Location: Exp 5_Agonist_effect_Coupled_Model @ 6912218ddc1d / NO_cGMP_Signalling_SMC.cellml
- Author:
- Fariba <fbir042@aucklanduni.ac.nz>
- Date:
- 2025-03-26 10:34:48+13:00
- Desc:
- initial commit
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/cdc/rawfile/6912218ddc1df744177bd8aaeeba8ecaee892d73/NO_cGMP_Signalling_SMC.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="Yang_2005" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#">
<component name="sGC_SMC">
<variable name="Eb" public_interface="out" units="dimensionless"/>
<variable initial_value="0" name="E6c" public_interface="out" units="dimensionless"/>
<variable initial_value="0" name="E5c" public_interface="out" units="dimensionless"/>
<variable initial_value="0" name="NO_SMC" public_interface="out" units="uM"/>
<variable initial_value="2000" name="h_one" units="per_uM_per_sec"/>
<variable initial_value="100" name="hm1" units="per_sec"/>
<variable initial_value="0.1" name="h_two" units="per_sec"/>
<variable initial_value="3" name="h_three" units="per_uM_per_sec"/>
<variable name="h_four" public_interface="out" units="per_sec"/>
<variable initial_value="0" name="cGMP_SMC" public_interface="out" units="uM"/>
<variable name="vd" public_interface="out" units="uM_per_sec"/>
<variable name="vp" public_interface="out" units="uM_per_sec"/>
<variable initial_value="0.8520" name="Vm_sgc" units="uM_per_sec"/>
<variable initial_value="2.0" name="Km_pde" units="uM"/>
<variable initial_value="0.0195" name="K_pde" units="per_sec"/>
<variable initial_value="0.01" name="k_dno" public_interface="out" units="per_sec"/>
<variable initial_value="0.003" name="J_no" public_interface="out" units="uM_per_sec"/>
<variable initial_value="2" name="m" units="dimensionless"/>
<variable initial_value="0.011" name="H_four" units="per_sec"/>
<variable name="time" public_interface="in" units="second"/>
<variable initial_value="0.0086" name="k_mlcpb" public_interface="out" units="per_sec"/>
<variable initial_value="0.0327" name="k_mlcpc" public_interface="out" units="per_sec"/>
<variable initial_value="5.5" name="k_mlcpm" public_interface="out" units="uM"/>
<variable initial_value="2" name="n_mlcph" public_interface="out" units="dimensionless"/>
<variable name="k2y" public_interface="out" units="per_sec"/>
<!-- k2y=k_mlcp in Yang et al. (2005)-->
<variable name="J_dif" public_interface="in" units="uM_per_sec"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>E6c</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci>h_one</ci>
<ci>Eb</ci>
<ci>NO_SMC</ci>
</apply>
<apply>
<times/>
<ci>hm1</ci>
<ci>E6c</ci>
</apply>
</apply>
<apply>
<times/>
<ci>h_two</ci>
<ci>E6c</ci>
</apply>
</apply>
<apply>
<times/>
<ci>h_three</ci>
<ci>E6c</ci>
<ci>NO_SMC</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>E5c</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>h_three</ci>
<ci>E6c</ci>
<ci>NO_SMC</ci>
</apply>
<apply>
<times/>
<ci>h_two</ci>
<ci>E6c</ci>
</apply>
</apply>
<apply>
<times/>
<ci>h_four</ci>
<ci>E5c</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Eb</ci>
<apply>
<minus/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>E5c</ci>
</apply>
<ci>E6c</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>cGMP_SMC</ci>
</apply>
<apply>
<minus/>
<ci>vp</ci>
<ci>vd</ci>
</apply>
</apply>
<!-- ode(NO_SMC, time) = J_dif-k_dno*NO_SMC;-->
<apply>
<eq/>
<ci>vp</ci>
<apply>
<times/>
<ci>Vm_sgc</ci>
<ci>E5c</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>vd</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<power/>
<ci>cGMP_SMC</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>K_pde</ci>
</apply>
<apply>
<plus/>
<ci>Km_pde</ci>
<ci>cGMP_SMC</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>h_four</ci>
<apply>
<times/>
<ci>H_four</ci>
<apply>
<power/>
<apply>
<times/>
<ci>cGMP_SMC</ci>
<cn cellml:units="per_uM">1</cn>
</apply>
<ci>m</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k2y</ci>
<apply>
<plus/>
<ci>k_mlcpb</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>k_mlcpc</ci>
<apply>
<power/>
<apply>
<times/>
<ci>cGMP_SMC</ci>
<cn cellml:units="per_uM">1</cn>
</apply>
<ci>n_mlcph</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<apply>
<times/>
<ci>cGMP_SMC</ci>
<cn cellml:units="per_uM">1</cn>
</apply>
<ci>n_mlcph</ci>
</apply>
<apply>
<power/>
<apply>
<times/>
<ci>k_mlcpm</ci>
<cn cellml:units="per_uM">1</cn>
</apply>
<ci>n_mlcph</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
</model>