- Author:
- pmr2.import <nobody@models.cellml.org>
- Date:
- 2008-06-24 21:52:36+12:00
- Desc:
- committing version01 of corrias_buist_2008
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/corrias_buist_2008/rawfile/30a56252f33b3b9a35e2b6dc5a3aa0469073eb90/corrias_buist_2008.cellml
<?xml version='1.0' encoding='utf-8'?>
<model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ns8="http://www.cellml.org/metadata/graphs/1.0#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#" name="ICC_model" cmeta:id="ICC_model">
<units name="conductance_units">
<unit units="siemens" prefix="nano"/>
</units>
<units name="millifarads">
<unit units="farad" prefix="milli"/>
</units>
<units name="voltage_units">
<unit units="volt" prefix="milli"/>
</units>
<units name="volume_units">
<unit units="litre"/>
</units>
<units name="Inverse_Voltage_units">
<unit units="voltage_units" exponent="-1"/>
</units>
<units name="Inverse_Voltage_Units_per_time_units">
<unit units="Inverse_Voltage_units"/>
<unit units="time_units" exponent="-1"/>
</units>
<units name="time_units">
<unit units="second"/>
</units>
<units name="current_units">
<unit units="voltage_units"/>
<unit units="conductance_units"/>
</units>
<units name="rate_constants_units">
<unit units="time_units" exponent="-1"/>
</units>
<units name="capacitance_units">
<unit units="farad" prefix="nano"/>
</units>
<units name="Temperature_units">
<unit units="kelvin"/>
</units>
<units name="Inverse_Temperature_units_times_conductance">
<unit units="Temperature_units" exponent="-1"/>
<unit units="conductance_units"/>
</units>
<units name="F_units">
<unit units="mole" prefix="nano" exponent="-1"/>
<unit units="coulomb" prefix="micro"/>
</units>
<units name="R_units">
<unit units="joule" prefix="nano"/>
<unit units="mole" prefix="nano" exponent="-1"/>
<unit units="kelvin" exponent="-1"/>
</units>
<units name="millimolar">
<unit units="mole" prefix="milli"/>
<unit units="litre" exponent="-1"/>
</units>
<units name="per_millimolar">
<unit units="litre"/>
<unit units="mole" prefix="milli" exponent="-1"/>
</units>
<units name="millimolar_per_second">
<unit units="mole" prefix="milli"/>
<unit units="litre" exponent="-1"/>
<unit units="second" exponent="-1"/>
</units>
<units name="millimolar_per_second_per_millivolt">
<unit units="mole" prefix="milli"/>
<unit units="litre" exponent="-1"/>
<unit units="second" exponent="-1"/>
<unit units="volt" prefix="milli" exponent="-1"/>
</units>
<units name="millimole_to_nanomole">
<unit units="mole" prefix="nano"/>
<unit units="mole" prefix="milli" exponent="-1"/>
</units>
<units name="microcoulomb_to_picocoulomb">
<unit units="coulomb" prefix="pico"/>
<unit units="coulomb" prefix="micro" exponent="-1"/>
</units>
<component name="Time">
<variable units="time_units" public_interface="out" private_interface="out" name="time" cmeta:id="time"/>
</component>
<component name="Environment">
<variable units="Temperature_units" private_interface="out" name="T" initial_value="310"/>
<variable units="Temperature_units" private_interface="out" name="T_exp" initial_value="297"/>
<variable units="F_units" public_interface="out" private_interface="out" name="F" initial_value="96.4846"/>
<variable units="R_units" private_interface="out" name="R" initial_value="8.3144"/>
<variable units="dimensionless" private_interface="out" name="Q10Ca" initial_value="2.1"/>
<variable units="dimensionless" private_interface="out" name="Q10K" initial_value="1.5"/>
<variable units="dimensionless" private_interface="out" name="Q10Na" initial_value="2.45"/>
<variable units="millimolar" public_interface="out" private_interface="out" name="Ca_o" initial_value="2.5"/>
<variable units="millimolar" public_interface="out" private_interface="out" name="Na_o" initial_value="137"/>
<variable units="millimolar" public_interface="out" private_interface="out" name="K_o" initial_value="7"/>
<variable units="millimolar" public_interface="out" private_interface="out" name="Cl_o" initial_value="134"/>
<variable units="dimensionless" public_interface="out" private_interface="out" name="T_correction_Na"/>
<variable units="dimensionless" public_interface="out" private_interface="out" name="T_correction_K"/>
<variable units="dimensionless" public_interface="out" private_interface="out" name="T_correction_Ca"/>
<variable units="conductance_units" public_interface="out" private_interface="out" name="T_correction_BK"/>
<variable units="Inverse_Voltage_units" public_interface="out" private_interface="out" name="FoRT"/>
<variable units="voltage_units" public_interface="out" private_interface="out" name="RToF"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>FoRT</ci>
<apply>
<divide/>
<ci>F</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>RToF</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>T_correction_Ca</ci>
<apply>
<power/>
<ci>Q10Ca</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>T</ci>
<ci>T_exp</ci>
</apply>
<cn cellml:units="Temperature_units">10</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>T_correction_K</ci>
<apply>
<power/>
<ci>Q10K</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>T</ci>
<ci>T_exp</ci>
</apply>
<cn cellml:units="Temperature_units">10</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>T_correction_Na</ci>
<apply>
<power/>
<ci>Q10Na</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>T</ci>
<ci>T_exp</ci>
</apply>
<cn cellml:units="Temperature_units">10</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>T_correction_BK</ci>
<apply>
<times/>
<cn cellml:units="Inverse_Temperature_units_times_conductance">1.1</cn>
<apply>
<minus/>
<ci>T</ci>
<ci>T_exp</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ICC_Membrane">
<variable units="capacitance_units" name="Cm" initial_value="0.025"/>
<variable units="volume_units" public_interface="out" private_interface="out" name="Vol" initial_value="1e-12"/>
<variable units="dimensionless" public_interface="out" private_interface="out" name="P_cyto" initial_value="0.7"/>
<variable units="volume_units" private_interface="out" name="V_cyto"/>
<variable units="dimensionless" private_interface="out" name="fc" initial_value="0.01"/>
<variable units="voltage_units" private_interface="out" name="Vm" cmeta:id="Vm" initial_value="-67"/>
<variable units="time_units" public_interface="in" private_interface="out" name="time"/>
<variable units="millimolar" public_interface="out" private_interface="out" name="Ca_i" initial_value="0.00000993087"/>
<variable units="millimolar" public_interface="out" private_interface="out" name="Na_i" initial_value="30"/>
<variable units="millimolar" private_interface="out" name="K_i" initial_value="120"/>
<variable units="millimolar" private_interface="out" name="Cl_i" initial_value="88"/>
<variable units="millimolar" public_interface="in" private_interface="out" name="Ca_o"/>
<variable units="millimolar" public_interface="in" private_interface="out" name="Na_o"/>
<variable units="millimolar" public_interface="in" private_interface="out" name="K_o"/>
<variable units="millimolar" public_interface="in" private_interface="out" name="Cl_o"/>
<variable units="dimensionless" public_interface="in" private_interface="out" name="T_correction_Ca"/>
<variable units="dimensionless" public_interface="in" private_interface="out" name="T_correction_Na"/>
<variable units="dimensionless" public_interface="in" private_interface="out" name="T_correction_K"/>
<variable units="conductance_units" public_interface="in" private_interface="out" name="T_correction_BK"/>
<variable units="voltage_units" public_interface="in" private_interface="out" name="RToF"/>
<variable units="Inverse_Voltage_units" public_interface="in" private_interface="out" name="FoRT"/>
<variable units="F_units" public_interface="in" private_interface="out" name="F"/>
<variable units="millimolar_per_second" private_interface="in" name="J_leak"/>
<variable units="current_units" private_interface="in" name="I_Na"/>
<variable units="current_units" private_interface="in" name="I_Ltype"/>
<variable units="current_units" private_interface="in" name="I_VDDR"/>
<variable units="current_units" private_interface="in" name="I_kv11"/>
<variable units="current_units" private_interface="in" name="I_BK"/>
<variable units="current_units" private_interface="in" name="I_ERG"/>
<variable units="current_units" private_interface="in" name="I_CaCl"/>
<variable units="current_units" private_interface="in" name="I_NSCC"/>
<variable units="current_units" private_interface="in" name="I_bk"/>
<variable units="millimolar_per_second" private_interface="in" name="J_PMCA"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_cyto</ci>
<apply>
<times/>
<ci>Vol</ci>
<ci>P_cyto</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Vm</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>Cm</ci>
</apply>
<apply>
<plus/>
<ci>I_Na</ci>
<ci>I_Ltype</ci>
<ci>I_VDDR</ci>
<ci>I_kv11</ci>
<ci>I_ERG</ci>
<ci>I_BK</ci>
<ci>I_CaCl</ci>
<ci>I_NSCC</ci>
<ci>I_bk</ci>
<apply>
<times/>
<ci>J_PMCA</ci>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="millimole_to_nanomole">1000000</cn>
<cn cellml:units="microcoulomb_to_picocoulomb">1000000</cn>
<ci>F</ci>
<ci>V_cyto</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_i</ci>
</apply>
<apply>
<times/>
<ci>fc</ci>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>I_Ltype</ci>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>I_VDDR</ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<cn cellml:units="millimole_to_nanomole">1000000</cn>
<cn cellml:units="microcoulomb_to_picocoulomb">1000000</cn>
<ci>F</ci>
<ci>V_cyto</ci>
</apply>
</apply>
<ci>J_leak</ci>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>J_PMCA</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="d_Ltype">
<variable units="voltage_units" public_interface="in" name="Vm"/>
<variable units="dimensionless" name="d_inf_Ltype"/>
<variable units="time_units" name="tau_d_Ltype"/>
<variable units="dimensionless" public_interface="out" name="d_Ltype" initial_value="0"/>
<variable units="time_units" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="T_correction_Ca"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>d_inf_Ltype</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">17</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="voltage_units">4.3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_d_Ltype</ci>
<apply>
<times/>
<ci>T_correction_Ca</ci>
<cn cellml:units="time_units">0.001</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>d_Ltype</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>d_inf_Ltype</ci>
<ci>d_Ltype</ci>
</apply>
<ci>tau_d_Ltype</ci>
</apply>
</apply>
</math>
</component>
<component name="f_Ltype">
<variable units="voltage_units" public_interface="in" name="Vm"/>
<variable units="dimensionless" name="f_inf_Ltype"/>
<variable units="time_units" name="tau_f_Ltype"/>
<variable units="dimensionless" public_interface="out" name="f_Ltype" initial_value="1"/>
<variable units="time_units" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="T_correction_Ca"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>f_inf_Ltype</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">43</cn>
</apply>
<cn cellml:units="voltage_units">8.9</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_f_Ltype</ci>
<apply>
<times/>
<ci>T_correction_Ca</ci>
<cn cellml:units="time_units">0.086</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>f_Ltype</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>f_inf_Ltype</ci>
<ci>f_Ltype</ci>
</apply>
<ci>tau_f_Ltype</ci>
</apply>
</apply>
</math>
</component>
<component name="f_ca_Ltype">
<variable units="millimolar" public_interface="in" name="Ca_i"/>
<variable units="dimensionless" name="f_ca_inf_Ltype"/>
<variable units="time_units" name="tau_f_ca_Ltype"/>
<variable units="dimensionless" public_interface="out" name="f_ca_Ltype" initial_value="1"/>
<variable units="time_units" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="T_correction_Ca"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>f_ca_inf_Ltype</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>Ca_i</ci>
<cn cellml:units="millimolar">0.0001</cn>
</apply>
<cn cellml:units="millimolar">0.000214</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millimolar">0.0000131</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_f_ca_Ltype</ci>
<apply>
<times/>
<ci>T_correction_Ca</ci>
<cn cellml:units="time_units">0.002</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>f_ca_Ltype</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>f_ca_inf_Ltype</ci>
<ci>f_ca_Ltype</ci>
</apply>
<ci>tau_f_ca_Ltype</ci>
</apply>
</apply>
</math>
</component>
<component name="I_Ltype">
<variable units="current_units" public_interface="out" name="I_Ltype"/>
<variable units="voltage_units" name="E_Ca"/>
<variable units="conductance_units" name="G_max_Ltype" initial_value="2"/>
<variable units="voltage_units" public_interface="in" private_interface="out" name="Vm"/>
<variable units="dimensionless" private_interface="in" name="f_Ltype"/>
<variable units="dimensionless" private_interface="in" name="d_Ltype"/>
<variable units="dimensionless" private_interface="in" name="f_ca_Ltype"/>
<variable units="voltage_units" public_interface="in" name="RToF"/>
<variable units="millimolar" public_interface="in" name="Ca_o"/>
<variable units="millimolar" public_interface="in" private_interface="out" name="Ca_i"/>
<variable units="dimensionless" public_interface="in" private_interface="out" name="T_correction_Ca"/>
<variable units="time_units" public_interface="in" private_interface="out" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_Ca</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5</cn>
<ci>RToF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ca_o</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_Ltype</ci>
<apply>
<times/>
<ci>G_max_Ltype</ci>
<ci>f_Ltype</ci>
<ci>d_Ltype</ci>
<ci>f_ca_Ltype</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_Ca</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_PMCA">
<variable units="millimolar_per_second" public_interface="out" name="J_PMCA"/>
<variable units="millimolar_per_second" name="J_max_PMCA" initial_value="0.088464"/>
<variable units="millimolar" public_interface="in" name="Ca_i"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_PMCA</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>J_max_PMCA</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<cn cellml:units="millimolar">0.000298</cn>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="d_VDDR">
<variable units="voltage_units" public_interface="in" name="Vm"/>
<variable units="dimensionless" name="d_inf_VDDR"/>
<variable units="time_units" name="tau_d_VDDR"/>
<variable units="dimensionless" public_interface="out" name="d_VDDR" initial_value="0"/>
<variable units="time_units" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="T_correction_Ca"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>d_inf_VDDR</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">26</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="voltage_units">6</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_d_VDDR</ci>
<apply>
<times/>
<ci>T_correction_Ca</ci>
<cn cellml:units="time_units">0.006</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>d_VDDR</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>d_inf_VDDR</ci>
<ci>d_VDDR</ci>
</apply>
<ci>tau_d_VDDR</ci>
</apply>
</apply>
</math>
</component>
<component name="f_VDDR">
<variable units="voltage_units" public_interface="in" name="Vm"/>
<variable units="dimensionless" name="f_inf_VDDR"/>
<variable units="time_units" name="tau_f_VDDR"/>
<variable units="dimensionless" public_interface="out" name="f_VDDR" initial_value="1"/>
<variable units="time_units" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="T_correction_Ca"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>f_inf_VDDR</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">66</cn>
</apply>
<cn cellml:units="voltage_units">6</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_f_VDDR</ci>
<apply>
<times/>
<ci>T_correction_Ca</ci>
<cn cellml:units="time_units">0.04</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>f_VDDR</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>f_inf_VDDR</ci>
<ci>f_VDDR</ci>
</apply>
<ci>tau_f_VDDR</ci>
</apply>
</apply>
</math>
</component>
<component name="I_VDDR">
<variable units="current_units" public_interface="out" name="I_VDDR"/>
<variable units="voltage_units" name="E_Ca"/>
<variable units="conductance_units" name="G_max_VDDR" initial_value="3"/>
<variable units="voltage_units" public_interface="in" private_interface="out" name="Vm"/>
<variable units="dimensionless" private_interface="in" name="f_VDDR"/>
<variable units="dimensionless" private_interface="in" name="d_VDDR"/>
<variable units="voltage_units" public_interface="in" name="RToF"/>
<variable units="millimolar" public_interface="in" name="Ca_o"/>
<variable units="millimolar" public_interface="in" name="Ca_i"/>
<variable units="dimensionless" public_interface="in" private_interface="out" name="T_correction_Ca"/>
<variable units="time_units" public_interface="in" private_interface="out" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_Ca</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5</cn>
<ci>RToF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ca_o</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_VDDR</ci>
<apply>
<times/>
<ci>G_max_VDDR</ci>
<ci>f_VDDR</ci>
<ci>d_VDDR</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_Ca</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="d_CaCl">
<variable units="millimolar" public_interface="in" name="Ca_i"/>
<variable units="dimensionless" name="d_inf_CaCl"/>
<variable units="time_units" name="tau_d_CaCl" initial_value="0.03"/>
<variable units="dimensionless" public_interface="out" name="d_CaCl" initial_value="0"/>
<variable units="time_units" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>d_inf_CaCl</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<cn cellml:units="millimolar">0.00014</cn>
<ci>Ca_i</ci>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>d_CaCl</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>d_inf_CaCl</ci>
<ci>d_CaCl</ci>
</apply>
<ci>tau_d_CaCl</ci>
</apply>
</apply>
</math>
</component>
<component name="I_CaCl">
<variable units="current_units" public_interface="out" name="I_CaCl"/>
<variable units="millimolar" public_interface="in" private_interface="out" name="Ca_i"/>
<variable units="voltage_units" name="E_Cl"/>
<variable units="conductance_units" name="G_max_CaCl" initial_value="10.1"/>
<variable units="voltage_units" public_interface="in" name="Vm"/>
<variable units="dimensionless" private_interface="in" name="d_CaCl"/>
<variable units="voltage_units" public_interface="in" name="RToF"/>
<variable units="millimolar" public_interface="in" name="Cl_o"/>
<variable units="millimolar" public_interface="in" name="Cl_i"/>
<variable units="time_units" public_interface="in" private_interface="out" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_Cl</ci>
<apply>
<times/>
<ci>RToF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Cl_i</ci>
<ci>Cl_o</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_CaCl</ci>
<apply>
<times/>
<ci>G_max_CaCl</ci>
<ci>d_CaCl</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_Cl</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="d_BK">
<variable units="voltage_units" public_interface="in" name="Vm"/>
<variable units="millimolar" public_interface="in" name="Ca_i"/>
<variable units="dimensionless" public_interface="out" name="d_BK"/>
<variable units="time_units" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>d_BK</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<divide/>
<ci>Vm</ci>
<apply>
<minus/>
<cn cellml:units="voltage_units">17</cn>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ca_i</ci>
<cn cellml:units="millimolar">0.001</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="I_BK">
<variable units="current_units" public_interface="out" name="I_BK"/>
<variable units="millimolar" public_interface="in" private_interface="out" name="Ca_i"/>
<variable units="voltage_units" name="E_K"/>
<variable units="conductance_units" name="G_max_BK" initial_value="23"/>
<variable units="voltage_units" public_interface="in" private_interface="out" name="Vm"/>
<variable units="dimensionless" private_interface="in" name="d_BK"/>
<variable units="voltage_units" public_interface="in" name="RToF"/>
<variable units="millimolar" public_interface="in" name="K_o"/>
<variable units="millimolar" public_interface="in" name="K_i"/>
<variable units="conductance_units" public_interface="in" name="T_correction_BK"/>
<variable units="time_units" public_interface="in" private_interface="out" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<ci>RToF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>K_o</ci>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_BK</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>G_max_BK</ci>
<ci>T_correction_BK</ci>
</apply>
<ci>d_BK</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="I_bk">
<variable units="current_units" public_interface="out" name="I_bk"/>
<variable units="voltage_units" name="E_K"/>
<variable units="conductance_units" name="G_max_bk" initial_value="0.15"/>
<variable units="voltage_units" public_interface="in" name="Vm"/>
<variable units="voltage_units" public_interface="in" name="RToF"/>
<variable units="millimolar" public_interface="in" name="K_o"/>
<variable units="millimolar" public_interface="in" name="K_i"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<ci>RToF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>K_o</ci>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_bk</ci>
<apply>
<times/>
<ci>G_max_bk</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="d_ERG">
<variable units="voltage_units" public_interface="in" name="Vm"/>
<variable units="dimensionless" name="d_inf_ERG"/>
<variable units="time_units" name="tau_d_ERG"/>
<variable units="dimensionless" public_interface="out" name="d_ERG" initial_value="0"/>
<variable units="time_units" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="T_correction_K"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>d_inf_ERG</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">0.2</cn>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.8</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">20</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="voltage_units">1.8</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_d_ERG</ci>
<apply>
<times/>
<ci>T_correction_K</ci>
<cn cellml:units="time_units">0.003</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>d_ERG</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>d_inf_ERG</ci>
<ci>d_ERG</ci>
</apply>
<ci>tau_d_ERG</ci>
</apply>
</apply>
</math>
</component>
<component name="I_ERG">
<variable units="current_units" public_interface="out" name="I_ERG"/>
<variable units="voltage_units" name="E_K"/>
<variable units="conductance_units" name="G_max_ERG" initial_value="2.5"/>
<variable units="voltage_units" public_interface="in" private_interface="out" name="Vm"/>
<variable units="dimensionless" private_interface="in" name="d_ERG"/>
<variable units="voltage_units" public_interface="in" name="RToF"/>
<variable units="millimolar" public_interface="in" name="K_o"/>
<variable units="millimolar" public_interface="in" name="K_i"/>
<variable units="dimensionless" public_interface="in" private_interface="out" name="T_correction_K"/>
<variable units="time_units" public_interface="in" private_interface="out" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<ci>RToF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>K_o</ci>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_ERG</ci>
<apply>
<times/>
<ci>G_max_ERG</ci>
<ci>d_ERG</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="d_kv11">
<variable units="voltage_units" public_interface="in" name="Vm"/>
<variable units="dimensionless" name="d_inf_kv11"/>
<variable units="time_units" name="tau_d_kv11"/>
<variable units="dimensionless" public_interface="out" name="d_kv11" initial_value="0"/>
<variable units="time_units" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="T_correction_K"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>d_inf_kv11</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">25</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="voltage_units">7.7</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_d_kv11</ci>
<apply>
<times/>
<ci>T_correction_K</ci>
<cn cellml:units="time_units">0.005</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>d_kv11</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>d_inf_kv11</ci>
<ci>d_kv11</ci>
</apply>
<ci>tau_d_kv11</ci>
</apply>
</apply>
</math>
</component>
<component name="f_kv11">
<variable units="voltage_units" public_interface="in" name="Vm"/>
<variable units="dimensionless" name="f_inf_kv11"/>
<variable units="time_units" name="tau_f_kv11"/>
<variable units="dimensionless" public_interface="out" name="f_kv11" initial_value="1"/>
<variable units="time_units" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="T_correction_K"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>f_inf_kv11</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">0.5</cn>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.5</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">44.8</cn>
</apply>
<cn cellml:units="voltage_units">4.4</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_f_kv11</ci>
<apply>
<times/>
<ci>T_correction_K</ci>
<cn cellml:units="time_units">0.005</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>f_kv11</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>f_inf_kv11</ci>
<ci>f_kv11</ci>
</apply>
<ci>tau_f_kv11</ci>
</apply>
</apply>
</math>
</component>
<component name="I_kv11">
<variable units="current_units" public_interface="out" name="I_kv11"/>
<variable units="voltage_units" name="E_K"/>
<variable units="conductance_units" name="G_max_kv11" initial_value="6.3"/>
<variable units="voltage_units" public_interface="in" private_interface="out" name="Vm"/>
<variable units="dimensionless" private_interface="in" name="f_kv11"/>
<variable units="dimensionless" private_interface="in" name="d_kv11"/>
<variable units="voltage_units" public_interface="in" name="RToF"/>
<variable units="millimolar" public_interface="in" name="K_o"/>
<variable units="millimolar" public_interface="in" name="K_i"/>
<variable units="dimensionless" public_interface="in" private_interface="out" name="T_correction_K"/>
<variable units="time_units" public_interface="in" private_interface="out" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<ci>RToF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>K_o</ci>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_kv11</ci>
<apply>
<times/>
<ci>G_max_kv11</ci>
<ci>f_kv11</ci>
<ci>d_kv11</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="d_Na">
<variable units="voltage_units" public_interface="in" name="Vm"/>
<variable units="dimensionless" name="d_inf_Na"/>
<variable units="time_units" name="tau_d_Na"/>
<variable units="dimensionless" public_interface="out" name="d_Na" initial_value="0"/>
<variable units="time_units" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="T_correction_Na"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>d_inf_Na</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">47</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="voltage_units">4.8</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_d_Na</ci>
<apply>
<times/>
<ci>T_correction_Na</ci>
<cn cellml:units="time_units">0.003</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>d_Na</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>d_inf_Na</ci>
<ci>d_Na</ci>
</apply>
<ci>tau_d_Na</ci>
</apply>
</apply>
</math>
</component>
<component name="f_Na">
<variable units="voltage_units" public_interface="in" name="Vm"/>
<variable units="dimensionless" name="f_inf_Na"/>
<variable units="time_units" name="tau_f_Na"/>
<variable units="dimensionless" public_interface="out" name="f_Na" initial_value="1"/>
<variable units="time_units" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="T_correction_Na"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>f_inf_Na</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">78</cn>
</apply>
<cn cellml:units="voltage_units">7</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_f_Na</ci>
<apply>
<times/>
<ci>T_correction_Na</ci>
<cn cellml:units="time_units">0.0016</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>f_Na</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>f_inf_Na</ci>
<ci>f_Na</ci>
</apply>
<ci>tau_f_Na</ci>
</apply>
</apply>
</math>
</component>
<component name="I_Na">
<variable units="current_units" public_interface="out" name="I_Na"/>
<variable units="voltage_units" name="E_Na"/>
<variable units="conductance_units" name="G_max_Na" initial_value="20"/>
<variable units="voltage_units" public_interface="in" private_interface="out" name="Vm"/>
<variable units="dimensionless" private_interface="in" name="f_Na"/>
<variable units="dimensionless" private_interface="in" name="d_Na"/>
<variable units="voltage_units" public_interface="in" name="RToF"/>
<variable units="millimolar" public_interface="in" name="Na_o"/>
<variable units="millimolar" public_interface="in" name="Na_i"/>
<variable units="dimensionless" public_interface="in" private_interface="out" name="T_correction_Na"/>
<variable units="time_units" public_interface="in" private_interface="out" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_Na</ci>
<apply>
<times/>
<ci>RToF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Na_o</ci>
<ci>Na_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_Na</ci>
<apply>
<times/>
<ci>G_max_Na</ci>
<ci>f_Na</ci>
<ci>d_Na</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="d_NSCC">
<variable units="millimolar" public_interface="in" name="Ca_PU"/>
<variable units="dimensionless" name="d_inf_NSCC"/>
<variable units="time_units" name="tau_d_NSCC" initial_value="0.35"/>
<variable units="dimensionless" public_interface="out" name="d_NSCC" initial_value="0"/>
<variable units="time_units" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>d_inf_NSCC</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<cn cellml:units="millimolar">0.0000745</cn>
<ci>Ca_PU</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">85</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>d_NSCC</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>d_inf_NSCC</ci>
<ci>d_NSCC</ci>
</apply>
<ci>tau_d_NSCC</ci>
</apply>
</apply>
</math>
</component>
<component name="I_NSCC">
<variable units="current_units" public_interface="out" name="I_NSCC"/>
<variable units="voltage_units" name="E_NSCC"/>
<variable units="conductance_units" name="G_max_NSCC" initial_value="12.15"/>
<variable units="voltage_units" public_interface="in" name="Vm"/>
<variable units="dimensionless" private_interface="in" name="d_NSCC"/>
<variable units="voltage_units" public_interface="in" name="RToF"/>
<variable units="millimolar" public_interface="in" name="Na_o"/>
<variable units="millimolar" public_interface="in" name="Na_i"/>
<variable units="millimolar" public_interface="in" name="K_o"/>
<variable units="millimolar" public_interface="in" name="K_i"/>
<variable units="dimensionless" name="NaPerm_o_Kperm" initial_value="1.056075"/>
<variable units="millimolar" public_interface="in" private_interface="out" name="Ca_PU"/>
<variable units="time_units" public_interface="in" private_interface="out" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_NSCC</ci>
<apply>
<times/>
<ci>RToF</ci>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<plus/>
<ci>K_o</ci>
<apply>
<times/>
<ci>Na_o</ci>
<ci>NaPerm_o_Kperm</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>K_i</ci>
<apply>
<times/>
<ci>Na_i</ci>
<ci>NaPerm_o_Kperm</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_NSCC</ci>
<apply>
<times/>
<ci>G_max_NSCC</ci>
<ci>d_NSCC</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_NSCC</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="PU_unit">
<variable units="volume_units" public_interface="in" name="Vol"/>
<variable units="dimensionless" name="P_PU" initial_value="0.001"/>
<variable units="dimensionless" name="P_mito" initial_value="0.12871"/>
<variable units="dimensionless" name="P_ER" initial_value="0.1"/>
<variable units="volume_units" name="V_MITO"/>
<variable units="volume_units" name="V_ER"/>
<variable units="volume_units" name="V_PU"/>
<variable units="dimensionless" name="fe" initial_value="0.01"/>
<variable units="dimensionless" name="fm" initial_value="0.0003"/>
<variable units="time_units" public_interface="in" name="time"/>
<variable units="dimensionless" public_interface="in" name="fc"/>
<variable units="millimolar" public_interface="in" name="Na_i"/>
<variable units="millimolar" public_interface="in" name="Ca_i"/>
<variable units="volume_units" public_interface="in" name="V_cyto"/>
<variable units="Inverse_Voltage_units" public_interface="in" name="FoRT"/>
<variable units="voltage_units" public_interface="in" name="RToF"/>
<variable units="millimolar" public_interface="out" private_interface="out" name="Ca_PU" initial_value="0.0000902"/>
<variable units="F_units" public_interface="in" name="F"/>
<variable units="millimolar" name="Ca_m" initial_value="0.000136"/>
<variable units="millimolar" name="Ca_ER" initial_value="0.007299"/>
<variable units="millimolar" name="ADP_m" initial_value="2.60093454"/>
<variable units="millimolar" name="ADP_i" initial_value="0.0077282"/>
<variable units="millimolar" name="NADH_m" initial_value="0.101476"/>
<variable units="dimensionless" name="h" initial_value="0.9397"/>
<variable units="millimolar" name="IP3" initial_value="0.0006"/>
<variable units="voltage_units" name="deltaPsi" initial_value="164.000044"/>
<variable units="dimensionless" name="deltapH" initial_value="-0.4"/>
<variable units="millifarads" name="Cmito" initial_value="0.006995"/>
<variable units="dimensionless" name="K_res" initial_value="1.35e18"/>
<variable units="dimensionless" name="r1" initial_value="2.077e-18"/>
<variable units="dimensionless" name="r2" initial_value="1.728e-9"/>
<variable units="dimensionless" name="r3" initial_value="1.059e-26"/>
<variable units="rate_constants_units" name="ra" initial_value="6.394e-10"/>
<variable units="rate_constants_units" name="rb" initial_value="1.762e-13"/>
<variable units="rate_constants_units" name="rc1" initial_value="2.656e-19"/>
<variable units="rate_constants_units" name="rc2" initial_value="8.632e-27"/>
<variable units="voltage_units" name="deltaPsi_B" initial_value="50"/>
<variable units="dimensionless" name="g" initial_value="0.85"/>
<variable units="millimolar" name="K_F1" initial_value="1.71e9"/>
<variable units="millimolar" name="Pi_m" initial_value="20"/>
<variable units="dimensionless" name="p1" initial_value="1.346e-8"/>
<variable units="dimensionless" name="p2" initial_value="7.739e-7"/>
<variable units="dimensionless" name="p3" initial_value="6.65e-15"/>
<variable units="rate_constants_units" name="pa" initial_value="1.656e-5"/>
<variable units="rate_constants_units" name="pb" initial_value="3.373e-7"/>
<variable units="rate_constants_units" name="pc1" initial_value="9.651e-14"/>
<variable units="rate_constants_units" name="pc2" initial_value="4.845e-19"/>
<variable units="dimensionless" name="frac" initial_value="0.5"/>
<variable units="millimolar" name="K_act" initial_value="0.00038"/>
<variable units="dimensionless" name="na" initial_value="2.8"/>
<variable units="voltage_units" name="deltaPsi_star" initial_value="91"/>
<variable units="millimolar" name="K_Na" initial_value="9.4"/>
<variable units="millimolar" name="K_Ca" initial_value="0.003"/>
<variable units="millimolar" name="K_trans" initial_value="0.006"/>
<variable units="dimensionless" name="L" initial_value="50"/>
<variable units="dimensionless" name="b" initial_value="0.5"/>
<variable units="rate_constants_units" name="beta_max" initial_value="2.055"/>
<variable units="per_millimolar" name="beta1" initial_value="1.66"/>
<variable units="per_millimolar" name="beta2" initial_value="0.0249"/>
<variable units="per_millimolar" name="beta3" initial_value="4"/>
<variable units="per_millimolar" name="beta4" initial_value="2.83"/>
<variable units="per_millimolar" name="beta5" initial_value="1.3"/>
<variable units="per_millimolar" name="beta6" initial_value="2.66"/>
<variable units="per_millimolar" name="beta7" initial_value="0.16"/>
<variable units="millimolar" name="KCa_PDH" initial_value="0.00005"/>
<variable units="dimensionless" name="u1" initial_value="15"/>
<variable units="dimensionless" name="u2" initial_value="1.1"/>
<variable units="dimensionless" name="n" initial_value="2"/>
<variable units="millimolar" name="K_Glc" initial_value="8.7"/>
<variable units="dimensionless" name="nhyd" initial_value="2.7"/>
<variable units="rate_constants_units" name="K_hyd" initial_value="0.05125"/>
<variable units="rate_constants_units" name="J_ERleak" initial_value="1.666667"/>
<variable units="rate_constants_units" name="Jmax_IP3" initial_value="50000"/>
<variable units="millimolar" name="d_IP3" initial_value="0.00025"/>
<variable units="millimolar" name="d_ACT" initial_value="0.001"/>
<variable units="millimolar" name="d_INH" initial_value="0.0014"/>
<variable units="time_units" name="tauh" initial_value="4"/>
<variable units="millimolar_per_second" name="Jmax_serca" initial_value="1.8333"/>
<variable units="millimolar" name="k_serca" initial_value="0.00042"/>
<variable units="millimolar" name="conc" initial_value="0.001"/>
<variable units="rate_constants_units" name="Jmax_uni" initial_value="5000"/>
<variable units="millimolar_per_second" name="Jmax_NaCa" initial_value="0.05"/>
<variable units="rate_constants_units" name="J_max_leak" initial_value="0.01"/>
<variable units="millimolar" name="rho_res" initial_value="0.4"/>
<variable units="millimolar" name="rho_F1" initial_value="0.7"/>
<variable units="millimolar_per_second_per_millivolt" name="g_H" initial_value="0.0033333"/>
<variable units="millimolar_per_second" name="J_red_basal" initial_value="0.3333"/>
<variable units="millimolar_per_second" name="Jmax_ANT" initial_value="15"/>
<variable units="millimolar_per_second" name="J_hyd_max" initial_value="0.037625"/>
<variable units="millimolar" name="Glc" initial_value="1"/>
<variable units="millimolar" name="total_NAD_m" initial_value="8"/>
<variable units="millimolar" name="total_ANP_m" initial_value="12"/>
<variable units="millimolar" name="total_ANP_i" initial_value="2"/>
<variable units="millimolar" name="NAD_m"/>
<variable units="millimolar" name="ATP_m"/>
<variable units="millimolar" name="ADP_mfree"/>
<variable units="millimolar" name="ADP3_m"/>
<variable units="millimolar" name="ATP4_m"/>
<variable units="millimolar" name="ATP_i"/>
<variable units="millimolar" name="ADP_ifree"/>
<variable units="millimolar" name="ADP3_i"/>
<variable units="millimolar" name="MgADP_i"/>
<variable units="millimolar" name="ATP4_i"/>
<variable units="millimolar_per_second" name="J_ERout"/>
<variable units="millimolar_per_second" name="J_SERCA"/>
<variable units="millimolar" name="MWC"/>
<variable units="millimolar_per_second" name="J_uni"/>
<variable units="millimolar_per_second" name="J_NaCa"/>
<variable units="millimolar_per_second" public_interface="out" name="J_leak"/>
<variable units="millimolar_per_second" name="J_red"/>
<variable units="millimolar_per_second" name="J_pTCA"/>
<variable units="voltage_units" name="A_F1"/>
<variable units="millimolar_per_second" name="J_pF1"/>
<variable units="millimolar_per_second" name="J_HF1"/>
<variable units="voltage_units" name="A_res"/>
<variable units="millimolar_per_second" name="J_o"/>
<variable units="millimolar_per_second" name="J_glyTotal"/>
<variable units="dimensionless" name="f_PDHa"/>
<variable units="millimolar_per_second" name="J_Hres"/>
<variable units="millimolar_per_second" name="J_ANT"/>
<variable units="voltage_units" name="PMF"/>
<variable units="millimolar_per_second" name="J_Hleak"/>
<variable units="millimolar_per_second" name="J_pGly"/>
<variable units="millimolar_per_second" name="J_hydSS"/>
<variable units="millimolar_per_second" name="J_hyd"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_MITO</ci>
<apply>
<times/>
<ci>Vol</ci>
<ci>P_mito</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>V_PU</ci>
<apply>
<times/>
<ci>Vol</ci>
<ci>P_PU</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>V_ER</ci>
<apply>
<times/>
<ci>Vol</ci>
<ci>P_ER</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_ERout</ci>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>Jmax_IP3</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>IP3</ci>
<apply>
<plus/>
<ci>IP3</ci>
<ci>d_IP3</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<apply>
<divide/>
<ci>Ca_PU</ci>
<apply>
<plus/>
<ci>Ca_PU</ci>
<ci>d_ACT</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<ci>h</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<ci>J_ERleak</ci>
</apply>
<apply>
<minus/>
<ci>Ca_ER</ci>
<ci>Ca_PU</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_SERCA</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Jmax_serca</ci>
<apply>
<power/>
<ci>Ca_PU</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>k_serca</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<ci>Ca_PU</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>MWC</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>conc</ci>
<ci>Ca_PU</ci>
</apply>
<ci>K_trans</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Ca_PU</ci>
<ci>K_trans</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Ca_PU</ci>
<ci>K_trans</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">4</cn>
</apply>
<apply>
<divide/>
<ci>L</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Ca_PU</ci>
<ci>K_act</ci>
</apply>
</apply>
<ci>na</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_uni</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Jmax_uni</ci>
<apply>
<minus/>
<ci>MWC</ci>
<apply>
<times/>
<ci>Ca_m</ci>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>FoRT</ci>
<apply>
<minus/>
<ci>deltaPsi</ci>
<ci>deltaPsi_star</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
<ci>FoRT</ci>
<apply>
<minus/>
<ci>deltaPsi</ci>
<ci>deltaPsi_star</ci>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>FoRT</ci>
<apply>
<minus/>
<ci>deltaPsi</ci>
<ci>deltaPsi_star</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_NaCa</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Jmax_NaCa</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>b</ci>
<ci>FoRT</ci>
<apply>
<minus/>
<ci>deltaPsi</ci>
<ci>deltaPsi_star</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>K_Na</ci>
<ci>Na_i</ci>
</apply>
<ci>n</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>K_Ca</ci>
<ci>Ca_m</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_leak</ci>
<apply>
<times/>
<ci>J_max_leak</ci>
<apply>
<minus/>
<ci>Ca_PU</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>A_res</ci>
<apply>
<times/>
<ci>RToF</ci>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<times/>
<ci>K_res</ci>
<apply>
<root/>
<ci>NADH_m</ci>
</apply>
</apply>
<apply>
<root/>
<ci>NAD_m</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_o</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>rho_res</ci>
<cn cellml:units="dimensionless">0.5</cn>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>ra</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">6</cn>
<ci>deltapH</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>rc1</ci>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">6</cn>
<ci>deltaPsi_B</ci>
<ci>FoRT</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<times/>
<ci>A_res</ci>
<ci>FoRT</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>ra</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>g</ci>
<cn cellml:units="dimensionless">6</cn>
<ci>FoRT</ci>
<ci>deltaPsi</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>rc2</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>FoRT</ci>
<ci>A_res</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<times/>
<ci>FoRT</ci>
<ci>deltaPsi</ci>
<cn cellml:units="dimensionless">6</cn>
<ci>g</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>r1</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>FoRT</ci>
<ci>A_res</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<times/>
<ci>FoRT</ci>
<ci>deltaPsi_B</ci>
<cn cellml:units="dimensionless">6</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>r2</ci>
<apply>
<times/>
<ci>r3</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>FoRT</ci>
<ci>A_res</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<times/>
<ci>FoRT</ci>
<ci>deltaPsi</ci>
<ci>g</ci>
<cn cellml:units="dimensionless">6</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_Hres</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>rho_res</ci>
<cn cellml:units="dimensionless">3.966</cn>
<apply>
<plus/>
<apply>
<times/>
<ci>ra</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">6</cn>
<ci>deltapH</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<times/>
<ci>FoRT</ci>
<ci>A_res</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>rb</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">6</cn>
<ci>deltapH</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<ci>ra</ci>
<ci>rb</ci>
</apply>
<apply>
<exp/>
<apply>
<times/>
<ci>g</ci>
<ci>FoRT</ci>
<ci>deltaPsi</ci>
<cn cellml:units="dimensionless">6</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>r1</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>FoRT</ci>
<ci>A_res</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">6</cn>
<ci>FoRT</ci>
<ci>deltaPsi_B</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>r2</ci>
<apply>
<times/>
<ci>r3</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>FoRT</ci>
<ci>A_res</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<times/>
<ci>g</ci>
<cn cellml:units="dimensionless">6</cn>
<ci>FoRT</ci>
<ci>deltaPsi</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_glyTotal</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>beta_max</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>beta1</ci>
<ci>Glc</ci>
</apply>
</apply>
<ci>beta2</ci>
<ci>Glc</ci>
<ci>ATP_i</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>beta3</ci>
<ci>ATP_i</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>beta4</ci>
<ci>ATP_i</ci>
</apply>
</apply>
<ci>beta5</ci>
<ci>Glc</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>beta6</ci>
<ci>ATP_i</ci>
</apply>
</apply>
<ci>beta7</ci>
<ci>Glc</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>f_PDHa</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>u2</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>u1</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Ca_m</ci>
<ci>KCa_PDH</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_red</ci>
<apply>
<plus/>
<ci>J_red_basal</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">6.3944</cn>
<ci>f_PDHa</ci>
<ci>J_glyTotal</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_pTCA</ci>
<apply>
<plus/>
<apply>
<divide/>
<ci>J_red_basal</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.84</cn>
<ci>f_PDHa</ci>
<ci>J_glyTotal</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>A_F1</ci>
<apply>
<times/>
<ci>RToF</ci>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<times/>
<ci>K_F1</ci>
<ci>ATP_m</ci>
</apply>
<apply>
<times/>
<ci>ADP_mfree</ci>
<ci>Pi_m</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_pF1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>rho_F1</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>pa</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>deltapH</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>pc1</ci>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>FoRT</ci>
<ci>deltaPsi_B</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<times/>
<ci>FoRT</ci>
<ci>A_F1</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>pa</ci>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>FoRT</ci>
<ci>deltaPsi</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>pc2</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>FoRT</ci>
<ci>A_F1</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>FoRT</ci>
<ci>deltaPsi</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>p1</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>FoRT</ci>
<ci>A_F1</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>FoRT</ci>
<ci>deltaPsi_B</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>p2</ci>
<apply>
<times/>
<ci>p3</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>FoRT</ci>
<ci>A_F1</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>FoRT</ci>
<ci>deltaPsi</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_HF1</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>rho_F1</ci>
<cn cellml:units="dimensionless">3</cn>
<apply>
<plus/>
<apply>
<times/>
<ci>pa</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>deltapH</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<times/>
<ci>FoRT</ci>
<ci>A_F1</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>pb</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>deltapH</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<ci>pa</ci>
<ci>pb</ci>
</apply>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>FoRT</ci>
<ci>deltaPsi</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>p1</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>FoRT</ci>
<ci>A_F1</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>FoRT</ci>
<ci>deltaPsi_B</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>p2</ci>
<apply>
<times/>
<ci>p3</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>FoRT</ci>
<ci>A_F1</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>FoRT</ci>
<ci>deltaPsi</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_ANT</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Jmax_ANT</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>ATP4_i</ci>
<ci>ADP3_m</ci>
</apply>
<apply>
<times/>
<ci>ADP3_i</ci>
<ci>ATP4_m</ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>FoRT</ci>
<ci>deltaPsi</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>ATP4_i</ci>
<ci>ADP3_i</ci>
</apply>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>frac</ci>
<ci>FoRT</ci>
<ci>deltaPsi</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>ADP3_m</ci>
<ci>ATP4_m</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>PMF</ci>
<apply>
<minus/>
<ci>deltaPsi</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2.303</cn>
<ci>RToF</ci>
<ci>deltapH</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_Hleak</ci>
<apply>
<times/>
<ci>g_H</ci>
<ci>PMF</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_pGly</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.15</cn>
<ci>J_glyTotal</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_hydSS</ci>
<apply>
<divide/>
<ci>J_hyd_max</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>K_Glc</ci>
<ci>Glc</ci>
</apply>
<ci>nhyd</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_hyd</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>K_hyd</ci>
<ci>ATP_i</ci>
</apply>
<ci>J_hydSS</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>NADH_m</ci>
</apply>
<apply>
<minus/>
<ci>J_red</ci>
<ci>J_o</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>NAD_m</ci>
<apply>
<minus/>
<ci>total_NAD_m</ci>
<ci>NADH_m</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ADP_m</ci>
</apply>
<apply>
<plus/>
<ci>J_ANT</ci>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>J_pTCA</ci>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>J_pF1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ATP_m</ci>
<apply>
<minus/>
<ci>total_ANP_m</ci>
<ci>ADP_m</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ADP_mfree</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.8</cn>
<ci>ADP_m</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ADP3_m</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.45</cn>
<ci>ADP_mfree</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ATP4_m</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.05</cn>
<ci>ATP_m</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ADP_i</ci>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>J_ANT</ci>
<ci>V_MITO</ci>
</apply>
<ci>V_cyto</ci>
</apply>
<ci>J_hyd</ci>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>J_pGly</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ATP_i</ci>
<apply>
<minus/>
<ci>total_ANP_i</ci>
<ci>ADP_i</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ADP_ifree</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.3</cn>
<ci>ADP_i</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ADP3_i</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.45</cn>
<ci>ADP_ifree</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>MgADP_i</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.55</cn>
<ci>ADP_ifree</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ATP4_i</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.05</cn>
<ci>ATP_i</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_PU</ci>
</apply>
<apply>
<times/>
<ci>fc</ci>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>J_NaCa</ci>
<ci>J_uni</ci>
</apply>
<ci>V_MITO</ci>
</apply>
<ci>V_PU</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>J_ERout</ci>
<ci>J_SERCA</ci>
</apply>
<ci>V_ER</ci>
</apply>
<ci>V_PU</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>J_leak</ci>
<ci>V_cyto</ci>
</apply>
<ci>V_PU</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_m</ci>
</apply>
<apply>
<times/>
<ci>fm</ci>
<apply>
<minus/>
<ci>J_uni</ci>
<ci>J_NaCa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_ER</ci>
</apply>
<apply>
<times/>
<ci>fe</ci>
<apply>
<minus/>
<ci>J_SERCA</ci>
<ci>J_ERout</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>deltaPsi</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>F</ci>
<ci>V_MITO</ci>
<cn cellml:units="millimole_to_nanomole">1000000</cn>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>Cmito</ci>
</apply>
<apply>
<plus/>
<ci>J_Hleak</ci>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>J_Hres</ci>
</apply>
<ci>J_ANT</ci>
<ci>J_HF1</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>J_uni</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>h</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millimolar">1</cn>
<apply>
<minus/>
<ci>d_INH</ci>
<apply>
<times/>
<ci>h</ci>
<apply>
<plus/>
<ci>Ca_PU</ci>
<ci>d_INH</ci>
</apply>
</apply>
</apply>
</apply>
<ci>tauh</ci>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="ICC_Membrane">
<component_ref component="I_Na">
<component_ref component="d_Na"/>
<component_ref component="f_Na"/>
</component_ref>
<component_ref component="I_Ltype">
<component_ref component="d_Ltype"/>
<component_ref component="f_Ltype"/>
<component_ref component="f_ca_Ltype"/>
</component_ref>
<component_ref component="I_VDDR">
<component_ref component="d_VDDR"/>
<component_ref component="f_VDDR"/>
</component_ref>
<component_ref component="I_BK">
<component_ref component="d_BK"/>
</component_ref>
<component_ref component="I_CaCl">
<component_ref component="d_CaCl"/>
</component_ref>
<component_ref component="I_kv11">
<component_ref component="d_kv11"/>
<component_ref component="f_kv11"/>
</component_ref>
<component_ref component="I_ERG">
<component_ref component="d_ERG"/>
</component_ref>
<component_ref component="I_bk"/>
<component_ref component="I_NSCC">
<component_ref component="d_NSCC"/>
</component_ref>
<component_ref component="J_PMCA"/>
<component_ref component="PU_unit"/>
</component_ref>
</group>
<connection>
<map_components component_2="I_Na" component_1="d_Na"/>
<map_variables variable_2="Vm" variable_1="Vm"/>
<map_variables variable_2="d_Na" variable_1="d_Na"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="T_correction_Na" variable_1="T_correction_Na"/>
</connection>
<connection>
<map_components component_2="I_Na" component_1="f_Na"/>
<map_variables variable_2="Vm" variable_1="Vm"/>
<map_variables variable_2="f_Na" variable_1="f_Na"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="T_correction_Na" variable_1="T_correction_Na"/>
</connection>
<connection>
<map_components component_2="ICC_Membrane" component_1="I_Na"/>
<map_variables variable_2="Na_i" variable_1="Na_i"/>
<map_variables variable_2="Vm" variable_1="Vm"/>
<map_variables variable_2="I_Na" variable_1="I_Na"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="RToF" variable_1="RToF"/>
<map_variables variable_2="Na_o" variable_1="Na_o"/>
<map_variables variable_2="T_correction_Na" variable_1="T_correction_Na"/>
</connection>
<connection>
<map_components component_2="I_Ltype" component_1="d_Ltype"/>
<map_variables variable_2="Vm" variable_1="Vm"/>
<map_variables variable_2="d_Ltype" variable_1="d_Ltype"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="T_correction_Ca" variable_1="T_correction_Ca"/>
</connection>
<connection>
<map_components component_2="I_Ltype" component_1="f_Ltype"/>
<map_variables variable_2="Vm" variable_1="Vm"/>
<map_variables variable_2="f_Ltype" variable_1="f_Ltype"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="T_correction_Ca" variable_1="T_correction_Ca"/>
</connection>
<connection>
<map_components component_2="I_Ltype" component_1="f_ca_Ltype"/>
<map_variables variable_2="f_ca_Ltype" variable_1="f_ca_Ltype"/>
<map_variables variable_2="Ca_i" variable_1="Ca_i"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="T_correction_Ca" variable_1="T_correction_Ca"/>
</connection>
<connection>
<map_components component_2="ICC_Membrane" component_1="I_Ltype"/>
<map_variables variable_2="Ca_i" variable_1="Ca_i"/>
<map_variables variable_2="Vm" variable_1="Vm"/>
<map_variables variable_2="I_Ltype" variable_1="I_Ltype"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="RToF" variable_1="RToF"/>
<map_variables variable_2="Ca_o" variable_1="Ca_o"/>
<map_variables variable_2="T_correction_Ca" variable_1="T_correction_Ca"/>
</connection>
<connection>
<map_components component_2="I_VDDR" component_1="d_VDDR"/>
<map_variables variable_2="Vm" variable_1="Vm"/>
<map_variables variable_2="d_VDDR" variable_1="d_VDDR"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="T_correction_Ca" variable_1="T_correction_Ca"/>
</connection>
<connection>
<map_components component_2="I_VDDR" component_1="f_VDDR"/>
<map_variables variable_2="Vm" variable_1="Vm"/>
<map_variables variable_2="f_VDDR" variable_1="f_VDDR"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="T_correction_Ca" variable_1="T_correction_Ca"/>
</connection>
<connection>
<map_components component_2="ICC_Membrane" component_1="I_VDDR"/>
<map_variables variable_2="Ca_i" variable_1="Ca_i"/>
<map_variables variable_2="Vm" variable_1="Vm"/>
<map_variables variable_2="I_VDDR" variable_1="I_VDDR"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="RToF" variable_1="RToF"/>
<map_variables variable_2="Ca_o" variable_1="Ca_o"/>
<map_variables variable_2="T_correction_Ca" variable_1="T_correction_Ca"/>
</connection>
<connection>
<map_components component_2="I_kv11" component_1="d_kv11"/>
<map_variables variable_2="Vm" variable_1="Vm"/>
<map_variables variable_2="d_kv11" variable_1="d_kv11"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="T_correction_K" variable_1="T_correction_K"/>
</connection>
<connection>
<map_components component_2="I_kv11" component_1="f_kv11"/>
<map_variables variable_2="Vm" variable_1="Vm"/>
<map_variables variable_2="f_kv11" variable_1="f_kv11"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="T_correction_K" variable_1="T_correction_K"/>
</connection>
<connection>
<map_components component_2="ICC_Membrane" component_1="I_kv11"/>
<map_variables variable_2="K_i" variable_1="K_i"/>
<map_variables variable_2="Vm" variable_1="Vm"/>
<map_variables variable_2="I_kv11" variable_1="I_kv11"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="RToF" variable_1="RToF"/>
<map_variables variable_2="K_o" variable_1="K_o"/>
<map_variables variable_2="T_correction_K" variable_1="T_correction_K"/>
</connection>
<connection>
<map_components component_2="I_ERG" component_1="d_ERG"/>
<map_variables variable_2="Vm" variable_1="Vm"/>
<map_variables variable_2="d_ERG" variable_1="d_ERG"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="T_correction_K" variable_1="T_correction_K"/>
</connection>
<connection>
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<map_variables variable_2="K_o" variable_1="K_o"/>
<map_variables variable_2="T_correction_K" variable_1="T_correction_K"/>
</connection>
<connection>
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<connection>
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<connection>
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<connection>
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</connection>
<connection>
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<map_variables variable_2="K_o" variable_1="K_o"/>
</connection>
<connection>
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<map_variables variable_2="d_NSCC" variable_1="d_NSCC"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="ICC_Membrane" component_1="I_NSCC"/>
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<map_variables variable_2="Na_i" variable_1="Na_i"/>
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<map_variables variable_2="K_o" variable_1="K_o"/>
<map_variables variable_2="Na_o" variable_1="Na_o"/>
</connection>
<connection>
<map_components component_2="I_NSCC" component_1="PU_unit"/>
<map_variables variable_2="Ca_PU" variable_1="Ca_PU"/>
</connection>
<connection>
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<map_variables variable_2="Vol" variable_1="Vol"/>
<map_variables variable_2="fc" variable_1="fc"/>
<map_variables variable_2="V_cyto" variable_1="V_cyto"/>
<map_variables variable_2="FoRT" variable_1="FoRT"/>
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<map_variables variable_2="J_leak" variable_1="J_leak"/>
<map_variables variable_2="F" variable_1="F"/>
</connection>
<connection>
<map_components component_2="ICC_Membrane" component_1="J_PMCA"/>
<map_variables variable_2="J_PMCA" variable_1="J_PMCA"/>
<map_variables variable_2="Ca_i" variable_1="Ca_i"/>
</connection>
<connection>
<map_components component_2="Environment" component_1="ICC_Membrane"/>
<map_variables variable_2="Ca_o" variable_1="Ca_o"/>
<map_variables variable_2="Na_o" variable_1="Na_o"/>
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<map_variables variable_2="FoRT" variable_1="FoRT"/>
<map_variables variable_2="F" variable_1="F"/>
<map_variables variable_2="T_correction_Ca" variable_1="T_correction_Ca"/>
<map_variables variable_2="T_correction_Na" variable_1="T_correction_Na"/>
<map_variables variable_2="T_correction_K" variable_1="T_correction_K"/>
<map_variables variable_2="T_correction_BK" variable_1="T_correction_BK"/>
</connection>
<connection>
<map_components component_2="ICC_Membrane" component_1="Time"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<rdf:RDF>
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<vCard:Given>Martin</vCard:Given>
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<dcterms:W3CDTF>2008</dcterms:W3CDTF>
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<vCard:FN>Geoff Nunns</vCard:FN>
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</model>
