Introduction
=============
This workspace illustrates how to connect multiscale models using the bond graph formalism.

The main CellML_ files in folder `models <models/>`_ are:

- `Cardiovascular model <models/cardiovascular.cellml>`_ encodes a cardiovascular system simplified from `Gee, Michelle M., et al.(2023)`_. The model follows the bond graph formalism.
- `Neural control model <models/neural_control.cellml>`_ encodes the neural control mechanism described in `Gee, Michelle M., et al.(2023)`_.
- `Cell action potential model <models/tentusscher_noble_noble_panfilov_2004_m.cellml>`_ encodes the M cell action potential model described in `Ten Tusscher et al. 2004`_
- `Combined model <models/Gee_whiz.cellml>`_ connects the M cell action potential model to the cardiovascular model via the tension model described in `HMT 1998`_
- the folder `CellMLV2 <models/CellMLV2>`_ includes `the flattened combined model using CellML version 2 <models/CellMLV2/Gee_whiz_flat.cellml>`_  and its SED-ML_ file. 

.. _CellML: https://www.cellml.org/
.. _OpenCOR: https://opencor.ws/
.. _SED-ML: https://sed-ml.org

.. _`Gee, Michelle M., et al.(2023)`: https://doi.org/10.1002/aic.18033
.. _`Ten Tusscher et al. 2004`: https://doi.org/10.1152/ajpheart.00794.2003
.. _`HMT 1998`: https://doi.org/10.1016/s0079-6107(98)00013-3