Location: multi_FCU_AP_and_EC @ 0e7bdac0084b / parameter_finder / output / TEMP.cellml.txt

Author:
Shelley Fong <sfon036@UoA.auckland.ac.nz>
Date:
2022-07-01 14:03:39+12:00
Desc:
Increasing amount of CMDN and TRPN moles
Permanent Source URI:
https://staging.physiomeproject.org/workspace/8a9/rawfile/0e7bdac0084b1d9173369db0f45b2bada11e28f9/parameter_finder/output/TEMP.cellml.txt
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def model FCU_AP_and_FCU_EC as
 def import using "units_and_constants/units_BG.cellml" for
            unit mM using unit mM;
unit fmol using unit fmol;
unit per_fmol using unit per_fmol;
            unit J_per_mol using unit J_per_mol;
unit fmol_per_sec using unit fmol_per_sec;
            unit C_per_mol using unit C_per_mol;
  unit J_per_C using unit J_per_C;
            unit microm3 using unit microm3;
  unit fF using unit fF;
            unit fC using unit fC;
  unit fA using unit fA;
            unit per_second using unit per_second;
  unit millivolt using unit millivolt;
            unit per_sec using unit per_sec;
  unit J_per_K_per_mol using unit J_per_K_per_mol;
            unit fmol_per_L using unit fmol_per_L;
  unit fmol_per_L_per_sec using unit fmol_per_L_per_sec;
            unit per_sec_per_fmol_per_L using unit per_sec_per_fmol_per_L;
  unit uM using unit uM;
            unit mM_per_sec using unit mM_per_sec;
  unit uM_per_sec using unit uM_per_sec;
            unit pL using unit pL;
  unit m_to_u using unit m_to_u;
 enddef;
def import using "units_and_constants/constants_BG.cellml" for
                comp constants using comp constants;
enddef;

def import using "FCU_AP/CaB/BG_CaB.cellml" for
comp CaB using comp CaB;
enddef;
def import using "FCU_EC/crossbridge_TRPN/BG_crossbridge_TRPN.cellml" for
comp crossbridge_TRPN using comp crossbridge_TRPN;
enddef;

def comp BG_parameters as
var kappa_CaB: fmol_per_sec {init: 0.000469987, pub: out};
var kappa_R_TRPNCa: fmol_per_sec {init: 82.4067, pub: out};
var kappa_R_BU: fmol_per_sec {init: 8.82154, pub: out};
var kappa_R_UW: fmol_per_sec {init: 0.283765, pub: out};
var kappa_R_WS: fmol_per_sec {init: 0.00667683, pub: out};
var kappa_R_SU: fmol_per_sec {init: 120183, pub: out};
var K_Ca_i: per_fmol {init: 0.624848, pub: out};
var K_Ca_o: per_fmol {init: 3.1158, pub: out};
var K_TRPN: per_fmol {init: 28.8225, pub: out};
var K_Ca_TRPN: per_fmol {init: 0.0469618, pub: out};
var K_B_XB: per_fmol {init: 9.45563, pub: out};
var K_U_XB: per_fmol {init: 3.54586, pub: out};
var K_W_XB: per_fmol {init: 23.1845, pub: out};
var K_S_XB: per_fmol {init: 5.79612e-06, pub: out};
enddef;
    def comp environment as
                var time: second {pub: out};
                var vol_myo: pL {init: 34.4, pub: out};
                var freq: dimensionless {init: 500};
var q_Ca_i: fmol {init: 1e-888, pub: out};
var q_Ca_o: fmol {init: 1e-888, pub: out};
var q_TRPN: fmol {init: 1e-888, pub: out};
var q_Ca_TRPN: fmol {init: 1e-888, pub: out};
var q_B_XB: fmol {init: 1e-888, pub: out};
var q_U_XB: fmol {init: 1e-888, pub: out};
var q_W_XB: fmol {init: 1e-888, pub: out};
var q_S_XB: fmol {init: 1e-888, pub: out};

// CaB imports
var v_CaB: fmol_per_sec {pub: in};


// crossbridge_TRPN imports
var v_R_TRPNCa: fmol_per_sec {pub: in};
var v_R_BU: fmol_per_sec {pub: in};
var v_R_UW: fmol_per_sec {pub: in};
var v_R_WS: fmol_per_sec {pub: in};
var v_R_SU: fmol_per_sec {pub: in};


ode(q_Ca_i, time) = + v_mCaB  + v_mcrossbridge_TRPN ;
ode(q_Ca_o, time) = + v_mCaB ;
ode(q_TRPN, time) = + v_mcrossbridge_TRPN ;
ode(q_Ca_TRPN, time) = + v_mcrossbridge_TRPN ;
ode(q_B_XB, time) = + v_mcrossbridge_TRPN ;
ode(q_U_XB, time) = + v_mcrossbridge_TRPN ;
ode(q_W_XB, time) = + v_mcrossbridge_TRPN ;
ode(q_S_XB, time) = + v_mcrossbridge_TRPN ;
enddef;

def map between environment and CaB for
vars time and time;
vars q_Ca_i and q_Ca_i;
vars q_Ca_o and q_Ca_o;
vars v_CaB and v_CaB;
enddef;

def map between environment and crossbridge_TRPN for
vars time and time;
vars q_TRPN and q_TRPN;
vars q_Ca_i and q_Ca_i;
vars q_Ca_TRPN and q_Ca_TRPN;
vars q_B_XB and q_B_XB;
vars q_U_XB and q_U_XB;
vars q_W_XB and q_W_XB;
vars q_S_XB and q_S_XB;
vars v_R_TRPNCa and v_R_TRPNCa;
vars v_R_BU and v_R_BU;
vars v_R_UW and v_R_UW;
vars v_R_WS and v_R_WS;
vars v_R_SU and v_R_SU;
enddef;

def map between BG_parameters and CaB for
vars kappa_CaB and kappa_CaB;
vars K_Ca_i and K_Ca_i;
vars K_Ca_o and K_Ca_o;
enddef;
def map between BG_parameters and crossbridge_TRPN for
vars kappa_R_TRPNCa and kappa_R_TRPNCa;
vars kappa_R_BU and kappa_R_BU;
vars kappa_R_UW and kappa_R_UW;
vars kappa_R_WS and kappa_R_WS;
vars kappa_R_SU and kappa_R_SU;
vars K_TRPN and K_TRPN;
vars K_Ca_i and K_Ca_i;
vars K_Ca_TRPN and K_Ca_TRPN;
vars K_B_XB and K_B_XB;
vars K_U_XB and K_U_XB;
vars K_W_XB and K_W_XB;
vars K_S_XB and K_S_XB;
enddef;

def map between constants and CaB for
	vars R and R;
	vars T and T;
enddef;
def map between constants and crossbridge_TRPN for
	vars R and R;
	vars T and T;
enddef;

enddef;