https://staging.physiomeproject.org/workspace/b34 en-us This model simulates how endothelial cells convert the mechanical stimulus of shear stress applied to the single-cell endothelial layer into chemical responses, including the generation of nitric oxide (NO). Subsequently, the shear-induced NO diffuses into the adjacent arterial layer, the smooth muscle layer, initiating a cell signalling pathway that modulates the vasoactivity of smooth muscle cells. Reference: Sriram, K., Laughlin, J. G., Rangamani, P., & Tartakovsky, D. M. (2016). Shear-induced nitric oxide production by endothelial cells. Biophysical journal, 111(1), 208-221. https://staging.physiomeproject.org/workspace/b34/@@file/d5fac872a590c28ecb66b07757cf5b1cd2ab6956 Endothelial_Cell_Model Fariba 2023-10-05