Location: Noble, DiFrancesco, Denyer, 1989 @ ed34856fa179 / simulation.json

Author:

Alan Garny <agarny@hellix.com>

Date:

2026-04-30 18:03:37+12:00

Desc:

Added some documentation.

Permanent Source URI:

https://staging.physiomeproject.org/workspace/da0/rawfile/ed34856fa1796d4654d076d482a9d1a82fd8dbe5/simulation.json

{
  "input": [
    {
      "id": "i_f_percentage",
      "name": "if (%)",
      "defaultValue": 100,
      "minimumValue": 0,
      "maximumValue": 200
    },
    {
      "id": "i_K_percentage",
      "name": "iK (%)",
      "defaultValue": 100,
      "minimumValue": 0,
      "maximumValue": 200
    },
    {
      "id": "i_K1_percentage",
      "name": "iK1 (%)",
      "defaultValue": 100,
      "minimumValue": 0,
      "maximumValue": 200
    },
    {
      "id": "i_Na_b_percentage",
      "name": "iNa,b (%)",
      "defaultValue": 100,
      "minimumValue": 0,
      "maximumValue": 200
    },
    {
      "id": "i_Ca_b_percentage",
      "name": "iCa,b (%)",
      "defaultValue": 100,
      "minimumValue": 0,
      "maximumValue": 200
    },
    {
      "id": "i_p_percentage",
      "name": "ip (%)",
      "defaultValue": 100,
      "minimumValue": 0,
      "maximumValue": 200
    },
    {
      "id": "i_NaCa_percentage",
      "name": "iNaCa (%)",
      "defaultValue": 100,
      "minimumValue": 0,
      "maximumValue": 200
    },
    {
      "id": "i_Na_percentage",
      "name": "iNa (%)",
      "defaultValue": 100,
      "minimumValue": 0,
      "maximumValue": 200
    },
    {
      "id": "i_si_percentage",
      "name": "isi (%)",
      "defaultValue": 100,
      "minimumValue": 0,
      "maximumValue": 200
    }
  ],
  "output": {
    "data": [
      {
        "id": "time",
        "name": "environment/time"
      },
      {
        "id": "V",
        "name": "membrane/V"
      },
      {
        "id": "i_f",
        "name": "hyperpolarising_activated_current/i_f"
      },
      {
        "id": "i_K",
        "name": "time_dependent_potassium_current/i_K"
      },
      {
        "id": "i_K1",
        "name": "time_independent_potassium_current/i_K1"
      },
      {
        "id": "i_Na_b",
        "name": "sodium_background_current/i_Na_b"
      },
      {
        "id": "i_Ca_b",
        "name": "calcium_background_current/i_Ca_b"
      },
      {
        "id": "i_p",
        "name": "sodium_potassium_pump/i_p"
      },
      {
        "id": "i_NaCa",
        "name": "Na_Ca_exchanger/i_NaCa"
      },
      {
        "id": "i_Na",
        "name": "fast_sodium_current/i_Na"
      },
      {
        "id": "i_si",
        "name": "second_inward_current/i_si"
      }
    ],
    "plots": [
      {
        "name": "V",
        "xValue": "time",
        "yValue": "V",
        "additionalTraces": [],
        "xAxisTitle": "Time (s)",
        "yAxisTitle": "Membrane potential (mV)"
      },
      {
        "name": "i<sub>f</sub>",
        "xValue": "time",
        "yValue": "i_f",
        "additionalTraces": [
          {
            "xValue": "time",
            "yValue": "i_K",
            "name": "i<sub>K</sub>"
          },
          {
            "xValue": "time",
            "yValue": "i_K1",
            "name": "i<sub>K1</sub>"
          },
          {
            "xValue": "time",
            "yValue": "i_Na_b",
            "name": "i<sub>Na<sub>b</sub></sub>"
          },
          {
            "xValue": "time",
            "yValue": "i_Ca_b",
            "name": "i<sub>Ca<sub>b</sub></sub>"
          },
          {
            "xValue": "time",
            "yValue": "i_p",
            "name": "i<sub>p</sub>"
          },
          {
            "xValue": "time",
            "yValue": "i_NaCa",
            "name": "i<sub>NaCa</sub>"
          },
          {
            "xValue": "time",
            "yValue": "i_Na",
            "name": "i<sub>Na</sub>"
          },
          {
            "xValue": "time",
            "yValue": "i_si",
            "name": "i<sub>si</sub>"
          }
        ],
        "xAxisTitle": "Time (s)",
        "yAxisTitle": "Current (nA)"
      }
    ]
  },
  "parameters": [
    {
      "name": "hyperpolarising_activated_current/g_f_Na",
      "value": "0.01*i_f_percentage*0.06"
    },
    {
      "name": "hyperpolarising_activated_current/g_f_K",
      "value": "0.01*i_f_percentage*0.06"
    },
    {
      "name": "time_dependent_potassium_current/i_K_max",
      "value": "0.01*i_K_percentage*0.8"
    },
    {
      "name": "time_independent_potassium_current/g_K1",
      "value": "0.01*i_K1_percentage*0.0075"
    },
    {
      "name": "sodium_background_current/g_Nab",
      "value": "0.01*i_Na_b_percentage*0.0007"
    },
    {
      "name": "calcium_background_current/g_Cab",
      "value": "0.01*i_Ca_b_percentage*0.0001"
    },
    {
      "name": "sodium_potassium_pump/I_p",
      "value": "0.01*i_p_percentage*0.45"
    },
    {
      "name": "Na_Ca_exchanger/K_NaCa",
      "value": "0.01*i_NaCa_percentage*2e-5"
    },
    {
      "name": "fast_sodium_current/g_Na",
      "value": "0.01*i_Na_percentage*0.0125"
    },
    {
      "name": "second_inward_current/P_si",
      "value": "0.01*i_si_percentage*0.12"
    }
  ]
}