Location: A Biophysically Based Mathematical Model of Unitary Potential Activity @ afe0649a295b / Components / IPR3(J_IPR3) / J_IPR3.cellml
- Author:
- Leyla <lnor300>
- Date:
- 2022-09-28 14:18:41+13:00
- Desc:
- ..
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/916/rawfile/afe0649a295b268b0f453c56ea726d6a4019a340/Components/IPR3(J_IPR3)/J_IPR3.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="J_IPR3" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<!-- IP3R-releases-Ca-from-ER-stores-into-the-cytosol-->
<import xlink:href="../Common/units.cellml">
<units name="flux" units_ref="flux"/>
<units name="first_order_rate_constant" units_ref="first_order_rate_constant"/>
<units name="per_second_squared" units_ref="per_second_squared"/>
<units name="micromolar" units_ref="micromolar"/>
</import>
<component name="JIPR">
<variable name="JIPR" public_interface="out" units="flux"/>
<variable initial_value="2000.0" name="kIPR" units="first_order_rate_constant"/>
<variable initial_value="6.4" name="k_1" units="flux"/>
<variable initial_value="0.0" name="k1" units="first_order_rate_constant"/>
<variable initial_value="4.0" name="k2" units="first_order_rate_constant"/>
<variable initial_value="200.0" name="r2" units="first_order_rate_constant"/>
<variable initial_value="0.0" name="r_2" units="flux"/>
<variable initial_value="750.0" name="r4" units="first_order_rate_constant"/>
<variable initial_value="36.0" name="R1" units="micromolar"/>
<variable initial_value="300.0" name="R3" units="micromolar"/>
<variable name="phi1" units="first_order_rate_constant"/>
<variable name="phi_1" units="flux"/>
<variable name="phi2" units="first_order_rate_constant"/>
<variable initial_value="0.306" name="phi3" units="first_order_rate_constant"/>
<variable initial_value="0.787" name="H" units="dimensionless"/>
<variable initial_value="300.0" name="g_beta" units="first_order_rate_constant"/>
<variable initial_value="2.0" name="h_beta" units="dimensionless"/>
<variable initial_value="0.02" name="g_alpha" units="per_second_squared"/>
<variable initial_value="2.0" name="K_beta" units="micromolar"/>
<variable name="alpha_phi3" units="per_second_squared"/>
<variable name="beta_phi3" units="first_order_rate_constant"/>
<variable name="CER" public_interface="in" units="micromolar"/>
<variable name="CS2" public_interface="in" units="micromolar"/>
<variable name="P" public_interface="in" units="micromolar"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>H</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>phi3</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>H</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>P</ci>
<ci>phi1</ci>
<ci>phi2</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>P</ci>
<ci>phi1</ci>
</apply>
<ci>phi_1</ci>
</apply>
</apply>
<ci>H</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>JIPR</ci>
<apply>
<times/>
<ci>kIPR</ci>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci>P</ci>
<ci>phi1</ci>
<ci>H</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>P</ci>
<ci>phi1</ci>
</apply>
<ci>phi_1</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">4.0</cn>
</apply>
<apply>
<minus/>
<ci>CER</ci>
<ci>CS2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>phi1</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<ci>k1</ci>
<ci>R1</ci>
</apply>
<apply>
<times/>
<ci>r2</ci>
<ci>CS2</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>R1</ci>
<ci>CS2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>phi_1</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>k_1</ci>
<ci>r_2</ci>
</apply>
<ci>R3</ci>
</apply>
<apply>
<plus/>
<ci>R3</ci>
<ci>CS2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>phi2</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<ci>k2</ci>
<ci>R3</ci>
</apply>
<apply>
<times/>
<ci>r4</ci>
<ci>CS2</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>R3</ci>
<ci>CS2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>phi3</ci>
</apply>
<apply>
<minus/>
<ci>alpha_phi3</ci>
<apply>
<times/>
<ci>beta_phi3</ci>
<ci>phi3</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_phi3</ci>
<ci>g_alpha</ci>
</apply>
<apply>
<eq/>
<ci>beta_phi3</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>g_beta</ci>
<apply>
<power/>
<ci>CS2</ci>
<ci>h_beta</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>K_beta</ci>
<ci>h_beta</ci>
</apply>
<apply>
<power/>
<ci>CS2</ci>
<ci>h_beta</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
</model>