- Author:
- Shelley Fong <sfon036@UoA.auckland.ac.nz>
- Date:
- 2025-03-28 11:55:50+13:00
- Desc:
- fix pic
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/886/rawfile/13ec7e6d78f3069bf156b7d1b14325648541b3dc/parameter_finder/kinetic_parameters_CO2_hyd.py
# Hydration of CO_2 by carbonic anhydrase to form bicarbonate and proton, taken from Crampin and Smith 2006
# Return kinetic parameters, constraints, and vector of volumes in each
# compartment (pL) (1 if gating variable, or in element corresponding to
# kappa)
import numpy as np
def kinetic_parameters(M, include_type2_reactions, dims, V):
# Set the kinetic rate constants
num_cols = dims['num_cols']
num_rows = dims['num_rows']
fkc = 1e6
# dissociation constants for A+B>C where Kd = k-/k+
# K_H is given as pK_H. K_H = 10^(-pK_H)
kr = [0.365 ] # [=] 1/s
kf = [0.48e6] # [=] 1/s
k_kinetic = kf + kr
# CONSTRAINTS
N_cT = []
K_C = []
# volume vector
# W = list(np.append([1] * num_cols, [V['V_myo']] * num_rows))
W = [1] * num_cols + [V['V_myo']]*num_rows
return (k_kinetic, N_cT, K_C, W)
