- Author:
- David Nickerson <david.nickerson@gmail.com>
- Date:
- 2021-09-17 15:50:49+12:00
- Desc:
- tweak html formatting
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/a1/rawfile/1b3862589abf79ae9119ee0b5e99a8b785d762e1/models/1975_hunter/experiments/voltage_clamp.xml
<?xml version="1.0" encoding="iso-8859-1"?>
<model
name="cubic_voltage_clamp"
cmeta:id="cubic_voltage_clamp"
xmlns="http://www.cellml.org/cellml/1.1#"
xmlns:cellml="http://www.cellml.org/cellml/1.1#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
xmlns:xlink="http://www.w3.org/1999/xlink">
<rdf:RDF
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
xmlns:bqs="http://www.cellml.org/bqs/1.0#"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#"
xmlns:cs="http://www.cellml.org/metadata/simulation/1.0#">
<rdf:Description rdf:about="">
<dc:creator rdf:parseType="Resource">
<vCard:N rdf:parseType="Resource">
<vCard:Family>Nickerson</vCard:Family>
<vCard:Given>David</vCard:Given>
</vCard:N>
<vCard:EMAIL rdf:parseType="Resource">
<rdf:value>d.nickerson@auckland.ac.nz</rdf:value>
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
</vCard:EMAIL>
<vCard:ORG rdf:parseType="Resource">
<vCard:Orgname>The University of Auckland</vCard:Orgname>
<vCard:Orgunit>Bioengineering Institute</vCard:Orgunit>
</vCard:ORG>
</dc:creator>
<dcterms:created rdf:parseType="Resource">
<dcterms:W3CDTF>2005-01-06</dcterms:W3CDTF>
</dcterms:created>
<dc:publisher>
Bioengineering Institute, The University of Auckland
</dc:publisher>
</rdf:Description>
<rdf:Description rdf:about="#cubic_voltage_clamp">
<dc:title>
Voltage clamp experiment using the cubic polynomial model,
Hunter et al. (1975)
</dc:title>
<cmeta:comment rdf:parseType="Resource">
<rdf:value>
This is the CellML description of a voltage clamp experiment
examining the response of the cubic polynomial model (Hunter
et al. 1975)
</rdf:value>
<dc:creator rdf:parseType="Resource">
<vCard:FN>David Nickerson</vCard:FN>
</dc:creator>
</cmeta:comment>
<bqs:reference>
<bqs:Pubmed_id>792954</bqs:Pubmed_id>
</bqs:reference>
<cs:simulation>
<rdf:Description rdf:ID="simulation">
<cs:multistepMethod>adams</cs:multistepMethod>
<cs:iterationMethod>functional</cs:iterationMethod>
<cs:boundIntervals rdf:parseType="Collection">
<rdf:Description>
<cs:boundVariable>
<rdf:Description rdf:about="#time"/>
</cs:boundVariable>
<cs:maximumStepSize rdf:datatype="http://www.w3.org/2001/XMLSchema#double">
0.1
</cs:maximumStepSize>
<cs:tabulationStepSize rdf:datatype="http://www.w3.org/2001/XMLSchema#double">
0.5
</cs:tabulationStepSize>
<cs:startingValue rdf:datatype="http://www.w3.org/2001/XMLSchema#double">
0
</cs:startingValue>
<cs:endingValue rdf:datatype="http://www.w3.org/2001/XMLSchema#double">
105
</cs:endingValue>
</rdf:Description>
</cs:boundIntervals>
</rdf:Description>
</cs:simulation>
</rdf:Description>
</rdf:RDF>
<import xlink:href="../../common/units.xml">
<units name="ms" units_ref="ms"/>
<units name="mV" units_ref="mV"/>
<units name="mV_per_ms" units_ref="mV_per_ms"/>
<units name="uF_per_mmsq" units_ref="uF_per_mmsq"/>
<units name="mS_per_mmsq" units_ref="mS_per_mmsq"/>
</import>
<import xlink:href="../1975_cubic_polynomial.xml">
<component name="current" component_ref="current"/>
</import>
<component name="voltage_clamp" cmeta:id="voltage_clamp">
<rdf:RDF
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description rdf:about="#voltage_clamp">
<cmeta:comment rdf:parseType="Resource">
<rdf:value>
We define here the voltage clamp experiment, in this case
a simple linear variation of membrane potential, expressed
as a differential equation.
</rdf:value>
</cmeta:comment>
</rdf:Description>
</rdf:RDF>
<variable name="time" cmeta:id="time" units="ms"/>
<variable name="Cm" initial_value="0.01" public_interface="out" units="uF_per_mmsq"/>
<variable name="Vm_rest" initial_value="-85.0" public_interface="out" units="mV"/>
<variable name="Vm_plateau" initial_value="15.0" public_interface="out" units="mV"/>
<variable name="Vm_threshold" initial_value="-75.0" public_interface="out" units="mV"/>
<variable name="Vm" cmeta:id="Vm" initial_value="Vm_rest" public_interface="out" units="mV"/>
<variable name="membrane_conductance" initial_value="0.004" public_interface="out" units="mS_per_mmsq"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply><eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>Vm</ci>
</apply>
<cn cellml:units="mV_per_ms">1.0</cn>
</apply>
</math>
</component>
<connection>
<map_components component_1="current" component_2="voltage_clamp"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
<map_variables variable_1="Vm_rest" variable_2="Vm_rest"/>
<map_variables variable_1="Vm_plateau" variable_2="Vm_plateau"/>
<map_variables variable_1="Vm_threshold" variable_2="Vm_threshold"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="membrane_conductance" variable_2="membrane_conductance"/>
</connection>
</model>
