- Author:
- pmr2.import <nobody@models.cellml.org>
- Date:
- 2006-07-09 07:17:04+12:00
- Desc:
- committing version01 of bakker_michels_opperdoes_westerhoff_1997
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/bakker_michels_opperdoes_westerhoff_1997/rawfile/872c5abf5a0d81d7ae6f92e6afa7f208c895569c/bakker_michels_opperdoes_westerhoff_1997.cellml
<?xml version='1.0' encoding='utf-8'?>
<!-- FILE : bakker_model_1997.xml
CREATED : 1st August 2002
LAST MODIFIED : 27th April 2005
AUTHOR : Catherine Lloyd
Department of Engineering Science
The University of Auckland
MODEL STATUS : This model conforms to the CellML 1.0 Specification released on
10th August 2001, and the 16/01/2002 CellML Metadata 1.0 Specification.
DESCRIPTION : This file contains a CellML description of the 1997 Bakker et al. mathematical model of glycolysis in the parasite Trypanosoma brucei.
CHANGES:
09/04/2003 - AAC - Added publication date information.
01/09/2003 - CML - Changed model structure to remove the model element from
the CellML.
27/04/2005 - PJV - Modified names to conform with cellml1.1 naming
conventions and alligned comment brackets correctly.
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:pathway_editor="http://www.physiome.com/pathway_editor/1.0#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" pathway_editor:rendering_config_file="bakker_model_1997_cellmlrender.xml" cmeta:id="bakker_michels_opperdoes_westerhoff_1997_version01" name="bakker_michels_opperdoes_westerhoff_1997_version01">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Modelling Glycolysis in Trypanosoma brucei, Bakker et al, 1997</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This is the original unchecked version of the model imported from the previous
CellML model repository, 24-Jan-2006.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
Salivarian trypanosomes are extracellular parasites of the blood and tissue fluids of mammals. When it is within the bloodstream of its host <emphasis>Homo sapiens</emphasis>, <emphasis>Trypanosoma brucei</emphasis>, (the parasite that causes African sleeping disease in humans), displays very simple metabolism. In the bloodstream form (within its host) the parasite lacks a Krebs cycle and oxidative phosphorylation, and its metabolism is restricted to the glycolytic pathway alone. As in all trypansomes, most of the glycolytic enzymes of <emphasis>Trypanosoma brucei</emphasis> are contained within a specialised organelle called a glycosome (see <xref linkend="fig_reaction_diagram"/> below). In addition to this structural difference beween trypanosomes and other eukaryotic cells, trypanosomes also display differences at the biochemical level of their metabolism. Their glycolitic pathway is simplier, with few side chains and reduced allosteric enzymatic regulation. These differences between the host and parasite metabolism make the glycolytic pathway a potential target for drugs against African sleeping disease.
</para>
<para>
Most of the glycolytic enzymes of <emphasis>Trypanosoma brucei</emphasis> have been isolated and kinetically characterised. From this experimental data, Bakker <emphasis>et al</emphasis>. developed a mathematical model of trypanosomal glycolysis. Model simulations predict how the steady-state glycolytic flux and metabolite concentrations depend on the substrate and product concentrations and the enzyme-kinetic parameters. The model explains certain aspects of cell physiology, but it does have its limitations. Further experimental data on the transmembrane flux dynamics of metabolites would help to improve the accuracey of the model.
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
<ulink url="http://www.jbc.org/cgi/content/abstract/272/6/3207">Glycolysis in Bloodstream Form <emphasis>Trypanosoma brucei</emphasis> Can Be Understood in Terms of the Kinetics of the Glycolytic Enzymes</ulink>, Barbara M. Bakker, Paul A. M. Michels, Fred R. Opperdoes, and Hans V. Westerhoff, 1997, <ulink url="http://www.jbc.org/">
<emphasis>The Journal of Biological Chemistry</emphasis>
</ulink>, 272, 3207-3215. (<ulink url="http://www.jbc.org/cgi/content/full/272/6/3207">Full text</ulink> and <ulink url="http://www.jbc.org/cgi/reprint/272/6/3207.pdf">PDF versions</ulink> of the article are available to subscribers of the JBC website.) <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9013556&dopt=Abstract">PubMed ID: 9013556</ulink>
</para>
<para>
The raw CellML description of the model of trypanosome glycolysis can be downloaded in various formats as described in <xref linkend="sec_download_this_model"/>.
</para>
<informalfigure float="0" id="fig_reaction_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>A reaction diagram of glycolysis</title>
</objectinfo>
<imagedata fileref="bakker_1997.png"/>
</imageobject>
</mediaobject>
<caption>The stoichiometric scheme of the model of glycolysis in the bloodstream form of the parasite <emphasis>Trypanosoma brucei</emphasis>.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
<!--
We start the model definition with a definition of some named
sets of units for use throughout the model.
-->
<units name="minute">
<unit units="second" multiplier="60.0"/>
</units>
<units name="micromolar">
<unit units="mole" prefix="micro"/>
<unit units="litre" exponent="-1"/>
</units>
<units name="millimolar">
<unit units="mole" prefix="milli"/>
<unit units="litre" exponent="-1"/>
</units>
<units name="nanomolar">
<unit units="mole" prefix="nano"/>
<unit units="litre" exponent="-1"/>
</units>
<units name="flux">
<unit units="nanomolar"/>
<unit units="minute" exponent="-1"/>
</units>
<units name="microlitre">
<unit units="litre" prefix="micro"/>
</units>
<component name="global_variables">
<variable units="second" public_interface="out" name="time"/>
</component>
<component name="volumes">
<variable units="microlitre" public_interface="out" name="Vc" initial_value="0.244"/>
<variable units="microlitre" public_interface="out" name="Vg" initial_value="5.46"/>
</component>
<!--
The following components describe all the reactants and products involved in
reactions.
-->
<component name="Glc_o" cmeta:id="Glc_o">
<rdf:RDF>
<rdf:Description rdf:about="Glc_o">
<dc:title>Glc_o</dc:title>
<dcterms:alternative>external glucose</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="millimolar" public_interface="out" name="Glc_o" initial_value="5.0"/>
</component>
<component name="Glc_i" cmeta:id="Glc_i">
<rdf:RDF>
<rdf:Description rdf:about="Glc_i">
<dc:title>Glc_i</dc:title>
<dcterms:alternative>cytosolic glucose</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="micromolar" public_interface="out" name="Glc_i"/>
<variable units="flux" public_interface="in" name="V_HK"/>
<variable units="flux" public_interface="in" name="V_glucose_transport"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Glc_i</ci>
</apply>
<apply>
<minus/>
<ci>V_glucose_transport</ci>
<ci>V_HK</ci>
</apply>
</apply>
</math>
</component>
<component name="Glc_6_P_g" cmeta:id="Glc_6_P_g">
<rdf:RDF>
<rdf:Description rdf:about="Glc_6_P_g">
<dc:title>Glc_6_P_g</dc:title>
<dcterms:alternative>glycosomal glucose-6-phopshate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="micromolar" public_interface="out" name="Glc_6_P_g"/>
<variable units="dimensionless" name="Keq_PGI" initial_value="0.29"/>
<variable units="micromolar" public_interface="in" name="Fru_6_P_g"/>
<variable units="micromolar" public_interface="in" name="hexose_P_g"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Glc_6_P_g</ci>
<apply>
<divide/>
<ci>hexose_P_g</ci>
<ci>Keq_PGI</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Keq_PGI</ci>
<apply>
<divide/>
<ci>Fru_6_P_g</ci>
<ci>Glc_6_P_g</ci>
</apply>
</apply>
</math>
</component>
<component name="Fru_6_P_g" cmeta:id="Fru_6_P_g">
<rdf:RDF>
<rdf:Description rdf:about="Fru_6_P_g">
<dc:title>Fru_6_P_g</dc:title>
<dcterms:alternative>glycosomal fructose 6-phopshate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="micromolar" public_interface="out" name="Fru_6_P_g"/>
<variable units="micromolar" public_interface="in" name="Glc_6_P_g"/>
<variable units="micromolar" public_interface="in" name="hexose_P_g"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Fru_6_P_g</ci>
<apply>
<divide/>
<ci>hexose_P_g</ci>
<ci>Glc_6_P_g</ci>
</apply>
</apply>
</math>
</component>
<component name="hexose_P_g" cmeta:id="hexose_P_g">
<rdf:RDF>
<rdf:Description rdf:about="hexose_P_g">
<dc:title>hexose_P_g</dc:title>
<dcterms:alternative>total concentration of glycosomal six carbon phosphates</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="micromolar" public_interface="out" name="hexose_P_g"/>
<variable units="flux" public_interface="in" name="V_HK"/>
<variable units="flux" public_interface="in" name="V_PFK"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>hexose_P_g</ci>
</apply>
<apply>
<minus/>
<ci>V_HK</ci>
<ci>V_PFK</ci>
</apply>
</apply>
</math>
</component>
<component name="Fru_1_6_BP_g" cmeta:id="Fru_1_6_BP_g">
<rdf:RDF>
<rdf:Description rdf:about="Fru_1_6_BP_g">
<dc:title>Fru_1_6_BP_g</dc:title>
<dcterms:alternative>glycosomal fructose 1,6-bisphopshate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="micromolar" public_interface="out" name="Fru_1_6_BP_g"/>
<variable units="flux" public_interface="in" name="V_PFK"/>
<variable units="flux" public_interface="in" name="V_ALD"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Fru_1_6_BP_g</ci>
</apply>
<apply>
<minus/>
<ci>V_PFK</ci>
<ci>V_ALD</ci>
</apply>
</apply>
</math>
</component>
<component name="GA_3_P_g" cmeta:id="GA_3_P_g">
<rdf:RDF>
<rdf:Description rdf:about="GA_3_P_g">
<dc:title>GA_3_P_g</dc:title>
<dcterms:alternative>glycosomal glyceraldehyde 3-phopshate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="micromolar" public_interface="out" name="GA_3_P_g"/>
<variable units="dimensionless" public_interface="in" name="Keq_TIM"/>
<variable units="micromolar" public_interface="in" name="DHAP_g"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>GA_3_P_g</ci>
<apply>
<times/>
<ci>Keq_TIM</ci>
<ci>DHAP_g</ci>
</apply>
</apply>
</math>
</component>
<component name="triose_P" cmeta:id="triose_P">
<rdf:RDF>
<rdf:Description rdf:about="triose_P">
<dc:title>triose_P</dc:title>
<dcterms:alternative>total concentration of three carbon phopshates</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="micromolar" public_interface="out" name="triose_P"/>
<variable units="flux" public_interface="in" name="V_ALD"/>
<variable units="flux" public_interface="in" name="V_GAPDH"/>
<variable units="flux" public_interface="in" name="V_GDH"/>
<variable units="flux" public_interface="in" name="V_GPO"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>triose_P</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless"> 2.0 </cn>
<ci>V_ALD</ci>
</apply>
<ci>V_GPO</ci>
</apply>
<apply>
<plus/>
<ci>V_GAPDH</ci>
<ci>V_GDH</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="one_three_BPGA_g" cmeta:id="one_three_BPGA_g">
<rdf:RDF>
<rdf:Description rdf:about="one_three_BPGA_g">
<dc:title>one_three_BPGA_g</dc:title>
<dcterms:alternative>glycosomal 1,3-bisphosphoglycerate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="micromolar" public_interface="out" name="one_three_BPGA_g"/>
<variable units="flux" public_interface="in" name="V_GAPDH"/>
<variable units="flux" public_interface="in" name="V_PGK"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>one_three_BPGA_g</ci>
</apply>
<apply>
<minus/>
<ci>V_GAPDH</ci>
<ci>V_PGK</ci>
</apply>
</apply>
</math>
</component>
<component name="three_PGA" cmeta:id="three_PGA">
<rdf:RDF>
<rdf:Description rdf:about="three_PGA">
<dc:title>three_PGA</dc:title>
<dcterms:alternative>3-phosphoglycerate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="micromolar" public_interface="out" name="three_PGA"/>
<variable units="micromolar" public_interface="in" name="N"/>
<variable units="microlitre" public_interface="in" name="Vg"/>
<variable units="microlitre" public_interface="in" name="Vc"/>
<variable units="dimensionless" public_interface="out" name="Keq_PGM" initial_value="0.187"/>
<variable units="dimensionless" public_interface="out" name="Keq_ENO" initial_value="6.7"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>three_PGA</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>N</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci>Vc</ci>
<ci>Vg</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<ci>Keq_PGM</ci>
<apply>
<times/>
<ci>Keq_PGM</ci>
<ci>Keq_ENO</ci>
</apply>
</apply>
<apply>
<divide/>
<ci>Vc</ci>
<ci>Vg</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="two_PGA_c" cmeta:id="two_PGA_c">
<rdf:RDF>
<rdf:Description rdf:about="two_PGA_c">
<dc:title>two_PGA_c</dc:title>
<dcterms:alternative>cytosolic 2-phosphoglycerate</dcterms:alternative> </rdf:Description>
</rdf:RDF>
<variable units="micromolar" public_interface="out" name="two_PGA_c"/>
<variable units="micromolar" public_interface="in" name="three_PGA"/>
<variable units="dimensionless" public_interface="in" name="Keq_PGM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>two_PGA_c</ci>
<apply>
<times/>
<ci>Keq_PGM</ci>
<ci>three_PGA</ci>
</apply>
</apply>
</math>
</component>
<component name="N" cmeta:id="N">
<rdf:RDF>
<rdf:Description rdf:about="N">
<dc:title>N</dc:title>
<dcterms:alternative>the sum of 3-phosphoglycerate, 2-phosphoglycerate, and phosphoenolpyruvate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="micromolar" public_interface="out" name="N"/>
<variable units="flux" public_interface="in" name="V_PGK"/>
<variable units="flux" public_interface="in" name="V_PYK"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>N</ci>
</apply>
<apply>
<minus/>
<ci>V_PGK</ci>
<ci>V_PYK</ci>
</apply>
</apply>
</math>
</component>
<component name="PEP_c" cmeta:id="PEP_c">
<rdf:RDF>
<rdf:Description rdf:about="PEP_c">
<dc:title>PEP_c</dc:title>
<dcterms:alternative>cytosolic phosphoenolpyruvate</dcterms:alternative> </rdf:Description>
</rdf:RDF>
<variable units="micromolar" public_interface="out" name="PEP_c"/>
<variable units="micromolar" public_interface="in" name="two_PGA_c"/>
<variable units="dimensionless" public_interface="in" name="Keq_ENO"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>PEP_c</ci>
<apply>
<times/>
<ci>Keq_ENO</ci>
<ci>two_PGA_c</ci>
</apply>
</apply>
</math>
</component>
<component name="PYR_c" cmeta:id="PYR_c">
<rdf:RDF>
<rdf:Description rdf:about="PYR_c">
<dc:title>PYR_c</dc:title>
<dcterms:alternative>cytosolic pyruvate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="micromolar" public_interface="out" name="PYR_c"/>
<variable units="flux" public_interface="in" name="V_PYK"/>
<variable units="flux" public_interface="in" name="V_pyruvate_transport"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PYR_c</ci>
</apply>
<apply>
<minus/>
<ci>V_PYK</ci>
<ci>V_pyruvate_transport</ci>
</apply>
</apply>
</math>
</component>
<component name="pyruvate_o" cmeta:id="pyruvate_o">
<rdf:RDF>
<rdf:Description rdf:about="pyruvate_o">
<dc:title>pyruvate_o</dc:title>
<dcterms:alternative>extracellular pyruvate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="micromolar" public_interface="out" name="pyruvate_o"/>
</component>
<component name="glycerol_g">
<variable units="micromolar" public_interface="out" name="glycerol_g"/>
</component>
<component name="DHAP_c" cmeta:id="DHAP_c">
<rdf:RDF>
<rdf:Description rdf:about="DHAP_c">
<dc:title>DHAP_c</dc:title>
<dcterms:alternative>cytosolic dihydroxyacetone phosphate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="micromolar" public_interface="out" name="DHAP_c"/>
<variable units="micromolar" public_interface="in" name="triose_P"/>
<variable units="micromolar" public_interface="in" name="Q"/>
<variable units="micromolar" public_interface="in" name="C5"/>
<variable units="microlitre" public_interface="in" name="Vg"/>
<variable units="microlitre" public_interface="in" name="Vc"/>
<variable units="dimensionless" public_interface="out" name="Keq_TIM" initial_value="0.045"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>DHAP_c</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>Q</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<ci>Keq_TIM</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>Vc</ci>
<ci>Vg</ci>
</apply>
<ci>C5</ci>
</apply>
</apply>
<apply>
<times/>
<ci>triose_P</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci>Vc</ci>
<ci>Vg</ci>
</apply>
</apply>
<ci>Keq_TIM</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>Q</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<ci>Keq_TIM</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>Vc</ci>
<ci>Vg</ci>
</apply>
<ci>C5</ci>
</apply>
</apply>
<apply>
<times/>
<ci>triose_P</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci>Vc</ci>
<ci>Vg</ci>
</apply>
</apply>
<ci>Keq_TIM</ci>
</apply>
</apply>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless"> 4.0 </cn>
<ci>Keq_TIM</ci>
<apply>
<divide/>
<ci>Vc</ci>
<ci>Vg</ci>
</apply>
<apply>
<minus/>
<ci>triose_P</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci>Vc</ci>
<ci>Vg</ci>
</apply>
<ci>C5</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless"> 0.5 </cn>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless"> 2.0 </cn>
<ci>Keq_TIM</ci>
<apply>
<divide/>
<ci>Vc</ci>
<ci>Vg</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="DHAP_g" cmeta:id="DHAP_g">
<rdf:RDF>
<rdf:Description rdf:about="DHAP_g">
<dc:title>DHAP_g</dc:title>
<dcterms:alternative>glycosomal dihydroxyacetone phosphate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="micromolar" public_interface="out" name="DHAP_g"/>
<variable units="micromolar" public_interface="in" name="DHAP_c"/>
<variable units="micromolar" public_interface="in" name="Q"/>
<variable units="micromolar" public_interface="in" name="C5"/>
<variable units="dimensionless" public_interface="in" name="Keq_TIM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>DHAP_g</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Q</ci>
<ci>DHAP_c</ci>
</apply>
<apply>
<plus/>
<ci>C5</ci>
<apply>
<times/>
<ci>Keq_TIM</ci>
<ci>DHAP_c</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Q">
<variable units="micromolar" public_interface="out" name="Q"/>
<variable units="micromolar" public_interface="in" name="DHAP_g"/>
<variable units="micromolar" public_interface="in" name="GA_3_P_g"/>
<variable units="micromolar" public_interface="in" name="Gly_3_P_g"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Q</ci>
<apply>
<plus/>
<ci>DHAP_g</ci>
<ci>GA_3_P_g</ci>
<ci>Gly_3_P_g</ci>
</apply>
</apply>
</math>
</component>
<component name="Gly_3_P_c" cmeta:id="Gly_3_P_c">
<rdf:RDF>
<rdf:Description rdf:about="Gly_3_P_c">
<dc:title>Gly_3_P_c</dc:title>
<dcterms:alternative>cytosolic glyceraldehyde 3-phopshate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="micromolar" public_interface="out" name="Gly_3_P_c"/>
<variable units="micromolar" public_interface="in" name="C5"/>
<variable units="micromolar" public_interface="in" name="DHAP_c"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Gly_3_P_c</ci>
<apply>
<minus/>
<ci>C5</ci>
<ci>DHAP_c</ci>
</apply>
</apply>
</math>
</component>
<component name="Gly_3_P_g" cmeta:id="Gly_3_P_g">
<rdf:RDF>
<rdf:Description rdf:about="Gly_3_P_g">
<dc:title>Gly_3_P_g</dc:title>
<dcterms:alternative>glycosomal glyceraldehyde 3-phopshate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="micromolar" public_interface="out" name="Gly_3_P_g"/>
<variable units="micromolar" public_interface="in" name="Q"/>
<variable units="micromolar" public_interface="in" name="GA_3_P_g"/>
<variable units="micromolar" public_interface="in" name="DHAP_g"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Gly_3_P_g</ci>
<apply>
<minus/>
<ci>Q</ci>
<apply>
<plus/>
<ci>DHAP_g</ci>
<ci>GA_3_P_g</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="H2O" cmeta:id="H2O">
<rdf:RDF>
<rdf:Description rdf:about="H2O">
<dc:title>H2O</dc:title>
<dcterms:alternative>water</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="micromolar" public_interface="out" name="H2O"/>
</component>
<component name="O2" cmeta:id="O2">
<rdf:RDF>
<rdf:Description rdf:about="O2">
<dc:title>O2</dc:title>
<dcterms:alternative>oxygen</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="micromolar" public_interface="out" name="O2"/>
</component>
<component name="NAD_g" cmeta:id="NAD_g">
<rdf:RDF>
<rdf:Description rdf:about="NAD_g">
<dc:title>NAD_g</dc:title>
<dcterms:alternative>glycosomal nicotinamide adenine dinucleotide positive</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="micromolar" public_interface="out" name="NAD_g"/>
<variable units="micromolar" public_interface="in" name="NADH_g"/>
<variable units="micromolar" public_interface="in" name="C3"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>NAD_g</ci>
<apply>
<minus/>
<ci>C3</ci>
<ci>NADH_g</ci>
</apply>
</apply>
</math>
</component>
<component name="NADH_g" cmeta:id="NADH_g">
<rdf:RDF>
<rdf:Description rdf:about="NADH_g">
<dc:title>NADH_g</dc:title>
<dcterms:alternative>glycosomal nicotinamide adenine dinucleotide</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="micromolar" public_interface="out" name="NADH_g"/>
<variable units="flux" public_interface="in" name="V_GAPDH"/>
<variable units="flux" public_interface="in" name="V_GDH"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>NADH_g</ci>
</apply>
<apply>
<minus/>
<ci>V_GAPDH</ci>
<ci>V_GDH</ci>
</apply>
</apply>
</math>
</component>
<component name="P_g" cmeta:id="P_g">
<rdf:RDF>
<rdf:Description rdf:about="P_g">
<dc:title>P_g</dc:title>
<dcterms:alternative>total concentration of glycosomal adenosine phosphates</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="micromolar" public_interface="out" name="P_g"/>
<variable units="flux" public_interface="in" name="V_HK"/>
<variable units="flux" public_interface="in" name="V_PGK"/>
<variable units="flux" public_interface="in" name="V_PFK"/>
<variable units="flux" public_interface="in" name="V_GK"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>P_g</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>V_PGK</ci>
<ci>V_GK</ci>
</apply>
<apply>
<plus/>
<ci>V_HK</ci>
<ci>V_PFK</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="P_c" cmeta:id="P_c">
<rdf:RDF>
<rdf:Description rdf:about="P_c">
<dc:title>P_c</dc:title>
<dcterms:alternative>total concentration of cytosolic adenosine phosphates</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="micromolar" public_interface="out" name="P_c"/>
<variable units="flux" public_interface="in" name="V_PYK"/>
<variable units="flux" public_interface="in" name="V_ATP_utilisation"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>P_c</ci>
</apply>
<apply>
<minus/>
<ci>V_PYK</ci>
<ci>V_ATP_utilisation</ci>
</apply>
</apply>
</math>
</component>
<component name="ATP_g" cmeta:id="ATP_g">
<rdf:RDF>
<rdf:Description rdf:about="ATP_g">
<dc:title>ATP_g</dc:title>
<dcterms:alternative>glycosomal adenosine triphosphate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="millimolar" public_interface="out" name="ATP_g"/>
<variable units="micromolar" public_interface="out" name="P_g"/>
<variable units="dimensionless" name="Keq_AK" initial_value="0.442"/>
<variable units="micromolar" public_interface="in" name="C1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ATP_g</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>C1</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>P_g</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<times/>
<cn cellml:units="dimensionless"> 4.0 </cn>
<ci>Keq_AK</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<power/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<minus/>
<ci>C1</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>P_g</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<times/>
<cn cellml:units="dimensionless"> 4.0 </cn>
<ci>Keq_AK</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless"> 4.0 </cn>
<apply>
<minus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<times/>
<cn cellml:units="dimensionless"> 4.0 </cn>
<ci>Keq_AK</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<minus/>
<ci>Keq_AK</ci>
</apply>
<apply>
<power/>
<ci>P_g</ci>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless"> 0.5 </cn>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless"> 2.0 </cn>
<apply>
<minus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<times/>
<cn cellml:units="dimensionless"> 4.0 </cn>
<ci>Keq_AK</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ATP_c" cmeta:id="ATP_c">
<rdf:RDF>
<rdf:Description rdf:about="ATP_c">
<dc:title>ATP_c</dc:title>
<dcterms:alternative>cytosolic adenosine triphosphate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="millimolar" public_interface="out" name="ATP_c"/>
<variable units="micromolar" public_interface="out" name="P_c"/>
<variable units="dimensionless" name="Keq_AK" initial_value="0.442"/>
<variable units="micromolar" public_interface="in" name="C1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ATP_c</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>C1</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>P_c</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<times/>
<cn cellml:units="dimensionless"> 4.0 </cn>
<ci>Keq_AK</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<power/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<minus/>
<ci>C1</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>P_c</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<times/>
<cn cellml:units="dimensionless"> 4.0 </cn>
<ci>Keq_AK</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless"> 4.0 </cn>
<apply>
<minus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<times/>
<cn cellml:units="dimensionless"> 4.0 </cn>
<ci>Keq_AK</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<minus/>
<ci>Keq_AK</ci>
</apply>
<apply>
<power/>
<ci>P_c</ci>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless"> 0.5 </cn>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless"> 2.0 </cn>
<apply>
<minus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<times/>
<cn cellml:units="dimensionless"> 4.0 </cn>
<ci>Keq_AK</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ADP_g" cmeta:id="ADP_g">
<rdf:RDF>
<rdf:Description rdf:about="ADP_g">
<dc:title>ADP_g</dc:title>
<dcterms:alternative>glycosomal adenosine diphosphate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="millimolar" public_interface="out" name="ADP_g"/>
<variable units="millimolar" public_interface="in" name="ATP_g"/>
<variable units="millimolar" public_interface="in" name="P_g"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ADP_g</ci>
<apply>
<minus/>
<ci>P_g</ci>
<apply>
<times/>
<cn cellml:units="dimensionless"> 2.0 </cn>
<ci>ATP_g</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ADP_c" cmeta:id="ADP_c">
<rdf:RDF>
<rdf:Description rdf:about="ADP_c">
<dc:title>ADP_c</dc:title>
<dcterms:alternative>cytosolic adenosine diphosphate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="millimolar" public_interface="out" name="ADP_c"/>
<variable units="millimolar" public_interface="in" name="ATP_c"/>
<variable units="millimolar" public_interface="in" name="P_c"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ADP_c</ci>
<apply>
<minus/>
<ci>P_c</ci>
<apply>
<times/>
<cn cellml:units="dimensionless"> 2.0 </cn>
<ci>ATP_c</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="AMP_g" cmeta:id="AMP_g">
<rdf:RDF>
<rdf:Description rdf:about="AMP_g">
<dc:title>AMP_g</dc:title>
<dcterms:alternative>glycosomal adenosine monophosphate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="millimolar" public_interface="out" name="AMP_g"/>
<variable units="millimolar" public_interface="in" name="ATP_g"/>
<variable units="millimolar" public_interface="in" name="ADP_g"/>
<variable units="millimolar" public_interface="in" name="C1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>AMP_g</ci>
<apply>
<minus/>
<ci>C1</ci>
<apply>
<plus/>
<ci>ATP_g</ci>
<ci>ADP_g</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="AMP_c" cmeta:id="AMP_c">
<rdf:RDF>
<rdf:Description rdf:about="AMP_c">
<dc:title>AMP_c</dc:title>
<dcterms:alternative>cytosolic adenosine monophosphate</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable units="millimolar" public_interface="out" name="AMP_c"/>
<variable units="millimolar" public_interface="in" name="ATP_c"/>
<variable units="millimolar" public_interface="in" name="ADP_c"/>
<variable units="millimolar" public_interface="in" name="C2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>AMP_c</ci>
<apply>
<minus/>
<ci>C2</ci>
<apply>
<plus/>
<ci>ATP_c</ci>
<ci>ADP_c</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="C1">
<variable units="millimolar" public_interface="out" name="C1" initial_value="4.0"/>
<variable units="millimolar" public_interface="in" name="AMP_g"/>
<variable units="millimolar" public_interface="in" name="ADP_g"/>
<variable units="millimolar" public_interface="in" name="ATP_g"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>C1</ci>
<apply>
<plus/>
<ci>ATP_g</ci>
<ci>ADP_g</ci>
<ci>AMP_g</ci>
</apply>
</apply>
</math>
</component>
<component name="C2">
<variable units="millimolar" public_interface="out" name="C2" initial_value="4.0"/>
<variable units="millimolar" public_interface="in" name="AMP_c"/>
<variable units="millimolar" public_interface="in" name="ADP_c"/>
<variable units="millimolar" public_interface="in" name="ATP_c"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>C2</ci>
<apply>
<plus/>
<ci>ATP_c</ci>
<ci>ADP_c</ci>
<ci>AMP_c</ci>
</apply>
</apply>
</math>
</component>
<component name="C3">
<variable units="millimolar" public_interface="out" name="C3" initial_value="4.0"/>
<variable units="millimolar" public_interface="in" name="NAD_g"/>
<variable units="millimolar" public_interface="in" name="NADH_g"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>C3</ci>
<apply>
<plus/>
<ci>NADH_g</ci>
<ci>NAD_g</ci>
</apply>
</apply>
</math>
</component>
<component name="C4">
<variable units="millimolar" public_interface="out" name="C4" initial_value="45.0"/>
<variable units="millimolar" public_interface="in" name="Gly_3_P_g"/>
<variable units="millimolar" public_interface="in" name="DHAP_g"/>
<variable units="millimolar" public_interface="in" name="Glc_6_P_g"/>
<variable units="millimolar" public_interface="in" name="Fru_6_P_g"/>
<variable units="millimolar" public_interface="in" name="Fru_1_6_BP_g"/>
<variable units="millimolar" public_interface="in" name="GA_3_P_g"/>
<variable units="millimolar" public_interface="in" name="one_three_BPGA_g"/>
<variable units="millimolar" public_interface="in" name="ATP_g"/>
<variable units="millimolar" public_interface="in" name="ADP_g"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>C4</ci>
<apply>
<plus/>
<ci>Gly_3_P_g</ci>
<ci>DHAP_g</ci>
<ci>Glc_6_P_g</ci>
<ci>Fru_6_P_g</ci>
<apply>
<times/>
<cn cellml:units="dimensionless"> 2.0 </cn>
<ci>Fru_1_6_BP_g</ci>
</apply>
<ci>GA_3_P_g</ci>
<ci>one_three_BPGA_g</ci>
<apply>
<times/>
<cn cellml:units="dimensionless"> 2.0 </cn>
<ci>ATP_g</ci>
</apply>
<ci>ADP_g</ci>
</apply>
</apply>
</math>
</component>
<component name="C5">
<variable units="millimolar" public_interface="out" name="C5" initial_value="5.0"/>
<variable units="millimolar" public_interface="in" name="Gly_3_P_c"/>
<variable units="millimolar" public_interface="in" name="DHAP_c"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>C5</ci>
<apply>
<plus/>
<ci>Gly_3_P_c</ci>
<ci>DHAP_c</ci>
</apply>
</apply>
</math>
</component>
<!--
The following components describe the reactions of the model.
-->
<component name="V_glucose_transport">
<variable units="flux" public_interface="out" name="V_glucose_transport"/>
<variable units="millimolar" public_interface="in" name="Glc_o"/>
<variable units="millimolar" public_interface="in" name="Glc_i"/>
<variable units="millimolar" name="K_Glc" initial_value="2.0"/>
<variable units="dimensionless" name="alpha" initial_value="0.75"/>
<variable units="flux" name="V_glucose_transport_max" initial_value="106.2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="V_glucose_transport_calculation">
<eq/>
<ci> V_glucose_transport </ci>
<apply>
<times/>
<ci> V_glucose_transport_max </ci>
<apply>
<divide/>
<apply>
<minus/>
<ci> Glc_o </ci>
<ci> Glc_i </ci>
</apply>
<apply>
<plus/>
<ci> K_Glc </ci>
<ci> Glc_o </ci>
<ci> Glc_i </ci>
<apply>
<times/>
<ci> alpha </ci>
<ci> Glc_o </ci>
<apply>
<divide/>
<ci> Glc_i </ci>
<ci> K_Glc </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="V_pyruvate_transport">
<variable units="flux" public_interface="out" name="V_pyruvate_transport"/>
<variable units="millimolar" public_interface="in" name="PYR_c"/>
<variable units="millimolar" name="K_pyruvate" initial_value="1.96"/>
<variable units="flux" name="V_pyruvate_transport_max" initial_value="200.0"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="V_pyruvate_transport_calculation">
<eq/>
<ci> V_pyruvate_transport </ci>
<apply>
<times/>
<ci> V_pyruvate_transport_max </ci>
<apply>
<divide/>
<ci> PYR_c </ci>
<ci> K_pyruvate </ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci> PYR_c </ci>
<ci> K_pyruvate </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="V_GPO">
<variable units="flux" public_interface="out" name="V_GPO"/>
<variable units="millimolar" public_interface="in" name="Gly_3_P_c"/>
<variable units="millimolar" name="K_Gly_3_P" initial_value="1.7"/>
<variable units="flux" name="V_GPO_max" initial_value="200.0"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="V_GPO_calculation">
<eq/>
<ci> V_GPO </ci>
<apply>
<times/>
<ci> V_GPO_max </ci>
<apply>
<divide/>
<ci> Gly_3_P_c </ci>
<ci> K_Gly_3_P </ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci> Gly_3_P_c </ci>
<ci> K_Gly_3_P </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="V_HK">
<variable units="flux" public_interface="out" name="V_HK"/>
<variable units="millimolar" public_interface="in" name="Glc_i"/>
<variable units="millimolar" public_interface="in" name="Glc_6_P_g"/>
<variable units="millimolar" public_interface="in" name="ATP_g"/>
<variable units="millimolar" public_interface="in" name="ADP_g"/>
<variable units="millimolar" name="K_Glc_i" initial_value="0.1"/>
<variable units="millimolar" name="K_Glc_6_P_g" initial_value="12.0"/>
<variable units="millimolar" name="K_ATP" initial_value="0.116"/>
<variable units="millimolar" name="K_ADP" initial_value="0.126"/>
<variable units="flux" name="V_HK_max" initial_value="625.0"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="V_HK_calculation">
<eq/>
<ci> V_HK </ci>
<apply>
<times/>
<ci> V_HK_max </ci>
<apply>
<divide/>
<apply>
<divide/>
<ci> Glc_i </ci>
<ci> K_Glc_i </ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci> Glc_i </ci>
<ci> K_Glc_i </ci>
</apply>
<apply>
<divide/>
<ci> Glc_6_P_g </ci>
<ci> K_Glc_6_P_g </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<divide/>
<ci> ATP_g </ci>
<ci> K_ATP </ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci> ATP_g </ci>
<ci> K_ATP </ci>
</apply>
<apply>
<divide/>
<ci> ADP_g </ci>
<ci> K_ADP </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="V_GAPDH">
<variable units="flux" public_interface="out" name="V_GAPDH"/>
<variable units="millimolar" public_interface="in" name="NAD_g"/>
<variable units="millimolar" public_interface="in" name="GA_3_P_g"/>
<variable units="millimolar" public_interface="in" name="one_three_BPGA_g"/>
<variable units="millimolar" public_interface="in" name="NADH_g"/>
<variable units="millimolar" name="K_NAD" initial_value="0.45"/>
<variable units="millimolar" name="K_GA_3_P" initial_value="0.15"/>
<variable units="millimolar" name="K_1_3_BPGA" initial_value="0.1"/>
<variable units="millimolar" name="K_NADH" initial_value="0.02"/>
<variable units="flux" name="V_GAPDH_max_plus" initial_value="1470.0"/>
<variable units="dimensionless" name="V_GAPDH_max_ratio" initial_value="0.67"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="V_GAPDH_calculation">
<eq/>
<ci> V_GAPDH </ci>
<apply>
<times/>
<ci> V_GAPDH_max_plus </ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci> GA_3_P_g </ci>
<ci> K_GA_3_P </ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<ci> NAD_g </ci>
<ci> K_NAD </ci>
</apply>
<ci> V_GAPDH_max_ratio </ci>
</apply>
<apply>
<divide/>
<ci> one_three_BPGA_g </ci>
<ci> K_1_3_BPGA </ci>
</apply>
<apply>
<divide/>
<ci> NADH_g </ci>
<ci> K_NADH </ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci> GA_3_P_g </ci>
<ci> K_GA_3_P </ci>
</apply>
<apply>
<divide/>
<ci> one_three_BPGA_g </ci>
<ci> K_1_3_BPGA </ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci> NAD_g </ci>
<ci> K_NAD </ci>
</apply>
<apply>
<divide/>
<ci> NADH_g </ci>
<ci> K_NADH </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="V_PGK">
<variable units="flux" public_interface="out" name="V_PGK"/>
<variable units="millimolar" public_interface="in" name="ADP_g"/>
<variable units="millimolar" public_interface="in" name="one_three_BPGA_g"/>
<variable units="millimolar" public_interface="in" name="three_PGA"/>
<variable units="millimolar" public_interface="in" name="ATP_g"/>
<variable units="millimolar" name="K_ADP" initial_value="0.1"/>
<variable units="millimolar" name="K_1_3_BPGA" initial_value="0.05"/>
<variable units="millimolar" name="K_3_PGA" initial_value="1.62"/>
<variable units="millimolar" name="K_ATP" initial_value="0.29"/>
<variable units="flux" name="V_PGK_max_plus" initial_value="640.0"/>
<variable units="dimensionless" name="V_PGK_max_ratio" initial_value="0.029"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="V_PGK_calculation">
<eq/>
<ci> V_PGK </ci>
<apply>
<times/>
<ci> V_PGK_max_plus </ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci> one_three_BPGA_g </ci>
<ci> K_1_3_BPGA </ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<ci> ADP_g </ci>
<ci> K_ADP </ci>
</apply>
<ci> V_PGK_max_ratio </ci>
</apply>
<apply>
<divide/>
<ci> three_PGA </ci>
<ci> K_3_PGA </ci>
</apply>
<apply>
<divide/>
<ci> ATP_g </ci>
<ci> K_ATP </ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci> one_three_BPGA_g </ci>
<ci> K_1_3_BPGA </ci>
</apply>
<apply>
<divide/>
<ci> three_PGA </ci>
<ci> K_3_PGA </ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci> ADP_g </ci>
<ci> K_ADP </ci>
</apply>
<apply>
<divide/>
<ci> ATP_g </ci>
<ci> K_ATP </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="V_GK">
<variable units="flux" public_interface="out" name="V_GK"/>
<variable units="millimolar" public_interface="in" name="ADP_g"/>
<variable units="millimolar" public_interface="in" name="Gly_3_P_g"/>
<variable units="millimolar" public_interface="in" name="glycerol_g"/>
<variable units="millimolar" public_interface="in" name="ATP_g"/>
<variable units="millimolar" name="K_ADP" initial_value="0.12"/>
<variable units="millimolar" name="K_Gly_3_P" initial_value="5.1"/>
<variable units="millimolar" name="K_glycerol" initial_value="0.12"/>
<variable units="millimolar" name="K_ATP" initial_value="0.19"/>
<variable units="flux" name="V_GK_max_plus" initial_value="0.0"/>
<variable units="dimensionless" name="V_GK_max_ratio" initial_value="167.0"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="V_GK_calculation">
<eq/>
<ci> V_GK </ci>
<apply>
<times/>
<ci> V_GK_max_plus </ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci> Gly_3_P_g </ci>
<ci> K_Gly_3_P </ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<ci> ADP_g </ci>
<ci> K_ADP </ci>
</apply>
<ci> V_GK_max_ratio </ci>
</apply>
<apply>
<divide/>
<ci> glycerol_g </ci>
<ci> K_glycerol </ci>
</apply>
<apply>
<divide/>
<ci> ATP_g </ci>
<ci> K_ATP </ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci> Gly_3_P_g </ci>
<ci> K_Gly_3_P </ci>
</apply>
<apply>
<divide/>
<ci> glycerol_g </ci>
<ci> K_glycerol </ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci> ADP_g </ci>
<ci> K_ADP </ci>
</apply>
<apply>
<divide/>
<ci> ATP_g </ci>
<ci> K_ATP </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="V_GDH">
<variable units="flux" public_interface="out" name="V_GDH"/>
<variable units="millimolar" public_interface="in" name="NADH_g"/>
<variable units="millimolar" public_interface="in" name="Gly_3_P_g"/>
<variable units="millimolar" public_interface="in" name="DHAP_g"/>
<variable units="millimolar" public_interface="in" name="NAD_g"/>
<variable units="millimolar" name="K_NADH" initial_value="0.01"/>
<variable units="millimolar" name="K_Gly_3_P" initial_value="2.0"/>
<variable units="millimolar" name="K_DHAP" initial_value="0.1"/>
<variable units="millimolar" name="K_NAD" initial_value="0.4"/>
<variable units="flux" name="V_GDH_max_plus" initial_value="533.0"/>
<variable units="dimensionless" name="V_GDH_max_ratio" initial_value="0.28"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="V_GDH_calculation">
<eq/>
<ci> V_GDH </ci>
<apply>
<times/>
<ci> V_GDH_max_plus </ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci> DHAP_g </ci>
<ci> K_DHAP </ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<ci> NADH_g </ci>
<ci> K_NADH </ci>
</apply>
<ci> V_GDH_max_ratio </ci>
</apply>
<apply>
<divide/>
<ci> Gly_3_P_g </ci>
<ci> K_Gly_3_P </ci>
</apply>
<apply>
<divide/>
<ci> NAD_g </ci>
<ci> K_NAD </ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci> DHAP_g </ci>
<ci> K_DHAP </ci>
</apply>
<apply>
<divide/>
<ci> Gly_3_P_g </ci>
<ci> K_Gly_3_P </ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci> NADH_g </ci>
<ci> K_NADH </ci>
</apply>
<apply>
<divide/>
<ci> NAD_g </ci>
<ci> K_NAD </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="V_PFK">
<variable units="flux" public_interface="out" name="V_PFK"/>
<variable units="millimolar" public_interface="in" name="Fru_6_P_g"/>
<variable units="millimolar" public_interface="in" name="Fru_1_6_BP_g"/>
<variable units="millimolar" public_interface="in" name="ATP_g"/>
<variable units="millimolar" name="Ki_1" initial_value="15.8"/>
<variable units="millimolar" name="Ki_2" initial_value="10.7"/>
<variable units="millimolar" name="Km_Fru_6_P" initial_value="0.82"/>
<variable units="millimolar" name="Km_ATP" initial_value="2.6E-2"/>
<variable units="flux" name="V_PFK_max" initial_value="780.0"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="V_PFK_calculation">
<eq/>
<ci> V_PFK </ci>
<apply>
<times/>
<ci> V_PFK_max </ci>
<apply>
<divide/>
<ci> Ki_1 </ci>
<apply>
<plus/>
<ci> Fru_1_6_BP_g </ci>
<ci> Ki_1 </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<divide/>
<ci> Fru_6_P_g </ci>
<ci> Km_Fru_6_P </ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci> Fru_6_P_g </ci>
<ci> Km_Fru_6_P </ci>
</apply>
<apply>
<divide/>
<ci> Fru_1_6_BP_g </ci>
<ci> Ki_2 </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<divide/>
<ci> ATP_g </ci>
<ci> Km_ATP </ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci> ATP_g </ci>
<ci> Km_ATP </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="V_PYK">
<variable units="flux" public_interface="out" name="V_PYK"/>
<variable units="millimolar" public_interface="in" name="PEP_c"/>
<variable units="millimolar" public_interface="in" name="ADP_c"/>
<variable units="millimolar" public_interface="in" name="ATP_c"/>
<variable units="millimolar" name="Km_PEP"/>
<variable units="millimolar" name="Km_ADP" initial_value="0.114"/>
<variable units="dimensionless" name="n" initial_value="2.5"/>
<variable units="flux" name="V_PYK_max" initial_value="2.6E3"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="V_PYK_calculation">
<eq/>
<ci> V_PYK </ci>
<apply>
<times/>
<ci> V_PYK_max </ci>
<apply>
<divide/>
<apply>
<power/>
<apply>
<divide/>
<ci> PEP_c </ci>
<ci> Km_PEP </ci>
</apply>
<ci> n </ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<power/>
<apply>
<divide/>
<ci> PEP_c </ci>
<ci> Km_PEP </ci>
</apply>
<ci> n </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<divide/>
<ci> ADP_c </ci>
<ci> Km_ADP </ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci> ADP_c </ci>
<ci> Km_ADP </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply id="Km_PEP_calculation">
<eq/>
<ci> Km_PEP </ci>
<apply>
<times/>
<cn cellml:units="millimolar"> 0.34 </cn>
<apply>
<plus/>
<cn cellml:units="millimolar"> 1.0 </cn>
<apply>
<divide/>
<ci> ATP_c </ci>
<cn cellml:units="millimolar"> 0.57 </cn>
</apply>
<apply>
<divide/>
<ci> ADP_c </ci>
<cn cellml:units="millimolar"> 0.64 </cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="V_ALD">
<variable units="flux" public_interface="out" name="V_ALD"/>
<variable units="millimolar" public_interface="in" name="Fru_1_6_BP_g"/>
<variable units="millimolar" public_interface="in" name="GA_3_P_g"/>
<variable units="millimolar" public_interface="in" name="DHAP_g"/>
<variable units="millimolar" public_interface="in" name="ATP_g"/>
<variable units="millimolar" public_interface="in" name="ADP_g"/>
<variable units="millimolar" public_interface="in" name="AMP_g"/>
<variable units="millimolar" name="Km_Fru_1_6_BP"/>
<variable units="millimolar" name="Km_GA_3_P" initial_value="6.7E-2"/>
<variable units="millimolar" name="Ki_GA_3_P" initial_value="9.8E-2"/>
<variable units="millimolar" name="Km_DHAP" initial_value="1.5E-2"/>
<variable units="flux" name="V_ALD_max_plus" initial_value="780.0"/>
<variable units="dimensionless" name="V_ALD_max_ratio" initial_value="1.19"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="V_ALD_calculation">
<eq/>
<ci> V_ALD </ci>
<apply>
<times/>
<ci> V_ALD_max_plus </ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<divide/>
<ci> Fru_1_6_BP_g </ci>
<ci> Km_Fru_1_6_BP </ci>
</apply>
<apply>
<times/>
<ci> V_ALD_max_ratio </ci>
<apply>
<divide/>
<ci> GA_3_P_g </ci>
<ci> DHAP_g </ci>
</apply>
<apply>
<times/>
<ci> Km_GA_3_P </ci>
<ci> Km_DHAP </ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<ci> Fru_1_6_BP_g </ci>
<ci> Km_Fru_1_6_BP </ci>
</apply>
<apply>
<divide/>
<ci> GA_3_P_g </ci>
<ci> Km_GA_3_P </ci>
</apply>
<apply>
<divide/>
<ci> DHAP_g </ci>
<ci> Km_DHAP </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> Fru_1_6_BP_g </ci>
<ci> GA_3_P_g </ci>
</apply>
<apply>
<times/>
<ci> Km_Fru_1_6_BP </ci>
<ci> Ki_GA_3_P </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> DHAP_g </ci>
<ci> GA_3_P_g </ci>
</apply>
<apply>
<times/>
<ci> Km_DHAP </ci>
<ci> Km_GA_3_P </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply id="Km_Fru_1_6_BP_calculation">
<eq/>
<ci> Km_Fru_1_6_BP </ci>
<apply>
<times/>
<cn cellml:units="millimolar"> 9.0E-3 </cn>
<apply>
<plus/>
<cn cellml:units="millimolar"> 1.0 </cn>
<apply>
<divide/>
<ci> ATP_g </ci>
<cn cellml:units="millimolar"> 0.68 </cn>
</apply>
<apply>
<divide/>
<ci> ADP_g </ci>
<cn cellml:units="millimolar"> 1.51 </cn>
</apply>
<apply>
<divide/>
<ci> AMP_g </ci>
<cn cellml:units="millimolar"> 3.65 </cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="V_ATP_utilisation">
<variable units="flux" public_interface="out" name="V_ATP_utilisation"/>
<variable units="millimolar" public_interface="in" name="ATP_c"/>
<variable units="millimolar" public_interface="in" name="ADP_c"/>
<variable units="flux" name="k" initial_value="50"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="V_ATP_utilisation_calculation">
<eq/>
<ci> V_ATP_utilisation </ci>
<apply>
<times/>
<ci> k </ci>
<apply>
<divide/>
<ci> ATP_c </ci>
<ci> ADP_c </ci>
</apply>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_2="V_glucose_transport" component_1="Glc_o"/>
<map_variables variable_2="Glc_o" variable_1="Glc_o"/>
</connection>
<connection>
<map_components component_2="V_glucose_transport" component_1="Glc_i"/>
<map_variables variable_2="Glc_i" variable_1="Glc_i"/>
<map_variables variable_2="V_glucose_transport" variable_1="V_glucose_transport"/>
</connection>
<connection>
<map_components component_2="V_HK" component_1="Glc_i"/>
<map_variables variable_2="Glc_i" variable_1="Glc_i"/>
<map_variables variable_2="V_HK" variable_1="V_HK"/>
</connection>
<connection>
<map_components component_2="V_HK" component_1="Glc_6_P_g"/>
<map_variables variable_2="Glc_6_P_g" variable_1="Glc_6_P_g"/>
</connection>
<connection>
<map_components component_2="V_HK" component_1="hexose_P_g"/>
<map_variables variable_2="V_HK" variable_1="V_HK"/>
</connection>
<connection>
<map_components component_2="V_PFK" component_1="Fru_6_P_g"/>
<map_variables variable_2="Fru_6_P_g" variable_1="Fru_6_P_g"/>
</connection>
<connection>
<map_components component_2="V_PFK" component_1="hexose_P_g"/>
<map_variables variable_2="V_PFK" variable_1="V_PFK"/>
</connection>
<connection>
<map_components component_2="V_PFK" component_1="Fru_1_6_BP_g"/>
<map_variables variable_2="Fru_1_6_BP_g" variable_1="Fru_1_6_BP_g"/>
<map_variables variable_2="V_PFK" variable_1="V_PFK"/>
</connection>
<connection>
<map_components component_2="V_ALD" component_1="Fru_1_6_BP_g"/>
<map_variables variable_2="Fru_1_6_BP_g" variable_1="Fru_1_6_BP_g"/>
<map_variables variable_2="V_ALD" variable_1="V_ALD"/>
</connection>
<connection>
<map_components component_2="V_ALD" component_1="DHAP_g"/>
<map_variables variable_2="DHAP_g" variable_1="DHAP_g"/>
</connection>
<connection>
<map_components component_2="V_GDH" component_1="DHAP_g"/>
<map_variables variable_2="DHAP_g" variable_1="DHAP_g"/>
</connection>
<connection>
<map_components component_2="V_ALD" component_1="triose_P"/>
<map_variables variable_2="V_ALD" variable_1="V_ALD"/>
</connection>
<connection>
<map_components component_2="V_GAPDH" component_1="triose_P"/>
<map_variables variable_2="V_GAPDH" variable_1="V_GAPDH"/>
</connection>
<connection>
<map_components component_2="V_GDH" component_1="triose_P"/>
<map_variables variable_2="V_GDH" variable_1="V_GDH"/>
</connection>
<connection>
<map_components component_2="V_GPO" component_1="triose_P"/>
<map_variables variable_2="V_GPO" variable_1="V_GPO"/>
</connection>
<connection>
<map_components component_2="V_ALD" component_1="GA_3_P_g"/>
<map_variables variable_2="GA_3_P_g" variable_1="GA_3_P_g"/>
</connection>
<connection>
<map_components component_2="V_GAPDH" component_1="GA_3_P_g"/>
<map_variables variable_2="GA_3_P_g" variable_1="GA_3_P_g"/>
</connection>
<connection>
<map_components component_2="V_GDH" component_1="Gly_3_P_g"/>
<map_variables variable_2="Gly_3_P_g" variable_1="Gly_3_P_g"/>
</connection>
<connection>
<map_components component_2="V_GK" component_1="Gly_3_P_g"/>
<map_variables variable_2="Gly_3_P_g" variable_1="Gly_3_P_g"/>
</connection>
<connection>
<map_components component_2="V_GAPDH" component_1="one_three_BPGA_g"/>
<map_variables variable_2="one_three_BPGA_g" variable_1="one_three_BPGA_g"/>
<map_variables variable_2="V_GAPDH" variable_1="V_GAPDH"/>
</connection>
<connection>
<map_components component_2="V_PGK" component_1="one_three_BPGA_g"/>
<map_variables variable_2="one_three_BPGA_g" variable_1="one_three_BPGA_g"/>
<map_variables variable_2="V_PGK" variable_1="V_PGK"/>
</connection>
<connection>
<map_components component_2="V_PYK" component_1="PEP_c"/>
<map_variables variable_2="PEP_c" variable_1="PEP_c"/>
</connection>
<connection>
<map_components component_2="V_PGK" component_1="N"/>
<map_variables variable_2="V_PGK" variable_1="V_PGK"/>
</connection>
<connection>
<map_components component_2="V_PYK" component_1="N"/>
<map_variables variable_2="V_PYK" variable_1="V_PYK"/>
</connection>
<connection>
<map_components component_2="V_PYK" component_1="PYR_c"/>
<map_variables variable_2="V_PYK" variable_1="V_PYK"/>
</connection>
<connection>
<map_components component_2="V_pyruvate_transport" component_1="PYR_c"/>
<map_variables variable_2="PYR_c" variable_1="PYR_c"/>
<map_variables variable_2="V_pyruvate_transport" variable_1="V_pyruvate_transport"/>
</connection>
<connection>
<map_components component_2="V_HK" component_1="P_g"/>
<map_variables variable_2="V_HK" variable_1="V_HK"/>
</connection>
<connection>
<map_components component_2="V_PFK" component_1="P_g"/>
<map_variables variable_2="V_PFK" variable_1="V_PFK"/>
</connection>
<connection>
<map_components component_2="V_PGK" component_1="P_g"/>
<map_variables variable_2="V_PGK" variable_1="V_PGK"/>
</connection>
<connection>
<map_components component_2="V_GK" component_1="P_g"/>
<map_variables variable_2="V_GK" variable_1="V_GK"/>
</connection>
<connection>
<map_components component_2="V_PYK" component_1="P_c"/>
<map_variables variable_2="V_PYK" variable_1="V_PYK"/>
</connection>
<connection>
<map_components component_2="V_ATP_utilisation" component_1="P_c"/>
<map_variables variable_2="V_ATP_utilisation" variable_1="V_ATP_utilisation"/>
</connection>
<connection>
<map_components component_2="global_variables" component_1="Glc_i"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="global_variables" component_1="Fru_1_6_BP_g"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="global_variables" component_1="one_three_BPGA_g"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="global_variables" component_1="PYR_c"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="global_variables" component_1="NADH_g"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="global_variables" component_1="hexose_P_g"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="global_variables" component_1="triose_P"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="global_variables" component_1="N"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="global_variables" component_1="P_c"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="global_variables" component_1="P_g"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="Glc_6_P_g" component_1="Fru_6_P_g"/>
<map_variables variable_2="Fru_6_P_g" variable_1="Fru_6_P_g"/>
<map_variables variable_2="Glc_6_P_g" variable_1="Glc_6_P_g"/>
</connection>
<connection>
<map_components component_2="Glc_6_P_g" component_1="hexose_P_g"/>
<map_variables variable_2="hexose_P_g" variable_1="hexose_P_g"/>
</connection>
<connection>
<map_components component_2="Fru_6_P_g" component_1="hexose_P_g"/>
<map_variables variable_2="hexose_P_g" variable_1="hexose_P_g"/>
</connection>
<connection>
<map_components component_2="DHAP_g" component_1="DHAP_c"/>
<map_variables variable_2="Keq_TIM" variable_1="Keq_TIM"/>
<map_variables variable_2="DHAP_c" variable_1="DHAP_c"/>
</connection>
<connection>
<map_components component_2="DHAP_g" component_1="GA_3_P_g"/>
<map_variables variable_2="DHAP_g" variable_1="DHAP_g"/>
</connection>
<connection>
<map_components component_2="DHAP_c" component_1="GA_3_P_g"/>
<map_variables variable_2="Keq_TIM" variable_1="Keq_TIM"/>
</connection>
<connection>
<map_components component_2="three_PGA" component_1="N"/>
<map_variables variable_2="N" variable_1="N"/>
</connection>
<connection>
<map_components component_2="two_PGA_c" component_1="three_PGA"/>
<map_variables variable_2="three_PGA" variable_1="three_PGA"/>
<map_variables variable_2="Keq_PGM" variable_1="Keq_PGM"/>
</connection>
<connection>
<map_components component_2="PEP_c" component_1="two_PGA_c"/>
<map_variables variable_2="two_PGA_c" variable_1="two_PGA_c"/>
</connection>
<connection>
<map_components component_2="PEP_c" component_1="three_PGA"/>
<map_variables variable_2="Keq_ENO" variable_1="Keq_ENO"/>
</connection>
<connection>
<map_components component_2="DHAP_c" component_1="triose_P"/>
<map_variables variable_2="triose_P" variable_1="triose_P"/>
</connection>
<connection>
<map_components component_2="V_GPO" component_1="Gly_3_P_c"/>
<map_variables variable_2="Gly_3_P_c" variable_1="Gly_3_P_c"/>
</connection>
<connection>
<map_components component_2="NADH_g" component_1="NAD_g"/>
<map_variables variable_2="NADH_g" variable_1="NADH_g"/>
</connection>
<connection>
<map_components component_2="C3" component_1="NAD_g"/>
<map_variables variable_2="C3" variable_1="C3"/>
<map_variables variable_2="NAD_g" variable_1="NAD_g"/>
</connection>
<connection>
<map_components component_2="C3" component_1="NADH_g"/>
<map_variables variable_2="NADH_g" variable_1="NADH_g"/>
</connection>
<connection>
<map_components component_2="V_GAPDH" component_1="NADH_g"/>
<map_variables variable_2="V_GAPDH" variable_1="V_GAPDH"/>
<map_variables variable_2="NADH_g" variable_1="NADH_g"/>
</connection>
<connection>
<map_components component_2="V_GDH" component_1="NADH_g"/>
<map_variables variable_2="V_GDH" variable_1="V_GDH"/>
<map_variables variable_2="NADH_g" variable_1="NADH_g"/>
</connection>
<connection>
<map_components component_2="C1" component_1="ATP_g"/>
<map_variables variable_2="C1" variable_1="C1"/>
<map_variables variable_2="ATP_g" variable_1="ATP_g"/>
</connection>
<connection>
<map_components component_2="C1" component_1="ATP_c"/>
<map_variables variable_2="C1" variable_1="C1"/>
</connection>
<connection>
<map_components component_2="ADP_g" component_1="ATP_g"/>
<map_variables variable_2="ATP_g" variable_1="ATP_g"/>
</connection>
<connection>
<map_components component_2="ADP_g" component_1="P_g"/>
<map_variables variable_2="P_g" variable_1="P_g"/>
</connection>
<connection>
<map_components component_2="AMP_g" component_1="ATP_g"/>
<map_variables variable_2="ATP_g" variable_1="ATP_g"/>
</connection>
<connection>
<map_components component_2="AMP_g" component_1="ADP_g"/>
<map_variables variable_2="ADP_g" variable_1="ADP_g"/>
</connection>
<connection>
<map_components component_2="C1" component_1="AMP_g"/>
<map_variables variable_2="C1" variable_1="C1"/>
<map_variables variable_2="AMP_g" variable_1="AMP_g"/>
</connection>
<connection>
<map_components component_2="C1" component_1="ADP_g"/>
<map_variables variable_2="ADP_g" variable_1="ADP_g"/>
</connection>
<connection>
<map_components component_2="C2" component_1="ATP_c"/>
<map_variables variable_2="ATP_c" variable_1="ATP_c"/>
</connection>
<connection>
<map_components component_2="ADP_c" component_1="ATP_c"/>
<map_variables variable_2="ATP_c" variable_1="ATP_c"/>
</connection>
<connection>
<map_components component_2="ADP_c" component_1="P_c"/>
<map_variables variable_2="P_c" variable_1="P_c"/>
</connection>
<connection>
<map_components component_2="AMP_c" component_1="ATP_c"/>
<map_variables variable_2="ATP_c" variable_1="ATP_c"/>
</connection>
<connection>
<map_components component_2="AMP_c" component_1="ADP_c"/>
<map_variables variable_2="ADP_c" variable_1="ADP_c"/>
</connection>
<connection>
<map_components component_2="C2" component_1="AMP_c"/>
<map_variables variable_2="C2" variable_1="C2"/>
<map_variables variable_2="AMP_c" variable_1="AMP_c"/>
</connection>
<connection>
<map_components component_2="C2" component_1="ADP_c"/>
<map_variables variable_2="ADP_c" variable_1="ADP_c"/>
</connection>
<connection>
<map_components component_2="V_HK" component_1="ATP_g"/>
<map_variables variable_2="ATP_g" variable_1="ATP_g"/>
</connection>
<connection>
<map_components component_2="V_GK" component_1="ATP_g"/>
<map_variables variable_2="ATP_g" variable_1="ATP_g"/>
</connection>
<connection>
<map_components component_2="V_PYK" component_1="ATP_c"/>
<map_variables variable_2="ATP_c" variable_1="ATP_c"/>
</connection>
<connection>
<map_components component_2="V_ALD" component_1="ATP_g"/>
<map_variables variable_2="ATP_g" variable_1="ATP_g"/>
</connection>
<connection>
<map_components component_2="V_ATP_utilisation" component_1="ATP_c"/>
<map_variables variable_2="ATP_c" variable_1="ATP_c"/>
</connection>
<connection>
<map_components component_2="V_ATP_utilisation" component_1="ADP_c"/>
<map_variables variable_2="ADP_c" variable_1="ADP_c"/>
</connection>
<connection>
<map_components component_2="V_HK" component_1="ADP_g"/>
<map_variables variable_2="ADP_g" variable_1="ADP_g"/>
</connection>
<connection>
<map_components component_2="V_ALD" component_1="ADP_g"/>
<map_variables variable_2="ADP_g" variable_1="ADP_g"/>
</connection>
<connection>
<map_components component_2="V_ALD" component_1="AMP_g"/>
<map_variables variable_2="AMP_g" variable_1="AMP_g"/>
</connection>
<connection>
<map_components component_2="V_PGK" component_1="ADP_g"/>
<map_variables variable_2="ADP_g" variable_1="ADP_g"/>
</connection>
<connection>
<map_components component_2="V_GK" component_1="ADP_g"/>
<map_variables variable_2="ADP_g" variable_1="ADP_g"/>
</connection>
<connection>
<map_components component_2="V_PYK" component_1="ADP_c"/>
<map_variables variable_2="ADP_c" variable_1="ADP_c"/>
</connection>
<connection>
<map_components component_2="V_GK" component_1="glycerol_g"/>
<map_variables variable_2="glycerol_g" variable_1="glycerol_g"/>
</connection>
<connection>
<map_components component_2="V_PGK" component_1="ATP_g"/>
<map_variables variable_2="ATP_g" variable_1="ATP_g"/>
</connection>
<connection>
<map_components component_2="V_PFK" component_1="ATP_g"/>
<map_variables variable_2="ATP_g" variable_1="ATP_g"/>
</connection>
<connection>
<map_components component_2="V_GAPDH" component_1="NAD_g"/>
<map_variables variable_2="NAD_g" variable_1="NAD_g"/>
</connection>
<connection>
<map_components component_2="V_PGK" component_1="three_PGA"/>
<map_variables variable_2="three_PGA" variable_1="three_PGA"/>
</connection>
<connection>
<map_components component_2="V_GDH" component_1="NAD_g"/>
<map_variables variable_2="NAD_g" variable_1="NAD_g"/>
</connection>
<connection>
<map_components component_2="three_PGA" component_1="volumes"/>
<map_variables variable_2="Vc" variable_1="Vc"/>
<map_variables variable_2="Vg" variable_1="Vg"/>
</connection>
<connection>
<map_components component_2="DHAP_c" component_1="volumes"/>
<map_variables variable_2="Vc" variable_1="Vc"/>
<map_variables variable_2="Vg" variable_1="Vg"/>
</connection>
<connection>
<map_components component_2="DHAP_c" component_1="Q"/>
<map_variables variable_2="Q" variable_1="Q"/>
</connection>
<connection>
<map_components component_2="C5" component_1="DHAP_c"/>
<map_variables variable_2="C5" variable_1="C5"/>
<map_variables variable_2="DHAP_c" variable_1="DHAP_c"/>
</connection>
<connection>
<map_components component_2="DHAP_g" component_1="Q"/>
<map_variables variable_2="Q" variable_1="Q"/>
<map_variables variable_2="DHAP_g" variable_1="DHAP_g"/>
</connection>
<connection>
<map_components component_2="C5" component_1="DHAP_g"/>
<map_variables variable_2="C5" variable_1="C5"/>
</connection>
<connection>
<map_components component_2="GA_3_P_g" component_1="Q"/>
<map_variables variable_2="GA_3_P_g" variable_1="GA_3_P_g"/>
</connection>
<connection>
<map_components component_2="Gly_3_P_g" component_1="Q"/>
<map_variables variable_2="Gly_3_P_g" variable_1="Gly_3_P_g"/>
<map_variables variable_2="Q" variable_1="Q"/>
</connection>
<connection>
<map_components component_2="C5" component_1="Gly_3_P_c"/>
<map_variables variable_2="C5" variable_1="C5"/>
<map_variables variable_2="Gly_3_P_c" variable_1="Gly_3_P_c"/>
</connection>
<connection>
<map_components component_2="DHAP_c" component_1="Gly_3_P_c"/>
<map_variables variable_2="DHAP_c" variable_1="DHAP_c"/>
</connection>
<connection>
<map_components component_2="DHAP_g" component_1="Gly_3_P_g"/>
<map_variables variable_2="DHAP_g" variable_1="DHAP_g"/>
</connection>
<connection>
<map_components component_2="GA_3_P_g" component_1="Gly_3_P_g"/>
<map_variables variable_2="GA_3_P_g" variable_1="GA_3_P_g"/>
</connection>
<connection>
<map_components component_2="C4" component_1="Gly_3_P_g"/>
<map_variables variable_2="Gly_3_P_g" variable_1="Gly_3_P_g"/>
</connection>
<connection>
<map_components component_2="C4" component_1="DHAP_g"/>
<map_variables variable_2="DHAP_g" variable_1="DHAP_g"/>
</connection>
<connection>
<map_components component_2="C4" component_1="Glc_6_P_g"/>
<map_variables variable_2="Glc_6_P_g" variable_1="Glc_6_P_g"/>
</connection>
<connection>
<map_components component_2="C4" component_1="Fru_6_P_g"/>
<map_variables variable_2="Fru_6_P_g" variable_1="Fru_6_P_g"/>
</connection>
<connection>
<map_components component_2="C4" component_1="Fru_1_6_BP_g"/>
<map_variables variable_2="Fru_1_6_BP_g" variable_1="Fru_1_6_BP_g"/>
</connection>
<connection>
<map_components component_2="C4" component_1="GA_3_P_g"/>
<map_variables variable_2="GA_3_P_g" variable_1="GA_3_P_g"/>
</connection>
<connection>
<map_components component_2="C4" component_1="one_three_BPGA_g"/>
<map_variables variable_2="one_three_BPGA_g" variable_1="one_three_BPGA_g"/>
</connection>
<connection>
<map_components component_2="C4" component_1="ATP_g"/>
<map_variables variable_2="ATP_g" variable_1="ATP_g"/>
</connection>
<connection>
<map_components component_2="C4" component_1="ADP_g"/>
<map_variables variable_2="ADP_g" variable_1="ADP_g"/>
</connection>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Seq rdf:about="rdf:#42ff1ff3-5e8e-4416-8aab-b4cd32bf7c60">
<rdf:li rdf:resource="rdf:#1b8513b8-4b1d-4acf-b4d7-d36cb95cced8"/>
<rdf:li rdf:resource="rdf:#8a322f3d-6bbc-4534-97bc-ef26c4896684"/>
<rdf:li rdf:resource="rdf:#5ef4c128-f037-4fe1-866b-ee4e027a86d1"/>
<rdf:li rdf:resource="rdf:#3ed5858c-71db-4d73-869d-d36d25ad19db"/>
</rdf:Seq>
<rdf:Description rdf:about="rdf:#70bf54c4-7bbf-489f-af68-f6e46b951f58">
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
<rdf:value>c.lloyd@auckland.ac.nz</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#3e31cc54-d6b6-4697-ba0b-316c0f10af90">
<dcterms:W3CDTF>2005-04-27</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="">
<dc:publisher>
The University of Auckland, Bioengineering Institute
</dc:publisher>
<cmeta:modification rdf:resource="rdf:#50ba4847-7bff-4cbe-81b9-3187546a42ec"/>
<cmeta:modification rdf:resource="rdf:#75a3b7b3-ea7d-46ab-90ed-4708e4a18c06"/>
<cmeta:modification rdf:resource="rdf:#faa003ff-a4f2-40b6-ac41-749c7c173c12"/>
<dcterms:created rdf:resource="rdf:#bd48305c-0ef8-425c-9e43-b94c426be8e6"/>
<dc:creator rdf:resource="rdf:#ed375932-cead-46cd-8802-cae86603621d"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#dd9d54ae-6ab3-4a2f-8119-41a02c3eb3e5">
<dcterms:W3CDTF>2003-04-09</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#75a3b7b3-ea7d-46ab-90ed-4708e4a18c06">
<dcterms:modified rdf:resource="rdf:#bbf2616f-66cf-4519-acf1-ec81b1fc8cd0"/>
<rdf:value>
Changed model structure to remove the model element from the CellML.
</rdf:value>
<cmeta:modifier rdf:resource="rdf:#25a9b8dd-3a16-444f-92a6-d36a37f7076f"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#3be789cd-abfe-415e-9ec0-e02bc9fcc131">
<vCard:Given>Paul</vCard:Given>
<vCard:Family>Michels</vCard:Family>
<vCard:Other>A</vCard:Other>
<vCard:Other>M</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#1b8513b8-4b1d-4acf-b4d7-d36cb95cced8">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#a165cc80-9d7d-48b4-bf42-c385d8bbda97"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#ed375932-cead-46cd-8802-cae86603621d">
<vCard:ORG rdf:resource="rdf:#5644fc86-f150-42f9-b518-37e1c06b000f"/>
<vCard:EMAIL rdf:resource="rdf:#70bf54c4-7bbf-489f-af68-f6e46b951f58"/>
<vCard:N rdf:resource="rdf:#e330375d-6d18-426a-90e1-7b3cb17c7bdb"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#a165cc80-9d7d-48b4-bf42-c385d8bbda97">
<vCard:Given>Barbara</vCard:Given>
<vCard:Family>Bakker</vCard:Family>
<vCard:Other>M</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#50ba4847-7bff-4cbe-81b9-3187546a42ec">
<dcterms:modified rdf:resource="rdf:#dd9d54ae-6ab3-4a2f-8119-41a02c3eb3e5"/>
<rdf:value>
Added publication date information.
</rdf:value>
<cmeta:modifier rdf:resource="rdf:#e256dd86-e28f-4a2e-a1d5-b0e0e11ad401"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#df4a1cf8-e9cf-43ec-b2c7-964292530d69">
<dc:subject rdf:resource="rdf:#b01244db-d754-4a3a-8fa4-cee13664f3c9"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#6882967f-c0c0-47e6-b272-200bbcd5a17e">
<bqs:Pubmed_id>9013556</bqs:Pubmed_id>
<bqs:JournalArticle rdf:resource="rdf:#48ff6c5f-057b-4c61-bb86-8f652ab9dc66"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#0cbe075f-698f-4fae-a130-d0cd3d5fd22e">
<vCard:Given>Peter</vCard:Given>
<vCard:Family>Villiger</vCard:Family>
<vCard:Other>John</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#9314edd7-211f-4079-8944-8724d81e1082">
<vCard:Given>Catherine</vCard:Given>
<vCard:Family>Lloyd</vCard:Family>
<vCard:Other>May</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#9b66d71b-7745-413a-9da1-5dded4b07042">
<vCard:Given>Hans</vCard:Given>
<vCard:Family>Westerhoff</vCard:Family>
<vCard:Other>V</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#9283b926-6304-4165-9060-ff45440dc159">
<vCard:Given>Fred</vCard:Given>
<vCard:Family>Opperdoes</vCard:Family>
<vCard:Other>R</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#7d679723-7ace-4333-b4a2-e73b75c8a553">
<dc:title>The Journal of Biological Chemistry</dc:title>
</rdf:Description>
<rdf:Description rdf:about="rdf:#9be95ef8-92fa-4abc-b200-ea5ef462f062">
<dcterms:W3CDTF>1997-02-07</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#b01244db-d754-4a3a-8fa4-cee13664f3c9">
<bqs:subject_type>keyword</bqs:subject_type>
<rdf:value>metabolism</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#25a9b8dd-3a16-444f-92a6-d36a37f7076f">
<vCard:N rdf:resource="rdf:#9314edd7-211f-4079-8944-8724d81e1082"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#bbf2616f-66cf-4519-acf1-ec81b1fc8cd0">
<dcterms:W3CDTF>2003-09-01</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#e256dd86-e28f-4a2e-a1d5-b0e0e11ad401">
<vCard:N rdf:resource="rdf:#ee01e3ae-e398-46be-a0ec-9a13860cb379"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#9ec6bb87-9534-4f20-bd65-c97beb36fceb">
<dc:creator rdf:resource="rdf:#78387dc1-140e-419a-bd59-54bfb2f8fbf0"/>
<rdf:value>
This is the CellML description of Bakker et al's 1997 mathematical
model of glycolysis in the parasite Trypanosoma brucei.
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#78387dc1-140e-419a-bd59-54bfb2f8fbf0">
<vCard:FN>Catherine Lloyd</vCard:FN>
</rdf:Description>
<rdf:Description rdf:about="rdf:#3ed5858c-71db-4d73-869d-d36d25ad19db">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#9b66d71b-7745-413a-9da1-5dded4b07042"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#e330375d-6d18-426a-90e1-7b3cb17c7bdb">
<vCard:Given>Catherine</vCard:Given>
<vCard:Family>Lloyd</vCard:Family>
<vCard:Other>May</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#5644fc86-f150-42f9-b518-37e1c06b000f">
<vCard:Orgname>The University of Auckland</vCard:Orgname>
<vCard:Orgunit>The Bioengineering Institute</vCard:Orgunit>
</rdf:Description>
<rdf:Description rdf:about="rdf:#48ff6c5f-057b-4c61-bb86-8f652ab9dc66">
<dc:creator rdf:resource="rdf:#42ff1ff3-5e8e-4416-8aab-b4cd32bf7c60"/>
<dc:title>
Glycolysis in Bloodstream Form Trypanosoma brucei Can Be Understood
in Terms of the Kinetics of the Glycolytic Enzymes
</dc:title>
<bqs:volume>272</bqs:volume>
<bqs:first_page>3207</bqs:first_page>
<bqs:Journal rdf:resource="rdf:#7d679723-7ace-4333-b4a2-e73b75c8a553"/>
<dcterms:issued rdf:resource="rdf:#9be95ef8-92fa-4abc-b200-ea5ef462f062"/>
<bqs:last_page>3215</bqs:last_page>
</rdf:Description>
<rdf:Description rdf:about="rdf:#bd48305c-0ef8-425c-9e43-b94c426be8e6">
<dcterms:W3CDTF>2002-08-01</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#faa003ff-a4f2-40b6-ac41-749c7c173c12">
<dcterms:modified rdf:resource="rdf:#3e31cc54-d6b6-4697-ba0b-316c0f10af90"/>
<rdf:value>
Modified names to conform with cellml 1.1 naming conventions
and modified comment brackets.
</rdf:value>
<cmeta:modifier rdf:resource="rdf:#3e218bf1-eb1e-4dee-81e3-13d64b555e8b"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#3e218bf1-eb1e-4dee-81e3-13d64b555e8b">
<vCard:N rdf:resource="rdf:#0cbe075f-698f-4fae-a130-d0cd3d5fd22e"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#ee01e3ae-e398-46be-a0ec-9a13860cb379">
<vCard:Given>Autumn</vCard:Given>
<vCard:Family>Cuellar</vCard:Family>
<vCard:Other>A</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#8a322f3d-6bbc-4534-97bc-ef26c4896684">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#3be789cd-abfe-415e-9ec0-e02bc9fcc131"/>
</rdf:Description>
<rdf:Description rdf:about="#bakker_michels_opperdoes_westerhoff_1997_version01">
<dc:title>
A model of glycolysis in the parasite Trypanosoma brucei.
</dc:title>
<cmeta:comment rdf:resource="rdf:#9ec6bb87-9534-4f20-bd65-c97beb36fceb"/>
<bqs:reference rdf:resource="rdf:#6882967f-c0c0-47e6-b272-200bbcd5a17e"/>
<bqs:reference rdf:resource="rdf:#df4a1cf8-e9cf-43ec-b2c7-964292530d69"/>
<cmeta:species>Trypanosoma brucei</cmeta:species>
</rdf:Description>
<rdf:Description rdf:about="rdf:#5ef4c128-f037-4fe1-866b-ee4e027a86d1">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#9283b926-6304-4165-9060-ff45440dc159"/>
</rdf:Description>
</rdf:RDF>
</model>
