- Author:
- Leyla <lnor300>
- Date:
- 2022-10-19 17:08:17+13:00
- Desc:
- ..
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/91e/rawfile/e03e451f1a7fe3d4ef8e00823ebbbb48da2ac121/Vm_ICC/Vm_ICC.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="Vm_ICC" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="../common/units.cellml">
<units name="current_units" units_ref="current_units"/>
<units name="voltage_units" units_ref="voltage_units"/>
<units name="time_units" units_ref="time_units"/>
<units name="conductance_units" units_ref="conductance_units"/>
<units name="capacitance_units" units_ref="capacitance_units"/>
<units name="millimolar" units_ref="millimolar"/>
<units name="volume_units" units_ref="volume_units"/>
<units name="Inverse_Voltage_units" units_ref="Inverse_Voltage_units"/>
<units name="millimolar_per_second" units_ref="millimolar_per_second"/>
<units name="F_units" units_ref="F_units"/>
<units name="millimole_to_nanomole" units_ref="millimole_to_nanomole"/>
<units name="microcoulomb_to_picocoulomb" units_ref="microcoulomb_to_picocoulomb"/>
</import>
<component name="ICC_Membrane">
<variable initial_value="0.025" name="Cm" units="capacitance_units"/>
<variable name="P_cyto" public_interface="in" units="dimensionless"/>
<variable name="Vol" public_interface="in" units="volume_units"/>
<variable name="V_cyto" public_interface="out" units="volume_units"/>
<variable name="fc" public_interface="in" units="dimensionless"/>
<variable initial_value="-67" name="Vm" public_interface="out" units="voltage_units"/>
<variable name="time" public_interface="in" units="time_units"/>
<variable initial_value="0.00000993087" name="Ca_i" public_interface="out" units="millimolar"/>
<variable name="Na_i" public_interface="in" units="millimolar"/>
<variable name="K_i" public_interface="in" units="millimolar"/>
<variable name="Cl_i" public_interface="in" units="millimolar"/>
<variable name="Ca_o" public_interface="in" units="millimolar"/>
<variable name="Na_o" public_interface="in" units="millimolar"/>
<variable name="K_o" public_interface="in" units="millimolar"/>
<variable name="Cl_o" public_interface="in" units="millimolar"/>
<variable name="T_correction_Ca" public_interface="in" units="dimensionless"/>
<variable name="T_correction_Na" public_interface="in" units="dimensionless"/>
<variable name="T_correction_K" public_interface="in" units="dimensionless"/>
<variable name="T_correction_BK" public_interface="in" units="conductance_units"/>
<variable name="RToF" public_interface="in" units="voltage_units"/>
<variable name="FoRT" public_interface="in" units="Inverse_Voltage_units"/>
<variable name="F" public_interface="in" units="F_units"/>
<variable name="J_leak" private_interface="in" public_interface="out" units="millimolar_per_second"/>
<variable name="I_Na" private_interface="in" public_interface="out" units="current_units"/>
<variable name="I_Ltype" private_interface="in" public_interface="out" units="current_units"/>
<variable name="d_Ltype" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="f_Ltype" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="f_ca_Ltype" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="I_VDDR" private_interface="in" public_interface="out" units="current_units"/>
<variable name="I_kv11" private_interface="in" public_interface="out" units="current_units"/>
<variable name="I_BK" private_interface="in" public_interface="out" units="current_units"/>
<variable name="I_ERG" private_interface="in" public_interface="out" units="current_units"/>
<variable name="I_CaCl" private_interface="in" public_interface="out" units="current_units"/>
<variable name="I_NSCC" private_interface="in" public_interface="out" units="current_units"/>
<variable name="I_bk" private_interface="in" public_interface="out" units="current_units"/>
<variable name="J_PMCA" private_interface="in" public_interface="out" units="millimolar_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_cyto</ci>
<apply>
<times/>
<ci>Vol</ci>
<ci>P_cyto</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Vm</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>Cm</ci>
</apply>
<apply>
<plus/>
<ci>I_Na</ci>
<ci>I_Ltype</ci>
<ci>I_VDDR</ci>
<ci>I_kv11</ci>
<ci>I_ERG</ci>
<ci>I_BK</ci>
<ci>I_CaCl</ci>
<ci>I_NSCC</ci>
<ci>I_bk</ci>
<apply>
<times/>
<ci>J_PMCA</ci>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="millimole_to_nanomole">1000000</cn>
<cn cellml:units="microcoulomb_to_picocoulomb">1000000</cn>
<ci>F</ci>
<ci>V_cyto</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_i</ci>
</apply>
<apply>
<times/>
<ci>fc</ci>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>I_Ltype</ci>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>I_VDDR</ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="millimole_to_nanomole">1000000</cn>
<cn cellml:units="microcoulomb_to_picocoulomb">1000000</cn>
<ci>F</ci>
<ci>V_cyto</ci>
</apply>
</apply>
<ci>J_leak</ci>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>J_PMCA</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
</model>
