- Author:
- David Nickerson <david.nickerson@gmail.com>
- Date:
- 2024-09-30 17:29:06+13:00
- Desc:
- Adding steadystate model and configuration to reproduce figure 5.
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/be4/rawfile/b26c22572cfc7416239226346d239a1c67d42c1d/parameters.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="my_model" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#">
<!-- (4 eqn model for Alzheimer calculation) -->
<units name="molecules">
<unit units="dimensionless"/>
</units>
<units name="hour">
<unit multiplier="3600" units="second"/>
</units>
<units name="per_hour">
<unit exponent="-1" units="hour"/>
</units>
<units name="molecules_per_hour">
<unit units="molecules"/>
<unit units="per_hour"/>
</units>
<units name="per_molecules_per_hour">
<unit exponent="-1" units="molecules"/>
<unit units="per_hour"/>
</units>
<units name="per_hour2">
<unit exponent="-2" units="hour"/>
</units>
<units name="per_hour4">
<unit exponent="-4" units="hour"/>
</units>
<units name="micrometer">
<unit prefix="micro" units="meter"/>
</units>
<units name="micrometer_cubed">
<unit exponent="3" units="micrometer"/>
</units>
<units name="nM">
<unit exponent="-1" units="micrometer_cubed"/>
</units>
<component name="cell_geometry">
<variable initial_value="4846" name="volume" public_interface="out" units="micrometer_cubed"/>
<variable initial_value="0.6023" name="A_N" public_interface="out" units="dimensionless"/>
</component>
<component name="LR_neurons">
<variable initial_value="0.1" name="beta" public_interface="out" units="per_hour"/>
<variable initial_value="0.005" name="gamma" public_interface="out" units="per_molecules_per_hour"/>
<variable initial_value="14500" name="tau" public_interface="out" units="molecules_per_hour"/>
<variable initial_value="0.05" name="rho" public_interface="out" units="per_hour"/>
<variable initial_value="0.02" name="delta" public_interface="out" units="per_hour"/>
<variable initial_value="12" name="eta" public_interface="out" units="per_hour"/>
<variable initial_value="0.65" name="kappa" public_interface="out" units="per_hour"/>
<variable initial_value="50000" name="G_tot" public_interface="out" units="molecules"/>
<variable initial_value="44000" name="alpha_infection" public_interface="out" units="molecules_per_hour"/>
<variable initial_value="1560" name="alpha_baseline" public_interface="out" units="molecules_per_hour"/>
</component>
<component name="Re_plus_alECLII_neurons">
<variable initial_value="0.1" name="beta" public_interface="out" units="per_hour"/>
<variable initial_value="0.005" name="gamma" public_interface="out" units="per_molecules_per_hour"/>
<variable initial_value="79000" name="tau" public_interface="out" units="molecules_per_hour"/>
<variable initial_value="0.05" name="rho" public_interface="out" units="per_hour"/>
<variable initial_value="0.02" name="delta" public_interface="out" units="per_hour"/>
<variable initial_value="12" name="eta" public_interface="out" units="per_hour"/>
<variable initial_value="0.65" name="kappa" public_interface="out" units="per_hour"/>
<variable initial_value="250000" name="G_tot" public_interface="out" units="molecules"/>
<variable initial_value="109000" name="alpha_infection" public_interface="out" units="molecules_per_hour"/>
<variable initial_value="4680" name="alpha_baseline" public_interface="out" units="molecules_per_hour"/>
</component>
</model>
