- Author:
- Leyla <lnor300>
- Date:
- 2022-10-19 17:08:17+13:00
- Desc:
- ..
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/91e/rawfile/e03e451f1a7fe3d4ef8e00823ebbbb48da2ac121/Vm_ICC/Experiment_Vm_ICC.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="experiment_Vm_ICC" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="../common/units.cellml">
<units name="time_units" units_ref="time_units"/>
<units name="millimolar" units_ref="millimolar"/>
<units name="R_units" units_ref="R_units"/>
<units name="F_units" units_ref="F_units"/>
<units name="capacitance_units" units_ref="capacitance_units"/>
<units name="Temperature_units" units_ref="Temperature_units"/>
<units name="conductance_units" units_ref="conductance_units"/>
<units name="Inverse_Voltage_units" units_ref="Inverse_Voltage_units"/>
<units name="voltage_units" units_ref="voltage_units"/>
<units name="current_units" units_ref="current_units"/>
<units name="volume_units" units_ref="volume_units"/>
<units name="millimolar_per_second" units_ref="millimolar_per_second"/>
<units name="millimole_to_nanomole" units_ref="millimole_to_nanomole"/>
<units name="microcoulomb_to_picocoulomb" units_ref="microcoulomb_to_picocoulomb"/>
</import>
<import xlink:href="../common/environment.cellml">
<component component_ref="environment" name="environment"/>
</import>
<import xlink:href="../common/parameters.cellml">
<component component_ref="parameter_values" name="parameter_values"/>
</import>
<import xlink:href="../A_type_K/IBK.cellml">
<component component_ref="I_BK" name="I_BK"/>
</import>
<import xlink:href="../Background_K/Ibk.cellml">
<component component_ref="I_bk" name="I_bk"/>
</import>
<import xlink:href="../CaNa_Exchanger/CaNa_Exchanger.cellml">
<component component_ref="J_PMCA" name="J_PMCA"/>
</import>
<import xlink:href="../Vm_ICC/Vm_ICC.cellml">
<component component_ref="ICC_Membrane" name="ICC_Membrane"/>
</import>
<import xlink:href="../Ca_PU/PU.cellml">
<component component_ref="PU_unit" name="PU_unit"/>
</import>
<import xlink:href="../CaCCs/ICaCl.cellml">
<component component_ref="I_CaCl" name="I_CaCl"/>
</import>
<import xlink:href="../Delayed_Rectifier/Ikr.cellml">
<component component_ref="I_kv11" name="I_kv11"/>
</import>
<import xlink:href="../L_type_Ca/ICa_L.cellml">
<component component_ref="I_Ltype" name="I_Ltype"/>
</import>
<import xlink:href="../NKCC/INKCC.cellml">
<component component_ref="I_Na" name="I_Na"/>
</import>
<import xlink:href="../NSCC/INSCC.cellml">
<component component_ref="I_NSCC" name="I_NSCC"/>
</import>
<import xlink:href="../Potasium_channel/IERG.cellml">
<component component_ref="I_ERG" name="I_ERG"/>
</import>
<import xlink:href="../T_type_Ca[VDDR]/IVDDR.cellml">
<component component_ref="I_VDDR" name="I_VDDR"/>
</import>
<connection>
<map_components component_1="I_BK" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="I_bk" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="ICC_Membrane" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="PU_unit" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="I_CaCl" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="I_kv11" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="I_Ltype" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="J_PMCA" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="I_NSCC" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="I_ERG" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="I_VDDR" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="I_Na" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="I_Na" component_2="ICC_Membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="I_Na" variable_2="I_Na"/>
</connection>
<connection>
<map_components component_1="parameter_values" component_2="I_Na"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
<map_variables variable_1="T_correction_Na" variable_2="T_correction_Na"/>
</connection>
<connection>
<map_components component_1="I_Ltype" component_2="ICC_Membrane"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="I_Ltype" variable_2="I_Ltype"/>
<map_variables variable_1="d_Ltype" variable_2="d_Ltype"/>
<map_variables variable_1="f_Ltype" variable_2="f_Ltype"/>
<map_variables variable_1="f_ca_Ltype" variable_2="f_ca_Ltype"/>
</connection>
<connection>
<map_components component_1="parameter_values" component_2="I_Ltype"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
<map_variables variable_1="T_correction_Ca" variable_2="T_correction_Ca"/>
</connection>
<connection>
<map_components component_1="I_VDDR" component_2="ICC_Membrane"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="I_VDDR" variable_2="I_VDDR"/>
</connection>
<connection>
<map_components component_1="I_VDDR" component_2="parameter_values"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
<map_variables variable_1="T_correction_Ca" variable_2="T_correction_Ca"/>
</connection>
<connection>
<map_components component_1="I_kv11" component_2="ICC_Membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="I_kv11" variable_2="I_kv11"/>
</connection>
<connection>
<map_components component_1="I_kv11" component_2="parameter_values"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
<map_variables variable_1="T_correction_K" variable_2="T_correction_K"/>
</connection>
<connection>
<map_components component_1="I_ERG" component_2="ICC_Membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="I_ERG" variable_2="I_ERG"/>
</connection>
<connection>
<map_components component_1="I_ERG" component_2="parameter_values"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
<map_variables variable_1="T_correction_K" variable_2="T_correction_K"/>
</connection>
<connection>
<map_components component_1="I_CaCl" component_2="ICC_Membrane"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="I_CaCl" variable_2="I_CaCl"/>
</connection>
<connection>
<map_components component_1="I_CaCl" component_2="parameter_values"/>
<map_variables variable_1="Cl_i" variable_2="Cl_i"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="Cl_o" variable_2="Cl_o"/>
</connection>
<connection>
<map_components component_1="I_BK" component_2="ICC_Membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="I_BK" variable_2="I_BK"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
</connection>
<connection>
<map_components component_1="I_BK" component_2="parameter_values"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
<map_variables variable_1="T_correction_BK" variable_2="T_correction_BK"/>
</connection>
<connection>
<map_components component_1="I_bk" component_2="ICC_Membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="I_bk" variable_2="I_bk"/>
</connection>
<connection>
<map_components component_1="I_bk" component_2="parameter_values"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection>
<map_components component_1="I_NSCC" component_2="ICC_Membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="I_NSCC" variable_2="I_NSCC"/>
</connection>
<connection>
<map_components component_1="I_NSCC" component_2="parameter_values"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
</connection>
<connection>
<map_components component_1="PU_unit" component_2="I_NSCC"/>
<map_variables variable_1="Ca_PU" variable_2="Ca_PU"/>
</connection>
<connection>
<map_components component_1="PU_unit" component_2="ICC_Membrane"/>
<map_variables variable_1="J_leak" variable_2="J_leak"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
</connection>
<connection>
<map_components component_1="PU_unit" component_2="parameter_values"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Vol" variable_2="Vol"/>
<map_variables variable_1="fc" variable_2="fc"/>
<map_variables variable_1="P_cyto" variable_2="P_cyto"/>
<map_variables variable_1="FoRT" variable_2="FoRT"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
</connection>
<connection>
<map_components component_1="J_PMCA" component_2="ICC_Membrane"/>
<map_variables variable_1="J_PMCA" variable_2="J_PMCA"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
</connection>
<connection>
<map_components component_1="ICC_Membrane" component_2="parameter_values"/>
<map_variables variable_1="Vol" variable_2="Vol"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
<map_variables variable_1="Cl_o" variable_2="Cl_o"/>
<map_variables variable_1="Cl_i" variable_2="Cl_i"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="FoRT" variable_2="FoRT"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="fc" variable_2="fc"/>
<map_variables variable_1="P_cyto" variable_2="P_cyto"/>
<map_variables variable_1="T_correction_Ca" variable_2="T_correction_Ca"/>
<map_variables variable_1="T_correction_Na" variable_2="T_correction_Na"/>
<map_variables variable_1="T_correction_K" variable_2="T_correction_K"/>
<map_variables variable_1="T_correction_BK" variable_2="T_correction_BK"/>
</connection>
<component name="outputs">
<variable name="time" public_interface="in" units="time_units"/>
<variable name="Vm" public_interface="in" units="voltage_units"/>
<variable name="J_leak" public_interface="in" units="millimolar_per_second"/>
<variable name="I_Na" public_interface="in" units="current_units"/>
<variable name="I_Ltype" public_interface="in" units="current_units"/>
<variable name="d_Ltype" public_interface="in" units="dimensionless"/>
<variable name="f_Ltype" public_interface="in" units="dimensionless"/>
<variable name="f_ca_Ltype" public_interface="in" units="dimensionless"/>
<variable name="I_VDDR" public_interface="in" units="current_units"/>
<variable name="I_kv11" public_interface="in" units="current_units"/>
<variable name="I_BK" public_interface="in" units="current_units"/>
<variable name="I_ERG" public_interface="in" units="current_units"/>
<variable name="I_CaCl" public_interface="in" units="current_units"/>
<variable name="I_NSCC" public_interface="in" units="current_units"/>
<variable name="I_bk" public_interface="in" units="current_units"/>
<variable name="J_PMCA" public_interface="in" units="millimolar_per_second"/>
</component>
<connection>
<map_components component_1="outputs" component_2="ICC_Membrane"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="J_leak" variable_2="J_leak"/>
<map_variables variable_1="I_Na" variable_2="I_Na"/>
<map_variables variable_1="I_Ltype" variable_2="I_Ltype"/>
<map_variables variable_1="d_Ltype" variable_2="d_Ltype"/>
<map_variables variable_1="f_Ltype" variable_2="f_Ltype"/>
<map_variables variable_1="f_ca_Ltype" variable_2="f_ca_Ltype"/>
<map_variables variable_1="I_VDDR" variable_2="I_VDDR"/>
<map_variables variable_1="I_kv11" variable_2="I_kv11"/>
<map_variables variable_1="I_BK" variable_2="I_BK"/>
<map_variables variable_1="I_ERG" variable_2="I_ERG"/>
<map_variables variable_1="I_CaCl" variable_2="I_CaCl"/>
<map_variables variable_1="I_NSCC" variable_2="I_NSCC"/>
<map_variables variable_1="I_bk" variable_2="I_bk"/>
<map_variables variable_1="J_PMCA" variable_2="J_PMCA"/>
</connection>
</model>
