- Author:
- termi-official <termi-official@users.noreply.github.com>
- Date:
- 2025-05-15 16:01:20+02:00
- Desc:
- Add documentation for submission
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/d20/rawfile/8465ce0a385cdc40e2f79b001798d600e9f9e4d2/models/mahajan_shiferaw_ogiermann_2025.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="mahajan_shieferaw_ogiermann" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<!-- Not sure how to do this in CellML 2.0-->
<import xlink:href="../units.cellml">
<units name="u_per_m" units_ref="u_per_m"/>
<units name="ms" units_ref="ms"/>
<units name="per_ms" units_ref="per_ms"/>
<units name="mV" units_ref="mV"/>
<units name="per_mV" units_ref="per_mV"/>
<units name="uS_per_nF" units_ref="uS_per_nF"/>
<units name="nA_per_nF" units_ref="nA_per_nF"/>
<units name="molar" units_ref="molar"/>
<units name="mM" units_ref="mM"/>
<units name="uM" units_ref="uM"/>
<units name="mM4" units_ref="mM4"/>
<units name="mV_per_uM" units_ref="mV_per_uM"/>
<units name="uM_per_ms" units_ref="uM_per_ms"/>
<units name="per_uM_per_ms" units_ref="per_uM_per_ms"/>
<units name="J_per_moleK" units_ref="J_per_moleK"/>
<units name="coulomb_per_mmole" units_ref="coulomb_per_mmole"/>
<units name="cm_per_s" units_ref="cm_per_s"/>
<units name="mA_per_cm2" units_ref="mA_per_cm2"/>
<units name="mmole_per_coulomb_cm" units_ref="mmole_per_coulomb_cm"/>
</import>
<import xlink:href="channels/mahajan_2008_LType_calcium_channel.cellml">
<component component_ref="ICaL" name="ICaL"/>
</import>
<import xlink:href="channels/na_channel.cellml">
<component component_ref="INa" name="INa"/>
</import>
<import xlink:href="channels/k1_channel.cellml">
<component component_ref="IK1" name="IK1"/>
</import>
<import xlink:href="channels/kr_channel.cellml">
<component component_ref="IKr" name="IKr"/>
</import>
<import xlink:href="channels/ks_channel.cellml">
<component component_ref="IKs" name="IKs"/>
</import>
<import xlink:href="channels/to_channel.cellml">
<component component_ref="Ito" name="Ito"/>
</import>
<import xlink:href="channels/ogiermann_2025_piezo1.cellml">
<component component_ref="kinetics" name="piezo1_kinetics"/>
</import>
<component name="IPz1">
<variable name="V" public_interface="in" units="mV"/>
<variable name="P_Open" public_interface="in" units="dimensionless"/>
<variable name="xiPz1" public_interface="out" units="nA_per_nF"/>
<variable name="xiCaPz1" public_interface="out" units="nA_per_nF"/>
<variable name="xiNaPz1" public_interface="out" units="nA_per_nF"/>
<variable name="xiKPz1" public_interface="out" units="nA_per_nF"/>
<variable name="jCaPz1" public_interface="out" units="uM_per_ms"/>
<variable name="jNaPz1" public_interface="out" units="uM_per_ms"/>
<variable name="jKPz1" public_interface="out" units="uM_per_ms"/>
<variable name="rPz1" public_interface="out" units="uM_per_ms"/>
<variable initial_value="0.93" name="gPz1K" units="uS_per_nF"/>
<variable initial_value="0.28" name="gPz1Ca" units="uS_per_nF"/>
<variable initial_value="1.0" name="gPz1Na" units="uS_per_nF"/>
<variable name="ena" public_interface="in" units="mV"/>
<variable name="ecas" public_interface="in" units="mV"/>
<variable name="eks" public_interface="in" units="mV"/>
<variable name="gradmuPz1" public_interface="out" units="mV"/>
<!-- This is a possible connection point for the true reversal potential for Pz1.
However, our preliminary studies suggest that we keep close to 0 during electromechanical pacing, hence we just keep it 0.
This choice is in line with some experimental measurements of the reversal potential.-->
<variable initial_value="0.0" name="eghkPz1" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>gradmuPz1</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>eghkPz1</ci>
</apply>
</apply>
</math>
<!-- Computed via 0.31/(2*2.58e-2*96.4853415) = C_m/(2*v_i*F)-->
<variable initial_value="0.0622659550620391" name="Cm_on_2Fvi" units="dimensionless"/>
<variable initial_value="0.18" name="scaling" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>xiCaPz1</ci>
<apply>
<times/>
<ci>scaling</ci>
<ci>P_Open</ci>
<ci>gPz1Ca</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>ecas</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>xiNaPz1</ci>
<apply>
<times/>
<ci>scaling</ci>
<ci>P_Open</ci>
<ci>gPz1Na</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>ena</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>xiKPz1</ci>
<apply>
<times/>
<ci>scaling</ci>
<ci>P_Open</ci>
<ci>gPz1K</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>eks</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>xiPz1</ci>
<apply>
<plus/>
<ci>xiCaPz1</ci>
<ci>xiNaPz1</ci>
<ci>xiKPz1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>jCaPz1</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>Cm_on_2Fvi</ci>
</apply>
<ci>xiCaPz1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>jNaPz1</ci>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>Cm_on_2Fvi</ci>
<ci>xiNaPz1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>jKPz1</ci>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>Cm_on_2Fvi</ci>
<ci>xiKPz1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>rPz1</ci>
<apply>
<times/>
<ci>scaling</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>gPz1Ca</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>ecas</ci>
</apply>
</apply>
<apply>
<times/>
<ci>gPz1Na</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>ena</ci>
</apply>
</apply>
<apply>
<times/>
<ci>gPz1K</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>eks</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<import xlink:href="pumps/nak_pump.cellml">
<component component_ref="INaK" name="INaK"/>
</import>
<import xlink:href="pumps/naca_pump.cellml">
<component component_ref="INaCa" name="INaCa"/>
</import>
<import xlink:href="concentrations/natrium.cellml">
<component component_ref="Na" name="Na"/>
</import>
<import xlink:href="concentrations/calcium.cellml">
<component component_ref="Ca" name="Ca"/>
<component component_ref="Ileak_Iup_Ixfer" name="Ileak_Iup_Ixfer"/>
<component component_ref="Irel" name="Irel"/>
</import>
<component name="interface">
<variable name="time" private_interface="out" public_interface="in" units="ms"/>
<variable name="i_stim" private_interface="out" public_interface="in" units="nA_per_nF"/>
<variable name="pressure" private_interface="out" public_interface="in" units="newton"/>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="interface">
<component_ref component="cell_membrane"/>
<component_ref component="INa"/>
<component_ref component="ICaL"/>
<component_ref component="IK1"/>
<component_ref component="IKr"/>
<component_ref component="IKs"/>
<component_ref component="Ito"/>
<component_ref component="INaK"/>
<component_ref component="INaCa"/>
<component_ref component="Irel"/>
<component_ref component="Ca"/>
<component_ref component="Ileak_Iup_Ixfer"/>
<component_ref component="Na"/>
<component_ref component="reversal_potentials"/>
<component_ref component="IPz1"/>
<component_ref component="piezo1_kinetics"/>
<!-- How to get rid of this?-->
<component_ref component="environment"/>
</component_ref>
</group>
<component name="environment">
<variable initial_value="8.314472" name="R" units="J_per_moleK"/>
<variable initial_value="308" name="T" units="kelvin"/>
<variable initial_value="96.4853415" name="F" public_interface="out" units="coulomb_per_mmole"/>
<variable initial_value="5.4" name="K_o" public_interface="out" units="mM"/>
<variable initial_value="1.8" name="Ca_o" public_interface="out" units="mM"/>
<variable initial_value="136" name="Na_o" public_interface="out" units="mM"/>
<variable name="FonRT" public_interface="out" units="per_mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>FonRT</ci>
<apply>
<divide/>
<ci>F</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="cell_membrane">
<variable name="time" public_interface="in" units="ms"/>
<variable initial_value="-87.169816169406" name="V" public_interface="out" units="mV"/>
<variable name="xik1" public_interface="in" units="nA_per_nF"/>
<variable name="xito" public_interface="in" units="nA_per_nF"/>
<variable name="xiNaK" public_interface="in" units="nA_per_nF"/>
<variable initial_value="8" name="wca" public_interface="out" units="mV_per_uM"/>
<variable name="xiNaCa" public_interface="in" units="nA_per_nF"/>
<variable name="xica" public_interface="in" units="nA_per_nF"/>
<variable name="xina" public_interface="in" units="nA_per_nF"/>
<variable name="xikr" public_interface="in" units="nA_per_nF"/>
<variable name="xiks" public_interface="in" units="nA_per_nF"/>
<variable name="xiPz1" public_interface="in" units="nA_per_nF"/>
<variable name="i_stim" public_interface="in" units="nA_per_nF"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>V</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>xina</ci>
<ci>xik1</ci>
<ci>xikr</ci>
<ci>xiks</ci>
<ci>xito</ci>
<ci>xiNaCa</ci>
<ci>xica</ci>
<ci>xiNaK</ci>
<ci>xiPz1</ci>
<ci>i_stim</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="reversal_potentials">
<variable name="ek" public_interface="out" units="mV"/>
<variable name="eks" public_interface="out" units="mV"/>
<variable name="ecas" public_interface="out" units="mV"/>
<variable name="ena" public_interface="out" units="mV"/>
<variable initial_value="140" name="K_i" units="mM"/>
<variable name="K_o" public_interface="in" units="mM"/>
<variable name="Na_i" public_interface="in" units="mM"/>
<variable name="Na_o" public_interface="in" units="mM"/>
<variable name="Ca_submem" public_interface="in" units="mM"/>
<variable name="Ca_o" public_interface="in" units="mM"/>
<variable name="FonRT" public_interface="in" units="per_mV"/>
<variable initial_value="0.01833" name="prNaK" units="dimensionless"/>
<!-- TODO sync with Pz1 vars-->
<variable name="eghkPz1" public_interface="out" units="mV"/>
<variable initial_value="0.93" name="gPz1K" units="uS_per_nF"/>
<variable initial_value="0.28" name="gPz1Ca" units="uS_per_nF"/>
<variable initial_value="1.0" name="gPz1Na" units="uS_per_nF"/>
<variable name="gPz1All" units="uS_per_nF"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>gPz1All</ci>
<apply>
<plus/>
<ci>gPz1K</ci>
<ci>gPz1Ca</ci>
<ci>gPz1Na</ci>
</apply>
</apply>
</math>
<variable name="PPz1Na" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>PPz1Na</ci>
<apply>
<divide/>
<ci>gPz1Na</ci>
<ci>gPz1All</ci>
</apply>
</apply>
</math>
<variable name="PPz1Ca" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>PPz1Ca</ci>
<apply>
<divide/>
<ci>gPz1Ca</ci>
<ci>gPz1All</ci>
</apply>
</apply>
</math>
<variable name="PPz1K" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>PPz1K</ci>
<apply>
<divide/>
<ci>gPz1K</ci>
<ci>gPz1All</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ek</ci>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>FonRT</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>K_o</ci>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>eks</ci>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>FonRT</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<plus/>
<ci>K_o</ci>
<apply>
<times/>
<ci>prNaK</ci>
<ci>Na_o</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>K_i</ci>
<apply>
<times/>
<ci>prNaK</ci>
<ci>Na_i</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ena</ci>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>FonRT</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Na_o</ci>
<ci>Na_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ecas</ci>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>FonRT</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ca_o</ci>
<ci>Ca_submem</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>eghkPz1</ci>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>FonRT</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<ci>PPz1K</ci>
<ci>K_o</ci>
</apply>
<apply>
<times/>
<ci>PPz1Ca</ci>
<ci>Ca_o</ci>
</apply>
<apply>
<times/>
<ci>PPz1Na</ci>
<ci>Na_o</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>PPz1K</ci>
<ci>K_i</ci>
</apply>
<apply>
<times/>
<ci>PPz1Ca</ci>
<ci>Ca_submem</ci>
</apply>
<apply>
<times/>
<ci>PPz1Na</ci>
<ci>Na_i</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="cell_membrane" component_2="interface"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="i_stim" variable_2="i_stim"/>
</connection>
<connection>
<map_components component_1="reversal_potentials" component_2="environment"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
<map_variables variable_1="FonRT" variable_2="FonRT"/>
</connection>
<connection>
<map_components component_1="INa" component_2="interface"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="ICaL" component_2="interface"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="ICaL" component_2="environment"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="FonRT" variable_2="FonRT"/>
</connection>
<connection>
<map_components component_1="IKr" component_2="interface"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="IKr" component_2="environment"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection>
<map_components component_1="IKs" component_2="interface"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="IK1" component_2="environment"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection>
<map_components component_1="Ito" component_2="interface"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="INaK" component_2="environment"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
<map_variables variable_1="FonRT" variable_2="FonRT"/>
</connection>
<connection>
<map_components component_1="INaCa" component_2="environment"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
<map_variables variable_1="FonRT" variable_2="FonRT"/>
</connection>
<connection>
<map_components component_1="Irel" component_2="interface"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ca" component_2="interface"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Na" component_2="interface"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="cell_membrane" component_2="INa"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="xina" variable_2="xina"/>
</connection>
<connection>
<map_components component_1="cell_membrane" component_2="ICaL"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="xica" variable_2="xica"/>
<map_variables variable_1="wca" variable_2="wca"/>
</connection>
<connection>
<map_components component_1="cell_membrane" component_2="IKr"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="xikr" variable_2="xikr"/>
</connection>
<connection>
<map_components component_1="cell_membrane" component_2="IKs"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="xiks" variable_2="xiks"/>
</connection>
<connection>
<map_components component_1="cell_membrane" component_2="Ito"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="xito" variable_2="xito"/>
</connection>
<connection>
<map_components component_1="cell_membrane" component_2="IK1"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="xik1" variable_2="xik1"/>
</connection>
<connection>
<map_components component_1="cell_membrane" component_2="INaK"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="xiNaK" variable_2="xiNaK"/>
</connection>
<connection>
<map_components component_1="cell_membrane" component_2="INaCa"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="xiNaCa" variable_2="xiNaCa"/>
<map_variables variable_1="wca" variable_2="wca"/>
</connection>
<connection>
<map_components component_1="cell_membrane" component_2="Irel"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="cell_membrane" component_2="Na"/>
<map_variables variable_1="wca" variable_2="wca"/>
</connection>
<connection>
<map_components component_1="reversal_potentials" component_2="IK1"/>
<map_variables variable_1="ek" variable_2="ek"/>
</connection>
<connection>
<map_components component_1="reversal_potentials" component_2="IKr"/>
<map_variables variable_1="ek" variable_2="ek"/>
</connection>
<connection>
<map_components component_1="reversal_potentials" component_2="Ito"/>
<map_variables variable_1="ek" variable_2="ek"/>
</connection>
<connection>
<map_components component_1="reversal_potentials" component_2="IKs"/>
<map_variables variable_1="eks" variable_2="eks"/>
</connection>
<connection>
<map_components component_1="reversal_potentials" component_2="INa"/>
<map_variables variable_1="ena" variable_2="ena"/>
</connection>
<connection>
<map_components component_1="reversal_potentials" component_2="IPz1"/>
<map_variables variable_1="ena" variable_2="ena"/>
<map_variables variable_1="eks" variable_2="eks"/>
<map_variables variable_1="ecas" variable_2="ecas"/>
</connection>
<connection>
<map_components component_1="reversal_potentials" component_2="Na"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
</connection>
<connection>
<map_components component_1="INa" component_2="Na"/>
<map_variables variable_1="xina" variable_2="xina"/>
</connection>
<connection>
<map_components component_1="INaK" component_2="Na"/>
<map_variables variable_1="xiNaK" variable_2="xiNaK"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
</connection>
<connection>
<map_components component_1="IPz1" component_2="Na"/>
<map_variables variable_1="xiNaPz1" variable_2="xiNaPz1"/>
</connection>
<connection>
<map_components component_1="INaCa" component_2="Na"/>
<map_variables variable_1="xiNaCa" variable_2="xiNaCa"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
</connection>
<connection>
<map_components component_1="INaCa" component_2="Ca"/>
<map_variables variable_1="jNaCa" variable_2="jNaCa"/>
<map_variables variable_1="Ca_submem" variable_2="Ca_submem"/>
<map_variables variable_1="csm" variable_2="csm"/>
</connection>
<connection>
<map_components component_1="Ca" component_2="reversal_potentials"/>
<map_variables variable_1="Ca_submem" variable_2="Ca_submem"/>
</connection>
<connection>
<map_components component_1="ICaL" component_2="Ca"/>
<map_variables variable_1="Ca_dyad" variable_2="Ca_dyad"/>
<map_variables variable_1="csm" variable_2="csm"/>
<map_variables variable_1="jca" variable_2="jca"/>
</connection>
<connection>
<map_components component_1="IKs" component_2="Ca"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
</connection>
<connection>
<map_components component_1="ICaL" component_2="Irel"/>
<map_variables variable_1="po" variable_2="po"/>
<map_variables variable_1="rxa" variable_2="rxa"/>
</connection>
<connection>
<map_components component_1="piezo1_kinetics" component_2="IPz1"/>
<map_variables variable_1="gradmu" variable_2="gradmuPz1"/>
</connection>
<connection>
<map_components component_1="cell_membrane" component_2="IPz1"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="xiPz1" variable_2="xiPz1"/>
</connection>
<connection>
<map_components component_1="piezo1_kinetics" component_2="IPz1"/>
<map_variables variable_1="P_Open" variable_2="P_Open"/>
</connection>
<connection>
<map_components component_1="piezo1_kinetics" component_2="interface"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="pressure" variable_2="pressure"/>
</connection>
<connection>
<map_components component_1="IPz1" component_2="Ca"/>
<map_variables variable_1="jCaPz1" variable_2="jCaPz1"/>
</connection>
</model>
