https://staging.physiomeproject.org/workspace/d42 en-us A novel, multi-compartment computational model of the pulmonary acinus, integrating pneumatic, hemodynamic, and chemical transport dynamics. The model represents the acinus as parallel alveolar compartments and incorporates mechanisms such as hypoxic pulmonary vasoconstriction and pharmacological modulation. It allows for direct simulation of pathophysiological states by tuning parameters for airway obstruction, alveolar collapse, and gas exchange impairment. https://staging.physiomeproject.org/workspace/d42/@@file/7a829c334cfa12d90cc0f489f2ea7b6edd74ac9a Manuscript draft commit Jagirhussan 2025-07-01