https://staging.physiomeproject.org/workspace/b01 en-us Neural regulation of gastric motility occurs partly through the regulation of gastric bioelectrical slow waves and phasic contractions. A mathematical model of gastric motility regulation by enteric neurons was developed to infer the relative importance of cellular mechanisms in inhibitory neural regulation of the stomach by enteric neurons and the interaction of inhibitory and excitatory stimulation. This model was coupled to updated models of the interstitial cells of Cajal and gastric smooth muscle cells, which are responsible for generating slow waves and active tension respectively. The proposed model comprises an electrophysiological model coupling ICC and SMC via gap junctions, an active tension model bridging electrophysiology and biomechanics, and a model simulating neural regulation through nitrergic, purinergic, and cholinergic pathways, as illustrated in Figure 1. The Lees-Green small intestinal ICC model (Lees-Green et al., 2014) was reparameterised for gastric SWs. Within this model, the Ano1, NSCC, and IP3R components (Figure 1) were modified to model enteric neural regulation. The Corrias and Buist (Corrias and Buist, 2007) gastric SMC model was used to simulate intracellular SMC Ca2+ concentration and new SK and active tension components were formulated to extend this model and incorporate enteric neural regulation affecting SMC. Licensed under CC BY 4.0. https://staging.physiomeproject.org/workspace/b01/@@file/fd4a7ac8dc4af994ade5119e5e7850a287f524d7 Manuscript rev1: Input is now in Hz. Fitted param values updated with fixed rng in optimisation script. Omkar Athavale 2023-10-25 https://staging.physiomeproject.org/workspace/b01/@@file/808838d25c22fcf0240a1ac88afceb170e10ed5c added illustrative images Omkar Athavale 2023-06-15 https://staging.physiomeproject.org/workspace/b01/@@file/6d4738f862c77bf62ad0352902fdf750c32e9d3b fixed typos in comments Omkar Athavale 2023-06-12 https://staging.physiomeproject.org/workspace/b01/@@file/ec7990e5032e58def983b8492526478c3fb838f7 removing intracellular stim pulse Omkar Athavale 2023-06-12 https://staging.physiomeproject.org/workspace/b01/@@file/ad9c6ee10175e2631dcaa5f229076fde24d1774c fixing unit inconsistency warnings Omkar Athavale 2023-06-12 https://staging.physiomeproject.org/workspace/b01/@@file/0356deaaad718429adab6b724c0b6bd03d3cc79b membrane sitm current annotationm Omkar Athavale 2023-05-30 https://staging.physiomeproject.org/workspace/b01/@@file/7a1a4e739515cc1e59e5dfc8e143d138710dd790 model name annotation Omkar Athavale 2023-05-30 https://staging.physiomeproject.org/workspace/b01/@@file/df0c54b3efe1606479cd729970a1c27c0f508356 stimulus current annotations Omkar Athavale 2023-05-30 https://staging.physiomeproject.org/workspace/b01/@@file/af087b046e957a6426dc1a05341919d67452b6ac removed unused components from ICC mdoela nd added annotations for Chaste Omkar Athavale 2023-05-30 https://staging.physiomeproject.org/workspace/b01/@@file/965dc29590af6e826dadf2c1f553e33ad0724464 removed unused unit definitions Omkar Athavale 2023-05-30 https://staging.physiomeproject.org/workspace/b01/@@file/9111ac2097bf0c8b5ea7be9d1684d1e5a2d411c6 internal rev 1 Omkar Athavale 2023-05-08