- Author:
- shawnm <shawnm@rocko.local>
- Date:
- 2025-06-03 15:47:26+12:00
- Desc:
- updated readme.rst
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/d28/rawfile/ee7c1be211c09cb9b1639edfc10505b89eae3510/README.txt
Files:
Parameter fit n find
matlab routines to fit the Tong, 2011 PMCA data
pmca_fun1p1.m <- script that generates PMCA data to fit, assembles the Higgins 6-state kinetic model parameters from Higgins, 2006 SERCA model, and fits the k’s
fitting routines
higgins_serc_fit_ktilde_phosph_s_v1.m
higgins_serc_fit_ktilde_v1.m
higgins_pmca_v1.m
higgins_pmca_s1p5_v1.m
plot file shows original data from Tong, 2011 PMCA (Sigmoidal function), original Higgins, 6-state SERCA, and fit of kinetic model to PMCA
note: two fits presented with Hille coefficient of ‘2’ that fails and ‘1.5’ that fits
higgins_6state_fit_tong_usmc_pmca_ncomp1.png
BG schematic
serca_pmca_map_electrogenic_t1p2.001.png
CELLML File:
Higgins_SERCA_to_PMCA_wVm_v1.cellml
Run above out to ~t = 100k to see solution approach expected steady-state moles of Ca2+ (inside/outside) as predicted by analytical steady-state flux
