Location: Vascular smooth muscle cell model from the Parthimos and Kapela articles @ 9827d3425e96 / Modele_KAPELA.cellml
- Author:
- MarionDospital <marion.dospital@gmail.com>
- Date:
- 2025-03-21 14:53:29+01:00
- Desc:
- modification du modele
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/cc8/rawfile/9827d3425e96c18746ff0ef29a66ea32376b0afd/Modele_KAPELA.cellml
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<divide/>
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<times/>
<apply>
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<plus/>
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<minus/>
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<plus/>
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<divide/>
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<plus/>
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<divide/>
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<variable name="I_NANSC" public_interface="in" units="pA"/>
<variable name="F" public_interface="in" units="coulomb_per_mole"/>
<variable name="vol_i" public_interface="in" units="pL"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<eq/>
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<plus/>
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<times/>
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<times/>
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<minus/>
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<times/>
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<variable name="I_KV" public_interface="in" units="pA"/>
<variable name="I_BKCA" public_interface="in" units="pA"/>
<variable name="I_KNSC" public_interface="in" units="pA"/>
<variable name="I_KATP" public_interface="in" units="pA"/>
<variable name="I_NAK" public_interface="in" units="pA"/>
<variable name="F" public_interface="in" units="coulomb_per_mole"/>
<variable name="vol_i" public_interface="in" units="pL"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<minus/>
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<plus/>
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<divide/>
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<minus/>
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<times/>
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<variable name="I_Cl_totalmembrane" units="pA"/>
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<plus/>
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<eq/>
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<variable name="I_NAKCL_CL" public_interface="out" units="pA"/>
<variable name="I_NAKCL_NA" public_interface="out" units="pA"/>
<variable name="I_NAKCL_K" public_interface="out" units="pA"/>
<variable name="Rnakcl_gmpc" units="dimensionless"/>
<variable initial_value="6.4e-3" name="R_value1" units="mM"/>
<variable name="c_GMP" public_interface="in" units="mM"/>
<variable name="Am" public_interface="in" units="cm2"/>
<variable name="F" public_interface="in" units="coulomb_per_mole"/>
<variable name="R" public_interface="in" units="mJ_per_mol_per_K"/>
<variable name="tempK" public_interface="in" units="kelvin"/>
<variable initial_value="1.79e-8" name="Lnakcl" units="nmol2_per_Jscm2"/>
<variable name="K_o" public_interface="in" units="mM"/>
<variable name="K_i" public_interface="in" units="mM"/>
<variable name="Na_o" public_interface="in" units="mM"/>
<variable name="Na_i" public_interface="in" units="mM"/>
<variable name="Cl_o" public_interface="in" units="mM"/>
<variable name="Cl_i" public_interface="in" units="mM"/>
<variable initial_value="1.0" name="Z_Na" units="dimensionless"/>
<variable initial_value="1.0" name="Z_K" units="dimensionless"/>
<variable name="z_Cl" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Rnakcl_gmpc</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">3.5</cn>
<ci>c_GMP</ci>
</apply>
<apply>
<plus/>
<ci>c_GMP</ci>
<ci>R_value1</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_NAKCL_CL</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="M">1</cn>
</apply>
<cn cellml:units="nM">1</cn>
</apply>
<ci>Rnakcl_gmpc</ci>
<ci>z_Cl</ci>
<ci>Am</ci>
<ci>Lnakcl</ci>
<ci>R</ci>
<ci>F</ci>
<ci>tempK</ci>
<apply>
<ln/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>Na_o</ci>
<ci>K_o</ci>
</apply>
<apply>
<times/>
<ci>Na_i</ci>
<ci>K_i</ci>
</apply>
</apply>
<apply>
<power/>
<apply>
<divide/>
<ci>Cl_o</ci>
<ci>Cl_i</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_NAKCL_NA</ci>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.5</cn>
</apply>
<ci>I_NAKCL_CL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_NAKCL_K</ci>
<ci>I_NAKCL_NA</ci>
</apply>
</math>
</component>
<component name="SOC">
<variable name="I_SOC" public_interface="out" units="pA"/>
<variable name="I_SOC_Ca" public_interface="out" units="pA"/>
<variable name="I_SOC_Na" public_interface="out" units="pA"/>
<variable initial_value="0.0083" name="g_SOC_Ca" units="nS"/>
<variable initial_value="0.0575" name="g_SOC_Na" units="nS"/>
<variable name="P_SOC" public_interface="out" units="dimensionless"/>
<variable name="Vm" public_interface="in" units="mV"/>
<variable name="E_Ca" public_interface="out" units="mV"/>
<variable name="E_Na" public_interface="out" units="mV"/>
<variable name="RT_F" public_interface="in" units="mV"/>
<variable name="z_Ca" public_interface="in" units="dimensionless"/>
<variable initial_value="1.0" name="z_Na" units="dimensionless"/>
<variable name="Na_i" public_interface="in" units="mM"/>
<variable name="Na_o" public_interface="in" units="mM"/>
<variable name="Ca_i" public_interface="in" units="mM"/>
<variable name="Ca_o" public_interface="in" units="mM"/>
<variable name="Ca_u" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_Ca</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>RT_F</ci>
<ci>z_Ca</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ca_o</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_Na</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>RT_F</ci>
<ci>z_Na</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Na_o</ci>
<ci>Na_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_SOC</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Ca_u</ci>
<cn cellml:units="mM">0.1</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_SOC_Na</ci>
<apply>
<times/>
<ci>g_SOC_Na</ci>
<ci>P_SOC</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_SOC_Ca</ci>
<apply>
<times/>
<ci>g_SOC_Ca</ci>
<ci>P_SOC</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_Ca</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_SOC</ci>
<apply>
<plus/>
<ci>I_SOC_Ca</ci>
<ci>I_SOC_Na</ci>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="VOCC">
<component_ref component="Dl_VOCC"/>
<component_ref component="Fl_VOCC"/>
</component_ref>
</group>
<component name="VOCC">
<variable name="Vm" private_interface="out" public_interface="in" units="mV"/>
<variable name="t" private_interface="out" public_interface="in" units="ms"/>
<variable name="I_VOCC" public_interface="out" units="pA"/>
<variable name="Am" public_interface="in" units="cm2"/>
<variable initial_value="1.88e-5" name="P_VOCC" units="cm_per_sec"/>
<variable name="Dl" private_interface="in" units="dimensionless"/>
<variable name="Fl" private_interface="in" units="dimensionless"/>
<variable name="z_Ca" public_interface="in" units="dimensionless"/>
<variable name="F" public_interface="in" units="coulomb_per_mole"/>
<variable name="RT_F" public_interface="in" units="mV"/>
<!-- var tempK: kelvin {pub: in};-->
<variable name="Ca_i" public_interface="in" units="mM"/>
<variable name="Ca_o" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>I_VOCC</ci>
<piecewise>
<piece>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="nM" type="e-notation">1<sep/>6</cn>
<cn cellml:units="mM">1</cn>
</apply>
<ci>Am</ci>
<ci>P_VOCC</ci>
<ci>Dl</ci>
<ci>Fl</ci>
<ci>z_Ca</ci>
<ci>F</ci>
<apply>
<minus/>
<ci>Ca_i</ci>
<ci>Ca_o</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Vm</ci>
<cn cellml:units="mV">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="nM" type="e-notation">1<sep/>6</cn>
<cn cellml:units="mM">1</cn>
</apply>
<ci>Am</ci>
<ci>P_VOCC</ci>
<ci>Dl</ci>
<ci>Fl</ci>
<ci>Vm</ci>
<ci>z_Ca</ci>
<ci>z_Ca</ci>
<ci>F</ci>
</apply>
<ci>RT_F</ci>
</apply>
<apply>
<minus/>
<ci>Ca_o</ci>
<apply>
<times/>
<ci>Ca_i</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>Vm</ci>
<ci>z_Ca</ci>
<ci>z_Ca</ci>
</apply>
<ci>RT_F</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>Vm</ci>
<ci>z_Ca</ci>
</apply>
<ci>RT_F</ci>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="Dl_VOCC">
<variable name="Vm" public_interface="in" units="mV"/>
<variable name="t" public_interface="in" units="ms"/>
<variable initial_value="0.000779" name="Dl" public_interface="out" units="dimensionless"/>
<variable name="Dl_bar" units="dimensionless"/>
<variable name="tau_Dl" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Dl_bar</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn cellml:units="mV">8.3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_Dl</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="ms">2.5</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="mV">40</cn>
</apply>
<cn cellml:units="mV">30</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="ms">1.15</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>Dl</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>Dl_bar</ci>
<ci>Dl</ci>
</apply>
<ci>tau_Dl</ci>
</apply>
</apply>
</math>
</component>
<component name="Fl_VOCC">
<variable name="Vm" public_interface="in" units="mV"/>
<variable name="t" public_interface="in" units="ms"/>
<variable initial_value="0.8713" name="Fl" public_interface="out" units="dimensionless"/>
<variable name="Fl_bar" units="dimensionless"/>
<variable name="tau_Fl" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Fl_bar</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="mV">42</cn>
</apply>
<cn cellml:units="mV">9.1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_Fl</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="ms">65</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="mV">35</cn>
</apply>
<cn cellml:units="mV">25</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="ms">45</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>Fl</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>Fl_bar</ci>
<ci>Fl</ci>
</apply>
<ci>tau_Fl</ci>
</apply>
</apply>
</math>
</component>
<component name="NCX">
<variable name="I_NCX" public_interface="out" units="pA"/>
<variable initial_value="0.487e-3" name="g_NCX" public_interface="out" units="nS"/>
<variable name="R_NCXcGMP" public_interface="out" units="mV"/>
<variable name="Na_i" public_interface="in" units="mM"/>
<variable name="Na_o" public_interface="in" units="mM"/>
<variable name="Ca_o" public_interface="in" units="mM"/>
<variable name="phi_F" public_interface="out" units="dimensionless"/>
<variable name="c_GMP" public_interface="in" units="mM"/>
<variable name="Ca_i" public_interface="in" units="mM"/>
<variable name="phi_R" public_interface="out" units="dimensionless"/>
<variable initial_value="0.0003" name="d_NCX" public_interface="out" units="dimensionless"/>
<variable initial_value="0.45" name="gamma" public_interface="out" units="dimensionless"/>
<variable name="Vm" public_interface="in" units="mV"/>
<variable name="RT_F" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>phi_F</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>gamma</ci>
<ci>Vm</ci>
</apply>
<ci>RT_F</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>phi_R</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>gamma</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>Vm</ci>
</apply>
<ci>RT_F</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>R_NCXcGMP</ci>
<apply>
<plus/>
<cn cellml:units="mV">1</cn>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="mV">0.55</cn>
<ci>c_GMP</ci>
</apply>
<apply>
<plus/>
<ci>c_GMP</ci>
<cn cellml:units="mM" type="e-notation">45<sep/>-3</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_NCX</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>g_NCX</ci>
<ci>R_NCXcGMP</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<power/>
<ci>Na_i</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Ca_o</ci>
<ci>phi_F</ci>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>Na_o</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Ca_i</ci>
<ci>phi_R</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="mM">1</cn>
<cn cellml:units="dimensionless">4</cn>
</apply>
<apply>
<times/>
<ci>d_NCX</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<power/>
<ci>Na_o</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Ca_i</ci>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>Na_i</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Ca_o</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="PMCA">
<variable name="I_PMCA" public_interface="out" units="pA"/>
<variable initial_value="5.37" name="I_PMCA_bar" public_interface="out" units="pA"/>
<variable name="Ca_i" public_interface="in" units="mM"/>
<variable initial_value="0.170e-3" name="K_mPMCA" public_interface="out" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>I_PMCA</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>I_PMCA_bar</ci>
<ci>Ca_i</ci>
</apply>
<apply>
<plus/>
<ci>Ca_i</ci>
<ci>K_mPMCA</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="NSC">
<variable name="Vm" public_interface="in" units="mV"/>
<variable name="I_NSC" public_interface="out" units="pA"/>
<variable name="I_NANSC" public_interface="out" units="pA"/>
<variable name="I_CANSC" public_interface="out" units="pA"/>
<variable name="I_KNSC" public_interface="out" units="pA"/>
<variable name="Am" public_interface="in" units="cm2"/>
<variable name="DAG" public_interface="in" units="mM"/>
<variable initial_value="3.0e-3" name="Knsc" units="mM"/>
<variable initial_value="0.0244" name="Dnscmin" units="dimensionless"/>
<variable name="Ponsc" public_interface="out" units="dimensionless"/>
<variable initial_value="5.11e-7" name="Pnansc" units="cm_per_sec"/>
<variable name="Na_i" public_interface="in" units="mM"/>
<variable name="Na_o" public_interface="in" units="mM"/>
<variable name="F" public_interface="in" units="coulomb_per_mole"/>
<variable name="RT_F" public_interface="in" units="mV"/>
<variable name="Pknsc" public_interface="out" units="cm_per_sec"/>
<variable name="K_i" public_interface="in" units="mM"/>
<variable name="K_o" public_interface="in" units="mM"/>
<variable name="z_Ca" public_interface="in" units="dimensionless"/>
<variable name="Pcansc" public_interface="out" units="cm_per_sec"/>
<variable name="Ca_o" public_interface="in" units="mM"/>
<variable name="Ca_i" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Ponsc</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">0.43</cn>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.57</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>Vm</ci>
<cn cellml:units="mV">47.12</cn>
</apply>
</apply>
<cn cellml:units="mV">24.24</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Pknsc</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">1.06</cn>
<ci>Pnansc</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Pcansc</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">4.54</cn>
<ci>Pnansc</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_NANSC</ci>
<piecewise>
<piece>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="nM" type="e-notation">1<sep/>6</cn>
<cn cellml:units="mM">1</cn>
</apply>
<ci>Am</ci>
<apply>
<plus/>
<apply>
<divide/>
<ci>DAG</ci>
<apply>
<plus/>
<ci>DAG</ci>
<ci>Knsc</ci>
</apply>
</apply>
<ci>Dnscmin</ci>
</apply>
<ci>Ponsc</ci>
<ci>Pnansc</ci>
<ci>F</ci>
<apply>
<minus/>
<ci>Na_i</ci>
<ci>Na_o</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Vm</ci>
<cn cellml:units="mV">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="nM" type="e-notation">1<sep/>6</cn>
<cn cellml:units="mM">1</cn>
</apply>
<ci>Am</ci>
<apply>
<plus/>
<apply>
<divide/>
<ci>DAG</ci>
<apply>
<plus/>
<ci>DAG</ci>
<ci>Knsc</ci>
</apply>
</apply>
<ci>Dnscmin</ci>
</apply>
<ci>Ponsc</ci>
<ci>Pnansc</ci>
<ci>Vm</ci>
<ci>F</ci>
</apply>
<ci>RT_F</ci>
</apply>
<apply>
<minus/>
<ci>Na_o</ci>
<apply>
<times/>
<ci>Na_i</ci>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<ci>RT_F</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<ci>RT_F</ci>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>I_KNSC</ci>
<piecewise>
<piece>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="nM" type="e-notation">1<sep/>6</cn>
<cn cellml:units="mM">1</cn>
</apply>
<ci>Am</ci>
<apply>
<plus/>
<apply>
<divide/>
<ci>DAG</ci>
<apply>
<plus/>
<ci>DAG</ci>
<ci>Knsc</ci>
</apply>
</apply>
<ci>Dnscmin</ci>
</apply>
<ci>Ponsc</ci>
<ci>Pknsc</ci>
<ci>F</ci>
<apply>
<minus/>
<ci>K_i</ci>
<ci>K_o</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Vm</ci>
<cn cellml:units="mV">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="nM" type="e-notation">1<sep/>6</cn>
<cn cellml:units="mM">1</cn>
</apply>
<ci>Am</ci>
<apply>
<plus/>
<apply>
<divide/>
<ci>DAG</ci>
<apply>
<plus/>
<ci>DAG</ci>
<ci>Knsc</ci>
</apply>
</apply>
<ci>Dnscmin</ci>
</apply>
<ci>Ponsc</ci>
<ci>Pknsc</ci>
<ci>Vm</ci>
<ci>F</ci>
</apply>
<ci>RT_F</ci>
</apply>
<apply>
<minus/>
<ci>K_o</ci>
<apply>
<times/>
<ci>K_i</ci>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<ci>RT_F</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<ci>RT_F</ci>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>I_CANSC</ci>
<piecewise>
<piece>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="nM" type="e-notation">1<sep/>6</cn>
<cn cellml:units="mM">1</cn>
</apply>
<ci>Am</ci>
<ci>Dnscmin</ci>
<ci>Ponsc</ci>
<ci>Pcansc</ci>
<ci>z_Ca</ci>
<ci>F</ci>
<apply>
<minus/>
<ci>Ca_i</ci>
<ci>Ca_o</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Vm</ci>
<cn cellml:units="mV">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="nM" type="e-notation">1<sep/>6</cn>
<cn cellml:units="mM">1</cn>
</apply>
<ci>Am</ci>
<ci>Dnscmin</ci>
<ci>Ponsc</ci>
<ci>Pcansc</ci>
<ci>Vm</ci>
<ci>z_Ca</ci>
<ci>z_Ca</ci>
<ci>F</ci>
</apply>
<ci>RT_F</ci>
</apply>
<apply>
<minus/>
<ci>Ca_o</ci>
<apply>
<times/>
<ci>Ca_i</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>z_Ca</ci>
<ci>Vm</ci>
</apply>
<ci>RT_F</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>z_Ca</ci>
<ci>Vm</ci>
</apply>
<ci>RT_F</ci>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>I_NSC</ci>
<apply>
<plus/>
<ci>I_NANSC</ci>
<ci>I_KNSC</ci>
<ci>I_CANSC</ci>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="KV">
<component_ref component="Q_KV"/>
<component_ref component="PK_KV"/>
</component_ref>
</group>
<component name="KV">
<variable name="Vm" private_interface="out" public_interface="in" units="mV"/>
<variable name="t" private_interface="out" public_interface="in" units="ms"/>
<variable name="I_KV" public_interface="out" units="pA"/>
<variable initial_value="1.35" name="Gkv" units="nS"/>
<variable name="Pk" private_interface="in" units="dimensionless"/>
<variable name="Q1" private_interface="in" units="dimensionless"/>
<variable name="Q2" private_interface="in" units="dimensionless"/>
<variable name="Ek" public_interface="out" units="mV"/>
<variable name="RT_F" public_interface="in" units="mV"/>
<variable initial_value="1.0" name="Z_k" units="dimensionless"/>
<variable name="K_i" public_interface="in" units="mM"/>
<variable name="K_o" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Ek</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>RT_F</ci>
<ci>Z_k</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>K_o</ci>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_KV</ci>
<apply>
<times/>
<ci>Gkv</ci>
<ci>Pk</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.45</cn>
<ci>Q1</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.55</cn>
<ci>Q2</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>Vm</ci>
<ci>Ek</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Q_KV">
<variable name="Vm" public_interface="in" units="mV"/>
<variable name="t" public_interface="in" units="ms"/>
<variable initial_value="0.7999" name="Q1" public_interface="out" units="dimensionless"/>
<variable initial_value="371.0" name="tau_Q1" units="ms"/>
<variable initial_value="0.7999" name="Q2" public_interface="out" units="dimensionless"/>
<variable initial_value="2884.0" name="tau_Q2" units="ms"/>
<variable name="Q_bar" public_interface="out" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Q_bar</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="mV">40</cn>
</apply>
<cn cellml:units="mV">14</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>Q1</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>Q_bar</ci>
<ci>Q1</ci>
</apply>
<ci>tau_Q1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>Q2</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>Q_bar</ci>
<ci>Q2</ci>
</apply>
<ci>tau_Q2</ci>
</apply>
</apply>
</math>
</component>
<component name="PK_KV">
<variable name="Vm" public_interface="in" units="mV"/>
<variable name="t" public_interface="in" units="ms"/>
<!-- 0.04556-->
<variable initial_value="0.03817" name="Pk" public_interface="out" units="dimensionless"/>
<variable name="Pk_bar" public_interface="out" units="dimensionless"/>
<variable name="tau_Pk" public_interface="out" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Pk_bar</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="mV">11</cn>
</apply>
</apply>
<cn cellml:units="mV">15</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_Pk</ci>
<apply>
<times/>
<cn cellml:units="ms">61.5</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.027</cn>
</apply>
<ci>Vm</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>Pk</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>Pk_bar</ci>
<ci>Pk</ci>
</apply>
<ci>tau_Pk</ci>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="KCA">
<component_ref component="Pf_KCA"/>
<component_ref component="Ps_KCA"/>
<component_ref component="Po_KCA"/>
</component_ref>
</group>
<component name="KCA">
<variable name="Vm" private_interface="out" public_interface="in" units="mV"/>
<variable name="t" private_interface="out" public_interface="in" units="ms"/>
<variable name="Ca_i" private_interface="out" public_interface="in" units="mM"/>
<variable name="I_BKCA" public_interface="out" units="pA"/>
<!-- il y a une formule d'initialisation-->
<variable name="c_GMP" private_interface="out" public_interface="in" units="mM"/>
<variable name="Am" public_interface="in" units="cm2"/>
<!-- channel density-->
<variable initial_value="6.6e6" name="Nbkca" units="per_cm2"/>
<variable initial_value="3.9e-13" name="Pbkca" units="cm3_per_sec"/>
<variable name="Pkca" public_interface="out" units="dimensionless"/>
<variable name="iKCA" public_interface="out" units="pA"/>
<variable name="F" public_interface="in" units="coulomb_per_mole"/>
<variable name="RT_F" public_interface="in" units="mV"/>
<variable name="K_i" public_interface="in" units="mM"/>
<variable name="K_o" public_interface="in" units="mM"/>
<variable name="Pf" private_interface="in" units="dimensionless"/>
<variable name="Ps" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Pkca</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.17</cn>
<ci>Pf</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.83</cn>
<ci>Ps</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>iKCA</ci>
<piecewise>
<piece>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="nM" type="e-notation">1<sep/>6</cn>
<cn cellml:units="mM">1</cn>
</apply>
<ci>Pbkca</ci>
<ci>F</ci>
<apply>
<minus/>
<ci>K_i</ci>
<ci>K_o</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Vm</ci>
<cn cellml:units="mV">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="nM" type="e-notation">1<sep/>6</cn>
<cn cellml:units="mM">1</cn>
</apply>
<ci>Pbkca</ci>
<ci>Vm</ci>
<ci>F</ci>
<apply>
<minus/>
<ci>K_o</ci>
<apply>
<times/>
<ci>K_i</ci>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<ci>RT_F</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>RT_F</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>Vm</ci>
<ci>RT_F</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>I_BKCA</ci>
<apply>
<times/>
<ci>Am</ci>
<ci>Nbkca</ci>
<ci>Pkca</ci>
<ci>iKCA</ci>
</apply>
</apply>
</math>
</component>
<component name="Pf_KCA">
<variable name="Vm" public_interface="in" units="mV"/>
<variable name="t" public_interface="in" units="ms"/>
<variable initial_value="3.16e-3" name="Pf" public_interface="out" units="dimensionless"/>
<variable name="Po_bar" public_interface="in" units="dimensionless"/>
<variable initial_value="0.84" name="tau_Pf" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>Pf</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>Po_bar</ci>
<ci>Pf</ci>
</apply>
<ci>tau_Pf</ci>
</apply>
</apply>
</math>
</component>
<component name="Ps_KCA">
<variable name="Vm" public_interface="in" units="mV"/>
<variable name="t" public_interface="in" units="ms"/>
<variable initial_value="3.16e-3" name="Ps" public_interface="out" units="dimensionless"/>
<variable name="Po_bar" public_interface="in" units="dimensionless"/>
<variable initial_value="35.9" name="tau_Ps" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>Ps</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>Po_bar</ci>
<ci>Ps</ci>
</apply>
<ci>tau_Ps</ci>
</apply>
</apply>
</math>
</component>
<component name="Po_KCA">
<variable name="Vm" public_interface="in" units="mV"/>
<variable name="t" public_interface="in" units="ms"/>
<variable name="Po_bar" public_interface="out" units="dimensionless"/>
<variable initial_value="18.25" name="Po_value" units="mV"/>
<variable name="VdemiKCa" units="mV"/>
<variable name="Ca_i" public_interface="in" units="mM"/>
<variable initial_value="46.3" name="dVdemiKCaNo" units="mV"/>
<variable initial_value="76" name="dVdemiKCacGMP" units="mV"/>
<variable name="Rno" public_interface="out" units="dimensionless"/>
<variable name="Rcgmp" public_interface="out" units="dimensionless"/>
<variable initial_value="0.0" name="NO" units="mM"/>
<variable initial_value="200e-6" name="Rno_value" units="mM"/>
<variable name="c_GMP" public_interface="in" units="mM"/>
<variable initial_value="1.5e-3" name="Rcgmp_value" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>VdemiKCa</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="mV">41.7</cn>
</apply>
<apply>
<log/>
<apply>
<divide/>
<ci>Ca_i</ci>
<cn cellml:units="mM">1</cn>
</apply>
</apply>
</apply>
<cn cellml:units="mV">128.2</cn>
</apply>
<apply>
<times/>
<ci>dVdemiKCaNo</ci>
<ci>Rno</ci>
</apply>
</apply>
<apply>
<times/>
<ci>dVdemiKCacGMP</ci>
<ci>Rcgmp</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Rno</ci>
<apply>
<divide/>
<ci>NO</ci>
<apply>
<plus/>
<ci>NO</ci>
<ci>Rno_value</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Rcgmp</ci>
<apply>
<divide/>
<apply>
<power/>
<ci>c_GMP</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>c_GMP</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<ci>Rcgmp_value</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Po_bar</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>Vm</ci>
<ci>VdemiKCa</ci>
</apply>
</apply>
<ci>Po_value</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="KATP">
<variable name="Vm" public_interface="in" units="mV"/>
<variable name="I_KATP" public_interface="out" units="pA"/>
<variable initial_value="0.067" name="Gk_atp" units="nS"/>
<variable name="Ek" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>I_KATP</ci>
<apply>
<times/>
<ci>Gk_atp</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>Ek</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="CLCA">
<variable name="Vm" public_interface="in" units="mV"/>
<variable name="I_CLCA" public_interface="out" units="pA"/>
<variable name="Cm" public_interface="in" units="pF"/>
<variable initial_value="0.23" name="g_ClCa" units="nS_per_pF"/>
<variable name="P_Cl" public_interface="out" units="dimensionless"/>
<variable name="E_Cl" units="mV"/>
<variable name="z_Cl" public_interface="in" units="dimensionless"/>
<variable name="Cl_o" public_interface="in" units="mM"/>
<variable name="Cl_i" public_interface="in" units="mM"/>
<variable name="RT_F" public_interface="in" units="mV"/>
<variable name="Ca_i" public_interface="in" units="mM"/>
<variable initial_value="2" name="n_ClCa" units="dimensionless"/>
<variable initial_value="0.365e-3" name="K_ClCa" units="mM"/>
<variable name="K_ClCacGMP" public_interface="out" units="mM"/>
<variable name="alpha_Cl" public_interface="out" units="dimensionless"/>
<variable name="c_GMP" public_interface="in" units="mM"/>
<variable initial_value="6.4e-3" name="K_ClcGMP" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_Cl</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>RT_F</ci>
<ci>z_Cl</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Cl_o</ci>
<ci>Cl_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_Cl</ci>
<apply>
<divide/>
<apply>
<power/>
<ci>c_GMP</ci>
<cn cellml:units="dimensionless">3.3</cn>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>c_GMP</ci>
<cn cellml:units="dimensionless">3.3</cn>
</apply>
<apply>
<power/>
<ci>K_ClcGMP</ci>
<cn cellml:units="dimensionless">3.3</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K_ClCacGMP</ci>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.9</cn>
<ci>alpha_Cl</ci>
</apply>
</apply>
<cn cellml:units="mM" type="e-notation">400<sep/>-6</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>P_Cl</ci>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0132</cn>
<apply>
<power/>
<ci>Ca_i</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>Ca_i</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<ci>K_ClCa</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_Cl</ci>
<apply>
<power/>
<ci>Ca_i</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>Ca_i</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<ci>K_ClCacGMP</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_CLCA</ci>
<apply>
<times/>
<ci>Cm</ci>
<ci>g_ClCa</ci>
<ci>P_Cl</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_Cl</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="NAK">
<variable name="Vm" public_interface="in" units="mV"/>
<variable name="I_NAK" public_interface="out" units="pA"/>
<variable name="Cm" public_interface="in" units="pF"/>
<variable initial_value="2.3081" name="I_NaK_bar" units="pA_per_pF"/>
<variable name="Q" public_interface="out" units="dimensionless"/>
<variable name="K_o" public_interface="in" units="mM"/>
<variable initial_value="1.600" name="K_dKo" public_interface="out" units="mM"/>
<variable name="Na_i" public_interface="in" units="mM"/>
<variable initial_value="22.000" name="Na_dNa_i" units="mM"/>
<variable initial_value="1.87" name="Q_10" units="dimensionless"/>
<variable name="tempK" public_interface="in" units="kelvin"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Q</ci>
<apply>
<power/>
<ci>Q_10</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>tempK</ci>
<cn cellml:units="kelvin">309.15</cn>
</apply>
<cn cellml:units="kelvin">10</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_NAK</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>Cm</ci>
<ci>I_NaK_bar</ci>
<ci>Q</ci>
<apply>
<power/>
<ci>K_o</ci>
<cn cellml:units="dimensionless">1.1</cn>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>K_o</ci>
<cn cellml:units="dimensionless">1.1</cn>
</apply>
<apply>
<power/>
<ci>K_dKo</ci>
<cn cellml:units="dimensionless">1.1</cn>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Na_i</ci>
<cn cellml:units="dimensionless">1.7</cn>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>Na_i</ci>
<cn cellml:units="dimensionless">1.7</cn>
</apply>
<apply>
<power/>
<ci>Na_dNa_i</ci>
<cn cellml:units="dimensionless">1.7</cn>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="mV">150</cn>
</apply>
</apply>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="mV">200</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="IP3">
<variable name="t" public_interface="in" units="ms"/>
<variable name="I_IP3" public_interface="out" units="pA"/>
<variable initial_value="2.880e-3" name="IP3_bar" units="per_ms"/>
<variable name="z_Ca" public_interface="in" units="dimensionless"/>
<variable name="vol_Ca" public_interface="in" units="pL"/>
<variable name="F" public_interface="in" units="coulomb_per_mole"/>
<variable initial_value="0.12e-3" name="Kip3" units="mM"/>
<variable name="IP3" public_interface="in" units="mM"/>
<variable name="Ca_i" public_interface="in" units="mM"/>
<variable initial_value="0.17e-3" name="KactIP3" units="mM"/>
<variable name="Ca_u" public_interface="in" units="mM"/>
<variable initial_value="0.5952" name="Hip3" public_interface="out" units="dimensionless"/>
<variable initial_value="0.1e-3" name="KinhIP3" units="mM"/>
<variable initial_value="1.4" name="KonIP3" units="per_mM_per_ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>Hip3</ci>
</apply>
<apply>
<times/>
<ci>KonIP3</ci>
<apply>
<minus/>
<ci>KinhIP3</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>Ca_i</ci>
<ci>KinhIP3</ci>
</apply>
<ci>Hip3</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_IP3</ci>
<apply>
<times/>
<ci>IP3_bar</ci>
<ci>z_Ca</ci>
<ci>vol_Ca</ci>
<ci>F</ci>
<apply>
<power/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>IP3</ci>
<apply>
<plus/>
<ci>IP3</ci>
<ci>Kip3</ci>
</apply>
</apply>
<ci>Ca_i</ci>
</apply>
<apply>
<plus/>
<ci>Ca_i</ci>
<ci>KactIP3</ci>
</apply>
</apply>
<ci>Hip3</ci>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<minus/>
<ci>Ca_u</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ADRENOR_FORMATION_IP3">
<variable name="t" public_interface="in" units="ms"/>
<variable initial_value="0.85" name="epsilon_G" units="dimensionless"/>
<variable initial_value="17000.0" name="R_sG" units="mM"/>
<variable initial_value="2.0e4" name="R_TG" units="mM"/>
<variable initial_value="1.75e-7" name="K_rG" units="per_ms"/>
<variable initial_value="0" name="K_pG" units="per_ms"/>
<variable name="NE" units="mM"/>
<variable initial_value="0.01" name="K_1G" units="mM"/>
<variable initial_value="0.0" name="R_sPG" units="mM"/>
<variable initial_value="6.0e-6" name="K_eG" units="per_ms"/>
<variable initial_value="0.2" name="K_2G" units="mM"/>
<variable initial_value="0.0" name="G" public_interface="out" units="mM"/>
<variable initial_value="0.17e-3" name="K_aG" units="per_ms"/>
<variable name="delta_G" public_interface="out" units="dimensionless"/>
<variable name="rho_G" public_interface="out" units="dimensionless"/>
<variable initial_value="1.0e5" name="G_TG" units="mM"/>
<variable initial_value="1.5e-3" name="K_dG" units="per_ms"/>
<variable name="r_hG" public_interface="out" units="per_ms"/>
<variable initial_value="1.25e-3" name="K_degG" units="per_ms"/>
<variable name="gamma_G" public_interface="out" units="dimensionless"/>
<variable initial_value="PIP2_T" name="PIP2" public_interface="out" units="mM"/>
<variable initial_value="0.0" name="IP3" public_interface="out" units="mM"/>
<variable name="Ca_i" public_interface="in" units="mM"/>
<variable initial_value="2.781e-8" name="alpha_G" units="per_mM_per_ms"/>
<variable initial_value="0.4e-3" name="K_cG" units="mM"/>
<variable initial_value="5.0e7" name="PIP2_T" units="mM"/>
<variable initial_value="0.015e-3" name="r_rG" units="per_ms"/>
<variable initial_value="6.022e23" name="N_AV" units="per_mole"/>
<variable initial_value="1" name="vol_i" public_interface="out" units="pL"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>NE</ci>
<piecewise>
<!-- 1e-3{mM};-->
<piece>
<cn cellml:units="mM">0</cn>
<apply>
<gt/>
<ci>t</ci>
<cn cellml:units="ms">10000</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="mM">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>gamma_G</ci>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="mole">1</cn>
<cn cellml:units="pL" type="e-notation">1<sep/>15</cn>
</apply>
<ci>N_AV</ci>
<ci>vol_i</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>r_hG</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_G</ci>
<ci>Ca_i</ci>
</apply>
<apply>
<plus/>
<ci>Ca_i</ci>
<ci>K_cG</ci>
</apply>
</apply>
<ci>G</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>delta_G</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>K_dG</ci>
<ci>G</ci>
</apply>
<apply>
<times/>
<ci>K_aG</ci>
<apply>
<minus/>
<ci>G_TG</ci>
<ci>G</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>rho_G</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>NE</ci>
<ci>R_sG</ci>
</apply>
<apply>
<times/>
<ci>epsilon_G</ci>
<ci>R_TG</ci>
<apply>
<plus/>
<ci>K_1G</ci>
<ci>NE</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>R_sG</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci>K_rG</ci>
<ci>epsilon_G</ci>
<ci>R_TG</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>K_rG</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>K_pG</ci>
<ci>NE</ci>
</apply>
<apply>
<plus/>
<ci>K_1G</ci>
<ci>NE</ci>
</apply>
</apply>
</apply>
<ci>R_sG</ci>
</apply>
</apply>
<apply>
<times/>
<ci>K_rG</ci>
<ci>R_sPG</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>R_sPG</ci>
</apply>
<apply>
<times/>
<ci>NE</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>K_pG</ci>
<ci>R_sG</ci>
</apply>
<apply>
<plus/>
<ci>K_1G</ci>
<ci>NE</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_eG</ci>
<ci>R_sPG</ci>
</apply>
<apply>
<plus/>
<ci>K_2G</ci>
<ci>NE</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>G</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>K_aG</ci>
<apply>
<plus/>
<ci>delta_G</ci>
<ci>rho_G</ci>
</apply>
<apply>
<minus/>
<ci>G_TG</ci>
<ci>G</ci>
</apply>
</apply>
<apply>
<times/>
<ci>K_dG</ci>
<ci>G</ci>
</apply>
</apply>
</apply>
<!-- DAG = IP3-->
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>IP3</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci>r_hG</ci>
<ci>gamma_G</ci>
</apply>
<ci>PIP2</ci>
</apply>
<apply>
<times/>
<ci>K_degG</ci>
<ci>IP3</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>PIP2</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>r_hG</ci>
<ci>r_rG</ci>
</apply>
</apply>
<ci>PIP2</ci>
</apply>
<apply>
<times/>
<ci>r_rG</ci>
<ci>gamma_G</ci>
<ci>IP3</ci>
</apply>
</apply>
<apply>
<times/>
<ci>r_rG</ci>
<ci>PIP2_T</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="SGC_ACTIVATION_GMPC_FORMATION">
<variable name="t" public_interface="in" units="ms"/>
<variable initial_value="0.0" name="c_GMP" public_interface="out" units="mM"/>
<variable initial_value="0.0" name="V_cGMP" public_interface="out" units="mM_per_ms"/>
<variable initial_value="0.0695e-3" name="K_pdecGMP" units="per_ms"/>
<variable initial_value="1.0e-3" name="Kmpde" units="mM"/>
<variable name="Vbar_cGMP" public_interface="out" units="mM_per_ms"/>
<variable name="tau_sGC" public_interface="out" units="ms"/>
<variable initial_value="1.26e-7" name="V_cGMPmax" units="mM_per_ms"/>
<variable name="A0_sGC" units="mM2"/>
<variable name="A1_sGC" units="mM"/>
<variable name="NO" units="mM"/>
<variable name="B5_sGC" units="mM"/>
<variable initial_value="0.64e-5" name="K_2sGC" units="per_ms"/>
<variable initial_value="0.1e-6" name="K_m2sGC" units="per_ms"/>
<variable initial_value="4.2" name="K_3sGC" units="per_mM_per_ms"/>
<variable initial_value="15.0e-3" name="K_m1sGC" units="per_ms"/>
<variable initial_value="2.0e3" name="K_1sGC" units="per_mM_per_ms"/>
<variable initial_value="0.4e-3" name="K_DsGC" units="per_ms"/>
<variable initial_value="230" name="tau_asGC" units="ms"/>
<variable initial_value="10000.0" name="tau_dsGC" units="ms"/>
<variable initial_value="4.2" name="k3sGC" units="per_mM_per_ms"/>
<variable initial_value="0.1e-3" name="kDact_deactsGC" units="per_ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>NO</ci>
<piecewise>
<piece>
<cn cellml:units="mM">0</cn>
<apply>
<gt/>
<ci>t</ci>
<cn cellml:units="ms">70000</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="mM">0</cn>
</otherwise>
</piecewise>
</apply>
<!--1e-3{mM};-->
<apply>
<eq/>
<ci>B5_sGC</ci>
<apply>
<divide/>
<ci>K_2sGC</ci>
<ci>K_3sGC</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>A0_sGC</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<ci>K_m1sGC</ci>
<ci>K_2sGC</ci>
</apply>
<ci>K_DsGC</ci>
</apply>
<apply>
<times/>
<ci>K_m1sGC</ci>
<ci>K_m2sGC</ci>
</apply>
</apply>
<apply>
<times/>
<ci>K_1sGC</ci>
<ci>K_3sGC</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>A1_sGC</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<ci>K_1sGC</ci>
<ci>K_3sGC</ci>
</apply>
<ci>K_DsGC</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>K_2sGC</ci>
<ci>K_m2sGC</ci>
</apply>
<ci>K_1sGC</ci>
</apply>
</apply>
<apply>
<times/>
<ci>K_1sGC</ci>
<ci>K_3sGC</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Vbar_cGMP</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>V_cGMPmax</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>B5_sGC</ci>
<ci>NO</ci>
</apply>
<apply>
<power/>
<ci>NO</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>A0_sGC</ci>
<apply>
<times/>
<ci>A1_sGC</ci>
<ci>NO</ci>
</apply>
<apply>
<power/>
<ci>NO</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_sGC</ci>
<piecewise>
<piece>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<apply>
<times/>
<ci>k3sGC</ci>
<ci>NO</ci>
</apply>
<ci>kDact_deactsGC</ci>
</apply>
</apply>
<apply>
<geq/>
<apply>
<minus/>
<ci>Vbar_cGMP</ci>
<ci>V_cGMP</ci>
</apply>
<cn cellml:units="mM_per_ms">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>kDact_deactsGC</ci>
<ci>K_2sGC</ci>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>V_cGMP</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vbar_cGMP</ci>
<ci>V_cGMP</ci>
</apply>
<ci>tau_sGC</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>c_GMP</ci>
</apply>
<apply>
<minus/>
<ci>V_cGMP</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>K_pdecGMP</ci>
<apply>
<power/>
<ci>c_GMP</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<plus/>
<ci>c_GMP</ci>
<ci>Kmpde</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="SGC_ACTIVATION_GMPC_FORMATION" component_2="KCA"/>
<map_variables variable_1="c_GMP" variable_2="c_GMP"/>
</connection>
<connection>
<map_components component_1="SGC_ACTIVATION_GMPC_FORMATION" component_2="NAKCL"/>
<map_variables variable_1="c_GMP" variable_2="c_GMP"/>
</connection>
<connection>
<map_components component_1="SGC_ACTIVATION_GMPC_FORMATION" component_2="NCX"/>
<map_variables variable_1="c_GMP" variable_2="c_GMP"/>
</connection>
<connection>
<map_components component_1="SGC_ACTIVATION_GMPC_FORMATION" component_2="CLCA"/>
<map_variables variable_1="c_GMP" variable_2="c_GMP"/>
</connection>
<connection>
<map_components component_1="SGC_ACTIVATION_GMPC_FORMATION" component_2="environment"/>
<map_variables variable_1="t" variable_2="t"/>
</connection>
<connection>
<map_components component_1="ADRENOR_FORMATION_IP3" component_2="environment"/>
<map_variables variable_1="t" variable_2="t"/>
</connection>
<connection>
<map_components component_1="ADRENOR_FORMATION_IP3" component_2="calcium_dynamics"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
</connection>
<connection>
<map_components component_1="ADRENOR_FORMATION_IP3" component_2="IP3"/>
<map_variables variable_1="IP3" variable_2="IP3"/>
</connection>
<connection>
<map_components component_1="ADRENOR_FORMATION_IP3" component_2="NSC"/>
<map_variables variable_1="IP3" variable_2="DAG"/>
</connection>
<connection>
<map_components component_1="potassium_dynamics" component_2="ADRENOR_FORMATION_IP3"/>
<map_variables variable_1="vol_i" variable_2="vol_i"/>
</connection>
<connection>
<map_components component_1="sodium_dynamics" component_2="ADRENOR_FORMATION_IP3"/>
<map_variables variable_1="vol_i" variable_2="vol_i"/>
</connection>
<connection>
<map_components component_1="chlore_dynamics" component_2="ADRENOR_FORMATION_IP3"/>
<map_variables variable_1="vol_i" variable_2="vol_i"/>
</connection>
<connection>
<map_components component_1="RYANODINE" component_2="calcium_dynamics"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="R10" variable_2="R10"/>
</connection>
<connection>
<map_components component_1="RYANODINE" component_2="environment"/>
<map_variables variable_1="t" variable_2="t"/>
</connection>
<connection>
<map_components component_1="chlore_dynamics" component_2="environment"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="chlore_dynamics" component_2="NAKCL"/>
<map_variables variable_1="I_NAKCL_CL" variable_2="I_NAKCL_CL"/>
<map_variables variable_1="z_Cl" variable_2="z_Cl"/>
<map_variables variable_1="Cl_i" variable_2="Cl_i"/>
<map_variables variable_1="Cl_o" variable_2="Cl_o"/>
</connection>
<connection>
<map_components component_1="chlore_dynamics" component_2="CLCA"/>
<map_variables variable_1="I_CLCA" variable_2="I_CLCA"/>
<map_variables variable_1="z_Cl" variable_2="z_Cl"/>
<map_variables variable_1="Cl_i" variable_2="Cl_i"/>
<map_variables variable_1="Cl_o" variable_2="Cl_o"/>
</connection>
<connection>
<map_components component_1="potassium_dynamics" component_2="KV"/>
<map_variables variable_1="I_KV" variable_2="I_KV"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection>
<map_components component_1="potassium_dynamics" component_2="NAKCL"/>
<map_variables variable_1="I_NAKCL_K" variable_2="I_NAKCL_K"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection>
<map_components component_1="potassium_dynamics" component_2="KCA"/>
<map_variables variable_1="I_BKCA" variable_2="I_BKCA"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection>
<map_components component_1="potassium_dynamics" component_2="NSC"/>
<map_variables variable_1="I_KNSC" variable_2="I_KNSC"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection>
<map_components component_1="potassium_dynamics" component_2="KATP"/>
<map_variables variable_1="I_KATP" variable_2="I_KATP"/>
</connection>
<connection>
<map_components component_1="potassium_dynamics" component_2="NAK"/>
<map_variables variable_1="I_NAK" variable_2="I_NAK"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection>
<map_components component_1="potassium_dynamics" component_2="environment"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="sodium_dynamics" component_2="NAK"/>
<map_variables variable_1="I_NAK" variable_2="I_NAK"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
</connection>
<connection>
<map_components component_1="sodium_dynamics" component_2="NCX"/>
<map_variables variable_1="I_NCX" variable_2="I_NCX"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
</connection>
<connection>
<map_components component_1="sodium_dynamics" component_2="NAKCL"/>
<map_variables variable_1="I_NAKCL_NA" variable_2="I_NAKCL_NA"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
</connection>
<connection>
<map_components component_1="sodium_dynamics" component_2="SOC"/>
<map_variables variable_1="I_SOC_Na" variable_2="I_SOC_Na"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
</connection>
<connection>
<map_components component_1="sodium_dynamics" component_2="NSC"/>
<map_variables variable_1="I_NANSC" variable_2="I_NANSC"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
</connection>
<connection>
<map_components component_1="KV" component_2="Q_KV"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="Q1" variable_2="Q1"/>
<map_variables variable_1="Q2" variable_2="Q2"/>
</connection>
<connection>
<map_components component_1="KV" component_2="PK_KV"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="Pk" variable_2="Pk"/>
</connection>
<connection>
<map_components component_1="KV" component_2="environment"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="RT_F" variable_2="RT_F"/>
</connection>
<connection>
<map_components component_1="CLCA" component_2="membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
<map_variables variable_1="I_CLCA" variable_2="I_CLCA"/>
</connection>
<connection>
<map_components component_1="NAK" component_2="membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
<map_variables variable_1="I_NAK" variable_2="I_NAK"/>
</connection>
<connection>
<map_components component_1="CLCA" component_2="calcium_dynamics"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
</connection>
<connection>
<map_components component_1="calcium_dynamics" component_2="environment"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="CLCA" component_2="environment"/>
<map_variables variable_1="RT_F" variable_2="RT_F"/>
</connection>
<connection>
<map_components component_1="NAK" component_2="environment"/>
<map_variables variable_1="tempK" variable_2="tempK"/>
</connection>
<connection>
<map_components component_1="VOCC" component_2="environment"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="RT_F" variable_2="RT_F"/>
</connection>
<connection>
<map_components component_1="SOC" component_2="environment"/>
<map_variables variable_1="RT_F" variable_2="RT_F"/>
</connection>
<connection>
<map_components component_1="NCX" component_2="environment"/>
<map_variables variable_1="RT_F" variable_2="RT_F"/>
</connection>
<connection>
<map_components component_1="NSC" component_2="environment"/>
<map_variables variable_1="RT_F" variable_2="RT_F"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="environment"/>
<map_variables variable_1="t" variable_2="t"/>
</connection>
<connection>
<map_components component_1="SOC" component_2="membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="I_SOC" variable_2="I_SOC"/>
</connection>
<connection>
<map_components component_1="KV" component_2="membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="I_KV" variable_2="I_KV"/>
</connection>
<connection>
<map_components component_1="NAKCL" component_2="membrane"/>
<map_variables variable_1="Am" variable_2="Am"/>
</connection>
<connection>
<map_components component_1="NAKCL" component_2="environment"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="tempK" variable_2="tempK"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="R" variable_2="R"/>
</connection>
<connection>
<map_components component_1="VOCC" component_2="membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="Am" variable_2="Am"/>
<map_variables variable_1="I_VOCC" variable_2="I_VOCC"/>
</connection>
<connection>
<map_components component_1="NSC" component_2="membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="Am" variable_2="Am"/>
<map_variables variable_1="I_NSC" variable_2="I_NSC"/>
</connection>
<connection>
<map_components component_1="NSC" component_2="calcium_dynamics"/>
<map_variables variable_1="I_CANSC" variable_2="I_CANSC"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="z_Ca" variable_2="z_Ca"/>
</connection>
<connection>
<map_components component_1="PMCA" component_2="membrane"/>
<map_variables variable_1="I_PMCA" variable_2="I_PMCA"/>
</connection>
<connection>
<map_components component_1="PMCA" component_2="calcium_dynamics"/>
<map_variables variable_1="I_PMCA" variable_2="I_PMCA"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
</connection>
<connection>
<map_components component_1="KATP" component_2="membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="I_KATP" variable_2="I_KATP"/>
</connection>
<connection>
<map_components component_1="KATP" component_2="KV"/>
<map_variables variable_1="Ek" variable_2="Ek"/>
</connection>
<connection>
<map_components component_1="IP3" component_2="calcium_dynamics"/>
<map_variables variable_1="I_IP3" variable_2="I_IP3"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Ca_u" variable_2="Ca_u"/>
<map_variables variable_1="z_Ca" variable_2="z_Ca"/>
<map_variables variable_1="vol_Ca" variable_2="vol_Ca"/>
</connection>
<connection>
<map_components component_1="IP3" component_2="environment"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="NCX" component_2="membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="I_NCX" variable_2="I_NCX"/>
</connection>
<connection>
<map_components component_1="calcium_dynamics" component_2="SOC"/>
<map_variables variable_1="I_SOC_Ca" variable_2="I_SOC_Ca"/>
<map_variables variable_1="Ca_u" variable_2="Ca_u"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
<map_variables variable_1="z_Ca" variable_2="z_Ca"/>
</connection>
<connection>
<map_components component_1="calcium_dynamics" component_2="VOCC"/>
<map_variables variable_1="I_VOCC" variable_2="I_VOCC"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="z_Ca" variable_2="z_Ca"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
</connection>
<connection>
<map_components component_1="calcium_dynamics" component_2="NCX"/>
<map_variables variable_1="I_NCX" variable_2="I_NCX"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
</connection>
<connection>
<map_components component_1="Dl_VOCC" component_2="VOCC"/>
<map_variables variable_1="Dl" variable_2="Dl"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="Fl_VOCC" component_2="VOCC"/>
<map_variables variable_1="Fl" variable_2="Fl"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="KCA" component_2="Pf_KCA"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="Pf" variable_2="Pf"/>
</connection>
<connection>
<map_components component_1="KCA" component_2="Ps_KCA"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="Ps" variable_2="Ps"/>
</connection>
<connection>
<map_components component_1="KCA" component_2="Po_KCA"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="c_GMP" variable_2="c_GMP"/>
</connection>
<connection>
<map_components component_1="Ps_KCA" component_2="Po_KCA"/>
<map_variables variable_1="Po_bar" variable_2="Po_bar"/>
</connection>
<connection>
<map_components component_1="calcium_dynamics" component_2="KCA"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
</connection>
<connection>
<map_components component_1="Pf_KCA" component_2="Po_KCA"/>
<map_variables variable_1="Po_bar" variable_2="Po_bar"/>
</connection>
<connection>
<map_components component_1="KCA" component_2="membrane"/>
<map_variables variable_1="I_BKCA" variable_2="I_BKCA"/>
<map_variables variable_1="Am" variable_2="Am"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="KCA" component_2="environment"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="RT_F" variable_2="RT_F"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="sodium_dynamics" component_2="environment"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
</model>