- Author:
- Catherine Lloyd <c.lloyd@auckland.ac.nz>
- Date:
- 2010-04-22 12:07:23+12:00
- Desc:
- Renamed filename extensions from .cellML to .cellml in the index.html file and in the import references.
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/cooling_hunter_crampin_CellML_2008/rawfile/b685dbf5397904b58aff4caa68cf2e75e90c6c18/GPCR_Cycle.cellml
<?xml version="1.0" encoding="iso-8859-1"?>
<model
name="GPCR_Cycle"
cmeta:id="GPCR_Cycle"
xmlns="http://www.cellml.org/cellml/1.1#"
xmlns:cellml="http://www.cellml.org/cellml/1.1#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:RDF
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
xmlns:bqs="http://www.cellml.org/bqs/1.0#"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description rdf:about="#GPCR_Cycle">
<dc:creator rdf:parseType="Resource">
<vCard:N rdf:parseType="Resource">
<vCard:Family>Cooling</vCard:Family>
<vCard:Given>Michael</vCard:Given>
</vCard:N>
<vCard:EMAIL rdf:parseType="Resource">
<rdf:value>m.cooling@auckland.ac.nz</rdf:value>
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet" />
</vCard:EMAIL>
</dc:creator>
<dc:title>Cooling's GPCR_Cycle Module</dc:title>
</rdf:Description>
</rdf:RDF>
<!--
*******************************************************
*** U N I T S ***
*******************************************************
-->
<units name="s">
<unit units="second" />
</units>
<units name="uM">
<unit prefix="micro" units="mole" />
<unit units="liter" exponent="-1" />
</units>
<units name="um2">
<unit prefix="micro" units="meter" exponent="2" />
</units>
<units name="per_um2">
<unit units="um2" exponent="-1" />
</units>
<units name="per_um2_per_s">
<unit units="um2" exponent="-1" />
<unit units="s" exponent="-1" />
</units>
<units name="per_s">
<unit units="s" exponent="-1" />
</units>
<units name="per_uM_per_s">
<unit units="uM" exponent="-1"/>
<unit units="s" exponent="-1" />
</units>
<units name="um2_per_s">
<unit units="um2" />
<unit units="s" exponent="-1" />
</units>
<!--
********************************************************
*** C O M P O N E N T S ***
********************************************************
-->
<component name="GPCR_Cycle">
<variable name="t" private_interface="in" units="s" />
<variable name="L" units="uM" public_interface="in" />
<variable name="Gd" units="per_um2" public_interface="in" />
<variable name="J2" units="per_um2_per_s" public_interface="out"/>
<variable name="J3" units="per_um2_per_s" public_interface="out"/>
<variable name="J6" units="per_um2_per_s" public_interface="out"/>
<variable name="J1" units="per_um2_per_s" />
<variable name="kf1" initial_value="0.0003" units="per_uM_per_s" />
<variable name="kr1" units="per_s" />
<variable name="Kd1" initial_value="3.00E-5" units="uM" />
<variable name="kf2" initial_value="2.75E-4" units="um2_per_s" />
<variable name="kr2" units="per_s" />
<variable name="Kd2" initial_value="27500" units="per_um2" />
<variable name="kf3" initial_value="1.00" units="um2_per_s" />
<variable name="kr3" initial_value="0.00100" units="per_s" />
<variable name="J4" units="per_um2_per_s" />
<variable name="kf4" initial_value="0.3" units="per_uM_per_s" />
<variable name="kr4" units="per_s" />
<variable name="Kd4" initial_value="3.00E-5" units="uM" />
<variable name="J5" units="per_um2_per_s" />
<variable name="kf5" initial_value="0.0004" units="per_s" />
<variable name="kf6" initial_value="1.00" units="per_s" />
<variable name="R" initial_value="13.9" units="per_um2" />
<variable name="Rl" initial_value="0.00" units="per_um2" />
<variable name="Rg" initial_value="5.06" units="per_um2" />
<variable name="Rlg" initial_value="0.00" units="per_um2" />
<variable name="Rlgp" initial_value="0.00" units="per_um2" />
<math xmlns="http://www.w3.org/1998/Math/MathML"
cmeta:id="kr1_eq">
<apply id="kr1_eq">
<eq/> />
<ci>kr1</ci>
<apply>
<times />
<ci>kf1</ci>
<ci>Kd1</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML"
cmeta:id="J1_eq">
<apply id="J1_eq">
<eq/> />
<ci>J1</ci>
<apply>
<minus />
<apply>
<times />
<ci>kf1</ci>
<ci>R</ci>
<ci>L</ci>
</apply>
<apply>
<times />
<ci>kr1</ci>
<ci>Rl</ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML"
cmeta:id="kr2_eq">
<apply id="kr2_eq">
<eq/>
<ci>kr2</ci>
<apply>
<times />
<ci>kf2</ci>
<ci>Kd2</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML"
cmeta:id="J2_eq">
<apply id="J2_eq">
<eq/> />
<ci>J2</ci>
<apply>
<minus />
<apply>
<times />
<ci>kf2</ci>
<ci>R</ci>
<ci>Gd</ci>
</apply>
<apply>
<times />
<ci>kr2</ci>
<ci>Rg</ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML"
cmeta:id="dR_dt_eq">
<apply id="dR_dt_eq">
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>R</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<cn cellml:units="dimensionless">-1.0</cn>
<ci>J1</ci>
</apply>
<ci>J2</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML"
cmeta:id="J3_eq">
<apply id="J3_eq">
<eq/>
<ci>J3</ci>
<apply>
<minus />
<apply>
<times />
<ci>kf3</ci>
<ci>Rl</ci>
<ci>Gd</ci>
</apply>
<apply>
<times />
<ci>kr3</ci>
<ci>Rlg</ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML"
cmeta:id="dRl_dt_eq">
<apply id="dRl_dt_eq">
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>Rl</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<ci>J1</ci>
<ci>J6</ci>
</apply>
<ci>J3</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML"
cmeta:id="kr4_eq">
<apply id="kr4_eq">
<eq/>
<ci>kr4</ci>
<apply>
<times />
<ci>kf4</ci>
<ci>Kd4</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML"
cmeta:id="J4_eq">
<apply id="J4_eq">
<eq/> />
<ci>J4</ci>
<apply>
<minus />
<apply>
<times />
<ci>kf4</ci>
<ci>L</ci>
<ci>Rg</ci>
</apply>
<apply>
<times />
<ci>kr4</ci>
<ci>Rlg</ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML"
cmeta:id="dRg_dt_eq">
<apply id="dRg_dt_eq">
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>Rg</ci>
</apply>
<apply>
<minus />
<ci>J2</ci>
<ci>J4</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML"
cmeta:id="J5_eq">
<apply id="J5_eq">
<eq/>
<ci>J5</ci>
<apply>
<times />
<ci>kf5</ci>
<ci>Rlg</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML"
cmeta:id="dRlgp_dt_eq">
<apply id="dRlgp_dt_eq">
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>Rlgp</ci>
</apply>
<ci>J5</ci>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML"
cmeta:id="J6_eq">
<apply id="J6_eq">
<eq/>
<ci>J6</ci>
<apply>
<times />
<ci>kf6</ci>
<ci>Rlg</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML"
cmeta:id="dRlg_dt_eq">
<apply id="dRlg_dt_eq">
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>Rlg</ci>
</apply>
<apply>
<plus/>
<apply>
<minus />
<ci>J3</ci>
<ci>J5</ci>
</apply>
<apply>
<minus />
<ci>J4</ci>
<ci>J6</ci>
</apply>
</apply>
</apply>
</math>
</component>
</model>
