- Author:
- Shelley Fong <sfon036@UoA.auckland.ac.nz>
- Date:
- 2022-05-13 13:42:24+12:00
- Desc:
- forgot to update forward matrix
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/856/rawfile/6a4e3e640452c398c30d4a60e8d041cc8896c6bd/yang_cGMP.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="cGMP" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#">
<units name="per_microM_per_s">
<unit exponent="-1.0" units="micromolar"/>
<unit units="per_s"/>
</units>
<units name="micromolar">
<unit exponent="-1.0" units="litre"/>
<unit prefix="micro" units="mole"/>
</units>
<units name="per_s">
<unit exponent="-1.0" units="second"/>
</units>
<units name="millivolt">
<unit prefix="milli" units="volt"/>
</units>
<units name="per_nM_per_s">
<unit exponent="-1.0" units="nanomolar"/>
<unit units="per_s"/>
</units>
<units name="microM_per_s">
<unit units="micromolar"/>
<unit units="per_s"/>
</units>
<units name="nanomolar">
<unit prefix="nano" units="mole"/>
<unit exponent="-1.0" units="litre"/>
</units>
<units name="nm_per_s">
<unit units="per_s"/>
<unit units="nanomolar"/>
</units>
<component name="environment">
<variable name="time" public_interface="out" units="second"/>
<variable name="V_max_sGC" public_interface="in" units="microM_per_s"/>
<variable initial_value="0" name="E_5c" public_interface="out" units="dimensionless"/>
<variable name="cGMP" public_interface="in" units="micromolar"/>
<variable name="k_pde" public_interface="in" units="per_s"/>
</component>
<component name="c_GMP">
<variable initial_value="0.8520" name="V_max_sGC" public_interface="out" units="microM_per_s"/>
<variable name="E_5c" public_interface="in" units="dimensionless"/>
<variable initial_value="0" name="cGMP" public_interface="out" units="micromolar"/>
<variable name="V_max_pde" units="microM_per_s"/>
<variable initial_value="2" name="K_m_pde" units="micromolar"/>
<variable initial_value="0.0195" name="k_pde" public_interface="out" units="per_s"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>cGMP</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>V_max_sGC</ci>
<ci>E_5c</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>cGMP</ci>
<ci>V_max_pde</ci>
</apply>
<apply>
<plus/>
<ci>K_m_pde</ci>
<ci>cGMP</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>V_max_pde</ci>
<apply>
<times/>
<ci>k_pde</ci>
<ci>cGMP</ci>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="environment" component_2="c_GMP"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V_max_sGC" variable_2="V_max_sGC"/>
<map_variables variable_1="E_5c" variable_2="E_5c"/>
<map_variables variable_1="cGMP" variable_2="cGMP"/>
<map_variables variable_1="k_pde" variable_2="k_pde"/>
</connection>
</model>
