Location: Aslanidi 2009 @ d7887fa5a6ba / aslanidi_2009.cellml

Author:

Catherine Lloyd <c.lloyd@auckland.ac.nz>

Date:

2009-10-08 11:38:12+13:00

Desc:

Added files to workspace for the first time

Permanent Source URI:

https://staging.physiomeproject.org/workspace/aslanidi_purkinje_model_2009/rawfile/d7887fa5a6ba46105d530439ad74cd5c86aeb3d0/aslanidi_2009.cellml

<?xml version="1.0" encoding="utf-8"?>

<model xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" name="aslanidi_2009" cmeta:id="aslanidi_2009" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">	

<documentation xmlns="http://cellml.org/tmp-documentation">
		<article>
			<articleinfo>
				<title>Optimal velocity and safety of discontinuous conduction through the heterogeneous Purkinje-ventricular junction
</title>
				<author>
					<firstname>Catherine</firstname>
					<surname>Lloyd</surname>
					<affiliation>
						<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
					</affiliation>
				</author>
			</articleinfo>
			<section id="sec_status">
				<title>Model Status</title>
				<para>
				This CellML model runs in both COR and PCEnv to reproduce the published results.  The CellML model has been based on both the published paper and the original C Code the model was written in.  Our thanks go to the authors Oleg and Philip for their help in curating the CellML model and getting it to reproduce their original results.
				</para>
			</section>
			<sect1 id="sec_structure">
				<title>Model Structure</title>
				<para>
ABSTRACT: Slow and discontinuous wave conduction through non-uniform junctions in cardiac tissues is generally considered unsafe and pro-arrythmogenic. However, the relationships between tissue structure, wave conduction velocity and safety at such junctions are unknown. We develop a structurally and electrophysiologically detailed model of the canine Purkinje-ventricular junction (PVJ) and vary its heterogeneity parameters in order to determine such relationships. We show that neither very fast nor very slow conduction is safe, and there exists an optimal velocity providing the maximum safety factor of conduction through the junction. The resultant conduction time delay across the PVJ is a natural consequence of the electrophysiological and morphological differences between the Purkinje fibre and ventricular tissue. The delay allows the PVJ to accumulate and pass sufficient charge to excite the adjacent ventricular tissue, but is not long enough for the source-to-load mismatch at the junction to be enhanced over time. The observed relationships between the conduction velocity and safety factor can provide new insights into optimal conditions for wave propagation through non-uniform junctions between various cardiac tissues.
</para>
				<informalfigure float="0" id="fig_reaction_diagram">
					<mediaobject>
						<imageobject>
							<objectinfo>
								<title>model diagram</title>
							</objectinfo>
							<imagedata fileref="aslanidi_2009.png"/>
						</imageobject>
					</mediaobject>
					<caption>Schematic diagram of the cell model.</caption>
				</informalfigure>
				<para>
The original paper reference is cited below:
</para>
				<para>
Optimal velocity and safety of discontinuous conduction through the heterogeneous Purkinje-ventricular junction, Oleg V. Aslanidi, Philip Stewart, Mark R. Boyett and Henggui Zhang, 2009, <emphasis>Biophysical Journal</emphasis>, volume 97, 20-39.  <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&amp;cmd=Retrieve&amp;dopt=AbstractPlus&amp;list_uids=19580741&amp;query_hl=1&amp;itool=pubmed_docsum">PubMed ID: 19580741</ulink>
				</para>
			</sect1>
		</article>
	</documentation>
	
	
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			<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">potassium-chloride cotransporter</dcterms:alternative>
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			<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">sodium-chloride cotransporter</dcterms:alternative>
		</rdf:Description>
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			<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">background_currents</dc:title>
			<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">background currents</dcterms:alternative>
		</rdf:Description>
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			<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">intracellular_ion_concentrations</dc:title>
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			<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">calcium-calmodulin-dependent protein kinase</dcterms:alternative>
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			<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Ca_NSR</dc:title>
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			<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">calcium concentration in the juctional sarcoplasmic reticulum</dcterms:alternative>
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			<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">restricted space calcium concentration</dcterms:alternative>
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            <eq/>
            <ci>E_Na</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <ci>F</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Na_o</ci>
                     <ci>Na_i</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>E_K</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <ci>F</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>K_o</ci>
                     <ci>K_i</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>E_Ca</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <ci>F</ci>
                  </apply>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Ca_o</ci>
                     <ci>Ca_i</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>E_Cl</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <ci>R</ci>
                     </apply>
                     <ci>T</ci>
                  </apply>
                  <ci>F</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Cl_o</ci>
                     <ci>Cl_i</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>E_Ks</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <ci>F</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <apply>
                        <plus/>
                        <ci>K_o</ci>
                        <apply>
                           <times/>
                           <ci>r_NaK</ci>
                           <ci>Na_o</ci>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>K_i</ci>
                        <apply>
                           <times/>
                           <ci>r_NaK</ci>
                           <ci>Na_i</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Na">
      <variable name="i_Na" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="8" name="g_Na" units="milliS_per_microF"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="E_Na" public_interface="in" units="millivolt"/>
      <variable name="m" private_interface="in" units="dimensionless"/>
      <variable name="h" private_interface="in" units="dimensionless"/>
      <variable name="j" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Na</ci>
            <apply>
               <times/>
               <ci>g_Na</ci>
               <apply>
                  <power/>
                  <ci>m</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.8</cn>
                     <ci>h</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
                     <ci>j</ci>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Na</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Na_m_gate">
      <variable initial_value="0.002003390432234504" name="m" public_interface="out" units="dimensionless"/>
      <variable name="tau_m" units="millisecond"/>
      <variable name="m_infinity" units="dimensionless"/>
      <variable name="alpha_m" units="per_millisecond"/>
      <variable name="beta_m" units="per_millisecond"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_m</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_millisecond">0.32</cn>
                  <apply>
                     <plus/>
                     <ci>V</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">47.13</cn>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1</cn>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">47.13</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_m</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.08</cn>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <minus/>
                        <ci>V</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>m_infinity</ci>
            <apply>
               <divide/>
               <ci>alpha_m</ci>
               <apply>
                  <plus/>
                  <ci>alpha_m</ci>
                  <ci>beta_m</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_m</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>alpha_m</ci>
                  <ci>beta_m</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>m</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>m_infinity</ci>
                  <ci>m</ci>
               </apply>
               <ci>tau_m</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Na_h_gate">
      <variable initial_value="0.9786390933308567" name="h" public_interface="out" units="dimensionless"/>
      <variable name="tau_h" units="millisecond"/>
      <variable name="h_infinity" units="dimensionless"/>
      <variable name="alpha_h" units="per_millisecond"/>
      <variable name="beta_h" units="per_millisecond"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_h</ci>
            <piecewise>
               <piece>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.135</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">80</cn>
                           </apply>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.8</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>beta_h</ci>
            <piecewise>
               <piece>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">3.56</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.079</cn>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">310000</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.35</cn>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">0.13</cn>
                        <apply>
                           <plus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.66</cn>
                                 </apply>
                                 <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11.1</cn>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>h_infinity</ci>
            <apply>
               <divide/>
               <ci>alpha_h</ci>
               <apply>
                  <plus/>
                  <ci>alpha_h</ci>
                  <ci>beta_h</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_h</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>alpha_h</ci>
                  <ci>beta_h</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>h</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>h_infinity</ci>
                  <ci>h</ci>
               </apply>
               <ci>tau_h</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Na_j_gate">
      <variable initial_value="0.09866447258167589" name="j" public_interface="out" units="dimensionless"/>
      <variable name="tau_j" units="millisecond"/>
      <variable name="j_infinity" units="dimensionless"/>
      <variable name="alpha_j" units="per_millisecond"/>
      <variable name="beta_j" units="per_millisecond"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_j</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_millisecond">127140</cn>
                              </apply>
                              <apply>
                                 <exp/>
                                 <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.2444</cn>
                                    <ci>V</ci>
                                 </apply>
                              </apply>
                           </apply>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_millisecond">0.00003474</cn>
                              <apply>
                                 <exp/>
                                 <apply>
                                    <times/>
                                    <apply>
                                       <minus/>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.04391</cn>
                                    </apply>
                                    <ci>V</ci>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">37.78</cn>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.311</cn>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">79.23</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>beta_j</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.1212</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.01052</cn>
                              </apply>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1378</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40.14</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.3</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0000002535</cn>
                              </apply>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">32</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>j_infinity</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
                  <ci>alpha_j</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>alpha_j</ci>
                  <ci>beta_j</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_j</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
               <apply>
                  <plus/>
                  <ci>alpha_j</ci>
                  <ci>beta_j</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>j</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>j_infinity</ci>
                  <ci>j</ci>
               </apply>
               <ci>tau_j</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Na_L">
      <variable name="i_Na_L" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="0.037375" name="g_Na_L" units="milliS_per_microF"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="E_Na" public_interface="in" units="millivolt"/>
      <variable name="m_L" private_interface="in" units="dimensionless"/>
      <variable name="h_L" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Na_L</ci>
            <apply>
               <times/>
               <ci>g_Na_L</ci>
               <apply>
                  <power/>
                  <ci>m_L</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
               </apply>
               <ci>h_L</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Na</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Na_L_m_L_gate">
      <variable initial_value="0.002003390432234504" name="m_L" public_interface="out" units="dimensionless"/>
      <variable name="tau_m_L" units="millisecond"/>
      <variable name="m_L_infinity" units="dimensionless"/>
      <variable name="alpha_m_L" units="per_millisecond"/>
      <variable name="beta_m_L" units="per_millisecond"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_m_L</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_millisecond">0.32</cn>
                  <apply>
                     <plus/>
                     <ci>V</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">47.13</cn>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1</cn>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">47.13</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_m_L</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.08</cn>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <minus/>
                        <ci>V</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>m_L_infinity</ci>
            <apply>
               <divide/>
               <ci>alpha_m_L</ci>
               <apply>
                  <plus/>
                  <ci>alpha_m_L</ci>
                  <ci>beta_m_L</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_m_L</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>alpha_m_L</ci>
                  <ci>beta_m_L</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>m_L</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>m_L_infinity</ci>
                  <ci>m_L</ci>
               </apply>
               <ci>tau_m_L</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Na_L_h_L_gate">
      <variable initial_value="0.8946968372659203" name="h_L" public_interface="out" units="dimensionless"/>
      <variable name="tau_h_L" units="millisecond"/>
      <variable name="h_L_infinity" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>h_L_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">69</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.1</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_h_L</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">175</cn>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">125</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>h_L</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>h_L_infinity</ci>
                  <ci>h_L</ci>
               </apply>
               <ci>tau_h_L</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Ca_L">
      <variable name="i_Ca_L" private_interface="out" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="0.3392328" name="g_Ca_L" public_interface="out" units="dimensionless"/>
      <variable name="i_Ca_L_max" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="0.000243" name="p_Ca" units="cm_per_second"/>
      <variable name="z_Ca" public_interface="in" units="dimensionless"/>
      <variable name="gamma_Cai" public_interface="in" units="dimensionless"/>
      <variable name="gamma_Cao" public_interface="in" units="dimensionless"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="Ca_r" private_interface="out" public_interface="in" units="millimolar"/>
      <variable name="Ca_MK_act" private_interface="out" public_interface="in" units="dimensionless"/>
      <variable name="km_Ca_MK" private_interface="out" public_interface="in" units="millimolar"/>
      <variable name="Ca_o" public_interface="in" units="millimolar"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="d" private_interface="in" units="dimensionless"/>
      <variable name="f" private_interface="in" units="dimensionless"/>
      <variable name="f2" private_interface="in" units="dimensionless"/>
      <variable name="f_Ca" private_interface="in" units="dimensionless"/>
      <variable name="f_Ca2" private_interface="in" units="dimensionless"/>
      <variable name="Cm" public_interface="in" units="microF_per_cm2"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Ca_L</ci>
            <apply>
               <times/>
               <ci>g_Ca_L</ci>
               <ci>d</ci>
               <ci>f</ci>
               <ci>f2</ci>
               <ci>f_Ca</ci>
               <ci>f_Ca2</ci>
               <ci>i_Ca_L_max</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ca_L_max</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                              <ci>p_Ca</ci>
                           </apply>
                           <ci>Cm</ci>
                        </apply>
                        <apply>
                           <power/>
                           <ci>z_Ca</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15</cn>
                        </apply>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Cai</ci>
                        <ci>Ca_r</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <ci>z_Ca</ci>
                                 <ci>F</ci>
                                 <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15</cn>
                                 </apply>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Cao</ci>
                        <ci>Ca_o</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>z_Ca</ci>
                           <ci>F</ci>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15</cn>
                           </apply>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Ca_L_d_gate">
      <variable initial_value="0.000002322223865147363" name="d" public_interface="out" units="dimensionless"/>
      <variable name="d_infinity" units="dimensionless"/>
      <variable name="tau_d" units="millisecond"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>d</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>d_infinity</ci>
                  <ci>d</ci>
               </apply>
               <ci>tau_d</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>d_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">4</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.74</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_d</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">0.59</cn>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">0.8</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.052</cn>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.132</cn>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Ca_L_f_gate">
      <variable initial_value="0.9985607329462358" name="f" public_interface="out" units="dimensionless"/>
      <variable name="f_infinity" units="dimensionless"/>
      <variable name="tau_f" units="millisecond"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>f</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>f_infinity</ci>
                  <ci>f</ci>
               </apply>
               <ci>tau_f</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>f_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">18</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_f</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">4</cn>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond_per_millivolt2">0.005</cn>
                  <apply>
                     <power/>
                     <apply>
                        <minus/>
                        <ci>V</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">2.5</cn>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Ca_L_f2_gate">
      <variable initial_value="0.8173435436674658" name="f2" public_interface="out" units="dimensionless"/>
      <variable name="f2_infinity" units="dimensionless"/>
      <variable name="tau_f2" units="millisecond"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>f2</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>f2_infinity</ci>
                  <ci>f2</ci>
               </apply>
               <ci>tau_f2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>f2_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">18</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_f2</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">38</cn>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond_per_millivolt2">0.07</cn>
                  <apply>
                     <power/>
                     <apply>
                        <minus/>
                        <ci>V</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">18.6</cn>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Ca_L_f_Ca_gate">
      <variable initial_value="0.9610551285529658" name="f_Ca" public_interface="out" units="dimensionless"/>
      <variable name="f_Ca_infinity" units="dimensionless"/>
      <variable name="tau_f_Ca" units="millisecond"/>
      <variable name="Ca_r" public_interface="in" units="millimolar"/>
      <variable name="i_Ca_L" public_interface="in" units="microA_per_microF"/>
      <variable name="Ca_MK_act" public_interface="in" units="dimensionless"/>
      <variable name="km_Ca_MK" public_interface="in" units="millimolar"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>f_Ca</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>f_Ca_infinity</ci>
                  <ci>f_Ca</ci>
               </apply>
               <ci>tau_f_Ca</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>f_Ca_infinity</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.3</cn>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <divide/>
                        <ci>i_Ca_L</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="microA_per_microF">0.05</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.55</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <divide/>
                        <ci>Ca_r</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.003</cn>
                     </apply>
                  </apply>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.15</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_f_Ca</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">0.5</cn>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">10</cn>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">1</cn>
                     <ci>Ca_MK_act</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">1</cn>
                        <ci>Ca_MK_act</ci>
                     </apply>
                     <ci>km_Ca_MK</ci>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <divide/>
                        <ci>Ca_r</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.003</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Ca_L_f_Ca2_gate">
      <variable initial_value="0.868690796671854" name="f_Ca2" public_interface="out" units="dimensionless"/>
      <variable name="f_Ca2_infinity" units="dimensionless"/>
      <variable name="tau_f_Ca2" units="millisecond"/>
      <variable name="i_Ca_L" public_interface="in" units="microA_per_microF"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>f_Ca2</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>f_Ca2_infinity</ci>
                  <ci>f_Ca2</ci>
               </apply>
               <ci>tau_f_Ca2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>f_Ca2_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>i_Ca_L</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="microA_per_microF">0.01</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_f_Ca2</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">125</cn>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">300</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <ci>i_Ca_L</ci>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="microA_per_microF">0.175</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="microA_per_microF">0.04</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Ca_T">
      <variable name="i_Ca_T" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="0.13" name="g_Ca_T" units="milliS_per_microF"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="b" private_interface="in" units="dimensionless"/>
      <variable name="g" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Ca_T</ci>
            <apply>
               <times/>
               <ci>g_Ca_T</ci>
               <ci>b</ci>
               <ci>g</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Ca_T_b_gate">
      <variable initial_value="0.0002563937630984438" name="b" public_interface="out" units="dimensionless"/>
      <variable name="tau_b" units="millisecond"/>
      <variable name="b_infinity" units="dimensionless"/>
      <variable name="alpha_b" units="per_millisecond"/>
      <variable name="beta_b" units="per_millisecond"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_b</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1.068</cn>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">16.3</cn>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_b</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1.068</cn>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <minus/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">16.3</cn>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>b_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">33</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.1</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_b</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>alpha_b</ci>
                  <ci>beta_b</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>b</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>b_infinity</ci>
                  <ci>b</ci>
               </apply>
               <ci>tau_b</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Ca_T_g_gate">
      <variable initial_value="0.9720432601848331" name="g" public_interface="out" units="dimensionless"/>
      <variable name="tau_g" units="millisecond"/>
      <variable name="g_infinity" units="dimensionless"/>
      <variable name="alpha_g" units="per_millisecond"/>
      <variable name="beta_g" units="per_millisecond"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_g</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.015</cn>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <minus/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">71.7</cn>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">83.3</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_g</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.015</cn>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">71.7</cn>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15.4</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>g_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">60</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.6</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_g</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>alpha_g</ci>
                  <ci>beta_g</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>g</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>g_infinity</ci>
                  <ci>g</ci>
               </apply>
               <ci>tau_g</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_to_1">
      <variable name="i_to_1" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="0.14135944" name="g_to_1" units="milliS_per_microF"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="a" private_interface="in" units="dimensionless"/>
      <variable name="i" private_interface="in" units="dimensionless"/>
      <variable name="i2" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_to_1</ci>
            <apply>
               <times/>
               <ci>g_to_1</ci>
               <ci>a</ci>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.8</cn>
                     <ci>i</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
                     <ci>i2</ci>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_to_1_a_gate">
      <variable initial_value="0.0004238729429342389" name="a" public_interface="out" units="dimensionless"/>
      <variable name="alpha_a" units="per_millisecond"/>
      <variable name="beta_a" units="per_millisecond"/>
      <variable name="tau_a" units="millisecond"/>
      <variable name="a_infinity" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>a</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>a_infinity</ci>
                  <ci>a</ci>
               </apply>
               <ci>tau_a</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_a</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">25</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">76</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">76</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_a</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">25</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">54</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">54</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_a</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>alpha_a</ci>
                  <ci>beta_a</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a_infinity</ci>
            <apply>
               <divide/>
               <ci>alpha_a</ci>
               <apply>
                  <plus/>
                  <ci>alpha_a</ci>
                  <ci>beta_a</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_to_1_i_gate">
      <variable initial_value="0.9990935802459496" name="i" public_interface="out" units="dimensionless"/>
      <variable name="alpha_i" units="per_millisecond"/>
      <variable name="beta_i" units="per_millisecond"/>
      <variable name="tau_i" units="millisecond"/>
      <variable name="i_infinity" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>i</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>i_infinity</ci>
                  <ci>i</ci>
               </apply>
               <ci>tau_i</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_i</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.03</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_i</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_i</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">6</cn>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">5</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">16.5</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_infinity</ci>
            <apply>
               <divide/>
               <ci>alpha_i</ci>
               <apply>
                  <plus/>
                  <ci>alpha_i</ci>
                  <ci>beta_i</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_to_1_i2_gate">
      <variable initial_value="0.9777368439681764" name="i2" public_interface="out" units="dimensionless"/>
      <variable name="alpha_i2" units="per_millisecond"/>
      <variable name="beta_i2" units="per_millisecond"/>
      <variable name="tau_i2" units="millisecond"/>
      <variable name="i2_infinity" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>i2</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>i2_infinity</ci>
                  <ci>i2</ci>
               </apply>
               <ci>tau_i2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_i2</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.00442</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">26</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_i2</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.05</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_i2</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">21.5</cn>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">30</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i2_infinity</ci>
            <apply>
               <divide/>
               <ci>alpha_i2</ci>
               <apply>
                  <plus/>
                  <ci>alpha_i2</ci>
                  <ci>beta_i2</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Kr">
      <variable name="i_Kr" public_interface="out" units="microA_per_microF"/>
      <variable name="g_Kr" units="milliS_per_microF"/>
      <variable name="rr_infinity" units="dimensionless"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="K_o" public_interface="in" units="millimolar"/>
      <variable name="xr" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Kr</ci>
            <apply>
               <times/>
               <ci>g_Kr</ci>
               <ci>xr</ci>
               <ci>rr_infinity</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>g_Kr</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="milliS_per_microF">0.040008488</cn>
               <apply>
                  <root/>
                  <apply>
                     <divide/>
                     <ci>K_o</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">5.4</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>rr_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.4</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20.4</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Kr_xr_gate">
      <variable initial_value="0.07084939408222911" name="xr" public_interface="out" units="dimensionless"/>
      <variable name="tau_xr" units="millisecond"/>
      <variable name="xr_infinity" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>xr</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>xr_infinity</ci>
                  <ci>xr</ci>
               </apply>
               <ci>tau_xr</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_xr</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">900</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">100</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>xr_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">0.085</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">12.25</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Ks">
      <variable name="i_Ks" public_interface="out" units="microA_per_microF"/>
      <variable name="g_Ks" units="milliS_per_microF"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="E_Ks" public_interface="in" units="millivolt"/>
      <variable name="Ca_i" public_interface="in" units="millimolar"/>
      <variable name="xs1" private_interface="in" units="dimensionless"/>
      <variable name="xs2" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Ks</ci>
            <apply>
               <times/>
               <ci>g_Ks</ci>
               <ci>xs1</ci>
               <ci>xs2</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ks</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>g_Ks</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="milliS_per_microF">0.052581329</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.6</cn>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.000038</cn>
                              <ci>Ca_i</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.4</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Ks_xs1_gate">
      <variable initial_value="0.0011737654433043125" name="xs1" public_interface="out" units="dimensionless"/>
      <variable name="tau_xs1" units="millisecond"/>
      <variable name="xs1_infinity" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>xs1</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>xs1_infinity</ci>
                  <ci>xs1</ci>
               </apply>
               <ci>tau_xs1</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_xs1</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0000761</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">44.6</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">9.97</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">44.6</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.00036</cn>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">0.55</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.128</cn>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">0.55</cn>
                              </apply>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>xs1_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">9</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13.7</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Ks_xs2_gate">
      <variable initial_value="0.001179442867470093" name="xs2" public_interface="out" units="dimensionless"/>
      <variable name="tau_xs2" units="millisecond"/>
      <variable name="xs2_infinity" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>xs2</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>xs2_infinity</ci>
                  <ci>xs2</ci>
               </apply>
               <ci>tau_xs2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_xs2</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0000761</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">44.6</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">9.97</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">44.6</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.00036</cn>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">0.55</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.128</cn>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">0.55</cn>
                              </apply>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>xs2_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">9</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13.7</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_K1">
      <variable name="i_K1" public_interface="out" units="microA_per_microF"/>
      <variable name="g_K1" units="milliS_per_microF"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="E_K" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="K_o" public_interface="in" units="millimolar"/>
      <variable name="xK1" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_K1</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>g_K1</ci>
                     <ci>xK1</ci>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="milliS_per_microF">0.004</cn>
               </apply>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>g_K1</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="milliS_per_microF">0.25</cn>
               <apply>
                  <root/>
                  <apply>
                     <divide/>
                     <ci>K_o</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">5.4</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_K1_xK1_gate">
      <variable name="xK1" public_interface="out" units="dimensionless"/>
      <variable name="alpha_xK1" units="dimensionless"/>
      <variable name="beta_xK1" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>xK1</ci>
            <apply>
               <divide/>
               <ci>alpha_xK1</ci>
               <apply>
                  <plus/>
                  <ci>alpha_xK1</ci>
                  <ci>beta_xK1</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_xK1</ci>
            <apply>
               <divide/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.49124</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.08032</cn>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.476</cn>
                              </apply>
                              <ci>E_K</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.06175</cn>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <apply>
                              <plus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">594.31</cn>
                              <ci>E_K</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.5143</cn>
                        </apply>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">4.753</cn>
                           </apply>
                           <ci>E_K</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_xK1</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.02</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.2385</cn>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <apply>
                              <plus/>
                              <ci>E_K</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">59.215</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_K_p">
      <variable name="i_K_p" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="0.00276" name="g_K_p" units="milliS_per_microF"/>
      <variable name="kp" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_K_p</ci>
            <apply>
               <times/>
               <ci>g_K_p</ci>
               <ci>kp</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>kp</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.488</cn>
                           <ci>V</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.98</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_to_2">
      <variable name="i_to_2" private_interface="out" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="0.0000004" name="p_Cl" units="cm_per_second"/>
      <variable initial_value="-1" name="z_Cl" units="dimensionless"/>
      <variable name="i_to_2_max" units="microA_per_microF"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="Ca_r" private_interface="out" public_interface="in" units="millimolar"/>
      <variable name="Cl_i" public_interface="in" units="millimolar"/>
      <variable name="Cl_o" public_interface="in" units="millimolar"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="a" private_interface="in" units="dimensionless"/>
      <variable name="Cm" public_interface="in" units="microF_per_cm2"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_to_2</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">20</cn>
               <ci>i_to_2_max</ci>
               <ci>a</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_to_2_max</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                              <ci>p_Cl</ci>
                           </apply>
                           <ci>Cm</ci>
                        </apply>
                        <apply>
                           <power/>
                           <ci>z_Cl</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>V</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <ci>Cl_i</ci>
                     <apply>
                        <times/>
                        <ci>Cl_o</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <apply>
                                    <minus/>
                                    <ci>z_Cl</ci>
                                 </apply>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <ci>z_Cl</ci>
                           </apply>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_to_2_a_gate">
      <variable initial_value="0.0014909437525000811" name="a" public_interface="out" units="dimensionless"/>
      <variable name="a_infinity" units="dimensionless"/>
      <variable name="tau_a" units="millisecond"/>
      <variable initial_value="0.1502" name="km_to_2" units="millimolar"/>
      <variable name="Ca_r" public_interface="in" units="millimolar"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>a</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>a_infinity</ci>
                  <ci>a</ci>
               </apply>
               <ci>tau_a</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>km_to_2</ci>
                     <ci>Ca_r</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_a</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
         </apply>
      </math>
   </component>
   <component name="i_NaCa">
      <variable name="i_NaCa" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="0.4" name="X_NaCa" units="dimensionless"/>
      <variable initial_value="4.5" name="i_NaCa_max" units="microA_per_microF"/>
      <variable initial_value="12.3" name="km_Na_i_1" units="millimolar"/>
      <variable initial_value="87.5" name="km_Na_o" units="millimolar"/>
      <variable initial_value="0.0036" name="km_Ca_i" units="millimolar"/>
      <variable initial_value="1.3" name="km_Ca_o" units="millimolar"/>
      <variable initial_value="0.000125" name="km_Ca_act" units="millimolar"/>
      <variable initial_value="0.27" name="k_sat" units="dimensionless"/>
      <variable name="dNaCa_1" units="millimolar4"/>
      <variable name="dNaCa_2" units="millimolar4"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="Na_i" public_interface="in" units="millimolar"/>
      <variable name="Na_o" public_interface="in" units="millimolar"/>
      <variable name="Ca_i" public_interface="in" units="millimolar"/>
      <variable name="Ca_o" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_NaCa</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>X_NaCa</ci>
                     <ci>i_NaCa_max</ci>
                     <apply>
                        <power/>
                        <ci>Na_i</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     </apply>
                     <ci>Ca_o</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.35</cn>
                              <ci>F</ci>
                              <ci>V</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="microA_per_microF">1.5</cn>
                     <apply>
                        <power/>
                        <ci>Na_o</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     </apply>
                     <ci>Ca_i</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.65</cn>
                              </apply>
                              <ci>F</ci>
                              <ci>V</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>km_Ca_act</ci>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
                              <ci>Ca_i</ci>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <times/>
                        <ci>k_sat</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.65</cn>
                                 </apply>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <plus/>
                     <ci>dNaCa_1</ci>
                     <ci>dNaCa_2</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dNaCa_1</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>km_Ca_o</ci>
                  <apply>
                     <power/>
                     <ci>Na_i</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
                  <apply>
                     <power/>
                     <ci>km_Na_o</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                  </apply>
                  <ci>Ca_i</ci>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <power/>
                     <ci>km_Na_i_1</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                  </apply>
                  <ci>Ca_o</ci>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
                           <ci>Ca_i</ci>
                        </apply>
                        <ci>km_Ca_i</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dNaCa_2</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>km_Ca_i</ci>
                  <apply>
                     <power/>
                     <ci>Na_o</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                  </apply>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <divide/>
                        <ci>Na_i</ci>
                        <ci>km_Na_i_1</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <power/>
                     <ci>Na_i</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                  </apply>
                  <ci>Ca_o</ci>
               </apply>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
                  <apply>
                     <power/>
                     <ci>Na_o</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                  </apply>
                  <ci>Ca_i</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_NaK">
      <variable name="i_NaK" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="0.61875" name="g_NaK" units="microA_per_microF"/>
      <variable initial_value="10" name="km_Na_i_2" units="millimolar"/>
      <variable initial_value="1.5" name="km_K_o" units="millimolar"/>
      <variable name="f_NaK" units="dimensionless"/>
      <variable name="sigma" units="dimensionless"/>
      <variable name="K_o" public_interface="in" units="millimolar"/>
      <variable name="Na_i" public_interface="in" units="millimolar"/>
      <variable name="Na_o" public_interface="in" units="millimolar"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_NaK</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>g_NaK</ci>
                        <ci>f_NaK</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <ci>km_Na_i_2</ci>
                              <ci>Na_i</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                  </apply>
                  <ci>K_o</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>K_o</ci>
                  <ci>km_K_o</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>f_NaK</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1245</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
                              </apply>
                              <ci>F</ci>
                              <ci>V</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0365</cn>
                     <ci>sigma</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <ci>F</ci>
                              </apply>
                              <ci>V</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>sigma</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">7</cn>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <ci>Na_o</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">67.3</cn>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Ca_p">
      <variable name="i_Ca_p" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="0.0575" name="i_Ca_p_max" units="microA_per_microF"/>
      <variable initial_value="0.0005" name="km_Ca_p" units="millimolar"/>
      <variable name="Ca_i" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Ca_p</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>i_Ca_p_max</ci>
                  <ci>Ca_i</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>km_Ca_p</ci>
                  <ci>Ca_i</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="CT_K_Cl">
      <variable name="CT_K_Cl" public_interface="out" units="millimolar_per_millisecond"/>
      <variable initial_value="7.0756e-6" name="CT_K_Cl_max" units="millimolar_per_millisecond"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="E_Cl" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>CT_K_Cl</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>CT_K_Cl_max</ci>
                  <apply>
                     <minus/>
                     <ci>E_K</ci>
                     <ci>E_Cl</ci>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <ci>E_K</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">87.8251</cn>
                  </apply>
                  <ci>E_Cl</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="CT_Na_Cl">
      <variable name="CT_Na_Cl" public_interface="out" units="millimolar_per_millisecond"/>
      <variable initial_value="9.8443e-6" name="CT_Na_Cl_max" units="millimolar_per_millisecond"/>
      <variable name="E_Na" public_interface="in" units="millivolt"/>
      <variable name="E_Cl" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>CT_Na_Cl</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>CT_Na_Cl_max</ci>
                  <apply>
                     <power/>
                     <apply>
                        <minus/>
                        <ci>E_Na</ci>
                        <ci>E_Cl</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <power/>
                     <apply>
                        <minus/>
                        <ci>E_Na</ci>
                        <ci>E_Cl</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                  </apply>
                  <apply>
                     <power/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">87.8251</cn>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="background_currents">
      <variable name="i_Na_b" public_interface="out" units="microA_per_microF"/>
      <variable name="i_Ca_b" public_interface="out" units="microA_per_microF"/>
      <variable name="i_K_b" public_interface="out" units="microA_per_microF"/>
      <variable name="i_Cl_b" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="0.0025" name="g_Na_b" units="milliS_per_microF"/>
      <variable initial_value="0.005" name="g_K_b" units="milliS_per_microF"/>
      <variable initial_value="1.995084e-7" name="p_Ca_b" units="cm_per_second"/>
      <variable initial_value="0.000225" name="g_Cl_b" units="milliS_per_microF"/>
      <variable name="z_Ca" public_interface="in" units="dimensionless"/>
      <variable name="gamma_Cai" public_interface="in" units="dimensionless"/>
      <variable name="gamma_Cao" public_interface="in" units="dimensionless"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="E_Cl" public_interface="in" units="millivolt"/>
      <variable name="E_Na" public_interface="in" units="millivolt"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="Ca_i" public_interface="in" units="millimolar"/>
      <variable name="Ca_o" public_interface="in" units="millimolar"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="Cm" public_interface="in" units="microF_per_cm2"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Na_b</ci>
            <apply>
               <times/>
               <ci>g_Na_b</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Na</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_K_b</ci>
            <apply>
               <times/>
               <ci>g_K_b</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Cl_b</ci>
            <apply>
               <times/>
               <ci>g_Cl_b</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Cl</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ca_b</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                              <ci>p_Ca_b</ci>
                           </apply>
                           <ci>Cm</ci>
                        </apply>
                        <apply>
                           <power/>
                           <ci>z_Ca</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>V</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Cai</ci>
                        <ci>Ca_i</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <ci>z_Ca</ci>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Cao</ci>
                        <ci>Ca_o</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>z_Ca</ci>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="intracellular_ion_concentrations">
      <variable initial_value="9.927155552932733" name="Na_i" public_interface="out" units="millimolar"/>
      <variable initial_value="18.904682470140408" name="Cl_i" public_interface="out" units="millimolar"/>
      <variable initial_value="141.9670801746057" name="K_i" public_interface="out" units="millimolar"/>
      <variable name="Vol_myo" public_interface="in" units="microlitre"/>
      <variable name="a_cap" public_interface="in" units="cm2"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="i_NaK" public_interface="in" units="microA_per_microF"/>
      <variable name="i_NaCa" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Na_b" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Na" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Na_L" public_interface="in" units="microA_per_microF"/>
      <variable name="i_K1" public_interface="in" units="microA_per_microF"/>
      <variable name="i_to_1" public_interface="in" units="microA_per_microF"/>
      <variable name="i_to_2" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Kr" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Ks" public_interface="in" units="microA_per_microF"/>
      <variable name="i_K_p" public_interface="in" units="microA_per_microF"/>
      <variable name="i_K_b" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Cl_b" public_interface="in" units="microA_per_microF"/>
      <variable name="CT_Na_Cl" public_interface="in" units="millimolar_per_millisecond"/>
      <variable name="CT_K_Cl" public_interface="in" units="millimolar_per_millisecond"/>
      <variable name="Cm" public_interface="in" units="microF_per_cm2"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Na_i</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <ci>Cm</ci>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>i_Na</ci>
                        <ci>i_Na_L</ci>
                        <ci>i_Na_b</ci>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                           <ci>i_NaK</ci>
                        </apply>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                           <ci>i_NaCa</ci>
                        </apply>
                     </apply>
                     <ci>a_cap</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>Vol_myo</ci>
                     <ci>F</ci>
                  </apply>
               </apply>
               <ci>CT_Na_Cl</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>K_i</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <ci>Cm</ci>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <plus/>
                           <ci>i_to_1</ci>
                           <ci>i_K1</ci>
                           <ci>i_Kr</ci>
                           <ci>i_Ks</ci>
                           <ci>i_K_p</ci>
                           <ci>i_K_b</ci>
                        </apply>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <ci>i_NaK</ci>
                        </apply>
                     </apply>
                     <ci>a_cap</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>Vol_myo</ci>
                     <ci>F</ci>
                  </apply>
               </apply>
               <ci>CT_K_Cl</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Cl_i</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <ci>Cm</ci>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>i_to_2</ci>
                        <ci>i_Cl_b</ci>
                     </apply>
                     <ci>a_cap</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>Vol_myo</ci>
                     <ci>F</ci>
                  </apply>
               </apply>
               <ci>CT_Na_Cl</ci>
               <ci>CT_K_Cl</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Ca_i">
      <variable initial_value="0.00022355433459434943" name="Ca_i" public_interface="out" units="millimolar"/>
      <variable initial_value="0.0005" name="km_TRPN" units="millimolar"/>
      <variable initial_value="0.00238" name="km_CMDN" units="millimolar"/>
      <variable initial_value="0.07" name="TRPN_max" units="millimolar"/>
      <variable initial_value="0.05" name="CMDN_max" units="millimolar"/>
      <variable name="TRPN" units="dimensionless"/>
      <variable name="CMDN" units="dimensionless"/>
      <variable name="b_myo" units="dimensionless"/>
      <variable name="Vol_myo" public_interface="in" units="microlitre"/>
      <variable name="Vol_nsr" public_interface="in" units="microlitre"/>
      <variable name="Vol_ss" public_interface="in" units="microlitre"/>
      <variable name="a_cap" public_interface="in" units="cm2"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="i_NaCa" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Ca_b" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Ca_p" public_interface="in" units="microA_per_microF"/>
      <variable name="q_up" public_interface="in" units="millimolar_per_millisecond"/>
      <variable name="q_leak" public_interface="in" units="millimolar_per_millisecond"/>
      <variable name="q_diff" public_interface="in" units="millimolar_per_millisecond"/>
      <variable name="Cm" public_interface="in" units="microF_per_cm2"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_i</ci>
            </apply>
            <apply>
               <times/>
               <apply>
                  <minus/>
                  <ci>b_myo</ci>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>Cm</ci>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>i_Ca_b</ci>
                                 <ci>i_Ca_p</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                 <ci>i_NaCa</ci>
                              </apply>
                           </apply>
                           <ci>a_cap</ci>
                        </apply>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <ci>Vol_myo</ci>
                           <ci>F</ci>
                        </apply>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <ci>q_up</ci>
                              <ci>q_leak</ci>
                           </apply>
                           <ci>Vol_nsr</ci>
                        </apply>
                        <ci>Vol_myo</ci>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>q_diff</ci>
                        <ci>Vol_ss</ci>
                     </apply>
                     <ci>Vol_myo</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>CMDN</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  <ci>CMDN_max</ci>
                  <ci>Ca_i</ci>
               </apply>
               <apply>
                  <power/>
                  <apply>
                     <plus/>
                     <ci>Ca_i</ci>
                     <ci>km_CMDN</ci>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>TRPN</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  <ci>TRPN_max</ci>
                  <ci>Ca_i</ci>
               </apply>
               <apply>
                  <power/>
                  <apply>
                     <plus/>
                     <ci>Ca_i</ci>
                     <ci>km_TRPN</ci>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>b_myo</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <ci>TRPN</ci>
                  <ci>CMDN</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Ca_MK_act">
      <variable name="Ca_MK_act" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.15" name="km_Ca_MK" public_interface="out" units="millimolar"/>
      <variable initial_value="0.000008789168284782809" name="Ca_MK_trap" units="dimensionless"/>
      <variable name="Ca_MK_bound" units="dimensionless"/>
      <variable initial_value="0.05" name="alpha_Ca_MK" units="per_millisecond"/>
      <variable initial_value="0.00068" name="beta_Ca_MK" units="per_millisecond"/>
      <variable initial_value="0.05" name="Ca_MK_0" units="dimensionless"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="Ca_r" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Ca_MK_act</ci>
            <apply>
               <plus/>
               <ci>Ca_MK_bound</ci>
               <ci>Ca_MK_trap</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_MK_trap</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_Ca_MK</ci>
                  <ci>Ca_MK_bound</ci>
                  <apply>
                     <plus/>
                     <ci>Ca_MK_bound</ci>
                     <ci>Ca_MK_trap</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_Ca_MK</ci>
                  <ci>Ca_MK_trap</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Ca_MK_bound</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Ca_MK_0</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>Ca_MK_trap</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>km_Ca_MK</ci>
                     <ci>Ca_r</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Ca_NSR">
      <variable initial_value="1.2132524695849454" name="Ca_NSR" public_interface="out" units="millimolar"/>
      <variable name="Vol_jsr" public_interface="in" units="microlitre"/>
      <variable name="Vol_nsr" public_interface="in" units="microlitre"/>
      <variable name="q_up" public_interface="in" units="millimolar_per_millisecond"/>
      <variable name="q_leak" public_interface="in" units="millimolar_per_millisecond"/>
      <variable name="q_tr" public_interface="in" units="millimolar_per_millisecond"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_NSR</ci>
            </apply>
            <apply>
               <minus/>
               <ci>q_up</ci>
               <apply>
                  <plus/>
                  <ci>q_leak</ci>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>q_tr</ci>
                        <ci>Vol_jsr</ci>
                     </apply>
                     <ci>Vol_nsr</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Ca_JSR">
      <variable initial_value="1.1433050636518596" name="Ca_JSR" public_interface="out" units="millimolar"/>
      <variable initial_value="10" name="CSQN_max" units="millimolar"/>
      <variable initial_value="0.8" name="km_CSQN" units="millimolar"/>
      <variable name="Vol_jsr" public_interface="in" units="microlitre"/>
      <variable name="Vol_nsr" public_interface="in" units="microlitre"/>
      <variable name="q_tr" public_interface="in" units="millimolar_per_millisecond"/>
      <variable name="q_rel" public_interface="in" units="millimolar_per_millisecond"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_JSR</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>q_tr</ci>
                  <ci>q_rel</ci>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>CSQN_max</ci>
                        <ci>km_CSQN</ci>
                     </apply>
                     <apply>
                        <power/>
                        <apply>
                           <plus/>
                           <ci>km_CSQN</ci>
                           <ci>Ca_JSR</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Ca_r">
      <variable initial_value="0.00022418117117903934" name="Ca_r" public_interface="out" units="millimolar"/>
      <variable name="q_diff" public_interface="out" units="millimolar_per_millisecond"/>
      <variable initial_value="0.00087" name="km_b_SR" units="millimolar"/>
      <variable initial_value="0.0087" name="km_b_SL" units="millimolar"/>
      <variable initial_value="0.047" name="b_SR_max" units="millimolar"/>
      <variable initial_value="1.124" name="b_SL_max" units="millimolar"/>
      <variable initial_value="0.2" name="tau_ss" units="millisecond"/>
      <variable name="b_SR" units="dimensionless"/>
      <variable name="b_SL" units="dimensionless"/>
      <variable name="Ca_r_tot" units="dimensionless"/>
      <variable name="Vol_jsr" public_interface="in" units="microlitre"/>
      <variable name="Vol_ss" public_interface="in" units="microlitre"/>
      <variable name="a_cap" public_interface="in" units="cm2"/>
      <variable name="z_Ca" public_interface="in" units="dimensionless"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="i_Ca_L" public_interface="in" units="microA_per_microF"/>
      <variable name="q_rel" public_interface="in" units="millimolar_per_millisecond"/>
      <variable name="Ca_i" public_interface="in" units="millimolar"/>
      <variable name="Cm" public_interface="in" units="microF_per_cm2"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_r</ci>
            </apply>
            <apply>
               <times/>
               <ci>Ca_r_tot</ci>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <ci>Cm</ci>
                           </apply>
                           <ci>i_Ca_L</ci>
                           <ci>a_cap</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>Vol_ss</ci>
                           <ci>z_Ca</ci>
                           <ci>F</ci>
                        </apply>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>q_rel</ci>
                           <ci>Vol_jsr</ci>
                        </apply>
                        <ci>Vol_ss</ci>
                     </apply>
                  </apply>
                  <ci>q_diff</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>q_diff</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>Ca_r</ci>
                  <ci>Ca_i</ci>
               </apply>
               <ci>tau_ss</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>b_SL</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  <ci>b_SL_max</ci>
                  <ci>Ca_r</ci>
               </apply>
               <apply>
                  <power/>
                  <apply>
                     <plus/>
                     <ci>Ca_r</ci>
                     <ci>km_b_SL</ci>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>b_SR</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  <ci>b_SR_max</ci>
                  <ci>Ca_r</ci>
               </apply>
               <apply>
                  <power/>
                  <apply>
                     <plus/>
                     <ci>Ca_r</ci>
                     <ci>km_b_SR</ci>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Ca_r_tot</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <ci>b_SR</ci>
                  <ci>b_SL</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="q_rel">
      <variable name="q_rel" public_interface="out" units="millimolar_per_millisecond"/>
      <variable name="g_rel" units="per_millisecond"/>
      <variable name="vg" units="dimensionless"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="Ca_MK_act" private_interface="out" public_interface="in" units="dimensionless"/>
      <variable name="km_Ca_MK" private_interface="out" public_interface="in" units="millimolar"/>
      <variable name="Ca_r" private_interface="out" public_interface="in" units="millimolar"/>
      <variable name="Ca_JSR" private_interface="out" public_interface="in" units="millimolar"/>
      <variable name="i_Ca_L" private_interface="out" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Ca_L_max" public_interface="in" units="microA_per_microF"/>
      <variable name="g_Ca_L" public_interface="in" units="dimensionless"/>
      <variable name="ri" private_interface="in" units="dimensionless"/>
      <variable name="ro" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>q_rel</ci>
            <apply>
               <times/>
               <ci>g_rel</ci>
               <ci>ro</ci>
               <ci>ri</ci>
               <apply>
                  <minus/>
                  <ci>Ca_JSR</ci>
                  <ci>Ca_r</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>g_rel</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">3000</cn>
               <ci>vg</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>vg</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <apply>
                              <times/>
                              <ci>g_Ca_L</ci>
                              <ci>i_Ca_L_max</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="microA_per_microF">13</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="microA_per_microF">5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="q_rel_ri_gate">
      <variable initial_value="0.7802870066567904" name="ri" public_interface="out" units="dimensionless"/>
      <variable name="tau_ri" units="millisecond"/>
      <variable name="tau_Ca_MK" units="millisecond"/>
      <variable initial_value="10" name="tau_Ca_MK_max" units="millisecond"/>
      <variable name="Ca_fac" units="millimolar"/>
      <variable name="ri_infinity" units="dimensionless"/>
      <variable name="Ca_r" public_interface="in" units="millimolar"/>
      <variable name="Ca_MK_act" public_interface="in" units="dimensionless"/>
      <variable name="km_Ca_MK" public_interface="in" units="millimolar"/>
      <variable name="i_Ca_L" public_interface="in" units="microA_per_microF"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>ri</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>ri_infinity</ci>
                  <ci>ri</ci>
               </apply>
               <ci>tau_ri</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_ri</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">350</cn>
                     <ci>tau_Ca_MK</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <apply>
                                 <minus/>
                                 <ci>Ca_r</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.003</cn>
                              </apply>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.003</cn>
                                 <ci>Ca_fac</ci>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.0002</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">3</cn>
               <ci>tau_Ca_MK</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ri_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <ci>Ca_r</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.0004</cn>
                           </apply>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.002</cn>
                              <ci>Ca_fac</ci>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.000025</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Ca_fac</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>i_Ca_L</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="microA_per_microF">0.05</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="microA_per_microF">0.015</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_Ca_MK</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>tau_Ca_MK_max</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">1</cn>
                  <ci>Ca_MK_act</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>km_Ca_MK</ci>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">1</cn>
                     <ci>Ca_MK_act</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="q_rel_ro_gate">
      <variable initial_value="1.2785734760674763e-9" name="ro" public_interface="out" units="dimensionless"/>
      <variable initial_value="3" name="tau_ro" units="millisecond"/>
      <variable name="ro_infinity" units="dimensionless"/>
      <variable name="ro_infinity_JSR" units="dimensionless"/>
      <variable name="Ca_r" public_interface="in" units="millimolar"/>
      <variable name="Ca_JSR" public_interface="in" units="millimolar"/>
      <variable name="i_Ca_L" public_interface="in" units="microA_per_microF"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>ro</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>ro_infinity</ci>
                  <ci>ro</ci>
               </apply>
               <ci>tau_ro</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ro_infinity</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>ro_infinity_JSR</ci>
                  <apply>
                     <power/>
                     <ci>i_Ca_L</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <power/>
                     <ci>i_Ca_L</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="microA_per_microF_2">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ro_infinity_JSR</ci>
            <apply>
               <divide/>
               <apply>
                  <power/>
                  <ci>Ca_JSR</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.9</cn>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <power/>
                     <ci>Ca_JSR</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.9</cn>
                  </apply>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">49.28</cn>
                           <ci>Ca_r</ci>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>Ca_r</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.0028</cn>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.9</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="q_leak">
      <variable name="q_leak" public_interface="out" units="millimolar_per_millisecond"/>
      <variable initial_value="0.004375" name="q_leak_max" units="millimolar_per_millisecond"/>
      <variable initial_value="15" name="NSR_max" units="millimolar"/>
      <variable name="Ca_NSR" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>q_leak</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>q_leak_max</ci>
                  <ci>Ca_NSR</ci>
               </apply>
               <ci>NSR_max</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="q_up">
      <variable name="q_up" public_interface="out" units="millimolar_per_millisecond"/>
      <variable initial_value="0.5" name="X_q_up" units="dimensionless"/>
      <variable initial_value="0.004375" name="q_up_max" units="millimolar_per_millisecond"/>
      <variable name="dq_up_Ca_MK" units="dimensionless"/>
      <variable initial_value="0.75" name="dq_up_Ca_MK_max" units="dimensionless"/>
      <variable name="dkm_plb" units="millimolar"/>
      <variable initial_value="0.00017" name="dkm_plb_max" units="millimolar"/>
      <variable initial_value="0.00092" name="km_up" units="millimolar"/>
      <variable name="Ca_MK_act" public_interface="in" units="dimensionless"/>
      <variable name="km_Ca_MK" public_interface="in" units="millimolar"/>
      <variable name="Ca_i" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>q_up</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>X_q_up</ci>
                  <apply>
                     <plus/>
                     <ci>dq_up_Ca_MK</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
                  <ci>q_up_max</ci>
                  <ci>Ca_i</ci>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <ci>Ca_i</ci>
                     <ci>km_up</ci>
                  </apply>
                  <ci>dkm_plb</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dq_up_Ca_MK</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>dq_up_Ca_MK_max</ci>
                  <ci>Ca_MK_act</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">1</cn>
               </apply>
               <apply>
                  <plus/>
                  <ci>km_Ca_MK</ci>
                  <apply>
                     <times/>
                     <ci>Ca_MK_act</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">1</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dkm_plb</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>dkm_plb_max</ci>
                  <ci>Ca_MK_act</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">1</cn>
               </apply>
               <apply>
                  <plus/>
                  <ci>km_Ca_MK</ci>
                  <apply>
                     <times/>
                     <ci>Ca_MK_act</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">1</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="q_tr">
      <variable name="q_tr" public_interface="out" units="millimolar_per_millisecond"/>
      <variable initial_value="120" name="tau_tr" units="millisecond"/>
      <variable name="Ca_NSR" public_interface="in" units="millimolar"/>
      <variable name="Ca_JSR" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>q_tr</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>Ca_NSR</ci>
                  <ci>Ca_JSR</ci>
               </apply>
               <ci>tau_tr</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="model_parameters">
      <variable initial_value="140" name="Na_o" public_interface="out" units="millimolar"/>
      <variable initial_value="1.8" name="Ca_o" public_interface="out" units="millimolar"/>
      <variable initial_value="5.4" name="K_o" public_interface="out" units="millimolar"/>
      <variable initial_value="100" name="Cl_o" public_interface="out" units="millimolar"/>
      <variable initial_value="8314" name="R" public_interface="out" units="joule_per_kilomole_kelvin"/>
      <variable initial_value="310" name="T" public_interface="out" units="kelvin"/>
      <variable initial_value="96485" name="F" public_interface="out" units="coulomb_per_mole"/>
      <variable initial_value="2" name="z_Ca" public_interface="out" units="dimensionless"/>
      <variable initial_value="1" name="gamma_Cai" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.341" name="gamma_Cao" public_interface="out" units="dimensionless"/>
      <variable name="Vol_myo" public_interface="out" units="microlitre"/>
      <variable name="Vol_jsr" public_interface="out" units="microlitre"/>
      <variable name="Vol_nsr" public_interface="out" units="microlitre"/>
      <variable name="Vol_ss" public_interface="out" units="microlitre"/>
      <variable name="a_cap" public_interface="out" units="cm2"/>
      <variable initial_value="0.3454" name="Vol_cell" public_interface="out" units="microlitre"/>
      <variable name="a_geo" units="cm2"/>
      <variable initial_value="0.0011" name="radius" units="cm"/>
      <variable initial_value="0.01" name="length" units="cm"/>
      <variable initial_value="2" name="rcg" units="dimensionless"/>
      <variable initial_value="1" name="Cm" public_interface="out" units="microF_per_cm2"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>a_geo</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.14</cn>
                  <apply>
                     <power/>
                     <ci>radius</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.14</cn>
                  <ci>radius</ci>
                  <ci>length</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a_cap</ci>
            <apply>
               <times/>
               <ci>rcg</ci>
               <ci>a_geo</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Vol_myo</ci>
            <apply>
               <times/>
               <ci>Vol_cell</ci>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.68</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Vol_nsr</ci>
            <apply>
               <times/>
               <ci>Vol_cell</ci>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0552</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Vol_jsr</ci>
            <apply>
               <times/>
               <ci>Vol_cell</ci>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0048</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Vol_ss</ci>
            <apply>
               <times/>
               <ci>Vol_cell</ci>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.02</cn>
            </apply>
         </apply>
      </math>
   </component>
   <group>
      <relationship_ref relationship="encapsulation"/>
      <component_ref component="i_Na">
         <component_ref component="i_Na_m_gate"/>
         <component_ref component="i_Na_h_gate"/>
         <component_ref component="i_Na_j_gate"/>
      </component_ref>
      <component_ref component="i_Na_L">
         <component_ref component="i_Na_L_m_L_gate"/>
         <component_ref component="i_Na_L_h_L_gate"/>
      </component_ref>
      <component_ref component="i_Ca_L">
         <component_ref component="i_Ca_L_d_gate"/>
         <component_ref component="i_Ca_L_f_gate"/>
         <component_ref component="i_Ca_L_f2_gate"/>
         <component_ref component="i_Ca_L_f_Ca_gate"/>
         <component_ref component="i_Ca_L_f_Ca2_gate"/>
      </component_ref>
      <component_ref component="i_Ca_T">
         <component_ref component="i_Ca_T_b_gate"/>
         <component_ref component="i_Ca_T_g_gate"/>
      </component_ref>
      <component_ref component="i_to_1">
         <component_ref component="i_to_1_a_gate"/>
         <component_ref component="i_to_1_i_gate"/>
         <component_ref component="i_to_1_i2_gate"/>
      </component_ref>
      <component_ref component="i_Kr">
         <component_ref component="i_Kr_xr_gate"/>
      </component_ref>
      <component_ref component="i_Ks">
         <component_ref component="i_Ks_xs1_gate"/>
         <component_ref component="i_Ks_xs2_gate"/>
      </component_ref>
      <component_ref component="i_K1">
         <component_ref component="i_K1_xK1_gate"/>
      </component_ref>
      <component_ref component="i_to_2">
         <component_ref component="i_to_2_a_gate"/>
      </component_ref>
      <component_ref component="q_rel">
         <component_ref component="q_rel_ri_gate"/>
         <component_ref component="q_rel_ro_gate"/>
      </component_ref>
   </group>
   <connection>
      <map_components component_1="membrane" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_Na" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_Na_L" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_Ca_L" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_Ca_T" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_to_1" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_Kr" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_Ks" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_K1" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_K_p" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_to_2" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="intracellular_ion_concentrations" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="Ca_i" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="Ca_MK_act" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="Ca_NSR" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="Ca_JSR" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="Ca_r" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="q_rel" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="i_Na"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Na" variable_2="i_Na"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="i_Na_L"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Na_L" variable_2="i_Na_L"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="i_Ca_L"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="i_Ca_T"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Ca_T" variable_2="i_Ca_T"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="i_to_1"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_to_1" variable_2="i_to_1"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="i_Kr"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Kr" variable_2="i_Kr"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="i_Ks"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Ks" variable_2="i_Ks"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="i_K1"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_K1" variable_2="i_K1"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="i_K_p"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_K_p" variable_2="i_K_p"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="i_to_2"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_to_2" variable_2="i_to_2"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="i_NaCa"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="i_NaK"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_NaK" variable_2="i_NaK"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="i_Ca_p"/>
      <map_variables variable_1="i_Ca_p" variable_2="i_Ca_p"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="background_currents"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Ca_b" variable_2="i_Ca_b"/>
      <map_variables variable_1="i_Na_b" variable_2="i_Na_b"/>
      <map_variables variable_1="i_Cl_b" variable_2="i_Cl_b"/>
      <map_variables variable_1="i_K_b" variable_2="i_K_b"/>
   </connection>
   <connection>
      <map_components component_1="intracellular_ion_concentrations" component_2="equilibrium_potentials"/>
      <map_variables variable_1="Na_i" variable_2="Na_i"/>
      <map_variables variable_1="K_i" variable_2="K_i"/>
      <map_variables variable_1="Cl_i" variable_2="Cl_i"/>
   </connection>
   <connection>
      <map_components component_1="Ca_i" component_2="equilibrium_potentials"/>
      <map_variables variable_1="Ca_i" variable_2="Ca_i"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="equilibrium_potentials"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Na_o" variable_2="Na_o"/>
      <map_variables variable_1="Ca_o" variable_2="Ca_o"/>
      <map_variables variable_1="K_o" variable_2="K_o"/>
      <map_variables variable_1="Cl_o" variable_2="Cl_o"/>
   </connection>
   <connection>
      <map_components component_1="i_Na" component_2="equilibrium_potentials"/>
      <map_variables variable_1="E_Na" variable_2="E_Na"/>
   </connection>
   <connection>
      <map_components component_1="i_Na_L" component_2="equilibrium_potentials"/>
      <map_variables variable_1="E_Na" variable_2="E_Na"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="i_Ca_L"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="z_Ca" variable_2="z_Ca"/>
      <map_variables variable_1="Ca_o" variable_2="Ca_o"/>
      <map_variables variable_1="gamma_Cai" variable_2="gamma_Cai"/>
      <map_variables variable_1="gamma_Cao" variable_2="gamma_Cao"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
   </connection>
   <connection>
      <map_components component_1="Ca_r" component_2="i_Ca_L"/>
      <map_variables variable_1="Ca_r" variable_2="Ca_r"/>
      <map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
   </connection>
   <connection>
      <map_components component_1="Ca_MK_act" component_2="i_Ca_L"/>
      <map_variables variable_1="Ca_MK_act" variable_2="Ca_MK_act"/>
      <map_variables variable_1="km_Ca_MK" variable_2="km_Ca_MK"/>
   </connection>
   <connection>
      <map_components component_1="i_to_1" component_2="equilibrium_potentials"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="i_Kr" component_2="equilibrium_potentials"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="i_Kr"/>
      <map_variables variable_1="K_o" variable_2="K_o"/>
   </connection>
   <connection>
      <map_components component_1="i_Ks" component_2="equilibrium_potentials"/>
      <map_variables variable_1="E_Ks" variable_2="E_Ks"/>
   </connection>
   <connection>
      <map_components component_1="Ca_i" component_2="i_Ks"/>
      <map_variables variable_1="Ca_i" variable_2="Ca_i"/>
   </connection>
   <connection>
      <map_components component_1="i_K1" component_2="equilibrium_potentials"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="i_K1"/>
      <map_variables variable_1="K_o" variable_2="K_o"/>
   </connection>
   <connection>
      <map_components component_1="i_K_p" component_2="equilibrium_potentials"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="Ca_r" component_2="i_to_2"/>
      <map_variables variable_1="Ca_r" variable_2="Ca_r"/>
   </connection>
   <connection>
      <map_components component_1="intracellular_ion_concentrations" component_2="i_to_2"/>
      <map_variables variable_1="Cl_i" variable_2="Cl_i"/>
      <map_variables variable_1="i_to_2" variable_2="i_to_2"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="i_to_2"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Cl_o" variable_2="Cl_o"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="i_NaCa"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Na_o" variable_2="Na_o"/>
      <map_variables variable_1="Ca_o" variable_2="Ca_o"/>
   </connection>
   <connection>
      <map_components component_1="intracellular_ion_concentrations" component_2="i_NaCa"/>
      <map_variables variable_1="Na_i" variable_2="Na_i"/>
      <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
   </connection>
   <connection>
      <map_components component_1="Ca_i" component_2="i_NaCa"/>
      <map_variables variable_1="Ca_i" variable_2="Ca_i"/>
      <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="i_NaK"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Na_o" variable_2="Na_o"/>
      <map_variables variable_1="K_o" variable_2="K_o"/>
   </connection>
   <connection>
      <map_components component_1="intracellular_ion_concentrations" component_2="i_NaK"/>
      <map_variables variable_1="Na_i" variable_2="Na_i"/>
      <map_variables variable_1="i_NaK" variable_2="i_NaK"/>
   </connection>
   <connection>
      <map_components component_1="Ca_i" component_2="i_Ca_p"/>
      <map_variables variable_1="Ca_i" variable_2="Ca_i"/>
      <map_variables variable_1="i_Ca_p" variable_2="i_Ca_p"/>
   </connection>
   <connection>
      <map_components component_1="CT_K_Cl" component_2="equilibrium_potentials"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
      <map_variables variable_1="E_Cl" variable_2="E_Cl"/>
   </connection>
   <connection>
      <map_components component_1="CT_Na_Cl" component_2="equilibrium_potentials"/>
      <map_variables variable_1="E_Na" variable_2="E_Na"/>
      <map_variables variable_1="E_Cl" variable_2="E_Cl"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="background_currents"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="z_Ca" variable_2="z_Ca"/>
      <map_variables variable_1="Ca_o" variable_2="Ca_o"/>
      <map_variables variable_1="gamma_Cai" variable_2="gamma_Cai"/>
      <map_variables variable_1="gamma_Cao" variable_2="gamma_Cao"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
   </connection>
   <connection>
      <map_components component_1="background_currents" component_2="equilibrium_potentials"/>
      <map_variables variable_1="E_Na" variable_2="E_Na"/>
      <map_variables variable_1="E_Cl" variable_2="E_Cl"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="Ca_i" component_2="background_currents"/>
      <map_variables variable_1="Ca_i" variable_2="Ca_i"/>
      <map_variables variable_1="i_Ca_b" variable_2="i_Ca_b"/>
   </connection>
   <connection>
      <map_components component_1="i_Na" component_2="intracellular_ion_concentrations"/>
      <map_variables variable_1="i_Na" variable_2="i_Na"/>
   </connection>
   <connection>
      <map_components component_1="i_Na_L" component_2="intracellular_ion_concentrations"/>
      <map_variables variable_1="i_Na_L" variable_2="i_Na_L"/>
   </connection>
   <connection>
      <map_components component_1="i_K1" component_2="intracellular_ion_concentrations"/>
      <map_variables variable_1="i_K1" variable_2="i_K1"/>
   </connection>
   <connection>
      <map_components component_1="i_to_1" component_2="intracellular_ion_concentrations"/>
      <map_variables variable_1="i_to_1" variable_2="i_to_1"/>
   </connection>
   <connection>
      <map_components component_1="i_Kr" component_2="intracellular_ion_concentrations"/>
      <map_variables variable_1="i_Kr" variable_2="i_Kr"/>
   </connection>
   <connection>
      <map_components component_1="i_Ks" component_2="intracellular_ion_concentrations"/>
      <map_variables variable_1="i_Ks" variable_2="i_Ks"/>
   </connection>
   <connection>
      <map_components component_1="i_K_p" component_2="intracellular_ion_concentrations"/>
      <map_variables variable_1="i_K_p" variable_2="i_K_p"/>
   </connection>
   <connection>
      <map_components component_1="background_currents" component_2="intracellular_ion_concentrations"/>
      <map_variables variable_1="i_Na_b" variable_2="i_Na_b"/>
      <map_variables variable_1="i_K_b" variable_2="i_K_b"/>
      <map_variables variable_1="i_Cl_b" variable_2="i_Cl_b"/>
   </connection>
   <connection>
      <map_components component_1="CT_K_Cl" component_2="intracellular_ion_concentrations"/>
      <map_variables variable_1="CT_K_Cl" variable_2="CT_K_Cl"/>
   </connection>
   <connection>
      <map_components component_1="CT_Na_Cl" component_2="intracellular_ion_concentrations"/>
      <map_variables variable_1="CT_Na_Cl" variable_2="CT_Na_Cl"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="intracellular_ion_concentrations"/>
      <map_variables variable_1="Vol_myo" variable_2="Vol_myo"/>
      <map_variables variable_1="a_cap" variable_2="a_cap"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="Ca_i"/>
      <map_variables variable_1="Vol_myo" variable_2="Vol_myo"/>
      <map_variables variable_1="Vol_nsr" variable_2="Vol_nsr"/>
      <map_variables variable_1="Vol_ss" variable_2="Vol_ss"/>
      <map_variables variable_1="a_cap" variable_2="a_cap"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
   </connection>
   <connection>
      <map_components component_1="q_up" component_2="Ca_i"/>
      <map_variables variable_1="q_up" variable_2="q_up"/>
      <map_variables variable_1="Ca_i" variable_2="Ca_i"/>
   </connection>
   <connection>
      <map_components component_1="q_leak" component_2="Ca_i"/>
      <map_variables variable_1="q_leak" variable_2="q_leak"/>
   </connection>
   <connection>
      <map_components component_1="Ca_r" component_2="Ca_MK_act"/>
      <map_variables variable_1="Ca_r" variable_2="Ca_r"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="Ca_NSR"/>
      <map_variables variable_1="Vol_jsr" variable_2="Vol_jsr"/>
      <map_variables variable_1="Vol_nsr" variable_2="Vol_nsr"/>
   </connection>
   <connection>
      <map_components component_1="q_leak" component_2="Ca_NSR"/>
      <map_variables variable_1="q_leak" variable_2="q_leak"/>
      <map_variables variable_1="Ca_NSR" variable_2="Ca_NSR"/>
   </connection>
   <connection>
      <map_components component_1="q_up" component_2="Ca_NSR"/>
      <map_variables variable_1="q_up" variable_2="q_up"/>
   </connection>
   <connection>
      <map_components component_1="q_tr" component_2="Ca_NSR"/>
      <map_variables variable_1="q_tr" variable_2="q_tr"/>
      <map_variables variable_1="Ca_NSR" variable_2="Ca_NSR"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="Ca_JSR"/>
      <map_variables variable_1="Vol_jsr" variable_2="Vol_jsr"/>
      <map_variables variable_1="Vol_nsr" variable_2="Vol_nsr"/>
   </connection>
   <connection>
      <map_components component_1="q_tr" component_2="Ca_JSR"/>
      <map_variables variable_1="q_tr" variable_2="q_tr"/>
      <map_variables variable_1="Ca_JSR" variable_2="Ca_JSR"/>
   </connection>
   <connection>
      <map_components component_1="q_rel" component_2="Ca_JSR"/>
      <map_variables variable_1="q_rel" variable_2="q_rel"/>
      <map_variables variable_1="Ca_JSR" variable_2="Ca_JSR"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="Ca_r"/>
      <map_variables variable_1="Vol_jsr" variable_2="Vol_jsr"/>
      <map_variables variable_1="Vol_ss" variable_2="Vol_ss"/>
      <map_variables variable_1="a_cap" variable_2="a_cap"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
      <map_variables variable_1="z_Ca" variable_2="z_Ca"/>
   </connection>
   <connection>
      <map_components component_1="Ca_i" component_2="Ca_r"/>
      <map_variables variable_1="Ca_i" variable_2="Ca_i"/>
      <map_variables variable_1="q_diff" variable_2="q_diff"/>
   </connection>
   <connection>
      <map_components component_1="q_rel" component_2="Ca_r"/>
      <map_variables variable_1="q_rel" variable_2="q_rel"/>
      <map_variables variable_1="Ca_r" variable_2="Ca_r"/>
   </connection>
   <connection>
      <map_components component_1="q_rel" component_2="Ca_MK_act"/>
      <map_variables variable_1="Ca_MK_act" variable_2="Ca_MK_act"/>
      <map_variables variable_1="km_Ca_MK" variable_2="km_Ca_MK"/>
   </connection>
   <connection>
      <map_components component_1="i_Ca_L" component_2="q_rel"/>
      <map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
      <map_variables variable_1="g_Ca_L" variable_2="g_Ca_L"/>
      <map_variables variable_1="i_Ca_L_max" variable_2="i_Ca_L_max"/>
   </connection>
   <connection>
      <map_components component_1="q_up" component_2="Ca_MK_act"/>
      <map_variables variable_1="Ca_MK_act" variable_2="Ca_MK_act"/>
      <map_variables variable_1="km_Ca_MK" variable_2="km_Ca_MK"/>
   </connection>
   <connection>
      <map_components component_1="i_Na" component_2="i_Na_m_gate"/>
      <map_variables variable_1="m" variable_2="m"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="i_Na" component_2="i_Na_h_gate"/>
      <map_variables variable_1="h" variable_2="h"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="i_Na" component_2="i_Na_j_gate"/>
      <map_variables variable_1="j" variable_2="j"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="i_Na_L" component_2="i_Na_L_m_L_gate"/>
      <map_variables variable_1="m_L" variable_2="m_L"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="i_Na_L" component_2="i_Na_L_h_L_gate"/>
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      <map_variables variable_1="time" variable_2="time"/>
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   <connection>
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   <connection>
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   <connection>
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      <map_variables variable_1="xr" variable_2="xr"/>
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      <map_variables variable_1="V" variable_2="V"/>
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   <connection>
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      <map_variables variable_1="xs1" variable_2="xs1"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
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   <connection>
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      <map_variables variable_1="xs2" variable_2="xs2"/>
      <map_variables variable_1="time" variable_2="time"/>
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   <connection>
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      <map_variables variable_1="E_K" variable_2="E_K"/>
      <map_variables variable_1="V" variable_2="V"/>
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   <connection>
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      <map_variables variable_1="a" variable_2="a"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="Ca_r" variable_2="Ca_r"/>
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   <connection>
      <map_components component_1="q_rel" component_2="q_rel_ri_gate"/>
      <map_variables variable_1="ri" variable_2="ri"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
      <map_variables variable_1="Ca_r" variable_2="Ca_r"/>
      <map_variables variable_1="Ca_MK_act" variable_2="Ca_MK_act"/>
      <map_variables variable_1="km_Ca_MK" variable_2="km_Ca_MK"/>
   </connection>
   <connection>
      <map_components component_1="q_rel" component_2="q_rel_ro_gate"/>
      <map_variables variable_1="ro" variable_2="ro"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
      <map_variables variable_1="Ca_r" variable_2="Ca_r"/>
      <map_variables variable_1="Ca_JSR" variable_2="Ca_JSR"/>
   </connection>
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          <vCard:Family>Lloyd</vCard:Family>
          <vCard:Given>Catherine</vCard:Given>
		  <vCard:Other>May</vCard:Other>
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        The Aslanidi et al. 2009 model of the caninine Purkinje-ventricular junction
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      <!-- A comment regarding the model. -->
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          This is the CellML description of Aslanidi et al.'s mathematical model of of the caninine Purkinje-ventricular junction
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          <vCard:FN>Catherine Lloyd</vCard:FN>
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	  <cmeta:species>Canine</cmeta:species>
	  
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            Optimal velocity and safety of discontinuous conduction through the heterogeneous Purkinje-ventricular junction
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