Location: Coupled Endothelial and Smooth Muscle Cell Model @ 5e6492173917 / Coupled_Main_EC_Model.cellml
- Author:
- Fariba <fbir042@aucklanduni.ac.nz>
- Date:
- 2025-02-19 21:55:52+13:00
- Desc:
- Second Commit
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/c88/rawfile/5e6492173917e6493bb53402aa50e0eb3562601b/Coupled_Main_EC_Model.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="EC_ShearStress" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#">
<component name="Activation_of_G_proteins">
<variable initial_value="0" name="G" public_interface="out" units="uM"/>
<variable initial_value="0.017" name="k_a" public_interface="out" units="per_sec"/>
<variable name="R_star" public_interface="out" units="dimensionless"/>
<variable initial_value="0.33" name="Gt" public_interface="out" units="uM"/>
<variable initial_value="0.15" name="k_d" public_interface="out" units="per_sec"/>
<variable name="tau" public_interface="in" units="dimensionless"/>
<variable initial_value="15" name="lambda" public_interface="out" units="dimensionless"/>
<variable initial_value="0" name="IP3" public_interface="out" units="uM"/>
<variable name="r_f" public_interface="out" units="per_sec"/>
<variable initial_value="10" name="PIP2" public_interface="out" units="uM"/>
<variable initial_value="0.2" name="mu1" public_interface="out" units="per_sec"/>
<variable initial_value="8.37" name="alpha" public_interface="out" units="per_sec"/>
<variable initial_value="0.002" name="K_cp" public_interface="out" units="per_uM"/>
<variable initial_value="0.7937" name="M_ATP" public_interface="out" units="dimensionless"/>
<variable initial_value="10" name="r_r" public_interface="out" units="per_sec"/>
<variable initial_value="10" name="PIP2_t" public_interface="out" units="uM"/>
<variable name="k_PIP2_positive" public_interface="in" units="per_sec"/>
<variable initial_value="0.7024" name="k_PIP2_negative" public_interface="out" units="per_sec"/>
<variable initial_value="0.116" name="PIP3" public_interface="out" units="uM"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>G</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_a</ci>
<ci>R_star</ci>
<apply>
<minus/>
<ci>Gt</ci>
<ci>G</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k_d</ci>
<ci>G</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>R_star</ci>
<apply>
<tanh/>
<apply>
<divide/>
<apply>
<times/>
<pi/>
<ci>tau</ci>
</apply>
<ci>lambda</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>IP3</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>r_f</ci>
<ci>PIP2</ci>
</apply>
<apply>
<times/>
<ci>mu1</ci>
<ci>IP3</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>r_f</ci>
<apply>
<times/>
<ci>alpha</ci>
<ci>K_cp</ci>
<ci>M_ATP</ci>
<ci>G</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PIP2</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>r_f</ci>
<ci>r_r</ci>
</apply>
</apply>
<ci>PIP2</ci>
</apply>
<apply>
<times/>
<ci>r_r</ci>
<ci>IP3</ci>
</apply>
</apply>
<apply>
<times/>
<ci>r_r</ci>
<ci>PIP2_t</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k_PIP2_positive</ci>
<ci>PIP2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k_PIP2_negative</ci>
<ci>PIP3</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PIP3</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_PIP2_positive</ci>
<ci>PIP2</ci>
</apply>
<apply>
<times/>
<ci>k_PIP2_negative</ci>
<ci>PIP3</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Calcium_signalling">
<variable name="time" public_interface="in" units="second"/>
<variable initial_value="0.1" name="Ca2_c" public_interface="out" units="uM"/>
<variable initial_value="3.8605" name="Ca2_b" public_interface="out" units="uM"/>
<variable initial_value="2823.7" name="Ca2_s" public_interface="out" units="uM"/>
<variable name="q_rel" public_interface="out" units="uM_per_sec"/>
<variable name="q_res" public_interface="out" units="uM_per_sec"/>
<variable name="q_out" public_interface="out" units="uM_per_sec"/>
<variable name="q_in" public_interface="out" units="uM_per_sec"/>
<variable initial_value="1e-07" name="k_leak" public_interface="out" units="per_uM_per_sec"/>
<variable initial_value="3.5" name="v_r" public_interface="out" units="dimensionless"/>
<variable initial_value="6.64" name="k_rel" public_interface="out" units="per_sec"/>
<variable name="IP3" public_interface="in" units="uM"/>
<variable initial_value="0.2" name="k_2" public_interface="out" units="uM"/>
<variable initial_value="5" name="k_res" public_interface="out" units="uM_per_sec"/>
<variable initial_value="0.15" name="k_3" public_interface="out" units="uM"/>
<variable initial_value="24.7" name="k_out" public_interface="out" units="uM_per_sec"/>
<variable initial_value="0.32" name="k_5" public_interface="out" units="uM"/>
<variable name="q_MSIC" public_interface="out" units="uM_per_sec"/>
<variable name="q_CCE" public_interface="out" units="uM_per_sec"/>
<variable initial_value="17.6" name="q_max" public_interface="out" units="uM_per_sec"/>
<variable initial_value="2" name="N" public_interface="out" units="dimensionless"/>
<variable name="W" public_interface="out" units="dimensionless"/>
<variable name="tau" public_interface="in" units="dimensionless"/>
<variable initial_value="28.6" name="Z" public_interface="out" units="dimensionless"/>
<variable initial_value="0.14" name="W_0" public_interface="out" units="dimensionless"/>
<variable initial_value="8e-07" name="k_CCE" public_interface="out" units="per_sec"/>
<variable initial_value="2828" name="Ca2_s0" public_interface="out" units="uM"/>
<variable initial_value="1500" name="Ca2_e" public_interface="out" units="uM"/>
<variable name="psi" public_interface="out" units="per_uM"/>
<variable initial_value="0.0075" name="xi" public_interface="out" units="per_uM2"/>
<variable name="cGMP_EC" public_interface="in" units="uM"/>
<variable initial_value="100" name="k_on" public_interface="out" units="per_uM_per_sec"/>
<variable initial_value="300" name="k_off" public_interface="out" units="per_sec"/>
<variable initial_value="120" name="B_tot" public_interface="out" units="uM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca2_c</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>q_rel</ci>
<ci>q_res</ci>
</apply>
<ci>q_out</ci>
</apply>
<ci>q_in</ci>
<apply>
<times/>
<ci>k_leak</ci>
<apply>
<power/>
<ci>Ca2_s</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>k_on</ci>
<ci>Ca2_c</ci>
<apply>
<minus/>
<ci>B_tot</ci>
<ci>Ca2_b</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>k_off</ci>
<ci>Ca2_b</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca2_s</ci>
</apply>
<apply>
<times/>
<apply>
<minus/>
<ci>v_r</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<ci>q_rel</ci>
<ci>q_res</ci>
</apply>
<apply>
<times/>
<ci>k_leak</ci>
<apply>
<power/>
<ci>Ca2_s</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>q_rel</ci>
<apply>
<times/>
<ci>k_rel</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>IP3</ci>
<apply>
<plus/>
<ci>k_2</ci>
<ci>IP3</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Ca2_s</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_res</ci>
<apply>
<times/>
<ci>k_res</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>Ca2_c</ci>
<apply>
<plus/>
<ci>k_3</ci>
<ci>Ca2_c</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>q_out</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>k_out</ci>
<ci>Ca2_c</ci>
</apply>
<apply>
<plus/>
<ci>k_5</ci>
<ci>Ca2_c</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>q_in</ci>
<apply>
<plus/>
<ci>q_MSIC</ci>
<ci>q_CCE</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_MSIC</ci>
<apply>
<divide/>
<ci>q_max</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>N</ci>
<apply>
<exp/>
<apply>
<minus/>
<ci>W</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>W</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>W_0</ci>
<apply>
<power/>
<apply>
<minus/>
<apply>
<plus/>
<ci>tau</ci>
<apply>
<root/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">16</cn>
<apply>
<power/>
<ci>Z</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<ci>tau</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>Z</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<plus/>
<ci>tau</ci>
<apply>
<root/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">16</cn>
<apply>
<power/>
<ci>Z</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<ci>tau</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>q_CCE</ci>
<apply>
<times/>
<ci>k_CCE</ci>
<ci>psi</ci>
<apply>
<minus/>
<ci>Ca2_s0</ci>
<ci>Ca2_s</ci>
</apply>
<apply>
<minus/>
<ci>Ca2_e</ci>
<ci>Ca2_c</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>psi</ci>
<apply>
<minus/>
<cn cellml:units="per_uM">1</cn>
<apply>
<times/>
<ci>xi</ci>
<ci>cGMP_EC</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca2_b</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_on</ci>
<ci>Ca2_c</ci>
<apply>
<minus/>
<ci>B_tot</ci>
<ci>Ca2_b</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k_off</ci>
<ci>Ca2_b</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Activation_of_protein_kinases">
<variable name="time" public_interface="in" units="second"/>
<variable initial_value="2.5" name="a_PI3K" public_interface="out" units="dimensionless"/>
<variable name="tau" public_interface="in" units="dimensionless"/>
<variable initial_value="24" name="delta" public_interface="out" units="dimensionless"/>
<variable initial_value="0.003" name="eta" public_interface="out" units="per_sec"/>
<variable name="k_PIP2_positive" public_interface="out" units="per_sec"/>
<variable initial_value="0.021" name="k_1p" public_interface="out" units="per_sec"/>
<variable initial_value="0.0022" name="k_2p" public_interface="out" units="per_sec"/>
<variable initial_value="0.0337" name="AKT_star" public_interface="out" units="uM"/>
<variable initial_value="1" name="AKT_tot" public_interface="out" units="uM"/>
<variable initial_value="1" name="PKC_tot" public_interface="out" units="uM"/>
<variable initial_value="0.0337" name="PKC_star" public_interface="out" units="uM"/>
<variable name="k_AKT_positive" public_interface="out" units="per_sec"/>
<variable name="k_PKC_positive" public_interface="out" units="per_sec"/>
<variable initial_value="0.1155" name="k_AKT_negative" public_interface="out" units="per_sec"/>
<variable initial_value="0.1155" name="k_PKC_negative" public_interface="out" units="per_sec"/>
<variable name="PIP3" public_interface="in" units="uM"/>
<variable name="PIP3_min" public_interface="out" units="uM"/>
<variable name="PIP3_max" public_interface="out" units="uM"/>
<variable initial_value="10" name="PIP2_tot" public_interface="out" units="uM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<eq/>
<ci>k_PIP2_positive</ci>
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<plus/>
<apply>
<divide/>
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<times/>
<ci>k_1p</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>a_PI3K</ci>
<apply>
<tanh/>
<apply>
<divide/>
<apply>
<times/>
<pi/>
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<ci>delta</ci>
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</apply>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
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<ci>time</ci>
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</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>a_PI3K</ci>
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<ci>k_2p</ci>
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</apply>
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<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>AKT_star</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_AKT_positive</ci>
<apply>
<minus/>
<cn cellml:units="uM">1</cn>
<ci>AKT_star</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k_AKT_negative</ci>
<ci>AKT_star</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PKC_star</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_PKC_positive</ci>
<apply>
<minus/>
<cn cellml:units="uM">1</cn>
<ci>PKC_star</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k_PKC_negative</ci>
<ci>PKC_star</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_AKT_positive</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1</cn>
<ci>k_AKT_negative</ci>
<apply>
<minus/>
<ci>PIP3</ci>
<ci>PIP3_min</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>PIP3_max</ci>
<ci>PIP3_min</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_PKC_positive</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1</cn>
<ci>k_PKC_negative</ci>
<apply>
<minus/>
<ci>PIP3</ci>
<ci>PIP3_min</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>PIP3_max</ci>
<ci>PIP3_min</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>PIP3_min</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0031</cn>
<ci>PIP2_tot</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>PIP3_max</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.031</cn>
<ci>PIP2_tot</ci>
</apply>
</apply>
</math>
</component>
<component name="Phosphorylation_and_formation_of_eNOS_complexes">
<variable name="time" public_interface="in" units="second"/>
<variable name="Ca2_c" public_interface="in" units="uM"/>
<variable initial_value="0.0002668" name="Ca4_CaM" public_interface="out" units="uM"/>
<variable initial_value="100" name="k_Ca4_CaM" public_interface="out" units="per_sec"/>
<variable initial_value="0.0045" name="theta" public_interface="out" units="dimensionless"/>
<variable initial_value="2.7" name="beta" public_interface="out" units="dimensionless"/>
<variable initial_value="30" name="CaM_tot" public_interface="out" units="uM"/>
<variable initial_value="1" name="k_dCaM" public_interface="out" units="dimensionless"/>
<variable initial_value="0.0019" name="eNOS_CaM" public_interface="out" units="uM"/>
<variable initial_value="0.001" name="eNOS_CaM_star" public_interface="out" units="uM"/>
<variable initial_value="7.5" name="k_CaM_positive" public_interface="out" units="per_sec"/>
<variable initial_value="0.01" name="k_CaM_negative" public_interface="out" units="per_sec"/>
<variable initial_value="3" name="k_half_CaM" public_interface="out" units="uM"/>
<variable name="eNOS_Cav" public_interface="out" units="uM"/>
<variable initial_value="0.04" name="eNOS_tot" public_interface="out" units="uM"/>
<variable name="k_eAKT_positive" public_interface="out" units="per_sec"/>
<variable name="k_eAKT_negative" public_interface="out" units="per_sec"/>
<variable initial_value="0.004" name="k_eAKT_max" public_interface="out" units="per_sec"/>
<variable name="AKT_star" public_interface="in" units="uM"/>
<variable name="AKT_tot" public_interface="in" units="uM"/>
<variable initial_value="0.002" name="k_Thr_positive" public_interface="out" units="per_sec"/>
<variable initial_value="0.0002222222" name="k_Thr_negative" public_interface="out" units="per_sec"/>
<variable initial_value="0.0078" name="eNOS_Cav_0" public_interface="out" units="uM"/>
<variable name="PKC_tot" public_interface="in" units="uM"/>
<variable name="PKC_star" public_interface="in" units="uM"/>
<variable initial_value="1" name="m_1" public_interface="out" units="per_uM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>k_eAKT_negative</ci>
<apply>
<divide/>
<ci>k_eAKT_max</ci>
<cn cellml:units="dimensionless">18</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca4_CaM</ci>
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<apply>
<times/>
<ci>k_Ca4_CaM</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>theta</ci>
<apply>
<power/>
<apply>
<times/>
<ci>Ca2_c</ci>
<ci>m_1</ci>
</apply>
<ci>beta</ci>
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<ci>CaM_tot</ci>
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<apply>
<plus/>
<ci>k_dCaM</ci>
<apply>
<power/>
<apply>
<times/>
<ci>Ca2_c</ci>
<ci>m_1</ci>
</apply>
<ci>beta</ci>
</apply>
</apply>
</apply>
<ci>Ca4_CaM</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>eNOS_CaM</ci>
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<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>k_CaM_positive</ci>
<ci>Ca4_CaM</ci>
</apply>
<apply>
<plus/>
<ci>k_half_CaM</ci>
<ci>Ca4_CaM</ci>
</apply>
</apply>
<ci>eNOS_Cav</ci>
</apply>
<apply>
<times/>
<ci>k_CaM_negative</ci>
<ci>eNOS_CaM</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_eAKT_positive</ci>
<ci>eNOS_CaM</ci>
</apply>
<apply>
<times/>
<ci>k_eAKT_negative</ci>
<ci>eNOS_CaM_star</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>eNOS_Cav</ci>
<apply>
<minus/>
<ci>eNOS_tot</ci>
<apply>
<plus/>
<ci>eNOS_Cav_0</ci>
<ci>eNOS_CaM</ci>
<ci>eNOS_CaM_star</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>eNOS_CaM_star</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_eAKT_positive</ci>
<ci>eNOS_CaM</ci>
</apply>
<apply>
<times/>
<ci>k_eAKT_negative</ci>
<ci>eNOS_CaM_star</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_eAKT_positive</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>k_eAKT_max</ci>
<ci>AKT_star</ci>
</apply>
<ci>AKT_tot</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>eNOS_Cav_0</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>k_Thr_positive</ci>
<ci>PKC_star</ci>
<ci>eNOS_Cav</ci>
</apply>
<ci>PKC_tot</ci>
</apply>
<apply>
<times/>
<ci>k_Thr_negative</ci>
<ci>eNOS_Cav_0</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="NO_production">
<variable name="time" public_interface="in" units="second"/>
<variable initial_value="0.0089" name="NO_EC" public_interface="out" units="uM"/>
<variable initial_value="382" name="lambda_NO" public_interface="out" units="per_sec"/>
<variable name="Q_NO" public_interface="out" units="uM_per_sec"/>
<variable initial_value="5" name="O2" public_interface="out" units="uM"/>
<variable initial_value="23.2" name="k_mNO" public_interface="out" units="uM"/>
<variable name="eNOS_CaM" public_interface="in" units="uM"/>
<variable name="eNOS_CaM_star" public_interface="in" units="uM"/>
<variable initial_value="9" name="Phi" public_interface="out" units="dimensionless"/>
<variable name="Q_sGC" public_interface="out" units="uM_per_sec"/>
<variable initial_value="0.1" name="sGC" public_interface="out" units="uM"/>
<variable initial_value="0.022" name="R_NO_max" public_interface="out" units="per_sec"/>
<variable initial_value="0.00120016" name="a_0" public_interface="out" units="uM2"/>
<variable initial_value="0.03733" name="a_1" public_interface="out" units="uM"/>
<variable initial_value="5.99" name="cGMP_EC" public_interface="out" units="uM"/>
<variable initial_value="1.26" name="v_cGMP_max" public_interface="out" units="uM_per_sec"/>
<variable initial_value="4.8e-06" name="g_0" public_interface="out" units="uM2"/>
<variable initial_value="0.03533" name="g_1" public_interface="out" units="uM"/>
<variable initial_value="0.0695" name="X" public_interface="out" units="per_sec"/>
<variable initial_value="2" name="k_cGMP" public_interface="out" units="uM"/>
<variable initial_value="300" name="r" public_interface="out" units="per_sec"/>
<variable initial_value="1" name="b_0" public_interface="out" units="dimensionless"/>
<variable initial_value="0.01515" name="b_1" public_interface="out" units="uM"/>
<variable name="J_dif" public_interface="in" units="uM_per_sec"/>
<variable name="n_EC" public_interface="in" units="dimensionless"/>
<variable name="All_NO" public_interface="out" units="uM_per_sec"/>
<variable name="NO_d" public_interface="out" units="uM_per_sec"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Q_NO</ci>
<apply>
<times/>
<ci>r</ci>
<apply>
<plus/>
<ci>eNOS_CaM</ci>
<apply>
<times/>
<ci>Phi</ci>
<ci>eNOS_CaM_star</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Q_sGC</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>R_NO_max</ci>
<ci>sGC</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>b_1</ci>
<ci>NO_EC</ci>
</apply>
<apply>
<times/>
<ci>b_0</ci>
<apply>
<power/>
<ci>NO_EC</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>a_0</ci>
<apply>
<times/>
<ci>a_1</ci>
<ci>NO_EC</ci>
</apply>
<apply>
<power/>
<ci>NO_EC</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>NO_EC</ci>
</apply>
<apply>
<times/>
<ci>n_EC</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>Q_NO</ci>
<ci>Q_sGC</ci>
</apply>
<apply>
<times/>
<ci>lambda_NO</ci>
<ci>NO_EC</ci>
</apply>
</apply>
<ci>J_dif</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>All_NO</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>Q_NO</ci>
<ci>Q_sGC</ci>
</apply>
<apply>
<times/>
<ci>lambda_NO</ci>
<ci>NO_EC</ci>
</apply>
</apply>
<ci>J_dif</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>NO_d</ci>
<apply>
<plus/>
<ci>Q_sGC</ci>
<apply>
<times/>
<ci>lambda_NO</ci>
<ci>NO_EC</ci>
</apply>
<ci>J_dif</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>cGMP_EC</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>v_cGMP_max</ci>
<apply>
<plus/>
<ci>g_0</ci>
<apply>
<times/>
<ci>g_1</ci>
<ci>NO_EC</ci>
</apply>
<apply>
<power/>
<ci>NO_EC</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>a_0</ci>
<apply>
<times/>
<ci>a_1</ci>
<ci>NO_EC</ci>
</apply>
<apply>
<power/>
<ci>NO_EC</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>X</ci>
<apply>
<power/>
<ci>cGMP_EC</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<plus/>
<ci>k_cGMP</ci>
<ci>cGMP_EC</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
</model>