Location: BG_Kp @ b2c93aa10b2e / parameter_finder / output / TEMP.cellml.txt

Author:

Shelley Fong <s.fong@auckland.ac.nz>

Date:

2022-03-02 14:22:32+13:00

Desc:

Rename

Permanent Source URI:

https://staging.physiomeproject.org/workspace/825/rawfile/b2c93aa10b2ee8d9bf9ddddd0db4130d75cb81e9/parameter_finder/output/TEMP.cellml.txt

def model individual_Kp_channel as
 def import using "units_and_constants/units_BG.cellml" for
        unit mM using unit mM;
unit fmol using unit fmol;
unit per_fmol using unit per_fmol;
        unit J_per_mol using unit J_per_mol;
unit fmol_per_sec using unit fmol_per_sec;
        unit C_per_mol using unit C_per_mol;
  unit J_per_C using unit J_per_C;
        unit microm3 using unit microm3;
  unit fF using unit fF;
        unit fC using unit fC;
  unit fA using unit fA;
        unit per_second using unit per_second;
  unit millivolt using unit millivolt;
        unit per_sec using unit per_sec;
  unit J_per_K_per_mol using unit J_per_K_per_mol;
        unit fmol_per_L using unit fmol_per_L;
  unit fmol_per_L_per_sec using unit fmol_per_L_per_sec;
        unit per_sec_per_fmol_per_L using unit per_sec_per_fmol_per_L;
  unit uM using unit uM;
        unit mM_per_sec using unit mM_per_sec;
  unit uM_per_sec using unit uM_per_sec;
        unit pL using unit pL;
  unit m_to_u using unit m_to_u;
 enddef;
def import using "units_and_constants/constants_BG.cellml" for
            comp constants using comp constants;
enddef;

    def comp environment as
    var time: second {pub: out};
    // initial values
var q_Ki: fmol {init: 1e-888, pub: out};
var q_Ko: fmol {init: 1e-888, pub: out};
var q_C_Kp: fmol {init: 1e-888, pub: out};
var q_O_Kp: fmol {init: 1e-888, pub: out};
// From submodule
var v_Kp: fmol_per_sec {pub: in};
var v_gKp: fmol_per_sec {pub: in};
ode(q_Ki, time) = vvv;
ode(q_Ko, time) = vvv;
ode(q_C_Kp, time) = vvv;
ode(q_O_Kp, time) = vvv;
enddef;

def comp Kp_channel_parameters as
var kappa_Kp: fmol_per_sec {init: 29.3467, pub: out};
var kappa_gKp: fmol_per_sec {init: 49.2085, pub: out};
var K_Ki: per_fmol {init: 0.157479, pub: out};
var K_Ko: per_fmol {init: 0.157479, pub: out};
var K_C_Kp: per_fmol {init: 20.3186, pub: out};
var K_O_Kp: per_fmol {init: 71.0732, pub: out};
enddef;
def comp Kp_channel as
        var time: second {pub: in};
        var R: J_per_K_per_mol {pub: in};
        var T: kelvin {pub: in};
        // parameters
var kappa_Kp: fmol_per_sec {pub: in};
var kappa_gKp: fmol_per_sec {pub: in};
var K_Ki: per_fmol {pub: in};
var K_Ko: per_fmol {pub: in};
var K_C_Kp: per_fmol {pub: in};
var K_O_Kp: per_fmol {pub: in};
// Input from global environment
var q_Ki: fmol {pub: in};
var q_Ko: fmol {pub: in};
var q_C_Kp: fmol {pub: in};
var q_O_Kp: fmol {pub: in};
// Constitutive parameters
var mu_Ki: J_per_mol;
var mu_Ko: J_per_mol;
var mu_C_Kp: J_per_mol;
var mu_O_Kp: J_per_mol;
var v_Kp: fmol_per_sec {pub: out};
var v_gKp: fmol_per_sec {pub: out};
mu_Ki = R*T*ln(K_Ki*q_Ki);
mu_Ko = R*T*ln(K_Ko*q_Ko);
mu_C_Kp = R*T*ln(K_C_Kp*q_C_Kp);
mu_O_Kp = R*T*ln(K_O_Kp*q_O_Kp);
v_Kp = ppp;
v_gKp = ppp;
enddef;
def map between environment and Kp_channel for
vars time and time;
vars q_Ki and q_Ki;
vars q_Ko and q_Ko;
vars q_C_Kp and q_C_Kp;
vars q_O_Kp and q_O_Kp;
vars v_Kp and v_Kp;
vars v_gKp and v_gKp;
enddef;
def map between Kp_channel and Kp_channel_parameters for
vars kappa_Kp and kappa_Kp;
vars kappa_gKp and kappa_gKp;
vars K_Ki and K_Ki;
vars K_Ko and K_Ko;
vars K_C_Kp and K_C_Kp;
vars K_O_Kp and K_O_Kp;
enddef;
def map between constants and Kp_channel for
vars R and R;
 vars T and T;
enddef;
enddef;