcium_current_p_VCa_gate.p_VCa">
<dcterms:description>current-voltage relationship of voltage-dependent calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#cell_and_external_parameters.Nao">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_103">
<semsim:physicalPropertyOf rdf:resource="#entity_5" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of extracellular sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#membrane.i_KCa">
<dcterms:description>voltage-dependent small conductance calcium-activated potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ATP_homeostasis.k_ADP">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>rate constant of ATP production</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#whole_cell_calcium_current.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="#SERCA_pump.Jer_p">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_68">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium uptake of the endoplasmic reticulum by SERCA pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_potassium_active_transport.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#ATP_dependent_potassium_current.gm_KATP">
<dcterms:description>maximum conductance of ATP-dependent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#cell_and_external_parameters.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="#cell_and_external_parameters.Cao">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_102">
<semsim:physicalPropertyOf rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of free extracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#voltage_dependent_potassium_current_n_gate.tau_n">
<dcterms:description>relaxation time constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#calcium_dependent_potassium_current.fCa">
<dcterms:description>voltage-independent component of calcium-dependent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#calcium_dependent_potassium_current_fCa_gate.fCa">
<dcterms:description>voltage-independent component of calcium-dependent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#ATP_homeostasis.i_Ca_pump">
<dcterms:description>plasma membrane calcium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.P_NaK">
<dcterms:description>current coefficient of sodium-potassium pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ATP_homeostasis.k_ATP">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>rate constant of calcium-dependent ATP consumption</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#membrane.i_VCa">
<dcterms:description>voltage-dependent calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#sodium_potassium_active_transport.b1">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#membrane.i_Na">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_5">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>inward sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.ADPi">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_0" />
<dcterms:description>concentration of cytosolic ADP</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_current.gm_Na">
<dcterms:description>maximum conductance of inward sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.i_NaK">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_6">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium-potassium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#calcium_and_sodium_dynamics.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="#voltage_dependent_potassium_current.i_KDr">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_48">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>delayed rectifier potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#voltage_dependent_potassium_current.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="#calcium_and_sodium_dynamics.Vi">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_84">
<semsim:physicalPropertyOf rdf:resource="#entity_1" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>intracellular volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_current.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.f6">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#sodium_potassium_active_transport.ADPi">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_46">
<semsim:physicalPropertyOf rdf:resource="#entity_11" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of cytosolic ADP</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_potassium_active_transport.b2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#sodium_potassium_active_transport.B3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#ATP_homeostasis.Cai">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_0" />
<dcterms:description>concentration of free intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#CaER_mobilisation.CaER">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_3" />
<dcterms:description>concentration of calcium in endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#calcium_and_sodium_dynamics.fi">
<dcterms:description>fraction of free calcium in cytoplasm</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_current.i_Na">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_33">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>inward sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current.Ki">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_0" />
<dcterms:description>concentration of intracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_potassium_active_transport.i_NaK">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_39">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium-potassium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_potassium_active_transport.b5_">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#calcium_and_sodium_dynamics.J_out">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_91">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium leak current out of the endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_potassium_active_transport.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_42">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#CaER_mobilisation.P_IP3">
<dcterms:description>maximum endoplasmic reticulum calcium permeability through open IP3-activated channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_potassium_active_transport.B2">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#sodium_current.p_Na">
<dcterms:description>current-voltage relationship of sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.f5">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#ATP_homeostasis.i_CRAN">
<dcterms:description>calcium release-activated nonselective cation current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#whole_cell_calcium_current.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#nonselective_cation_current.gm_CRAN">
<dcterms:description>maximum conductance coefficient of calcium release-activated nonselective cation current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#ATP_dependent_potassium_current.Ktd">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_4" />
<dcterms:description>dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#environment.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current_n_gate.V">
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="#calcium_and_sodium_dynamics.ksg">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>coefficient of calcium sequestration rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ATP_homeostasis.i_CRAN">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_99">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>calcium release-activated nonselective cation current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#calcium_and_sodium_dynamics.i_NaK">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_88">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium-potassium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#voltage_dependent_potassium_current_n_gate.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_53">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#voltage_dependent_potassium_current.gm_KDr">
<dcterms:description>maximum conductance of delayed rectifier potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#IP3_metabolism.kIP">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>IP3 production rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.F5">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.f4">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#sodium_potassium_active_transport.b4">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="#voltage_dependent_potassium_current.Ki">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_51">
<semsim:physicalPropertyOf rdf:resource="#entity_13" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of intracellular potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#membrane.i_KATP">
<dcterms:description>ATP-dependent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.Cm">
<dcterms:description>membrane capacitance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ATP_homeostasis.i_NaK">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_100">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium-potassium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_current.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_35">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ATP_dependent_potassium_current.Ktt">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_63">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#nonselective_cation_current.f_CRAN">
<dcterms:description>voltage-independent component of non-selective cation current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#CaER_mobilisation.CaER">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_79">
<semsim:physicalPropertyOf rdf:resource="#entity_8" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of calcium in endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.i_KATP">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_9">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>ATP-dependent potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ATP_homeostasis.F">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_00089" />
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current.gm_KDr">
<dcterms:description>maximum conductance of delayed rectifier potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#calcium_and_sodium_dynamics.i_Ca_pump">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_87">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>plasma membrane calcium pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#calcium_and_sodium_dynamics.ksg">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
<dcterms:description>coefficient of calcium sequestration rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_calcium_exchanger.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_22">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#IP3_metabolism.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#ATP_dependent_potassium_current.Kdd">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_4" />
<dcterms:description>dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#whole_cell_calcium_current.gm_VCa">
<dcterms:description>maximum conductance of voltage-dependent calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_potassium_active_transport.b3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.F4">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#calcium_and_sodium_dynamics.i_VCa">
<dcterms:description>voltage-dependent calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_potassium_active_transport.B4">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.f3">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
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<rdf:Description rdf:about="#voltage_dependent_potassium_current.V_K">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_49">
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</semsim:isComputationalComponentFor>
<dcterms:description>potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_calcium_exchanger.T">
<dcterms:description>absolute temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_potassium_active_transport.P">
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</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:about="#whole_cell_calcium_current_p_VCa_gate.K_Cah">
<dcterms:description>slope of voltage-dependent calcium current at half-maximum potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#whole_cell_calcium_current.Cai">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_13">
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</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of free intracellular calcium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_potassium_active_transport.b6">
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</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#nonselective_cation_current.V_Na">
<dcterms:description>sodium reversal potential</dcterms:description>
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.f2">
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#IP3_metabolism.IP3i">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_0" />
<dcterms:description>concentration of cytosolic IP3</dcterms:description>
</rdf:Description>
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<rdf:Description rdf:about="#sodium_current.V_Na">
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<rdf:Description rdf:about="#property_34">
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</semsim:isComputationalComponentFor>
<dcterms:description>sodium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#voltage_dependent_potassium_current.n">
<dcterms:description>gating variable of voltage-dependent potassium current</dcterms:description>
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<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#sodium_potassium_active_transport.Nai">
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<dcterms:description>concentration of intracellular sodium</dcterms:description>
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<rdf:Description rdf:about="#calcium_dependent_potassium_current.V">
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</semsim:isComputationalComponentFor>
<dcterms:description>membrane potential</dcterms:description>
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<rdf:Description rdf:about="#calcium_and_sodium_dynamics.Jer_p">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_92">
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00593" />
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</semsim:isComputationalComponentFor>
<dcterms:description>calcium uptake of the endoplasmic reticulum by SERCA pumps</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#voltage_dependent_potassium_current_n_gate.time">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#sodium_potassium_active_transport.R">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01682" />
</rdf:Description>
<rdf:Description rdf:about="#ATP_homeostasis.ATPi">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_93">
<semsim:physicalPropertyOf rdf:resource="#entity_10" />
<semsim:hasPhysicalDefinition rdf:resource="https://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of cytosolic ATP</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_potassium_active_transport.B6">
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</rdf:Description>
<rdf:Description rdf:about="fridlyand_tamarina_philipson_2003.cellml#calcium_and_sodium_dynamics.CaER">
<bqbiol:isPropertyOf rdf:resource="fridlyand_tamarina_philipson_2003.cellml#entity_3" />
<dcterms:description>concentration of calcium in endoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_potassium_active_transport.b5">
<bqbiol:is rdf:resource="https://identifiers.org/opb/OPB_01296" />
</rdf:Description>
</rdf:RDF>
</model>
