- Author:
- Shelley Fong <sfon036@UoA.auckland.ac.nz>
- Date:
- 2024-11-12 14:16:20+13:00
- Desc:
- init
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/c17/rawfile/d44e06713a1dab8aa3c903ad6a6582e69adab1e1/RST/Fig6_to.rst
About this model
====================
:Original publication: `Kernik et al. (2019)`_:
"A computational model of induced pluripotent stem-cell derived cardiomyocytes
incorporating experimental variability from multiple data sources" J Physiol. 2019 Sep 1; 597(17): 4533-4564.
:DOI: https://dx.doi.org/10.1113%2FJP277724
.. _`Kernik et al. (2019)`: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767694/
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Figure 06
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Transient outward potassium current (:math:`I_to`) model
****************************************************************************
Current_Ito.cellml is the main CellML file which contains the formulation for the transient outward current. Its associated SED-ML file contains all the simulation settings.
To execute the code, all the files related to this channel need to be downloaded in a same folder:
1. fig6_to.py
2. Current_Ito.cellml
3. Current_Ito.sedml
4. parameter_Ito.cellml
5. parameter.cellml
6. gating_Ito.cellml
7. unit.cellml
To reproduce Figure 6, save all the files to the same folder and
execute the following script from the command line:
``$ cd [PathToThisFile]``
``$ [PathToOpenCOR]/pythonshell fig6_to.py``
.. figure:: figures/Figure6_to.png
:width: 85%
:align: center
:alt: Transient outward potassium current model
A, optimized activation with dataset-specific model fits. B. I-V curves, C, Time constant of :math:`I_to` activation gate. D,
Time constant of :math:`I_to` inactivation gate.
