- Author:
- shawnm <shawnm@rocko.local>
- Date:
- 2025-06-03 15:30:57+12:00
- Desc:
- update plot png
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/d7e/rawfile/7a11ada311694433258bad734b851dc18d78f3ce/README.rst
About this model
=====================
The plasma membrane Ca2+ ATPase pump (PMCA) as parameterised in the Means, 2023 uterine smooth muscle cell model (uSMC).
:Original Publication: 'Means SA, Roesler MW, Garrett AS, Cheng L, Clark AR (2023) Steady-state approximations for Hodgkin-Huxley cell models: Reduction of order for uterine smooth muscle cell model. PLoS Comput Biol 19(8): e1011359.'
:DOI: https://doi.org/10.1371/journal.pcbi.1011359
Model status
=====================
This is but one of the ion transporter sub-models of the Means, 2023 uSMC model. We converted a 6-state SERCA model into a 6-state PMCA model (see schematic).
.. figure:: serca_pmca_map_electrogenic_t1p2.001.png
:width: 85%
:align: center
:alt: Schematic of the model
Modifications were necessary to the underlying original PMCA model from Tong, 2011. Originally the model was a Hille function with an exponent of 2 indicating a stoichiometry of 2 Ca2+ per cycle, yet evidence indicates stoichiometry in the range of 1.3-1.7 (Tong, 2011). Fits between the Tong, 2011 Hille and the 6-state model show poor correspondence between them (see plot). We thus modified the Hille coefficient to '1.5' and the 6-state model to '1.5' as well with improved fit as shown.
.. figure:: higgins_6state_fit_tong_usmc_pmca_ncomp1.png
:width: 85%
:align: center
:alt: Plots fits sigmoidal PMCA with 6-state model
