Location: BG_funny @ 7253f3ad1bea / V_clamp_exp / BG_Vclamp.cellml
- Author:
- Shelley Fong <sfon036@UoA.auckland.ac.nz>
- Date:
- 2024-12-13 14:19:08+13:00
- Desc:
- Updating params to match LRd cell vol
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/838/rawfile/7253f3ad1bea5077430a219a92f3b191ae3e4aa0/V_clamp_exp/BG_Vclamp.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="funny" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="../units_and_constants/units_BG.cellml">
<units name="mM" units_ref="mM"/>
<units name="per_mol" units_ref="per_mol"/>
<units name="J_per_mol" units_ref="J_per_mol"/>
<units name="J_per_C" units_ref="J_per_C"/>
<units name="J_per_K_per_mol" units_ref="J_per_K_per_mol"/>
<units name="mol_per_s" units_ref="mol_per_s"/>
<units name="C_per_mol" units_ref="C_per_mol"/>
<units name="microm3" units_ref="microm3"/>
<units name="fF" units_ref="fF"/>
<units name="fC" units_ref="fC"/>
<units name="fA" units_ref="fA"/>
<units name="fmol" units_ref="fmol"/>
<units name="fmol_per_sec" units_ref="fmol_per_sec"/>
<units name="per_fmol" units_ref="per_fmol"/>
<units name="pL" units_ref="pL"/>
<units name="mA_per_mM" units_ref="mA_per_mM"/>
<units name="per_sec" units_ref="per_sec"/>
</import>
<units name="mV">
<unit prefix="milli" units="volt"/>
</units>
<units name="microA_per_microF">
<unit prefix="micro" units="ampere"/>
<unit exponent="-1" prefix="micro" units="farad"/>
</units>
<units name="milliS_per_microF">
<unit prefix="milli" units="siemens"/>
<unit exponent="-1" prefix="milli" units="farad"/>
</units>
<units name="V_to_mV">
<unit exponent="-1" units="volt"/>
<unit prefix="milli" units="volt"/>
</units>
<units name="per_mV">
<unit exponent="-1" prefix="milli" units="volt"/>
</units>
<component name="environment">
<variable name="t" public_interface="out" units="second"/>
<variable initial_value="153400" name="C_m" public_interface="out" units="fF"/>
<variable initial_value="27.9828" name="q_K_o" public_interface="out" units="fmol"/>
<variable initial_value="5510" name="q_K_i" public_interface="out" units="fmol"/>
<variable initial_value="9.3276" name="q_Na_o" public_interface="out" units="fmol"/>
<variable initial_value="0.00456" name="q_Na_i" public_interface="out" units="fmol"/>
<variable name="q_mem" public_interface="out" units="fC"/>
<variable initial_value="8.31" name="R" public_interface="out" units="J_per_K_per_mol"/>
<variable initial_value="310" name="T" public_interface="out" units="kelvin"/>
<variable initial_value="96500" name="F" public_interface="out" units="C_per_mol"/>
<variable name="v_funny_K" public_interface="in" units="fmol_per_sec"/>
<variable name="v_funny_Na" public_interface="in" units="fmol_per_sec"/>
<variable name="I_mem_funny" public_interface="in" units="fA"/>
<variable name="I_funny_K_BG" units="fA"/>
<variable name="I_funny_Na_BG" units="fA"/>
<variable name="I_funny_total_BG" units="fA"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_K_i</ci>
</apply>
<apply>
<minus/>
<ci>v_funny_K</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_K_o</ci>
</apply>
<ci>v_funny_K</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_Na_i</ci>
</apply>
<apply>
<minus/>
<ci>v_funny_Na</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_Na_o</ci>
</apply>
<ci>v_funny_Na</ci>
</apply>
</math>
<variable name="V_mem" public_interface="out" units="J_per_C"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_mem</ci>
<piecewise>
<piece>
<apply>
<minus/>
<cn cellml:units="volt">0.09</cn>
</apply>
<apply>
<and/>
<apply>
<geq/>
<ci>t</ci>
<cn cellml:units="second">0</cn>
</apply>
<apply>
<lt/>
<ci>t</ci>
<cn cellml:units="second">4</cn>
</apply>
</apply>
</piece>
<piece>
<apply>
<minus/>
<cn cellml:units="volt">0.06</cn>
</apply>
<apply>
<and/>
<apply>
<gt/>
<ci>t</ci>
<cn cellml:units="second">10.1</cn>
</apply>
<apply>
<lt/>
<ci>t</ci>
<cn cellml:units="second">13.1</cn>
</apply>
</apply>
</piece>
<piece>
<apply>
<minus/>
<cn cellml:units="volt">0.04</cn>
</apply>
<apply>
<and/>
<apply>
<gt/>
<ci>t</ci>
<cn cellml:units="second">14.1</cn>
</apply>
<apply>
<lt/>
<ci>t</ci>
<cn cellml:units="second">15.1</cn>
</apply>
</apply>
</piece>
<piece>
<apply>
<minus/>
<cn cellml:units="volt">0.09</cn>
</apply>
<apply>
<gt/>
<ci>t</ci>
<cn cellml:units="second">17.0</cn>
</apply>
</piece>
<otherwise>
<apply>
<minus/>
<cn cellml:units="volt">0.08</cn>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>q_mem</ci>
<apply>
<times/>
<ci>V_mem</ci>
<ci>C_m</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_funny_K_BG</ci>
<apply>
<times/>
<ci>F</ci>
<ci>v_funny_K</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_funny_Na_BG</ci>
<apply>
<times/>
<ci>F</ci>
<ci>v_funny_Na</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_funny_total_BG</ci>
<apply>
<plus/>
<ci>I_funny_Na_BG</ci>
<ci>I_funny_K_BG</ci>
</apply>
</apply>
</math>
<!-- kinetic-->
<variable initial_value="38" name="vol" units="pL"/>
<variable initial_value="5.18" name="volo" units="pL"/>
<variable name="Nai" public_interface="out" units="mM"/>
<variable name="Nao" public_interface="out" units="mM"/>
<variable name="Ki" public_interface="out" units="mM"/>
<variable name="Ko" public_interface="out" units="mM"/>
<variable name="i_fNa_kinetic" public_interface="in" units="microA_per_microF"/>
<variable name="i_fNa_kinetic_fA" units="fA"/>
<variable name="i_fK_kinetic" public_interface="in" units="microA_per_microF"/>
<variable name="i_fK_kinetic_fA" units="fA"/>
<variable name="i_ftotal_kinetic_fA" units="fA"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Nai</ci>
<apply>
<divide/>
<ci>q_Na_i</ci>
<ci>vol</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Nao</ci>
<apply>
<divide/>
<ci>q_Na_o</ci>
<ci>volo</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Ki</ci>
<apply>
<divide/>
<ci>q_K_i</ci>
<ci>vol</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Ko</ci>
<apply>
<divide/>
<ci>q_K_o</ci>
<ci>volo</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_fNa_kinetic_fA</ci>
<apply>
<times/>
<ci>i_fNa_kinetic</ci>
<ci>C_m</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_fK_kinetic_fA</ci>
<apply>
<times/>
<ci>i_fK_kinetic</ci>
<ci>C_m</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_ftotal_kinetic_fA</ci>
<apply>
<plus/>
<ci>i_fNa_kinetic_fA</ci>
<ci>i_fK_kinetic_fA</ci>
</apply>
</apply>
</math>
</component>
<component name="funny_parameters">
<variable initial_value="0.0615965" name="kappa_funny_Na" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.00580799" name="kappa_funny_K" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.0947738" name="kappa_R_xf" public_interface="out" units="fmol_per_sec"/>
<variable initial_value="0.00721472" name="K_Na_i" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0478939" name="K_Na_o" public_interface="out" units="per_fmol"/>
<variable initial_value="0.00221541" name="K_K_i" public_interface="out" units="per_fmol"/>
<variable initial_value="0.0147067" name="K_K_o" public_interface="out" units="per_fmol"/>
<variable initial_value="0.000958774" name="K_x0_funny" public_interface="out" units="per_fmol"/>
<variable initial_value="98.8489" name="K_x1_funny" public_interface="out" units="per_fmol"/>
<variable initial_value="1" name="zNa" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="zK" public_interface="out" units="dimensionless"/>
<variable initial_value="-2.29569" name="z_xff" public_interface="out" units="dimensionless"/>
<variable initial_value="0.707659" name="z_xfr" public_interface="out" units="dimensionless"/>
</component>
<component name="funny">
<variable name="t" public_interface="in" units="second"/>
<variable name="R" public_interface="in" units="J_per_K_per_mol"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="zNa" public_interface="in" units="dimensionless"/>
<variable name="zK" public_interface="in" units="dimensionless"/>
<variable name="F" public_interface="in" units="C_per_mol"/>
<variable name="C_m" public_interface="in" units="fF"/>
<variable name="kappa_funny_Na" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_funny_K" public_interface="in" units="fmol_per_sec"/>
<variable name="K_Na_i" public_interface="in" units="per_fmol"/>
<variable name="K_Na_o" public_interface="in" units="per_fmol"/>
<variable name="K_K_i" public_interface="in" units="per_fmol"/>
<variable name="K_K_o" public_interface="in" units="per_fmol"/>
<!-- state variables-->
<variable name="q_K_i" public_interface="in" units="fmol"/>
<variable name="q_K_o" public_interface="in" units="fmol"/>
<variable name="q_Na_i" public_interface="in" units="fmol"/>
<variable name="q_Na_o" public_interface="in" units="fmol"/>
<variable name="q_mem" public_interface="in" units="fC"/>
<variable name="v_funny_K" public_interface="out" units="fmol_per_sec"/>
<variable name="v_funny_Na" public_interface="out" units="fmol_per_sec"/>
<variable name="I_mem_funny" public_interface="out" units="fA"/>
<variable name="mu_K_i" units="J_per_mol"/>
<variable name="mu_K_o" units="J_per_mol"/>
<variable name="mu_Na_i" units="J_per_mol"/>
<variable name="mu_Na_o" units="J_per_mol"/>
<variable name="V_mem" units="J_per_C"/>
<variable name="Am_Na" units="J_per_mol"/>
<variable name="Am_K" units="J_per_mol"/>
<variable name="Af_K" units="J_per_mol"/>
<variable name="Ar_K" units="J_per_mol"/>
<variable name="Af_Na" units="J_per_mol"/>
<variable name="Ar_Na" units="J_per_mol"/>
<!-- Convention: positive flow from inside to outside-->
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Am_K</ci>
<apply>
<times/>
<ci>zK</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Am_Na</ci>
<apply>
<times/>
<ci>zNa</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_K_i</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_K_i</ci>
<ci>q_K_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_K_o</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_K_o</ci>
<ci>q_K_o</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_K</ci>
<apply>
<plus/>
<ci>mu_x1_funny</ci>
<ci>mu_K_i</ci>
<ci>Am_K</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_K</ci>
<apply>
<plus/>
<ci>mu_x1_funny</ci>
<ci>mu_K_o</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_Na_i</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Na_i</ci>
<ci>q_Na_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_Na_o</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_Na_o</ci>
<ci>q_Na_o</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_Na</ci>
<apply>
<plus/>
<ci>mu_x1_funny</ci>
<ci>mu_Na_i</ci>
<ci>Am_Na</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_Na</ci>
<apply>
<plus/>
<ci>mu_x1_funny</ci>
<ci>mu_Na_o</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_funny_K</ci>
<piecewise>
<piece>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<ci>kappa_funny_K</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_K</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_K</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Am_K</ci>
<cn cellml:units="J_per_mol">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<ci>kappa_funny_K</ci>
<ci>Am_K</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Am_K</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_K</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_K</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>v_funny_Na</ci>
<piecewise>
<piece>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<ci>kappa_funny_Na</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_Na</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_Na</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Am_Na</ci>
<cn cellml:units="J_per_mol">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<ci>kappa_funny_Na</ci>
<ci>Am_Na</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Am_Na</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_Na</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_Na</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>V_mem</ci>
<apply>
<divide/>
<ci>q_mem</ci>
<ci>C_m</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_mem_funny</ci>
<apply>
<times/>
<ci>F</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<ci>zK</ci>
</apply>
<ci>v_funny_K</ci>
</apply>
<apply>
<times/>
<ci>zNa</ci>
<ci>v_funny_Na</ci>
</apply>
<apply>
<times/>
<ci>z_xfr</ci>
<ci>v_xf</ci>
</apply>
</apply>
<apply>
<times/>
<ci>z_xff</ci>
<ci>v_xf</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<!-- GATE
x0 state = closed
x1_state = open-->
<variable initial_value="1" name="q_x0_funny" units="fmol"/>
<variable initial_value="1e-12" name="q_x1_funny" units="fmol"/>
<variable name="kappa_R_xf" public_interface="in" units="fmol_per_sec"/>
<variable name="K_x0_funny" public_interface="in" units="per_fmol"/>
<variable name="K_x1_funny" public_interface="in" units="per_fmol"/>
<variable name="mu_x0_funny" units="J_per_mol"/>
<variable name="mu_x1_funny" units="J_per_mol"/>
<variable name="Af_R_xf" units="J_per_mol"/>
<variable name="Ar_R_xf" units="J_per_mol"/>
<variable name="z_xff" public_interface="in" units="dimensionless"/>
<variable name="z_xfr" public_interface="in" units="dimensionless"/>
<variable name="v_xf" units="fmol_per_sec"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>mu_x0_funny</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_x0_funny</ci>
<ci>q_x0_funny</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_x1_funny</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<times/>
<ci>K_x1_funny</ci>
<ci>q_x1_funny</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Af_R_xf</ci>
<apply>
<plus/>
<ci>mu_x0_funny</ci>
<apply>
<times/>
<ci>z_xff</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ar_R_xf</ci>
<apply>
<plus/>
<ci>mu_x1_funny</ci>
<apply>
<times/>
<ci>z_xfr</ci>
<ci>F</ci>
<ci>V_mem</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_xf</ci>
<apply>
<times/>
<ci>kappa_R_xf</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Af_R_xf</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>Ar_R_xf</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_x0_funny</ci>
</apply>
<apply>
<minus/>
<ci>v_xf</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_x1_funny</ci>
</apply>
<ci>v_xf</ci>
</apply>
</math>
</component>
<component name="funny_kernik">
<variable name="E_K" units="mV"/>
<variable name="E_Na" units="mV"/>
<variable name="Nai" public_interface="in" units="mM"/>
<variable name="Nao" public_interface="in" units="mM"/>
<variable name="Ki" public_interface="in" units="mM"/>
<variable name="Ko" public_interface="in" units="mM"/>
<variable name="Na_frac" units="dimensionless"/>
<variable initial_value="0.491" name="NatoK_ratio" units="dimensionless"/>
<variable name="V" public_interface="in" units="volt"/>
<variable name="mV" units="mV"/>
<variable initial_value="6.40338504912615469e-03" name="Xf" units="dimensionless"/>
<variable initial_value="0.0435" name="g_f" units="milliS_per_microF"/>
<variable name="i_f_kinetic" public_interface="out" units="microA_per_microF"/>
<variable name="i_fK_kinetic" public_interface="out" units="microA_per_microF"/>
<variable name="i_fNa_kinetic" public_interface="out" units="microA_per_microF"/>
<variable name="ifunny_Xf_a" units="milliS_per_microF"/>
<variable name="ifunny_Xf_b" units="milliS_per_microF"/>
<variable name="ifunny_Xf_inf" units="dimensionless"/>
<variable name="ifunny_Xf_tau" units="second"/>
<variable name="t" public_interface="in" units="second"/>
<variable name="R" public_interface="in" units="J_per_K_per_mol"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="C_per_mol"/>
<variable initial_value="5.78970000000000002e-07" name="xF1" units="milliS_per_microF"/>
<variable name="xF2" units="mV"/>
<variable name="xF3" units="milliS_per_microF"/>
<variable name="xF4" units="mV"/>
<variable initial_value="2.00866502378844016e+04" name="xF5" units="dimensionless"/>
<variable initial_value="1.02023528452800001e+01" name="xF6" units="mV"/>
<variable initial_value="2.39452913465299986e-2" name="xF_const" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>mV</ci>
<apply>
<times/>
<cn cellml:units="V_to_mV" type="e-notation">1<sep/>3</cn>
<ci>V</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>E_Na</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="V_to_mV" type="e-notation">1<sep/>3</cn>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>Nai</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="V_to_mV" type="e-notation">1<sep/>3</cn>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Na_frac</ci>
<apply>
<divide/>
<ci>NatoK_ratio</ci>
<apply>
<plus/>
<ci>NatoK_ratio</ci>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>Xf</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>ifunny_Xf_inf</ci>
<ci>Xf</ci>
</apply>
<ci>ifunny_Xf_tau</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_f_kinetic</ci>
<apply>
<plus/>
<ci>i_fNa_kinetic</ci>
<ci>i_fK_kinetic</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_fK_kinetic</ci>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>Na_frac</ci>
</apply>
<ci>g_f</ci>
<ci>Xf</ci>
<apply>
<minus/>
<ci>mV</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_fNa_kinetic</ci>
<apply>
<times/>
<ci>Na_frac</ci>
<ci>g_f</ci>
<ci>Xf</ci>
<apply>
<minus/>
<ci>mV</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ifunny_Xf_a</ci>
<apply>
<times/>
<ci>xF1</ci>
<apply>
<exp/>
<apply>
<divide/>
<ci>mV</ci>
<ci>xF2</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ifunny_Xf_b</ci>
<apply>
<times/>
<ci>xF3</ci>
<apply>
<exp/>
<apply>
<divide/>
<ci>mV</ci>
<ci>xF4</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ifunny_Xf_inf</ci>
<apply>
<divide/>
<ci>ifunny_Xf_a</ci>
<apply>
<plus/>
<ci>ifunny_Xf_a</ci>
<ci>ifunny_Xf_b</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ifunny_Xf_tau</ci>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="second" type="e-notation">1<sep/>-3</cn>
<cn cellml:units="milliS_per_microF">1</cn>
</apply>
<apply>
<plus/>
<ci>ifunny_Xf_a</ci>
<ci>ifunny_Xf_b</ci>
</apply>
</apply>
<ci>xF_const</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>xF2</ci>
<apply>
<minus/>
<cn cellml:units="mV" type="e-notation">1.45897121702000003<sep/>1</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>xF3</ci>
<apply>
<times/>
<ci>xF5</ci>
<ci>xF1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>xF4</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>xF2</ci>
</apply>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>xF6</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="environment" component_2="funny"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="q_K_i" variable_2="q_K_i"/>
<map_variables variable_1="q_K_o" variable_2="q_K_o"/>
<map_variables variable_1="q_Na_i" variable_2="q_Na_i"/>
<map_variables variable_1="q_Na_o" variable_2="q_Na_o"/>
<map_variables variable_1="q_mem" variable_2="q_mem"/>
<map_variables variable_1="C_m" variable_2="C_m"/>
<map_variables variable_1="v_funny_K" variable_2="v_funny_K"/>
<map_variables variable_1="v_funny_Na" variable_2="v_funny_Na"/>
<map_variables variable_1="I_mem_funny" variable_2="I_mem_funny"/>
</connection>
<connection>
<map_components component_1="funny" component_2="funny_parameters"/>
<map_variables variable_1="kappa_funny_Na" variable_2="kappa_funny_Na"/>
<map_variables variable_1="kappa_funny_K" variable_2="kappa_funny_K"/>
<map_variables variable_1="kappa_R_xf" variable_2="kappa_R_xf"/>
<map_variables variable_1="K_Na_i" variable_2="K_Na_i"/>
<map_variables variable_1="K_Na_o" variable_2="K_Na_o"/>
<map_variables variable_1="K_K_i" variable_2="K_K_i"/>
<map_variables variable_1="K_K_o" variable_2="K_K_o"/>
<map_variables variable_1="K_x0_funny" variable_2="K_x0_funny"/>
<map_variables variable_1="K_x1_funny" variable_2="K_x1_funny"/>
<map_variables variable_1="z_xff" variable_2="z_xff"/>
<map_variables variable_1="z_xfr" variable_2="z_xfr"/>
<map_variables variable_1="zNa" variable_2="zNa"/>
<map_variables variable_1="zK" variable_2="zK"/>
</connection>
<connection>
<map_components component_1="environment" component_2="funny_kernik"/>
<map_variables variable_1="V_mem" variable_2="V"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="i_fNa_kinetic" variable_2="i_fNa_kinetic"/>
<map_variables variable_1="i_fK_kinetic" variable_2="i_fK_kinetic"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
</model>