- Author:
- Shelley Fong <sfon036@UoA.auckland.ac.nz>
- Date:
- 2025-03-25 13:32:57+13:00
- Desc:
- fixes
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/cd4/rawfile/c56ddacadeb1f722c559abd95bbbb35ee9710340/README.rst
ATPase pumps: NKE
======================================================================================
Sodium potassium exchanger
This transporter allows entry of two potassium ion in exchange for the extrusion of three sodium ions from the cell, at the expense of ATP being hydrolysed to release energy for the process. The bond-graph model is illustrated in the figure below, with the CellML model added for simulation purposes.
.. figure:: NKE_BG_simplification.png
:width: 95%
:align: center
:alt: Schematic and bond graph of the model
The bond graph representation of the four state NKE model, showing simplification of the full bond graph into the reduced form.
.. figure:: NKE_BG_diagram_6state.png
:width: 60%
:align: center
:alt: 6 state bond graph of the model
The bond graph representation of the six state NKE model.
After clicking the CellML file, the **Views Available** menu to the right provides various options to explore this model here in the Physiome Model Repository.
Of particular interest is the *Launch with OpenCOR* menu item, which will load the simulation experiment shown below directly into the `OpenCOR`_ desktop application.
.. figure:: results_4state.png
:width: 95%
:align: center
:alt: OpenCOR showing simulation experiment 4 state.
Showing the result of launching the four state model simulation experiment from this exposure in OpenCOR and executing the simulation.
.. figure:: results_6state.png
:width: 95%
:align: center
:alt: OpenCOR showing simulation experiment 6 state.
Showing the result of launching the six state model simulation experiment.
.. _CellML: https://www.cellml.org/
.. _OpenCOR: https://opencor.ws/
.. _SED-ML: https://sed-ml.org
