- Author:
- mtcooling <mtcooling.development@gmail.com>
- Date:
- 2015-08-24 10:57:56+12:00
- Desc:
- Split the annotation for the protocols into separate files in line with the metadata spec 2.0
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/cooling_hunter_crampin_2009/rawfile/e4e4bc1366292fd3387f8391e774271f5a4e9c14/NFATCycling_ShenProtocol.cellml
<?xml version="1.0" encoding="iso-8859-1"?>
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name="NFATCycling"
cmeta:id="NFATCycling"
xmlns="http://www.cellml.org/cellml/1.1#"
xmlns:cellml="http://www.cellml.org/cellml/1.1#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
>
<!--
*******************************************************
*** U N I T S ***
*******************************************************
-->
<units name="s">
<unit units="second"/>
</units>
<units name="nM">
<unit units="mole" prefix="nano"/>
<unit units="liter" exponent="-1"/>
</units>
<units name="per_s">
<unit units="s" exponent="-1"/>
</units>
<units name="nM_per_s">
<unit units="nM"/>
<unit units="s" exponent="-1"/>
</units>
<units name="per_nM_s">
<unit units="nM" exponent="-1"/>
<unit units="s" exponent="-1"/>
</units>
<!--
*********************************************************
*** C O M P O N E N T S ***
*********************************************************
-->
<component name="NFAT_Cycling">
<variable cmeta:id="v0" name="J1" units="nM_per_s"/>
<variable cmeta:id="v1" name="J2" units="nM_per_s"/>
<variable cmeta:id="v2" name="J3" units="nM_per_s"/>
<variable cmeta:id="v3" name="J4" units="nM_per_s"/>
<variable cmeta:id="v4" name="k_f1" units="per_nM_s" initial_value="7.68934e-6"/>
<variable cmeta:id="v5" name="k_f2" units="per_s" initial_value="0.00144192"/>
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<variable cmeta:id="v9" name="k_r3" units="per_nM_s" initial_value="4.70813e-5"/>
<variable cmeta:id="v10" name="NFATp_n" units="nM" initial_value="0.27638027" public_interface="out"/>
<variable cmeta:id="v11" name="NFATp_c" units="nM" initial_value="0.9825855442"/>
<variable cmeta:id="v12" name="NFATN_n" units="nM" initial_value="0.50910553" public_interface="out"/>
<variable cmeta:id="v13" name="NFATN_c" units="nM" initial_value="0.0017047398"/>
<variable cmeta:id="v14" name="act_N" units="dimensionless" public_interface="in"/>
<variable cmeta:id="v15" name="Ntot" units="nM" public_interface="in"/>
<variable cmeta:id="v16" name="Ccn" units="dimensionless" public_interface="in"/>
<variable cmeta:id="v17" name="t" units="s" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J1</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>k_f1</ci>
<ci>NFATp_c</ci>
<ci>Ntot</ci>
<ci>act_N</ci>
</apply>
<apply>
<times/>
<ci>k_r1</ci>
<ci>NFATN_c</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>act_N</ci>
</apply>
</apply>
</apply>
</apply>
<apply id="eq_0">
<eq/>
<ci>J2</ci>
<apply>
<times/>
<ci>k_f2</ci>
<ci>NFATN_c</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J3</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>k_f3</ci>
<ci>NFATN_n</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>act_N</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k_r3</ci>
<ci>NFATp_n</ci>
<ci>Ntot</ci>
<ci>act_N</ci>
</apply>
</apply>
</apply>
<apply id="eq_1">
<eq/>
<ci>J4</ci>
<apply>
<times/>
<ci>k_f4</ci>
<ci>NFATp_n</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>NFATp_c</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<ci>J4</ci>
<ci>Ccn</ci>
</apply>
<ci>J1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
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</bvar>
<ci>NFATN_c</ci>
</apply>
<apply>
<minus/>
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<ci>J2</ci>
</apply>
</apply>
<apply>
<eq/>
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</bvar>
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<apply>
<minus/>
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<times/>
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<ci>Ccn</ci>
</apply>
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</apply>
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<apply>
<eq/>
<apply>
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<ci>NFATp_n</ci>
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