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Biol.","volume":"98","number":"1","year":"2008","month":"7","day":"9","startPage":"38","endPage":"51","authors":["David Nickerson","Martin Buist"]},{"id":"anon_6","subType":"journal-article","pmid":"18310619","doi":"10.1093/bioinformatics/btn080","title":"Reference descriptions of cellular electrophysiology models.","journal":"Bioinformatics","volume":"24","number":"8","year":"2008","month":"3","day":"4","startPage":"1112","endPage":"1116","authors":["David P Nickerson","Alberto Corrias","Martin L Buist"]}],"abstract":"This reference description is attempting to document a introductory tutorial for CellML emphasising the modularity, reuse, and exchange features that are available when developing models in a CellML 1.1 framework. The basic premise based on first biophysical cardiac cellular electrophysiology model, published by Denis Noble in 1962, which defines a modification of the Hodgkin-Huxley 1952 squid axon model capable of reproducing the action and pacemaker potentials observed in Purkinje fibres. In this tutorial we start with a CellML description of the Hodgkin-Huxley model and gradually modify it to reproduce some of the key features of the Noble 1962 model.","description":"<p class=\"cmeta-comment\">The reference description can be browsed via the tree hierarchy over on the left hand side of the page or by navigating from the list of tasks given below. 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[<span class=\"vCard-FN\">David Nickerson</span>]</p>","modifications":[{"id":"anon_246","modifier":{"id":"anon_247","type":"person","name":"David Nickerson"},"modification":"Update to use the new INa gating rates model in order to work around a possible bug in the API implementation (or my understanding of the CellML specification) which doesn't like importing encapsulated children 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initial value of y.","sourceVariable":{"_reference":"named_185"},"units":"mV"},{"id":"named_152","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#alpha_n","name":"alpha","title":"alpha","description":"<p class=\"cmeta-comment\">The temperature corrected activation rate constant of the n gate for the potassium current.</p>","connectedVariables":[{"_reference":"named_174"}],"units":"per_ms","definedIn":"named_142","usedIn":[["named_144","named_174"]]},{"id":"named_174","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#alpha_steady_state","name":"alpha","title":"alpha","description":"<p class=\"cmeta-comment\">The rate of activation of the gating 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class=\"cmeta-comment\">The Q10 for the temperature dependence of the inactivation rate constant of the n gate for the potassium current.</p>","sourceVariable":{"_reference":"named_153"},"units":"dimensionless"},{"id":"named_155","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#T","name":"T","title":"T","initialValue":"279.45","connectedVariables":[{"_reference":"named_156"},{"_reference":"named_164"}],"units":"K","usedIn":[["named_142","named_156"],["named_143","named_164"]]},{"id":"named_156","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#alpha_n_T","name":"T","title":"T","description":"<p class=\"cmeta-comment\">The actual temperature at which the activation rate constant for the n gate of the potassium current is desired.</p>","sourceVariable":{"_reference":"named_155"},"units":"K"},{"id":"named_164","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#beta_n_T","name":"T","title":"T","description":"<p class=\"cmeta-comment\">The actual temperature at which the inactivation rate constant for the n gate of the potassium current is desired.</p>","sourceVariable":{"_reference":"named_155"},"units":"K"},{"id":"named_157","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#Tref_rates","name":"Tref_rates","title":"Tref_rates","initialValue":"279.45","connectedVariables":[{"_reference":"named_158"},{"_reference":"named_165"}],"units":"K","usedIn":[["named_142","named_158"],["named_143","named_165"]]},{"id":"named_158","type":"variable","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#alpha_n_Tref","name":"Tref","title":"Tref","description":"<p 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& Huxley (1952) with voltage clamp of -5 mV applied.","created":{"id":"anon_328","creator":{"id":"anon_329","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205406000000},"description":"<p class=\"cmeta-comment\">Import the base voltage clamp model and set the clamp potential to -5 mV. 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definition of the time variable.</p>"},{"id":"named_200","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/voltage-clamp.xml#parameters","title":"parameters","created":{"id":"anon_342","creator":{"id":"anon_343","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205406000000},"description":"<p class=\"cmeta-comment\">The model parameters which differ from default.</p>"},{"id":"named_201","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/voltage-clamp.xml#initial_conditions","title":"initial_conditions","created":{"id":"anon_344","creator":{"id":"anon_345","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205406000000},"description":"<p class=\"cmeta-comment\">The initial 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description of the voltage-dependent activation rate constant for the m gate of the Hodgkin & Huxley (1952) sodium current.</p>","importedAs":{"_reference":"named_260"},"math":"named_207.xml"},{"id":"named_260","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#alpha_m","title":"alpha_m","created":{"id":"anon_368","creator":{"id":"anon_369","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_208","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#beta_m_component","title":"beta_m","created":{"id":"anon_370","creator":{"id":"anon_371","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of 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dynamic Hodgkin & Huxley gating variable.</p>","importedAs":{"_reference":"named_291"},"math":"named_211.xml"},{"id":"named_291","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#m_gate","title":"Hodgkin-Huxley sodium current's activation gate.","created":{"id":"anon_384","creator":{"id":"anon_385","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"abstract":"We import the standard HH voltage-dependent gating variable description to use as the sodium channel's activation gating variable - 'm'."},{"id":"named_212","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#hh_gating_variable_dynamic","title":"Standard Hodgkin-Huxley dynamic gating kinetics.","created":{"id":"anon_386","creator":{"id":"anon_387","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205146800000},"description":"<p class=\"cmeta-comment\">The standard definition of a dynamic Hodgkin & Huxley gating variable.</p>","importedAs":{"_reference":"named_295"},"math":"named_212.xml"},{"id":"named_295","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#h_gate","title":"Hodgkin-Huxley sodium current's inactivation gate.","created":{"id":"anon_388","creator":{"id":"anon_389","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"abstract":"We import the standard HH voltage-dependent gating variable description to use as the sodium channel's inactivation gating variable - 'h'.","modifications":[{"id":"anon_390","modifier":{"id":"anon_391","type":"person","name":"David Nickerson"},"modification":"Splitting out the gating rate equation components to their own model to test out a possible bug in the API implementation which arises when importing encapsulated children directly into other models.","modified":1218369600000}]},{"id":"named_213","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#alpha_n_component","title":"Description of the activation rate constant for the n gate.","created":{"id":"anon_392","creator":{"id":"anon_393","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"description":"<p class=\"cmeta-comment\">A description of the voltage-dependent activation rate constant for the n gate of the Hodgkin & Huxley (1952) potassium 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inactivation rate constant for the n gate of the Hodgkin & Huxley (1952) potassium current.</p>","importedAs":{"_reference":"named_306"},"math":"named_214.xml"},{"id":"named_306","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK.xml#beta_n_component","title":"beta_n","created":{"id":"anon_398","creator":{"id":"anon_399","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_215","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#hh_gating_variable_dynamic","title":"Standard Hodgkin-Huxley dynamic gating kinetics.","created":{"id":"anon_400","creator":{"id":"anon_401","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of 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description of the voltage-dependent activation rate constant for the m gate of the Hodgkin & Huxley (1952) sodium current.</p>","importedAs":{"_reference":"named_872"},"math":"named_819.xml"},{"id":"named_872","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#alpha_m","title":"alpha_m","created":{"id":"anon_672","creator":{"id":"anon_673","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_820","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#beta_m_component","title":"beta_m","created":{"id":"anon_674","creator":{"id":"anon_675","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of 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voltage-dependent activation rate constant for the h gate of the Hodgkin & Huxley (1952) sodium current.</p>","importedAs":{"_reference":"named_889"},"math":"named_821.xml"},{"id":"named_889","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#alpha_h","title":"alpha_h","created":{"id":"anon_680","creator":{"id":"anon_681","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_822","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#beta_h_component","title":"beta_h","created":{"id":"anon_682","creator":{"id":"anon_683","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of 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dynamic Hodgkin & Huxley gating variable.</p>","importedAs":{"_reference":"named_903"},"math":"named_823.xml"},{"id":"named_903","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#m_gate","title":"Hodgkin-Huxley sodium current's activation gate.","created":{"id":"anon_688","creator":{"id":"anon_689","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"abstract":"We import the standard HH voltage-dependent gating variable description to use as the sodium channel's activation gating variable - 'm'."},{"id":"named_824","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#hh_gating_variable_dynamic","title":"Standard Hodgkin-Huxley dynamic gating kinetics.","created":{"id":"anon_690","creator":{"id":"anon_691","type":"person","name":"David 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Nickerson"},"modification":"Splitting out the gating rate equation components to their own model to test out a possible bug in the API implementation which arises when importing encapsulated children directly into other models.","modified":1218369600000}]},{"id":"named_825","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#alpha_n_component","title":"Description of the activation rate constant for the n gate.","created":{"id":"anon_696","creator":{"id":"anon_697","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"description":"<p class=\"cmeta-comment\">A description of the voltage-dependent activation rate constant for the n gate of the Hodgkin & Huxley (1952) potassium 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inactivation rate constant for the n gate of the Hodgkin & Huxley (1952) potassium current.</p>","importedAs":{"_reference":"named_918"},"math":"named_826.xml"},{"id":"named_918","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK.xml#beta_n_component","title":"beta_n","created":{"id":"anon_702","creator":{"id":"anon_703","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_827","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#hh_gating_variable_dynamic","title":"Standard Hodgkin-Huxley dynamic gating kinetics.","created":{"id":"anon_704","creator":{"id":"anon_705","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of 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the total membrane current is calculated for a given step in holding potential.</p>","importedAs":{"_reference":"named_1135"},"math":"named_1116.xml"},{"id":"named_1135","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/voltage-clamp.xml#cellmlelement--anonymous-72","title":"model","created":{"id":"anon_794","creator":{"id":"anon_795","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205406000000}},{"id":"named_1117","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/voltage-clamp.xml#time_component","title":"time","created":{"id":"anon_796","creator":{"id":"anon_797","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205406000000},"description":"<p class=\"cmeta-comment\">The actual definition of the time variable.</p>"},{"id":"named_1118","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/voltage-clamp.xml#parameters","title":"parameters","created":{"id":"anon_798","creator":{"id":"anon_799","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205406000000},"description":"<p class=\"cmeta-comment\">The model parameters which differ from default.</p>"},{"id":"named_1119","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/voltage-clamp.xml#initial_conditions","title":"initial_conditions","created":{"id":"anon_800","creator":{"id":"anon_801","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205406000000},"description":"<p class=\"cmeta-comment\">The initial conditions - using all default values in this case.</p>"},{"id":"named_1120","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#parameters_component","title":"Hodgkin & Huxley default parameters.","created":{"id":"anon_802","creator":{"id":"anon_803","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"description":"<p class=\"cmeta-comment\">Here we define the complete set of default parameter values.</p>","importedAs":{"_reference":"named_1150"}},{"id":"named_1150","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/voltage-clamp.xml#cellmlelement--anonymous-73","title":"default_parameters","created":{"id":"anon_804","creator":{"id":"anon_805","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of 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model.</p>","importedAs":{"_reference":"named_1152"},"math":"named_1122.xml"},{"id":"named_1152","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/voltage-clamp.xml#cellmlelement--anonymous-75","title":"INa","created":{"id":"anon_812","creator":{"id":"anon_813","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205406000000}},{"id":"named_1123","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK.xml#IK_component","title":"Hodgkin & Huxley potassium current.","created":{"id":"anon_814","creator":{"id":"anon_815","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"description":"<p class=\"cmeta-comment\">A description of the membrane potassium current of the Hodgkin & 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the Hodgkin & Huxley (1952) model.</p>","importedAs":{"_reference":"named_1172"},"math":"named_1124.xml"},{"id":"named_1172","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/voltage-clamp.xml#cellmlelement--anonymous-77","title":"Ileak","created":{"id":"anon_820","creator":{"id":"anon_821","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205406000000}},{"id":"named_1125","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#alpha_m_component","title":"Description of the activation rate constant for the m gate.","created":{"id":"anon_822","creator":{"id":"anon_823","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"description":"<p class=\"cmeta-comment\">A description of the voltage-dependent activation rate constant for the m gate of the Hodgkin & Huxley (1952) sodium current.</p>","importedAs":{"_reference":"named_1178"},"math":"named_1125.xml"},{"id":"named_1178","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#alpha_m","title":"alpha_m","created":{"id":"anon_824","creator":{"id":"anon_825","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_1126","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#beta_m_component","title":"beta_m","created":{"id":"anon_826","creator":{"id":"anon_827","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of 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Singapore"},"created":1218369600000},"importedAs":{"_reference":"named_1202"},"math":"named_1128.xml"},{"id":"named_1202","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#beta_h","title":"beta_h","created":{"id":"anon_836","creator":{"id":"anon_837","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_1129","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#hh_gating_variable_dynamic","title":"Standard Hodgkin-Huxley dynamic gating kinetics.","created":{"id":"anon_838","creator":{"id":"anon_839","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205146800000},"description":"<p class=\"cmeta-comment\">The standard definition of a dynamic Hodgkin & Huxley gating variable.</p>","importedAs":{"_reference":"named_1209"},"math":"named_1129.xml"},{"id":"named_1209","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#m_gate","title":"Hodgkin-Huxley sodium current's activation gate.","created":{"id":"anon_840","creator":{"id":"anon_841","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"abstract":"We import the standard HH voltage-dependent gating variable description to use as the sodium channel's activation gating variable - 'm'."},{"id":"named_1130","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#hh_gating_variable_dynamic","title":"Standard Hodgkin-Huxley dynamic gating kinetics.","created":{"id":"anon_842","creator":{"id":"anon_843","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205146800000},"description":"<p class=\"cmeta-comment\">The standard definition of a dynamic Hodgkin & Huxley gating variable.</p>","importedAs":{"_reference":"named_1213"},"math":"named_1130.xml"},{"id":"named_1213","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#h_gate","title":"Hodgkin-Huxley sodium current's inactivation gate.","created":{"id":"anon_844","creator":{"id":"anon_845","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"abstract":"We import the standard HH voltage-dependent gating variable description to use as the sodium channel's inactivation gating variable - 'h'.","modifications":[{"id":"anon_846","modifier":{"id":"anon_847","type":"person","name":"David Nickerson"},"modification":"Splitting out the gating rate equation components to their own model to test out a possible bug in the API implementation which arises when importing encapsulated children directly into other models.","modified":1218369600000}]},{"id":"named_1131","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#alpha_n_component","title":"Description of the activation rate constant for the n gate.","created":{"id":"anon_848","creator":{"id":"anon_849","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"description":"<p class=\"cmeta-comment\">A description of the voltage-dependent activation rate constant for the n gate of the Hodgkin & Huxley (1952) potassium current.</p>","importedAs":{"_reference":"named_1217"},"math":"named_1131.xml"},{"id":"named_1217","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK.xml#alpha_n_component","title":"alpha_n","created":{"id":"anon_850","creator":{"id":"anon_851","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_1132","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#beta_n_component","title":"Description of the inactivation rate constant for the n gate.","created":{"id":"anon_852","creator":{"id":"anon_853","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"description":"<p class=\"cmeta-comment\">A description of the voltage-dependent inactivation rate constant for the n gate of the Hodgkin & Huxley (1952) potassium current.</p>","importedAs":{"_reference":"named_1224"},"math":"named_1132.xml"},{"id":"named_1224","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK.xml#beta_n_component","title":"beta_n","created":{"id":"anon_854","creator":{"id":"anon_855","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_1133","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#hh_gating_variable_dynamic","title":"Standard Hodgkin-Huxley dynamic gating kinetics.","created":{"id":"anon_856","creator":{"id":"anon_857","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of 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class=\"cmeta-comment\">The initial value of the dynamic gating variable, must be defined in order to solve the dynamic expression of the gating 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class=\"cmeta-comment\">The initial value of the dynamic gating variable, must be defined in order to solve the dynamic expression of the gating 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University of Singapore"},"created":1205406000000},"description":"<p class=\"cmeta-comment\">Simply defining the clamp potential variable to connect to the voltage clamp model.</p>"},{"id":"named_1421","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/voltage-clamp.xml#interface","title":"interface","created":{"id":"anon_940","creator":{"id":"anon_941","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205406000000},"description":"<p class=\"cmeta-comment\">Here we define an interface to a fully specified voltage clamp model which requires only the new potential value to be 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the total membrane current is calculated for a given step in holding potential.</p>","importedAs":{"_reference":"named_1441"},"math":"named_1422.xml"},{"id":"named_1441","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/voltage-clamp.xml#cellmlelement--anonymous-90","title":"model","created":{"id":"anon_946","creator":{"id":"anon_947","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205406000000}},{"id":"named_1423","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/voltage-clamp.xml#time_component","title":"time","created":{"id":"anon_948","creator":{"id":"anon_949","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205406000000},"description":"<p class=\"cmeta-comment\">The actual definition of the time variable.</p>"},{"id":"named_1424","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/voltage-clamp.xml#parameters","title":"parameters","created":{"id":"anon_950","creator":{"id":"anon_951","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205406000000},"description":"<p class=\"cmeta-comment\">The model parameters which differ from default.</p>"},{"id":"named_1425","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/voltage-clamp.xml#initial_conditions","title":"initial_conditions","created":{"id":"anon_952","creator":{"id":"anon_953","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205406000000},"description":"<p class=\"cmeta-comment\">The initial conditions - using all default values in this case.</p>"},{"id":"named_1426","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#parameters_component","title":"Hodgkin & Huxley default parameters.","created":{"id":"anon_954","creator":{"id":"anon_955","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"description":"<p class=\"cmeta-comment\">Here we define the complete set of default parameter values.</p>","importedAs":{"_reference":"named_1456"}},{"id":"named_1456","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/voltage-clamp.xml#cellmlelement--anonymous-91","title":"default_parameters","created":{"id":"anon_956","creator":{"id":"anon_957","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of 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model.</p>","importedAs":{"_reference":"named_1458"},"math":"named_1428.xml"},{"id":"named_1458","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/voltage-clamp.xml#cellmlelement--anonymous-93","title":"INa","created":{"id":"anon_964","creator":{"id":"anon_965","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205406000000}},{"id":"named_1429","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK.xml#IK_component","title":"Hodgkin & Huxley potassium current.","created":{"id":"anon_966","creator":{"id":"anon_967","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"description":"<p class=\"cmeta-comment\">A description of the membrane potassium current of the Hodgkin & Huxley (1952) model.</p>","importedAs":{"_reference":"named_1469"},"math":"named_1429.xml"},{"id":"named_1469","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/voltage-clamp.xml#cellmlelement--anonymous-94","title":"IK","created":{"id":"anon_968","creator":{"id":"anon_969","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205406000000}},{"id":"named_1430","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/Ileak.xml#Ileak_component","title":"Hodgkin & Huxley leakage current.","created":{"id":"anon_970","creator":{"id":"anon_971","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"description":"<p class=\"cmeta-comment\">A description of the membrane leakage current of the Hodgkin & Huxley (1952) model.</p>","importedAs":{"_reference":"named_1478"},"math":"named_1430.xml"},{"id":"named_1478","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/voltage-clamp.xml#cellmlelement--anonymous-95","title":"Ileak","created":{"id":"anon_972","creator":{"id":"anon_973","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205406000000}},{"id":"named_1431","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#alpha_m_component","title":"Description of the activation rate constant for the m gate.","created":{"id":"anon_974","creator":{"id":"anon_975","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"description":"<p class=\"cmeta-comment\">A description of the voltage-dependent activation rate constant for the m gate of the Hodgkin & Huxley (1952) sodium current.</p>","importedAs":{"_reference":"named_1484"},"math":"named_1431.xml"},{"id":"named_1484","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#alpha_m","title":"alpha_m","created":{"id":"anon_976","creator":{"id":"anon_977","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_1432","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#beta_m_component","title":"beta_m","created":{"id":"anon_978","creator":{"id":"anon_979","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of 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voltage-dependent activation rate constant for the h gate of the Hodgkin & Huxley (1952) sodium current.</p>","importedAs":{"_reference":"named_1501"},"math":"named_1433.xml"},{"id":"named_1501","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#alpha_h","title":"alpha_h","created":{"id":"anon_984","creator":{"id":"anon_985","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_1434","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#beta_h_component","title":"beta_h","created":{"id":"anon_986","creator":{"id":"anon_987","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"importedAs":{"_reference":"named_1508"},"math":"named_1434.xml"},{"id":"named_1508","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#beta_h","title":"beta_h","created":{"id":"anon_988","creator":{"id":"anon_989","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_1435","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#hh_gating_variable_dynamic","title":"Standard Hodgkin-Huxley dynamic gating kinetics.","created":{"id":"anon_990","creator":{"id":"anon_991","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205146800000},"description":"<p class=\"cmeta-comment\">The standard definition of a dynamic Hodgkin & Huxley gating variable.</p>","importedAs":{"_reference":"named_1515"},"math":"named_1435.xml"},{"id":"named_1515","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#m_gate","title":"Hodgkin-Huxley sodium current's activation gate.","created":{"id":"anon_992","creator":{"id":"anon_993","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"abstract":"We import the standard HH voltage-dependent gating variable description to use as the sodium channel's activation gating variable - 'm'."},{"id":"named_1436","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#hh_gating_variable_dynamic","title":"Standard Hodgkin-Huxley dynamic gating kinetics.","created":{"id":"anon_994","creator":{"id":"anon_995","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205146800000},"description":"<p class=\"cmeta-comment\">The standard definition of a dynamic Hodgkin & Huxley gating variable.</p>","importedAs":{"_reference":"named_1519"},"math":"named_1436.xml"},{"id":"named_1519","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#h_gate","title":"Hodgkin-Huxley sodium current's inactivation gate.","created":{"id":"anon_996","creator":{"id":"anon_997","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"abstract":"We import the standard HH voltage-dependent gating variable description to use as the sodium channel's inactivation gating variable - 'h'.","modifications":[{"id":"anon_998","modifier":{"id":"anon_999","type":"person","name":"David Nickerson"},"modification":"Splitting out the gating rate equation components to their own model to test out a possible bug in the API implementation which arises when importing encapsulated children directly into other models.","modified":1218369600000}]},{"id":"named_1437","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#alpha_n_component","title":"Description of the activation rate constant for the n gate.","created":{"id":"anon_1000","creator":{"id":"anon_1001","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"description":"<p class=\"cmeta-comment\">A description of the voltage-dependent activation rate constant for the n gate of the Hodgkin & Huxley (1952) potassium current.</p>","importedAs":{"_reference":"named_1523"},"math":"named_1437.xml"},{"id":"named_1523","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK.xml#alpha_n_component","title":"alpha_n","created":{"id":"anon_1002","creator":{"id":"anon_1003","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_1438","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#beta_n_component","title":"Description of the inactivation rate constant for the n gate.","created":{"id":"anon_1004","creator":{"id":"anon_1005","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"description":"<p class=\"cmeta-comment\">A description of the voltage-dependent inactivation rate constant for the n gate of the Hodgkin & Huxley (1952) potassium current.</p>","importedAs":{"_reference":"named_1530"},"math":"named_1438.xml"},{"id":"named_1530","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK.xml#beta_n_component","title":"beta_n","created":{"id":"anon_1006","creator":{"id":"anon_1007","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_1439","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#hh_gating_variable_dynamic","title":"Standard Hodgkin-Huxley dynamic gating kinetics.","created":{"id":"anon_1008","creator":{"id":"anon_1009","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of 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class=\"cmeta-comment\">The initial value of the dynamic gating variable, must be defined in order to solve the dynamic expression of the gating 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class=\"cmeta-comment\">The initial value of the dynamic gating variable, must be defined in order to solve the dynamic expression of the gating 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Singapore"},"created":1205233200000},"description":"<p class=\"cmeta-comment\">The actual definition of the time variable.</p>"},{"id":"named_1727","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/periodic-stimulus.xml#stimulus_protocol_params","title":"stimulus_protocol_params","created":{"id":"anon_1092","creator":{"id":"anon_1093","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"description":"<p class=\"cmeta-comment\">Here we define the parameters for the applied periodic stimulus.</p>"},{"id":"named_1728","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/periodic-stimulus.xml#parameters","title":"parameters","created":{"id":"anon_1094","creator":{"id":"anon_1095","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of 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University of Singapore"},"created":1205233200000}},{"id":"named_1732","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#parameters_component","title":"Hodgkin & Huxley default parameters.","created":{"id":"anon_1106","creator":{"id":"anon_1107","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"description":"<p class=\"cmeta-comment\">Here we define the complete set of default parameter values.</p>","importedAs":{"_reference":"named_1769"}},{"id":"named_1769","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/periodic-stimulus.xml#cellmlelement--anonymous-116","title":"default_parameters","created":{"id":"anon_1108","creator":{"id":"anon_1109","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_1733","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/default-variable-values.xml#initial_conditions_component","title":"Hodgkin & Huxley default initial conditions.","created":{"id":"anon_1110","creator":{"id":"anon_1111","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"description":"<p class=\"cmeta-comment\">Here we define the complete set set of default initial conditions for the model's differental variables.</p>","importedAs":{"_reference":"named_1770"}},{"id":"named_1770","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/experiments/periodic-stimulus.xml#cellmlelement--anonymous-117","title":"default_initial_conditions","created":{"id":"anon_1112","creator":{"id":"anon_1113","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_1734","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#INa_component","title":"Hodgkin & Huxley sodium current.","created":{"id":"anon_1114","creator":{"id":"anon_1115","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"description":"<p class=\"cmeta-comment\">A description of the membrane sodium current of the Hodgkin & Huxley (1952) model.</p>","importedAs":{"_reference":"named_1771"},"math":"named_1734.xml"},{"id":"named_1771","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/stimulated.xml#cellmlelement--anonymous-118","title":"INa","created":{"id":"anon_1116","creator":{"id":"anon_1117","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_1735","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK.xml#IK_component","title":"Hodgkin & Huxley potassium current.","created":{"id":"anon_1118","creator":{"id":"anon_1119","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"description":"<p class=\"cmeta-comment\">A description of the membrane potassium current of the Hodgkin & Huxley (1952) model.</p>","importedAs":{"_reference":"named_1782"},"math":"named_1735.xml"},{"id":"named_1782","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/stimulated.xml#cellmlelement--anonymous-119","title":"IK","created":{"id":"anon_1120","creator":{"id":"anon_1121","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_1736","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/Ileak.xml#Ileak_component","title":"Hodgkin & Huxley leakage current.","created":{"id":"anon_1122","creator":{"id":"anon_1123","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"description":"<p class=\"cmeta-comment\">A description of the membrane leakage current of the Hodgkin & Huxley (1952) model.</p>","importedAs":{"_reference":"named_1791"},"math":"named_1736.xml"},{"id":"named_1791","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/stimulated.xml#cellmlelement--anonymous-120","title":"Ileak","created":{"id":"anon_1124","creator":{"id":"anon_1125","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_1737","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#alpha_m_component","title":"Description of the activation rate constant for the m gate.","created":{"id":"anon_1126","creator":{"id":"anon_1127","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of 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National University of Singapore"},"created":1218369600000},"importedAs":{"_reference":"named_1807"},"math":"named_1738.xml"},{"id":"named_1807","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#beta_m","title":"beta_m","created":{"id":"anon_1132","creator":{"id":"anon_1133","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_1739","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#alpha_h_component","title":"Description of the activation rate constant for the h gate.","created":{"id":"anon_1134","creator":{"id":"anon_1135","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"description":"<p class=\"cmeta-comment\">A description of the voltage-dependent activation rate constant for the h gate of the Hodgkin & Huxley (1952) sodium current.</p>","importedAs":{"_reference":"named_1814"},"math":"named_1739.xml"},{"id":"named_1814","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#alpha_h","title":"alpha_h","created":{"id":"anon_1136","creator":{"id":"anon_1137","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_1740","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa-gating-rates.xml#beta_h_component","title":"beta_h","created":{"id":"anon_1138","creator":{"id":"anon_1139","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"importedAs":{"_reference":"named_1821"},"math":"named_1740.xml"},{"id":"named_1821","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#beta_h","title":"beta_h","created":{"id":"anon_1140","creator":{"id":"anon_1141","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_1741","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#hh_gating_variable_dynamic","title":"Standard Hodgkin-Huxley dynamic gating kinetics.","created":{"id":"anon_1142","creator":{"id":"anon_1143","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205146800000},"description":"<p class=\"cmeta-comment\">The standard definition of a dynamic Hodgkin & Huxley gating variable.</p>","importedAs":{"_reference":"named_1828"},"math":"named_1741.xml"},{"id":"named_1828","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#m_gate","title":"Hodgkin-Huxley sodium current's activation gate.","created":{"id":"anon_1144","creator":{"id":"anon_1145","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"abstract":"We import the standard HH voltage-dependent gating variable description to use as the sodium channel's activation gating variable - 'm'."},{"id":"named_1742","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#hh_gating_variable_dynamic","title":"Standard Hodgkin-Huxley dynamic gating kinetics.","created":{"id":"anon_1146","creator":{"id":"anon_1147","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205146800000},"description":"<p class=\"cmeta-comment\">The standard definition of a dynamic Hodgkin & Huxley gating variable.</p>","importedAs":{"_reference":"named_1832"},"math":"named_1742.xml"},{"id":"named_1832","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/INa.xml#h_gate","title":"Hodgkin-Huxley sodium current's inactivation gate.","created":{"id":"anon_1148","creator":{"id":"anon_1149","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000},"abstract":"We import the standard HH voltage-dependent gating variable description to use as the sodium channel's inactivation gating variable - 'h'.","modifications":[{"id":"anon_1150","modifier":{"id":"anon_1151","type":"person","name":"David Nickerson"},"modification":"Splitting out the gating rate equation components to their own model to test out a possible bug in the API implementation which arises when importing encapsulated children directly into other models.","modified":1218369600000}]},{"id":"named_1743","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#alpha_n_component","title":"Description of the activation rate constant for the n gate.","created":{"id":"anon_1152","creator":{"id":"anon_1153","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"description":"<p class=\"cmeta-comment\">A description of the voltage-dependent activation rate constant for the n gate of the Hodgkin & Huxley (1952) potassium current.</p>","importedAs":{"_reference":"named_1836"},"math":"named_1743.xml"},{"id":"named_1836","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK.xml#alpha_n_component","title":"alpha_n","created":{"id":"anon_1154","creator":{"id":"anon_1155","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_1744","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK-gating-rates.xml#beta_n_component","title":"Description of the inactivation rate constant for the n gate.","created":{"id":"anon_1156","creator":{"id":"anon_1157","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1218369600000},"description":"<p class=\"cmeta-comment\">A description of the voltage-dependent inactivation rate constant for the n gate of the Hodgkin & Huxley (1952) potassium current.</p>","importedAs":{"_reference":"named_1843"},"math":"named_1744.xml"},{"id":"named_1843","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/IK.xml#beta_n_component","title":"beta_n","created":{"id":"anon_1158","creator":{"id":"anon_1159","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of Singapore"},"created":1205233200000}},{"id":"named_1745","type":"component","uri":"http://www.bioeng.nus.edu.sg/compbiolab/p3/cellml/components/gating-variable.xml#hh_gating_variable_dynamic","title":"Standard Hodgkin-Huxley dynamic gating kinetics.","created":{"id":"anon_1160","creator":{"id":"anon_1161","type":"person","name":"David Nickerson","email":"david.nickerson@nus.edu.sg","organisation":"Division of Bioengineering, National University of 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