- Author:
- David Nickerson <david.nickerson@gmail.com>
- Date:
- 2025-08-24 23:17:42+12:00
- Desc:
- tweaking periodic stimulus settings and update docs to reflect change.
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/d59/rawfile/c44d712701866e6c4500696867baa97381fbf454/README.rst
Toward a generic cardiomyocyte model
====================================
Here we track development of generic cardiomyocyte model.
The figure below shows a preliminary diagram of a bond graph based approach to modelling the cardiomyocyte (see `Hunter et al. (2025) <https://doi.org/10.1016/j.bpj.2024.12.006>`_ for some background reading).
.. figure:: Cardiomyocyte.jpg
:width: 80%
:align: center
:alt: Schematic of the bond graph cardiomyocyte model.
This figure depicts the preliminary components of the generic cardiomyocyte bond graph model.
Electrophysiology
-----------------
Initially, we work from the "Noble 2000" guinea pig ventricular cell model (`PMR <https://models.physiomeproject.org/e/d58/>`_).
For convenience we include here versions of that model producing a `single stimulated action potential <noble_2000_a.cellml/view>`_ and a version with a `periodic stimulus applied <noble_2000_b.cellml/view>`_.
For each of those simulation protocols, the *Launch with OpenCOR* menu item from the right hand "Views Available" menu, on the respective pages, can be used to open each of these simulation experiments in the `OpenCOR <https://opencor.ws/>`_ desktop application to produce the results shown below.
.. figure:: noble_2000_a_results.jpg
:width: 80%
:align: center
:alt: Single action potential simulation results
This figure shows the results in OpenCOR for when a single stimulus pulse is applied to the Noble 2000 ventricular myocyte model.
.. figure:: noble_2000_b_results.jpg
:width: 80%
:align: center
:alt: Simulation results when a periodic stimulus applied
This figure shows the results in OpenCOR for the case when a stimulus pulse is applied with a 1 Hz frequency during the period 10 seconds to 110 seconds.
