- Author:
- Leyla <lnor300>
- Date:
- 2022-10-19 17:08:17+13:00
- Desc:
- ..
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/91e/rawfile/e03e451f1a7fe3d4ef8e00823ebbbb48da2ac121/NKCC/INKCC.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model cmeta:id="INKCC" name="INKCC" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="../common/units.cellml">
<units name="current_units" units_ref="current_units"/>
<units name="voltage_units" units_ref="voltage_units"/>
<units name="time_units" units_ref="time_units"/>
<units name="conductance_units" units_ref="conductance_units"/>
<units name="millimolar" units_ref="millimolar"/>
</import>
<component name="d_Na">
<variable name="Vm" public_interface="in" units="voltage_units"/>
<variable name="d_inf_Na" units="dimensionless"/>
<variable name="tau_d_Na" units="time_units"/>
<variable initial_value="0.005" name="d_Na" public_interface="out" units="dimensionless"/>
<variable name="time" public_interface="in" units="time_units"/>
<variable name="T_correction_Na" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>d_inf_Na</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">47</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="voltage_units">4.8</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_d_Na</ci>
<apply>
<times/>
<ci>T_correction_Na</ci>
<cn cellml:units="time_units">0.003</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>d_Na</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>d_inf_Na</ci>
<ci>d_Na</ci>
</apply>
<ci>tau_d_Na</ci>
</apply>
</apply>
</math>
</component>
<component name="f_Na">
<variable name="Vm" private_interface="out" public_interface="in" units="voltage_units"/>
<variable name="f_inf_Na" units="dimensionless"/>
<variable name="tau_f_Na" units="time_units"/>
<variable initial_value="0.05787" name="f_Na" public_interface="out" units="dimensionless"/>
<variable name="time" private_interface="out" public_interface="in" units="time_units"/>
<variable name="T_correction_Na" private_interface="out" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>f_inf_Na</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">78</cn>
</apply>
<cn cellml:units="voltage_units">7</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_f_Na</ci>
<apply>
<times/>
<ci>T_correction_Na</ci>
<cn cellml:units="time_units">0.0016</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>f_Na</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>f_inf_Na</ci>
<ci>f_Na</ci>
</apply>
<ci>tau_f_Na</ci>
</apply>
</apply>
</math>
</component>
<component name="I_Na">
<variable name="I_Na" private_interface="out" public_interface="out" units="current_units"/>
<variable name="E_Na" units="voltage_units"/>
<variable initial_value="3" name="G_max_Na" units="conductance_units"/>
<variable name="Vm" private_interface="out" public_interface="in" units="voltage_units"/>
<variable name="f_Na" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="d_Na" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="RToF" private_interface="out" public_interface="in" units="voltage_units"/>
<variable name="Na_o" private_interface="out" public_interface="in" units="millimolar"/>
<variable name="Na_i" private_interface="out" public_interface="in" units="millimolar"/>
<variable name="T_correction_Na" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="time" private_interface="out" public_interface="in" units="time_units"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_Na</ci>
<apply>
<times/>
<ci>RToF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Na_o</ci>
<ci>Na_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_Na</ci>
<apply>
<times/>
<ci>G_max_Na</ci>
<ci>f_Na</ci>
<ci>d_Na</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="f_Na" component_2="I_Na"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="f_Na" variable_2="f_Na"/>
<map_variables variable_1="T_correction_Na" variable_2="T_correction_Na"/>
</connection>
<connection>
<map_components component_1="d_Na" component_2="I_Na"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="d_Na" variable_2="d_Na"/>
<map_variables variable_1="T_correction_Na" variable_2="T_correction_Na"/>
</connection>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="I_Na">
<component_ref component="f_Na"/>
<component_ref component="d_Na"/>
</component_ref>
</group>
</model>
