Modelling the Morphogenesis Checkpoint in the Budding Yeast Cell Cycle
Catherine
Lloyd
Auckland Bioengineering Institute, The University of Auckland
Model Status
This CellML version of the model has been checked in COR and OpenCell and the model runs to replicate the results in the original published paper. The model was checked against the XPP code as there is an inconsistency between the code and the published equation for the variable 'PSwe1'. The units have been checked and they are consistent.
Model Structure
ABSTRACT: The morphogenesis checkpoint in budding yeast delays progression through the cell cycle in response to stimuli that prevent bud formation. Central to the checkpoint mechanism is Swe1 kinase: normally inactive, its activation halts cell cycle progression in G2. We propose a molecular network for Swe1 control, based on published observations of budding yeast and analogous control signals in fission yeast. The proposed Swe1 network is merged with a model of cyclin-dependent kinase regulation, converted into a set of differential equations and studied by numerical simulation. The simulations accurately reproduce the phenotypes of a dozen checkpoint mutants. Among other predictions, the model attributes a new role to Hsl1, a kinase known to play a role in Swe1 degradation: Hsl1 must also be indirectly responsible for potent inhibition of Swe1 activity. The model supports the idea that the morphogenesis checkpoint, like other checkpoints, raises the cell size threshold for progression from one phase of the cell cycle to the next.
The original paper reference is cited below:
Mathematical model of the morphogenesis checkpoint in budding yeast, Andrea Ciliberto, Bela Novak, and John J. Tyson, 2003,
The Journal of Cell Biology
, 163, 1243-1254. PubMed ID: 14691135
reaction diagram1
A schematic diagram of the molecular mechanisms underlying the regulation of the cell cycle in budding yeast.
reaction diagram2
A schematic diagram of the Swe1 box - a process which is central to the morphogenesis checkpoint in budding yeast.
Mathematical Model of the Morphogenesis Checkpoint in Budding Yeast
163
1243
1254
John
Tyson
J
The University of Auckland
Auckland Bioengineering Institute
Some variable names were modified to distinguish between the normal and the active form of several proteins. Initial conditions were made dimensionless in order to balance units. The equation for PSwe1 was corrected to match the XPP code instead of the published report, in order to reproduce the published graphs.
The Journal Of Cell Biology
2009-02-18T12:25:53+13:00
Added cmeta id's to several variables
2004-01-05T00:00:00+00:00
Jeelean Lim
150
Andrea
Ciliberto
This is the CellML description of Ciliberto et al.'s 2003 mathematical model of the morphogenesis checkpoint in the budding yeast cell cycle.
Ciliberto et al.'s 2003 mathematical model of the morphogenesis
checkpoint in the budding yeast cell cycle.
keyword
morphogenesis
cell cycle
Saccharomyces cerevisiae
The University of Auckland, Auckland Bioengineering Institute
This CellML version of the model has been checked in COR and PCEnv and the model runs to replicate the results in the original published paper. The units have been checked and are consistent. The model was checked against the XPP code as there is an inconsistency between the code and the published equation for the variable 'PSwe1'.
14691135
Catherine Lloyd
Bela
Novak
c.lloyd@auckland.ac.nz
Jeelean
Lim
2008-12-15T11:28:11+13:00
Jeelean
Lim
Catherine
Lloyd
May
keyword
cell cycle
2003-12-22