- Author:
- pmr2.import <nobody@models.cellml.org>
- Date:
- 2008-03-19 22:52:50+13:00
- Desc:
- committing version04 of garny_kohl_hunter_boyett_noble_2003
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/garny_kohl_hunter_boyett_noble_2003/rawfile/13e5afa4c77c60b3bd20129536ee07cc3c8b89ad/garny_kohl_hunter_boyett_noble_2003.cellml
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<!--
This CellML file was generated on 20/06/2005 at 12:19:40 using:
COR (0.9.31.71)
Copyright 2002-2005 Oxford Cardiac Electrophysiology Group
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk
CellML 1.0 was used to generate this cellular model
http://www.CellML.org/
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<title>Mathematical Model Of Action Potentials In The Periphery Of The Sinoatrial Node, 2000</title>
<author>
<firstname>Penny</firstname>
<surname>Noble</surname>
<affiliation>
<shortaffil>Oxford University</shortaffil>
</affiliation>
</author>
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<section id="sec_status">
<title>Model Status</title>
<para>
This version was created by Penny Noble of Oxford University and is unit consistent ande known to read in COR and PCEnv to reproduce the results shown in the publication. This version contains the parameterisations for the OD and 1D capable simulations of both central and peripheral SA node cells.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
In 2000 H. Zhang <emphasis>et al</emphasis> published a mathematical model which describes the action potentials in the periphery and center of the rabbit sinoatrial node (see the figure below). The SA node is functionally, anatomically and electrophysiologically heterogeneous. In their model, Zhang <emphasis>et al</emphasis> accounted for this heterogeneity by defining two distinct models for the peripheral and the central cells of the SA node. These models have the same equations to define the ionic currents, but they vary in their parameters. The CellML description here is of the peripheral SA node cell model. To make it appropriate for the central SA node cells, certain parameters need to be changed (refer to the original paper reference which is cited below).
</para>
<para>
<ulink url="http://ajpheart.physiology.org/cgi/content/abstract/279/1/H397">Mathematical models of action potentials in the periphery and center of the rabbit sinoatrial node</ulink>, H. Zhang, A.V. Holden, I. Honjo, M. Lei, T. Varghese and M.R. Boyett, 2000, <ulink url="http://ajpheart.physiology.org/">
<emphasis>Am. J. Physiol. Heart Circ. Physiol.</emphasis>
</ulink>, 279, H397-H421. (The <ulink url="http://ajpheart.physiology.org/cgi/content/full/279/1/H397">full text</ulink> of the article is available on the American Journal of Physiology website for Journal Members.) <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10899081&dopt=Abstract">PubMed ID: 10899081</ulink>
</para>
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<caption>A schematic diagram describing the current flows across the cell membrane that are captured in the Zhang <emphasis>et al</emphasis> 2000 model of the action potentials in the peripheral cells of the SA node.</caption>
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<cn cellml:units="dimensionless">1.662</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.2251</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="dimensionless">63.7</cn>
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</apply>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">0.08693</cn>
</apply>
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<eq/>
<ci>h</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>F_Na</ci>
</apply>
<ci>h1</ci>
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<apply>
<times/>
<ci>F_Na</ci>
<ci>h2</ci>
</apply>
</apply>
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<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>h1</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>h1_infinity</ci>
<ci>h1</ci>
</apply>
<ci>tau_h1</ci>
</apply>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>h2</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>h2_infinity</ci>
<ci>h2</ci>
</apply>
<ci>tau_h2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>h1_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">66.1</cn>
</apply>
<cn cellml:units="millivolt">6.4</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>h2_infinity</ci>
<ci>h1_infinity</ci>
</apply>
<apply>
<eq/>
<ci>tau_h1</ci>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="second">3.717e-6</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.2815</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">17.11</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="second">0.003732</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.3426</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">37.76</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="second">0.0005977</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_h2</ci>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="second">3.186e-8</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.6219</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">18.8</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="second">7.189e-5</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.6683</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">34.07</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="second">0.003556</cn>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_channel">
<variable units="dimensionless" public_interface="in" private_interface="out" name="Version"/>
<variable units="dimensionless" public_interface="in" private_interface="out" name="FCell"/>
<variable units="nanoA" public_interface="out" name="i_Ca_L"/>
<variable units="microS" name="g_Ca_L_Centre_Published" initial_value="0.0058"/>
<variable units="microS" name="g_Ca_L_Centre_0DCapable" initial_value="0.0057938"/>
<variable units="microS" name="g_Ca_L_Centre_1DCapable" initial_value="0.0082"/>
<variable units="microS" name="g_Ca_L_Periphery_Published" initial_value="0.0659"/>
<variable units="microS" name="g_Ca_L_Periphery_0DCapable" initial_value="0.06588648"/>
<variable units="microS" name="g_Ca_L_Periphery_1DCapable" initial_value="0.0659"/>
<variable units="microS" name="g_Ca_L"/>
<variable units="millivolt" name="E_Ca_L" initial_value="46.4"/>
<variable units="second" public_interface="in" private_interface="out" name="time"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
<variable units="dimensionless" private_interface="in" name="d_L"/>
<variable units="dimensionless" private_interface="in" name="f_L"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_Ca_L</ci>
<piecewise>
<piece>
<apply>
<plus/>
<ci>g_Ca_L_Centre_Published</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_Ca_L_Periphery_Published</ci>
<ci>g_Ca_L_Centre_Published</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<piece>
<apply>
<plus/>
<ci>g_Ca_L_Centre_0DCapable</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_Ca_L_Periphery_0DCapable</ci>
<ci>g_Ca_L_Centre_0DCapable</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<apply>
<plus/>
<ci>g_Ca_L_Centre_1DCapable</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_Ca_L_Periphery_1DCapable</ci>
<ci>g_Ca_L_Centre_1DCapable</ci>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>i_Ca_L</ci>
<apply>
<times/>
<ci>g_Ca_L</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>f_L</ci>
<ci>d_L</ci>
</apply>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.006</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">14.1</cn>
</apply>
</apply>
<cn cellml:units="millivolt">6</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Ca_L</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_channel_d_gate">
<variable units="dimensionless" public_interface="in" name="Version"/>
<variable units="dimensionless" public_interface="in" name="FCell"/>
<variable units="dimensionless" public_interface="out" name="d_L" initial_value="0.04804900895"/>
<variable units="per_second" name="alpha_d_L"/>
<variable units="per_second" name="beta_d_L"/>
<variable units="dimensionless" name="d_L_infinity"/>
<variable units="second" name="tau_d_L"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>d_L</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>d_L_infinity</ci>
<ci>d_L</ci>
</apply>
<ci>tau_d_L</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_d_L</ci>
<piecewise>
<piece>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt_second">28.38</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">35</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">35</cn>
</apply>
</apply>
<cn cellml:units="millivolt">2.5</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt">84.9</cn>
<ci>V</ci>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.208</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<piece>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt_second">28.39</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">35</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">35</cn>
</apply>
</apply>
<cn cellml:units="millivolt">2.5</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt">84.9</cn>
<ci>V</ci>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.208</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt_second">28.4</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">35</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">35</cn>
</apply>
</apply>
<cn cellml:units="millivolt">2.5</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt">84.9</cn>
<ci>V</ci>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.208</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>beta_d_L</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_second">11.43</cn>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.4</cn>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
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<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_second">11.42</cn>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.4</cn>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</otherwise>
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</apply>
<apply>
<eq/>
<ci>tau_d_L</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">2</cn>
<apply>
<plus/>
<ci>alpha_d_L</ci>
<ci>beta_d_L</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>d_L_infinity</ci>
<piecewise>
<piece>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">23.1</cn>
</apply>
</apply>
<cn cellml:units="millivolt">6</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<piece>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">22.3</cn>
<apply>
<times/>
<cn cellml:units="millivolt">0.8</cn>
<ci>FCell</ci>
</apply>
</apply>
</apply>
<cn cellml:units="millivolt">6</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">22.2</cn>
</apply>
</apply>
<cn cellml:units="millivolt">6</cn>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="L_type_Ca_channel_f_gate">
<variable units="dimensionless" public_interface="in" name="Version"/>
<variable units="dimensionless" public_interface="in" name="FCell"/>
<variable units="dimensionless" public_interface="out" name="f_L" initial_value="0.48779845203"/>
<variable units="per_second" name="alpha_f_L"/>
<variable units="per_second" name="beta_f_L"/>
<variable units="dimensionless" name="f_L_infinity"/>
<variable units="second" name="tau_f_L"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>f_L</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>f_L_infinity</ci>
<ci>f_L</ci>
</apply>
<ci>tau_f_L</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_f_L</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_second">3.75</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">28</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">28</cn>
</apply>
<cn cellml:units="millivolt">4</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_second">3.12</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">28</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">28</cn>
</apply>
<cn cellml:units="millivolt">4</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>beta_f_L</ci>
<piecewise>
<piece>
<apply>
<divide/>
<cn cellml:units="per_second">30</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">28</cn>
</apply>
</apply>
<cn cellml:units="millivolt">4</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<cn cellml:units="per_second">25</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">28</cn>
</apply>
</apply>
<cn cellml:units="millivolt">4</cn>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>tau_f_L</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.2</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.2</cn>
<ci>FCell</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>alpha_f_L</ci>
<ci>beta_f_L</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>alpha_f_L</ci>
<ci>beta_f_L</ci>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>f_L_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">45</cn>
</apply>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="T_type_Ca_channel">
<variable units="dimensionless" public_interface="in" private_interface="out" name="Version"/>
<variable units="dimensionless" public_interface="in" private_interface="out" name="FCell"/>
<variable units="nanoA" public_interface="out" name="i_Ca_T"/>
<variable units="microS" name="g_Ca_T_Centre_Published" initial_value="0.0043"/>
<variable units="microS" name="g_Ca_T_Centre_0DCapable" initial_value="0.00427806"/>
<variable units="microS" name="g_Ca_T_Centre_1DCapable" initial_value="0.0021"/>
<variable units="microS" name="g_Ca_T_Periphery_Published" initial_value="0.0139"/>
<variable units="microS" name="g_Ca_T_Periphery_0DCapable" initial_value="0.0138823"/>
<variable units="microS" name="g_Ca_T_Periphery_1DCapable" initial_value="0.00694"/>
<variable units="microS" name="g_Ca_T"/>
<variable units="millivolt" name="E_Ca_T" initial_value="45"/>
<variable units="second" public_interface="in" private_interface="out" name="time"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
<variable units="dimensionless" private_interface="in" name="d_T"/>
<variable units="dimensionless" private_interface="in" name="f_T"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_Ca_T</ci>
<piecewise>
<piece>
<apply>
<plus/>
<ci>g_Ca_T_Centre_Published</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_Ca_T_Periphery_Published</ci>
<ci>g_Ca_T_Centre_Published</ci>
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</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
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<piece>
<apply>
<plus/>
<ci>g_Ca_T_Centre_0DCapable</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_Ca_T_Periphery_0DCapable</ci>
<ci>g_Ca_T_Centre_0DCapable</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
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</apply>
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<apply>
<plus/>
<ci>g_Ca_T_Centre_1DCapable</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_Ca_T_Periphery_1DCapable</ci>
<ci>g_Ca_T_Centre_1DCapable</ci>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>i_Ca_T</ci>
<apply>
<times/>
<ci>g_Ca_T</ci>
<ci>d_T</ci>
<ci>f_T</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Ca_T</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="T_type_Ca_channel_d_gate">
<variable units="dimensionless" public_interface="out" name="d_T" initial_value="0.42074047435"/>
<variable units="per_second" name="alpha_d_T"/>
<variable units="per_second" name="beta_d_T"/>
<variable units="dimensionless" name="d_T_infinity"/>
<variable units="second" name="tau_d_T"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>d_T</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>d_T_infinity</ci>
<ci>d_T</ci>
</apply>
<ci>tau_d_T</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_d_T</ci>
<apply>
<times/>
<cn cellml:units="per_second">1068</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">26.3</cn>
</apply>
<cn cellml:units="millivolt">30</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_d_T</ci>
<apply>
<times/>
<cn cellml:units="per_second">1068</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">26.3</cn>
</apply>
</apply>
<cn cellml:units="millivolt">30</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_d_T</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>alpha_d_T</ci>
<ci>beta_d_T</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>d_T_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">37</cn>
</apply>
</apply>
<cn cellml:units="millivolt">6.8</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="T_type_Ca_channel_f_gate">
<variable units="dimensionless" public_interface="in" name="Version"/>
<variable units="dimensionless" public_interface="in" name="FCell"/>
<variable units="dimensionless" public_interface="out" name="f_T" initial_value="0.038968420558"/>
<variable units="per_second" name="alpha_f_T"/>
<variable units="per_second" name="beta_f_T"/>
<variable units="dimensionless" name="f_T_infinity"/>
<variable units="second" name="tau_f_T"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>f_T</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>f_T_infinity</ci>
<ci>f_T</ci>
</apply>
<ci>tau_f_T</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_f_T</ci>
<piecewise>
<piece>
<apply>
<times/>
<cn cellml:units="per_second">15.3</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="dimensionless">71</cn>
<apply>
<times/>
<cn cellml:units="millivolt">0.7</cn>
<ci>FCell</ci>
</apply>
</apply>
</apply>
<cn cellml:units="millivolt">83.3</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<cn cellml:units="per_second">15.3</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">71.7</cn>
</apply>
</apply>
<cn cellml:units="millivolt">83.3</cn>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>beta_f_T</ci>
<piecewise>
<piece>
<apply>
<times/>
<cn cellml:units="per_second">15</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">71</cn>
</apply>
<cn cellml:units="millivolt">15.38</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<cn cellml:units="per_second">15</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">71.7</cn>
</apply>
<cn cellml:units="millivolt">15.38</cn>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>tau_f_T</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>alpha_f_T</ci>
<ci>beta_f_T</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>f_T_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">71</cn>
</apply>
<cn cellml:units="millivolt">9</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="four_AP_sensitive_currents">
<variable units="dimensionless" public_interface="in" private_interface="out" name="Version"/>
<variable units="dimensionless" public_interface="in" private_interface="out" name="FCell"/>
<variable units="nanoA" public_interface="out" name="i_to"/>
<variable units="nanoA" public_interface="out" name="i_sus"/>
<variable units="microS" name="g_to_Centre_Published" initial_value="0.00491"/>
<variable units="microS" name="g_to_Centre_0DCapable" initial_value="0.004905"/>
<variable units="microS" name="g_to_Centre_1DCapable" initial_value="0.004905"/>
<variable units="microS" name="g_to_Periphery_Published" initial_value="0.03649"/>
<variable units="microS" name="g_to_Periphery_0DCapable" initial_value="0.036495"/>
<variable units="microS" name="g_to_Periphery_1DCapable" initial_value="0.0365"/>
<variable units="microS" name="g_to"/>
<variable units="microS" name="g_sus_Centre_Published" initial_value="6.65e-5"/>
<variable units="microS" name="g_sus_Centre_0DCapable" initial_value="6.645504e-5"/>
<variable units="microS" name="g_sus_Centre_1DCapable" initial_value="0.000266"/>
<variable units="microS" name="g_sus_Periphery_Published" initial_value="0.0114"/>
<variable units="microS" name="g_sus_Periphery_0DCapable" initial_value="0.01138376"/>
<variable units="microS" name="g_sus_Periphery_1DCapable" initial_value="0.0114"/>
<variable units="microS" name="g_sus"/>
<variable units="millivolt" public_interface="in" name="E_K"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
<variable units="second" public_interface="in" private_interface="out" name="time"/>
<variable units="dimensionless" private_interface="in" name="q"/>
<variable units="dimensionless" private_interface="in" name="r"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_to</ci>
<piecewise>
<piece>
<apply>
<plus/>
<ci>g_to_Centre_Published</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_to_Periphery_Published</ci>
<ci>g_to_Centre_Published</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<piece>
<apply>
<plus/>
<ci>g_to_Centre_0DCapable</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_to_Periphery_0DCapable</ci>
<ci>g_to_Centre_0DCapable</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<apply>
<plus/>
<ci>g_to_Centre_1DCapable</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_to_Periphery_1DCapable</ci>
<ci>g_to_Centre_1DCapable</ci>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>g_sus</ci>
<piecewise>
<piece>
<apply>
<plus/>
<ci>g_sus_Centre_Published</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_sus_Periphery_Published</ci>
<ci>g_sus_Centre_Published</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<piece>
<apply>
<plus/>
<ci>g_sus_Centre_0DCapable</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_sus_Periphery_0DCapable</ci>
<ci>g_sus_Centre_0DCapable</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<apply>
<plus/>
<ci>g_sus_Centre_1DCapable</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_sus_Periphery_1DCapable</ci>
<ci>g_sus_Centre_1DCapable</ci>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>i_to</ci>
<apply>
<times/>
<ci>g_to</ci>
<ci>q</ci>
<ci>r</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_sus</ci>
<apply>
<times/>
<ci>g_sus</ci>
<ci>r</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="four_AP_sensitive_currents_q_gate">
<variable units="dimensionless" public_interface="in" name="Version"/>
<variable units="dimensionless" public_interface="in" name="FCell"/>
<variable units="dimensionless" public_interface="out" name="q" initial_value="0.29760539675"/>
<variable units="dimensionless" name="q_infinity"/>
<variable units="second" name="tau_q"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>q_infinity</ci>
<ci>q</ci>
</apply>
<ci>tau_q</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">59.37</cn>
</apply>
<cn cellml:units="millivolt">13.1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_q</ci>
<piecewise>
<piece>
<apply>
<plus/>
<cn cellml:units="second">0.0101</cn>
<apply>
<divide/>
<cn cellml:units="second">0.06517</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.57</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="millivolt">0.08</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">49</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="second">2.4e-5</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="millivolt">0.1</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">50.93</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<piece>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="second">0.001</cn>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="second">30.31</cn>
<apply>
<divide/>
<cn cellml:units="second">195.5</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5686</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="millivolt">0.08161</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">39</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">10</cn>
<ci>FCell</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="second">0.7174</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="millivolt">0.2719</cn>
<apply>
<times/>
<cn cellml:units="millivolt">0.1719</cn>
<ci>FCell</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">40.93</cn>
<apply>
<times/>
<cn cellml:units="millivolt">10</cn>
<ci>FCell</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<apply>
<plus/>
<cn cellml:units="second">0.0101</cn>
<apply>
<divide/>
<cn cellml:units="second">0.06517</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5686</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="millivolt">0.08161</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">39</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="second">0.7174</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="millivolt">0.2719</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">40.93</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="four_AP_sensitive_currents_r_gate">
<variable units="dimensionless" public_interface="in" name="Version"/>
<variable units="dimensionless" public_interface="out" name="r" initial_value="0.064402950262"/>
<variable units="dimensionless" name="r_infinity"/>
<variable units="second" name="tau_r"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>r</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>r_infinity</ci>
<ci>r</ci>
</apply>
<ci>tau_r</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>r_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">10.93</cn>
</apply>
</apply>
<cn cellml:units="millivolt">19.7</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_r</ci>
<piecewise>
<piece>
<apply>
<times/>
<cn cellml:units="dimensionless">0.001</cn>
<apply>
<plus/>
<cn cellml:units="second">2.98</cn>
<apply>
<divide/>
<cn cellml:units="second">15.59</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.037</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="millivolt">0.09</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">30.61</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.369</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="millivolt">0.12</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">23.84</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<piece>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0025</cn>
<apply>
<plus/>
<cn cellml:units="second">1.191</cn>
<apply>
<divide/>
<cn cellml:units="second">7.838</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.037</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="millivolt">0.09012</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">30.61</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.369</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="millivolt">0.119</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">23.84</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<cn cellml:units="dimensionless">0.001</cn>
<apply>
<plus/>
<cn cellml:units="second">2.98</cn>
<apply>
<divide/>
<cn cellml:units="second">19.59</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.037</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="millivolt">0.09012</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">30.61</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.369</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="millivolt">0.119</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">23.84</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="rapid_delayed_rectifying_potassium_current">
<variable units="dimensionless" public_interface="in" private_interface="out" name="Version"/>
<variable units="dimensionless" public_interface="in" name="FCell"/>
<variable units="nanoA" public_interface="out" name="i_K_r"/>
<variable units="microS" name="g_K_r_Centre_Published" initial_value="0.000797"/>
<variable units="microS" name="g_K_r_Centre_0DCapable" initial_value="0.00079704"/>
<variable units="microS" name="g_K_r_Centre_1DCapable" initial_value="0.000738"/>
<variable units="microS" name="g_K_r_Periphery_Published" initial_value="0.016"/>
<variable units="microS" name="g_K_r_Periphery_0DCapable" initial_value="0.016"/>
<variable units="microS" name="g_K_r_Periphery_1DCapable" initial_value="0.0208"/>
<variable units="microS" name="g_K_r"/>
<variable units="dimensionless" name="P_a"/>
<variable units="millivolt" public_interface="in" name="E_K"/>
<variable units="second" public_interface="in" private_interface="out" name="time"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
<variable units="dimensionless" private_interface="in" name="P_af"/>
<variable units="dimensionless" private_interface="in" name="P_as"/>
<variable units="dimensionless" private_interface="in" name="P_i"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_K_r</ci>
<piecewise>
<piece>
<apply>
<plus/>
<ci>g_K_r_Centre_Published</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_K_r_Periphery_Published</ci>
<ci>g_K_r_Centre_Published</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<piece>
<apply>
<plus/>
<ci>g_K_r_Centre_0DCapable</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_K_r_Periphery_0DCapable</ci>
<ci>g_K_r_Centre_0DCapable</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<apply>
<plus/>
<ci>g_K_r_Centre_1DCapable</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_K_r_Periphery_1DCapable</ci>
<ci>g_K_r_Centre_1DCapable</ci>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>i_K_r</ci>
<apply>
<times/>
<ci>g_K_r</ci>
<ci>P_a</ci>
<ci>P_i</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_a</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.6</cn>
<ci>P_af</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.4</cn>
<ci>P_as</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="rapid_delayed_rectifying_potassium_current_P_af_gate">
<variable units="dimensionless" public_interface="in" name="Version"/>
<variable units="dimensionless" public_interface="out" name="P_af" initial_value="0.13034201158"/>
<variable units="dimensionless" public_interface="out" name="P_af_infinity"/>
<variable units="second" name="tau_P_af"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>P_af</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>P_af_infinity</ci>
<ci>P_af</ci>
</apply>
<ci>tau_P_af</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>P_af_infinity</ci>
<piecewise>
<piece>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">14.2</cn>
</apply>
</apply>
<cn cellml:units="millivolt">10.6</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<neq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">13.2</cn>
</apply>
</apply>
<cn cellml:units="millivolt">10.6</cn>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>tau_P_af</ci>
<piecewise>
<piece>
<apply>
<divide/>
<cn cellml:units="second">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">37.2</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">9</cn>
</apply>
<cn cellml:units="millivolt">15.9</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.96</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">9</cn>
</apply>
</apply>
<cn cellml:units="millivolt">22.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<neq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<cn cellml:units="second">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">37.2</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">10</cn>
</apply>
<cn cellml:units="millivolt">15.9</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.96</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
<cn cellml:units="millivolt">22.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="rapid_delayed_rectifying_potassium_current_P_as_gate">
<variable units="dimensionless" public_interface="in" name="Version"/>
<variable units="dimensionless" public_interface="out" name="P_as" initial_value="0.46960956028"/>
<variable units="dimensionless" name="P_as_infinity"/>
<variable units="second" name="tau_P_as"/>
<variable units="dimensionless" public_interface="in" name="P_af_infinity"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>P_as</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>P_as_infinity</ci>
<ci>P_as</ci>
</apply>
<ci>tau_P_as</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>P_as_infinity</ci>
<ci>P_af_infinity</ci>
</apply>
<apply>
<eq/>
<ci>tau_P_as</ci>
<piecewise>
<piece>
<apply>
<divide/>
<cn cellml:units="second">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4.2</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">9</cn>
</apply>
<cn cellml:units="millivolt">17</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.15</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">9</cn>
</apply>
</apply>
<cn cellml:units="millivolt">21.6</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<neq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<cn cellml:units="second">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4.2</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">10</cn>
</apply>
<cn cellml:units="millivolt">17</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.15</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
<cn cellml:units="millivolt">21.6</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="rapid_delayed_rectifying_potassium_current_P_i_gate">
<variable units="dimensionless" public_interface="in" name="Version"/>
<variable units="dimensionless" public_interface="out" name="P_i" initial_value="0.87993375273"/>
<variable units="dimensionless" name="P_i_infinity"/>
<variable units="second" name="tau_P_i"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>tau_P_i</ci>
<piecewise>
<piece>
<cn cellml:units="second">0.002</cn>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<piece>
<cn cellml:units="second">0.002</cn>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="second">0.006</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>P_i</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>P_i_infinity</ci>
<ci>P_i</ci>
</apply>
<ci>tau_P_i</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>P_i_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">18.6</cn>
</apply>
<cn cellml:units="millivolt">10.1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="slow_delayed_rectifying_potassium_current">
<variable units="dimensionless" public_interface="in" name="Version"/>
<variable units="dimensionless" public_interface="in" name="FCell"/>
<variable units="nanoA" public_interface="out" name="i_K_s"/>
<variable units="microS" name="g_K_s_Centre_Published" initial_value="0.000518"/>
<variable units="microS" name="g_K_s_Centre_0DCapable" initial_value="0.0003445"/>
<variable units="microS" name="g_K_s_Centre_1DCapable" initial_value="0.000345"/>
<variable units="microS" name="g_K_s_Periphery_Published" initial_value="0.0104"/>
<variable units="microS" name="g_K_s_Periphery_0DCapable" initial_value="0.0104"/>
<variable units="microS" name="g_K_s_Periphery_1DCapable" initial_value="0.0104"/>
<variable units="microS" name="g_K_s"/>
<variable units="millivolt" public_interface="in" name="E_K_s"/>
<variable units="second" public_interface="in" private_interface="out" name="time"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
<variable units="dimensionless" private_interface="in" name="xs"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_K_s</ci>
<piecewise>
<piece>
<apply>
<plus/>
<ci>g_K_s_Centre_Published</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_K_s_Periphery_Published</ci>
<ci>g_K_s_Centre_Published</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<piece>
<apply>
<plus/>
<ci>g_K_s_Centre_0DCapable</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_K_s_Periphery_0DCapable</ci>
<ci>g_K_s_Centre_0DCapable</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<apply>
<plus/>
<ci>g_K_s_Centre_1DCapable</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_K_s_Periphery_1DCapable</ci>
<ci>g_K_s_Centre_1DCapable</ci>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>i_K_s</ci>
<apply>
<times/>
<ci>g_K_s</ci>
<apply>
<power/>
<ci>xs</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K_s</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="slow_delayed_rectifying_potassium_current_xs_gate">
<variable units="dimensionless" public_interface="out" name="xs" initial_value="0.082293827208"/>
<variable units="per_second" name="alpha_xs"/>
<variable units="per_second" name="beta_xs"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>xs</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_xs</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>xs</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_xs</ci>
<ci>xs</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_xs</ci>
<apply>
<divide/>
<cn cellml:units="per_second">14</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">40</cn>
</apply>
</apply>
<cn cellml:units="millivolt">9</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_xs</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">45</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="hyperpolarisation_activated_current">
<variable units="dimensionless" public_interface="in" private_interface="out" name="Version"/>
<variable units="dimensionless" public_interface="in" name="FCell"/>
<variable units="nanoA" public_interface="out" name="i_f_Na"/>
<variable units="nanoA" public_interface="out" name="i_f_K"/>
<variable units="microS" name="g_f_Na_Centre_Published" initial_value="0.000548"/>
<variable units="microS" name="g_f_Na_Centre_0DCapable" initial_value="0.0005465"/>
<variable units="microS" name="g_f_Na_Centre_1DCapable" initial_value="0.000437"/>
<variable units="microS" name="g_f_Na_Periphery_Published" initial_value="0.0069"/>
<variable units="microS" name="g_f_Na_Periphery_0DCapable" initial_value="0.006875"/>
<variable units="microS" name="g_f_Na_Periphery_1DCapable" initial_value="0.0055"/>
<variable units="microS" name="g_f_Na"/>
<variable units="microS" name="g_f_K_Centre_Published" initial_value="0.000548"/>
<variable units="microS" name="g_f_K_Centre_0DCapable" initial_value="0.0005465"/>
<variable units="microS" name="g_f_K_Centre_1DCapable" initial_value="0.000437"/>
<variable units="microS" name="g_f_K_Periphery_Published" initial_value="0.0069"/>
<variable units="microS" name="g_f_K_Periphery_0DCapable" initial_value="0.006875"/>
<variable units="microS" name="g_f_K_Periphery_1DCapable" initial_value="0.0055"/>
<variable units="microS" name="g_f_K"/>
<variable units="millivolt" public_interface="in" name="E_K"/>
<variable units="millivolt" public_interface="in" name="E_Na"/>
<variable units="second" public_interface="in" private_interface="out" name="time"/>
<variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
<variable units="dimensionless" private_interface="in" name="y"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_f_Na</ci>
<piecewise>
<piece>
<apply>
<plus/>
<ci>g_f_Na_Centre_Published</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_f_Na_Periphery_Published</ci>
<ci>g_f_Na_Centre_Published</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<piece>
<apply>
<plus/>
<ci>g_f_Na_Centre_0DCapable</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_f_Na_Periphery_0DCapable</ci>
<ci>g_f_Na_Centre_0DCapable</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<apply>
<plus/>
<ci>g_f_Na_Centre_1DCapable</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_f_Na_Periphery_1DCapable</ci>
<ci>g_f_Na_Centre_1DCapable</ci>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>i_f_Na</ci>
<piecewise>
<piece>
<apply>
<times/>
<ci>g_f_Na</ci>
<ci>y</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
<apply>
<neq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<ci>g_f_Na</ci>
<ci>y</ci>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">77.6</cn>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>g_f_K</ci>
<piecewise>
<piece>
<apply>
<plus/>
<ci>g_f_K_Centre_Published</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_f_K_Periphery_Published</ci>
<ci>g_f_K_Centre_Published</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<piece>
<apply>
<plus/>
<ci>g_f_K_Centre_0DCapable</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_f_K_Periphery_0DCapable</ci>
<ci>g_f_K_Centre_0DCapable</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<apply>
<plus/>
<ci>g_f_K_Centre_1DCapable</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_f_K_Periphery_1DCapable</ci>
<ci>g_f_K_Centre_1DCapable</ci>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>i_f_K</ci>
<piecewise>
<piece>
<apply>
<times/>
<ci>g_f_K</ci>
<ci>y</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
<apply>
<neq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<ci>g_f_K</ci>
<ci>y</ci>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="dimensionless">102</cn>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="hyperpolarisation_activated_current_y_gate">
<variable units="dimensionless" public_interface="in" name="Version"/>
<variable units="dimensionless" public_interface="out" name="y" initial_value="0.03889291759"/>
<variable units="per_second" name="alpha_y"/>
<variable units="per_second" name="beta_y"/>
<variable units="millivolt" public_interface="in" name="V"/>
<variable units="second" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_y</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>y</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_y</ci>
<ci>y</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_y</ci>
<piecewise>
<piece>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">78.91</cn>
</apply>
</apply>
<cn cellml:units="millivolt">26.62</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">78.91</cn>
</apply>
</apply>
<cn cellml:units="millivolt">26.63</cn>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>beta_y</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">75.13</cn>
</apply>
<cn cellml:units="millivolt">21.25</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_background_current">
<variable units="dimensionless" public_interface="in" name="Version"/>
<variable units="dimensionless" public_interface="in" name="FCell"/>
<variable units="nanoA" public_interface="out" name="i_b_Na"/>
<variable units="microS" name="g_b_Na_Centre_Published" initial_value="5.8e-5"/>
<variable units="microS" name="g_b_Na_Centre_0DCapable" initial_value="5.81818e-5"/>
<variable units="microS" name="g_b_Na_Centre_1DCapable" initial_value="5.8e-5"/>
<variable units="microS" name="g_b_Na_Periphery_Published" initial_value="0.000189"/>
<variable units="microS" name="g_b_Na_Periphery_0DCapable" initial_value="0.0001888"/>
<variable units="microS" name="g_b_Na_Periphery_1DCapable" initial_value="0.000189"/>
<variable units="microS" name="g_b_Na"/>
<variable units="millivolt" public_interface="in" name="E_Na"/>
<variable units="millivolt" public_interface="in" name="V"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_b_Na</ci>
<piecewise>
<piece>
<apply>
<plus/>
<ci>g_b_Na_Centre_Published</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_b_Na_Periphery_Published</ci>
<ci>g_b_Na_Centre_Published</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<piece>
<apply>
<plus/>
<ci>g_b_Na_Centre_0DCapable</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_b_Na_Periphery_0DCapable</ci>
<ci>g_b_Na_Centre_0DCapable</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<apply>
<plus/>
<ci>g_b_Na_Centre_1DCapable</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_b_Na_Periphery_1DCapable</ci>
<ci>g_b_Na_Centre_1DCapable</ci>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>i_b_Na</ci>
<apply>
<times/>
<ci>g_b_Na</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="potassium_background_current">
<variable units="dimensionless" public_interface="in" name="Version"/>
<variable units="dimensionless" public_interface="in" name="FCell"/>
<variable units="nanoA" public_interface="out" name="i_b_K"/>
<variable units="microS" name="g_b_K_Centre_Published" initial_value="2.52e-5"/>
<variable units="microS" name="g_b_K_Centre_0DCapable" initial_value="2.523636e-5"/>
<variable units="microS" name="g_b_K_Centre_1DCapable" initial_value="2.52e-5"/>
<variable units="microS" name="g_b_K_Periphery_Published" initial_value="8.19e-5"/>
<variable units="microS" name="g_b_K_Periphery_0DCapable" initial_value="8.1892e-5"/>
<variable units="microS" name="g_b_K_Periphery_1DCapable" initial_value="8.19e-5"/>
<variable units="microS" name="g_b_K"/>
<variable units="millivolt" public_interface="in" name="E_K"/>
<variable units="millivolt" public_interface="in" name="V"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_b_K</ci>
<piecewise>
<piece>
<apply>
<plus/>
<ci>g_b_K_Centre_Published</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_b_K_Periphery_Published</ci>
<ci>g_b_K_Centre_Published</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<piece>
<apply>
<plus/>
<ci>g_b_K_Centre_0DCapable</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_b_K_Periphery_0DCapable</ci>
<ci>g_b_K_Centre_0DCapable</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<apply>
<plus/>
<ci>g_b_K_Centre_1DCapable</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_b_K_Periphery_1DCapable</ci>
<ci>g_b_K_Centre_1DCapable</ci>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>i_b_K</ci>
<apply>
<times/>
<ci>g_b_K</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calcium_background_current">
<variable units="dimensionless" public_interface="in" name="Version"/>
<variable units="dimensionless" public_interface="in" name="FCell"/>
<variable units="nanoA" public_interface="out" name="i_b_Ca"/>
<variable units="microS" name="g_b_Ca_Centre_Published" initial_value="1.32e-5"/>
<variable units="microS" name="g_b_Ca_Centre_0DCapable" initial_value="1.3236e-5"/>
<variable units="microS" name="g_b_Ca_Centre_1DCapable" initial_value="1.323e-5"/>
<variable units="microS" name="g_b_Ca_Periphery_Published" initial_value="4.3e-5"/>
<variable units="microS" name="g_b_Ca_Periphery_0DCapable" initial_value="4.2952e-5"/>
<variable units="microS" name="g_b_Ca_Periphery_1DCapable" initial_value="4.29e-5"/>
<variable units="microS" name="g_b_Ca"/>
<variable units="millivolt" public_interface="in" name="E_Ca"/>
<variable units="millivolt" public_interface="in" name="V"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_b_Ca</ci>
<piecewise>
<piece>
<apply>
<plus/>
<ci>g_b_Ca_Centre_Published</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_b_Ca_Periphery_Published</ci>
<ci>g_b_Ca_Centre_Published</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<piece>
<apply>
<plus/>
<ci>g_b_Ca_Centre_0DCapable</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_b_Ca_Periphery_0DCapable</ci>
<ci>g_b_Ca_Centre_0DCapable</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<apply>
<plus/>
<ci>g_b_Ca_Centre_1DCapable</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>g_b_Ca_Periphery_1DCapable</ci>
<ci>g_b_Ca_Centre_1DCapable</ci>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>i_b_Ca</ci>
<apply>
<times/>
<ci>g_b_Ca</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Ca</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_calcium_exchanger">
<variable units="dimensionless" public_interface="in" name="Version"/>
<variable units="dimensionless" public_interface="in" name="FCell"/>
<variable units="nanoA" public_interface="out" name="i_NaCa"/>
<variable units="nanoA" name="k_NaCa_Centre_Published" initial_value="2.7e-6"/>
<variable units="nanoA" name="k_NaCa_Centre_0DCapable" initial_value="2.7229e-6"/>
<variable units="nanoA" name="k_NaCa_Centre_1DCapable" initial_value="2.8e-6"/>
<variable units="nanoA" name="k_NaCa_Periphery_Published" initial_value="8.8e-6"/>
<variable units="nanoA" name="k_NaCa_Periphery_0DCapable" initial_value="8.83584e-6"/>
<variable units="nanoA" name="k_NaCa_Periphery_1DCapable" initial_value="8.8e-6"/>
<variable units="nanoA" name="k_NaCa"/>
<variable units="dimensionless" name="d_NaCa" initial_value="0.0001"/>
<variable units="dimensionless" name="gamma_NaCa" initial_value="0.5"/>
<variable units="millimolar" public_interface="in" name="Na_i"/>
<variable units="millimolar" public_interface="in" name="Na_o"/>
<variable units="millimolar" public_interface="in" name="Ca_i"/>
<variable units="millimolar" public_interface="in" name="Ca_o"/>
<variable units="millivolt" public_interface="in" name="V"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>k_NaCa</ci>
<piecewise>
<piece>
<apply>
<plus/>
<ci>k_NaCa_Centre_Published</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>k_NaCa_Periphery_Published</ci>
<ci>k_NaCa_Centre_Published</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<piece>
<apply>
<plus/>
<ci>k_NaCa_Centre_0DCapable</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>k_NaCa_Periphery_0DCapable</ci>
<ci>k_NaCa_Centre_0DCapable</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<apply>
<plus/>
<ci>k_NaCa_Centre_1DCapable</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>k_NaCa_Periphery_1DCapable</ci>
<ci>k_NaCa_Centre_1DCapable</ci>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>i_NaCa</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<ci>k_NaCa</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<power/>
<ci>Na_i</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Ca_o</ci>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.03743</cn>
<ci>V</ci>
<ci>gamma_NaCa</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>Na_o</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Ca_i</ci>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0374</cn>
<ci>V</ci>
<apply>
<minus/>
<ci>gamma_NaCa</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>d_NaCa</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>Ca_i</ci>
<apply>
<power/>
<ci>Na_o</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<apply>
<times/>
<ci>Ca_o</ci>
<apply>
<power/>
<ci>Na_i</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<ci>k_NaCa</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<power/>
<ci>Na_i</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Ca_o</ci>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.03743</cn>
<ci>V</ci>
<ci>gamma_NaCa</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>Na_o</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Ca_i</ci>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.03743</cn>
<ci>V</ci>
<apply>
<minus/>
<ci>gamma_NaCa</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>d_NaCa</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>Ca_i</ci>
<apply>
<power/>
<ci>Na_o</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<apply>
<times/>
<ci>Ca_o</ci>
<apply>
<power/>
<ci>Na_i</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="sodium_potassium_pump">
<variable units="dimensionless" public_interface="in" name="Version"/>
<variable units="dimensionless" public_interface="in" name="FCell"/>
<variable units="nanoA" public_interface="out" name="i_p"/>
<variable units="millimolar" name="K_m_Na" initial_value="5.64"/>
<variable units="millimolar" name="K_m_K" initial_value="0.621"/>
<variable units="nanoA" name="i_p_max_Centre_Published" initial_value="0.0478"/>
<variable units="nanoA" name="i_p_max_Centre_0DCapable" initial_value="0.04782545"/>
<variable units="nanoA" name="i_p_max_Centre_1DCapable" initial_value="0.0478"/>
<variable units="nanoA" name="i_p_max_Periphery_Published" initial_value="0.16"/>
<variable units="nanoA" name="i_p_max_Periphery_0DCapable" initial_value="0.1551936"/>
<variable units="nanoA" name="i_p_max_Periphery_1DCapable" initial_value="0.16"/>
<variable units="nanoA" name="i_p_max"/>
<variable units="millimolar" public_interface="in" name="Na_i"/>
<variable units="millimolar" public_interface="in" name="K_o"/>
<variable units="millivolt" public_interface="in" name="V"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_p_max</ci>
<piecewise>
<piece>
<apply>
<plus/>
<ci>i_p_max_Centre_Published</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>i_p_max_Periphery_Published</ci>
<ci>i_p_max_Centre_Published</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<piece>
<apply>
<plus/>
<ci>i_p_max_Centre_0DCapable</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>i_p_max_Periphery_0DCapable</ci>
<ci>i_p_max_Centre_0DCapable</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<apply>
<plus/>
<ci>i_p_max_Centre_1DCapable</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>i_p_max_Periphery_1DCapable</ci>
<ci>i_p_max_Centre_1DCapable</ci>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>i_p</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>i_p_max</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>Na_i</ci>
<apply>
<plus/>
<ci>K_m_Na</ci>
<ci>Na_i</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<apply>
<divide/>
<ci>K_o</ci>
<apply>
<plus/>
<ci>K_m_K</ci>
<ci>K_o</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
<cn cellml:units="dimensionless">1.6</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.5</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">60</cn>
</apply>
</apply>
<cn cellml:units="millivolt">40</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="persistent_calcium_current">
<variable units="dimensionless" public_interface="in" name="Version"/>
<variable units="dimensionless" public_interface="in" name="FCell"/>
<variable units="nanoA" public_interface="out" name="i_Ca_p"/>
<variable units="nanoA" name="i_Ca_p_max_Centre_Published" initial_value="0"/>
<variable units="nanoA" name="i_Ca_p_max_Centre_0DCapable" initial_value="0"/>
<variable units="nanoA" name="i_Ca_p_max_Centre_1DCapable" initial_value="0.0042"/>
<variable units="nanoA" name="i_Ca_p_max_Periphery_Published" initial_value="0"/>
<variable units="nanoA" name="i_Ca_p_max_Periphery_0DCapable" initial_value="0"/>
<variable units="nanoA" name="i_Ca_p_max_Periphery_1DCapable" initial_value="0.03339"/>
<variable units="nanoA" name="i_Ca_p_max"/>
<variable units="millimolar" public_interface="in" name="Ca_i"/>
<variable units="millivolt" public_interface="in" name="V"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Ca_p_max</ci>
<piecewise>
<piece>
<apply>
<plus/>
<ci>i_Ca_p_max_Centre_Published</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>i_Ca_p_max_Periphery_Published</ci>
<ci>i_Ca_p_max_Centre_Published</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<piece>
<apply>
<plus/>
<ci>i_Ca_p_max_Centre_0DCapable</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>i_Ca_p_max_Periphery_0DCapable</ci>
<ci>i_Ca_p_max_Centre_0DCapable</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<apply>
<plus/>
<ci>i_Ca_p_max_Centre_1DCapable</ci>
<apply>
<times/>
<ci>FCell</ci>
<apply>
<minus/>
<ci>i_Ca_p_max_Periphery_1DCapable</ci>
<ci>i_Ca_p_max_Centre_1DCapable</ci>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>i_Ca_p</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>i_Ca_p_max</ci>
<ci>Ca_i</ci>
</apply>
<apply>
<plus/>
<ci>Ca_i</ci>
<cn cellml:units="millimolar">0.0004</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ionic_concentrations">
<variable units="millimolar" public_interface="out" name="Na_i" initial_value="8"/>
<variable units="millimolar" public_interface="out" name="Na_o" initial_value="140"/>
<variable units="millimolar" public_interface="out" name="Ca_i" initial_value="0.0001"/>
<variable units="millimolar" public_interface="out" name="Ca_o" initial_value="2"/>
<variable units="millimolar" public_interface="out" name="K_i" initial_value="140"/>
<variable units="millimolar" public_interface="out" name="K_o" initial_value="5.4"/>
</component>
<component name="reversal_and_equilibrium_potentials">
<variable units="dimensionless" public_interface="in" name="Version"/>
<variable units="millivolt" public_interface="out" name="E_Na"/>
<variable units="millivolt" public_interface="out" name="E_K"/>
<variable units="millivolt" public_interface="out" name="E_K_s"/>
<variable units="millivolt" public_interface="out" name="E_Ca"/>
<variable units="millimolar" public_interface="in" name="K_o"/>
<variable units="millimolar" public_interface="in" name="Na_o"/>
<variable units="millimolar" public_interface="in" name="K_i"/>
<variable units="millimolar" public_interface="in" name="Na_i"/>
<variable units="millimolar" public_interface="in" name="Ca_o"/>
<variable units="millimolar" public_interface="in" name="Ca_i"/>
<variable units="millijoule_per_mole_kelvin" public_interface="in" name="R"/>
<variable units="coulomb_per_mole" public_interface="in" name="F"/>
<variable units="kelvin" public_interface="in" name="T"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_Na</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Na_o</ci>
<ci>Na_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>K_o</ci>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_Ca</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
</apply>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ca_o</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_K_s</ci>
<piecewise>
<piece>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<plus/>
<ci>K_o</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.12</cn>
<ci>Na_o</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>K_i</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.12</cn>
<ci>Na_i</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Version</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<plus/>
<ci>K_o</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.03</cn>
<ci>Na_o</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>K_i</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.03</cn>
<ci>Na_i</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="containment"/>
<component_ref component="membrane">
<component_ref component="sodium_current">
<component_ref component="sodium_current_m_gate"/>
<component_ref component="sodium_current_h_gate"/>
</component_ref>
<component_ref component="L_type_Ca_channel">
<component_ref component="L_type_Ca_channel_d_gate"/>
<component_ref component="L_type_Ca_channel_f_gate"/>
</component_ref>
<component_ref component="T_type_Ca_channel">
<component_ref component="T_type_Ca_channel_d_gate"/>
<component_ref component="T_type_Ca_channel_f_gate"/>
</component_ref>
<component_ref component="four_AP_sensitive_currents">
<component_ref component="four_AP_sensitive_currents_q_gate"/>
<component_ref component="four_AP_sensitive_currents_r_gate"/>
</component_ref>
<component_ref component="rapid_delayed_rectifying_potassium_current">
<component_ref component="rapid_delayed_rectifying_potassium_current_P_af_gate"/>
<component_ref component="rapid_delayed_rectifying_potassium_current_P_as_gate"/>
<component_ref component="rapid_delayed_rectifying_potassium_current_P_i_gate"/>
</component_ref>
<component_ref component="slow_delayed_rectifying_potassium_current">
<component_ref component="slow_delayed_rectifying_potassium_current_xs_gate"/>
</component_ref>
<component_ref component="hyperpolarisation_activated_current">
<component_ref component="hyperpolarisation_activated_current_y_gate"/>
</component_ref>
<component_ref component="sodium_background_current"/>
<component_ref component="calcium_background_current"/>
<component_ref component="potassium_background_current"/>
<component_ref component="sodium_calcium_exchanger"/>
<component_ref component="sodium_potassium_pump"/>
<component_ref component="persistent_calcium_current"/>
<component_ref component="ionic_concentrations"/>
<component_ref component="reversal_and_equilibrium_potentials"/>
</component_ref>
</group>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="sodium_current">
<component_ref component="sodium_current_m_gate"/>
<component_ref component="sodium_current_h_gate"/>
</component_ref>
<component_ref component="L_type_Ca_channel">
<component_ref component="L_type_Ca_channel_d_gate"/>
<component_ref component="L_type_Ca_channel_f_gate"/>
</component_ref>
<component_ref component="T_type_Ca_channel">
<component_ref component="T_type_Ca_channel_d_gate"/>
<component_ref component="T_type_Ca_channel_f_gate"/>
</component_ref>
<component_ref component="four_AP_sensitive_currents">
<component_ref component="four_AP_sensitive_currents_q_gate"/>
<component_ref component="four_AP_sensitive_currents_r_gate"/>
</component_ref>
<component_ref component="rapid_delayed_rectifying_potassium_current">
<component_ref component="rapid_delayed_rectifying_potassium_current_P_af_gate"/>
<component_ref component="rapid_delayed_rectifying_potassium_current_P_as_gate"/>
<component_ref component="rapid_delayed_rectifying_potassium_current_P_i_gate"/>
</component_ref>
<component_ref component="slow_delayed_rectifying_potassium_current">
<component_ref component="slow_delayed_rectifying_potassium_current_xs_gate"/>
</component_ref>
<component_ref component="hyperpolarisation_activated_current">
<component_ref component="hyperpolarisation_activated_current_y_gate"/>
</component_ref>
</group>
<connection>
<map_components component_2="environment" component_1="membrane"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="sodium_current"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="L_type_Ca_channel"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="T_type_Ca_channel"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="four_AP_sensitive_currents"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="rapid_delayed_rectifying_potassium_current"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="slow_delayed_rectifying_potassium_current"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="hyperpolarisation_activated_current"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="sodium_current" component_1="membrane"/>
<map_variables variable_2="Version" variable_1="Version"/>
<map_variables variable_2="FCell" variable_1="FCell"/>
<map_variables variable_2="i_Na" variable_1="i_Na"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="R" variable_1="R"/>
<map_variables variable_2="T" variable_1="T"/>
<map_variables variable_2="F" variable_1="F"/>
</connection>
<connection>
<map_components component_2="L_type_Ca_channel" component_1="membrane"/>
<map_variables variable_2="Version" variable_1="Version"/>
<map_variables variable_2="FCell" variable_1="FCell"/>
<map_variables variable_2="i_Ca_L" variable_1="i_Ca_L"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="T_type_Ca_channel" component_1="membrane"/>
<map_variables variable_2="Version" variable_1="Version"/>
<map_variables variable_2="FCell" variable_1="FCell"/>
<map_variables variable_2="i_Ca_T" variable_1="i_Ca_T"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="four_AP_sensitive_currents" component_1="membrane"/>
<map_variables variable_2="Version" variable_1="Version"/>
<map_variables variable_2="FCell" variable_1="FCell"/>
<map_variables variable_2="i_to" variable_1="i_to"/>
<map_variables variable_2="i_sus" variable_1="i_sus"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="rapid_delayed_rectifying_potassium_current" component_1="membrane"/>
<map_variables variable_2="Version" variable_1="Version"/>
<map_variables variable_2="FCell" variable_1="FCell"/>
<map_variables variable_2="i_K_r" variable_1="i_K_r"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="slow_delayed_rectifying_potassium_current" component_1="membrane"/>
<map_variables variable_2="Version" variable_1="Version"/>
<map_variables variable_2="FCell" variable_1="FCell"/>
<map_variables variable_2="i_K_s" variable_1="i_K_s"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="hyperpolarisation_activated_current" component_1="membrane"/>
<map_variables variable_2="Version" variable_1="Version"/>
<map_variables variable_2="FCell" variable_1="FCell"/>
<map_variables variable_2="i_f_Na" variable_1="i_f_Na"/>
<map_variables variable_2="i_f_K" variable_1="i_f_K"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="sodium_background_current" component_1="membrane"/>
<map_variables variable_2="Version" variable_1="Version"/>
<map_variables variable_2="FCell" variable_1="FCell"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_b_Na" variable_1="i_b_Na"/>
</connection>
<connection>
<map_components component_2="potassium_background_current" component_1="membrane"/>
<map_variables variable_2="Version" variable_1="Version"/>
<map_variables variable_2="FCell" variable_1="FCell"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_b_K" variable_1="i_b_K"/>
</connection>
<connection>
<map_components component_2="calcium_background_current" component_1="membrane"/>
<map_variables variable_2="Version" variable_1="Version"/>
<map_variables variable_2="FCell" variable_1="FCell"/>
<map_variables variable_2="V" variable_1="V"/>
<map_variables variable_2="i_b_Ca" variable_1="i_b_Ca"/>
</connection>
<connection>
<map_components component_2="sodium_calcium_exchanger" component_1="membrane"/>
<map_variables variable_2="Version" variable_1="Version"/>
<map_variables variable_2="FCell" variable_1="FCell"/>
<map_variables variable_2="i_NaCa" variable_1="i_NaCa"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="sodium_potassium_pump" component_1="membrane"/>
<map_variables variable_2="Version" variable_1="Version"/>
<map_variables variable_2="FCell" variable_1="FCell"/>
<map_variables variable_2="i_p" variable_1="i_p"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="persistent_calcium_current" component_1="membrane"/>
<map_variables variable_2="Version" variable_1="Version"/>
<map_variables variable_2="FCell" variable_1="FCell"/>
<map_variables variable_2="i_Ca_p" variable_1="i_Ca_p"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="reversal_and_equilibrium_potentials" component_1="membrane"/>
<map_variables variable_2="Version" variable_1="Version"/>
<map_variables variable_2="R" variable_1="R"/>
<map_variables variable_2="T" variable_1="T"/>
<map_variables variable_2="F" variable_1="F"/>
</connection>
<connection>
<map_components component_2="sodium_current" component_1="reversal_and_equilibrium_potentials"/>
<map_variables variable_2="E_Na" variable_1="E_Na"/>
</connection>
<connection>
<map_components component_2="sodium_current" component_1="ionic_concentrations"/>
<map_variables variable_2="Na_o" variable_1="Na_o"/>
</connection>
<connection>
<map_components component_2="four_AP_sensitive_currents" component_1="reversal_and_equilibrium_potentials"/>
<map_variables variable_2="E_K" variable_1="E_K"/>
</connection>
<connection>
<map_components component_2="rapid_delayed_rectifying_potassium_current" component_1="reversal_and_equilibrium_potentials"/>
<map_variables variable_2="E_K" variable_1="E_K"/>
</connection>
<connection>
<map_components component_2="slow_delayed_rectifying_potassium_current" component_1="reversal_and_equilibrium_potentials"/>
<map_variables variable_2="E_K_s" variable_1="E_K_s"/>
</connection>
<connection>
<map_components component_2="hyperpolarisation_activated_current" component_1="reversal_and_equilibrium_potentials"/>
<map_variables variable_2="E_K" variable_1="E_K"/>
<map_variables variable_2="E_Na" variable_1="E_Na"/>
</connection>
<connection>
<map_components component_2="sodium_background_current" component_1="reversal_and_equilibrium_potentials"/>
<map_variables variable_2="E_Na" variable_1="E_Na"/>
</connection>
<connection>
<map_components component_2="potassium_background_current" component_1="reversal_and_equilibrium_potentials"/>
<map_variables variable_2="E_K" variable_1="E_K"/>
</connection>
<connection>
<map_components component_2="calcium_background_current" component_1="reversal_and_equilibrium_potentials"/>
<map_variables variable_2="E_Ca" variable_1="E_Ca"/>
</connection>
<connection>
<map_components component_2="ionic_concentrations" component_1="sodium_calcium_exchanger"/>
<map_variables variable_2="Ca_i" variable_1="Ca_i"/>
<map_variables variable_2="Na_i" variable_1="Na_i"/>
<map_variables variable_2="Ca_o" variable_1="Ca_o"/>
<map_variables variable_2="Na_o" variable_1="Na_o"/>
</connection>
<connection>
<map_components component_2="ionic_concentrations" component_1="sodium_potassium_pump"/>
<map_variables variable_2="Na_i" variable_1="Na_i"/>
<map_variables variable_2="K_o" variable_1="K_o"/>
</connection>
<connection>
<map_components component_2="ionic_concentrations" component_1="reversal_and_equilibrium_potentials"/>
<map_variables variable_2="K_o" variable_1="K_o"/>
<map_variables variable_2="Na_o" variable_1="Na_o"/>
<map_variables variable_2="K_i" variable_1="K_i"/>
<map_variables variable_2="Na_i" variable_1="Na_i"/>
<map_variables variable_2="Ca_o" variable_1="Ca_o"/>
<map_variables variable_2="Ca_i" variable_1="Ca_i"/>
</connection>
<connection>
<map_components component_2="ionic_concentrations" component_1="persistent_calcium_current"/>
<map_variables variable_2="Ca_i" variable_1="Ca_i"/>
</connection>
<connection>
<map_components component_2="sodium_current_m_gate" component_1="sodium_current"/>
<map_variables variable_2="Version" variable_1="Version"/>
<map_variables variable_2="m" variable_1="m"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="sodium_current_h_gate" component_1="sodium_current"/>
<map_variables variable_2="Version" variable_1="Version"/>
<map_variables variable_2="h" variable_1="h"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="L_type_Ca_channel_d_gate" component_1="L_type_Ca_channel"/>
<map_variables variable_2="Version" variable_1="Version"/>
<map_variables variable_2="FCell" variable_1="FCell"/>
<map_variables variable_2="d_L" variable_1="d_L"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="L_type_Ca_channel_f_gate" component_1="L_type_Ca_channel"/>
<map_variables variable_2="Version" variable_1="Version"/>
<map_variables variable_2="FCell" variable_1="FCell"/>
<map_variables variable_2="f_L" variable_1="f_L"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="T_type_Ca_channel_d_gate" component_1="T_type_Ca_channel"/>
<map_variables variable_2="d_T" variable_1="d_T"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="T_type_Ca_channel_f_gate" component_1="T_type_Ca_channel"/>
<map_variables variable_2="Version" variable_1="Version"/>
<map_variables variable_2="FCell" variable_1="FCell"/>
<map_variables variable_2="f_T" variable_1="f_T"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="four_AP_sensitive_currents_q_gate" component_1="four_AP_sensitive_currents"/>
<map_variables variable_2="Version" variable_1="Version"/>
<map_variables variable_2="FCell" variable_1="FCell"/>
<map_variables variable_2="q" variable_1="q"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="four_AP_sensitive_currents_r_gate" component_1="four_AP_sensitive_currents"/>
<map_variables variable_2="Version" variable_1="Version"/>
<map_variables variable_2="r" variable_1="r"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="rapid_delayed_rectifying_potassium_current_P_af_gate" component_1="rapid_delayed_rectifying_potassium_current"/>
<map_variables variable_2="Version" variable_1="Version"/>
<map_variables variable_2="P_af" variable_1="P_af"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="rapid_delayed_rectifying_potassium_current_P_as_gate" component_1="rapid_delayed_rectifying_potassium_current"/>
<map_variables variable_2="Version" variable_1="Version"/>
<map_variables variable_2="P_as" variable_1="P_as"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
</connection>
<connection>
<map_components component_2="rapid_delayed_rectifying_potassium_current_P_as_gate" component_1="rapid_delayed_rectifying_potassium_current_P_af_gate"/>
<map_variables variable_2="P_af_infinity" variable_1="P_af_infinity"/>
</connection>
<connection>
<map_components component_2="rapid_delayed_rectifying_potassium_current_P_i_gate" component_1="rapid_delayed_rectifying_potassium_current"/>
<map_variables variable_2="Version" variable_1="Version"/>
<map_variables variable_2="P_i" variable_1="P_i"/>
<map_variables variable_2="time" variable_1="time"/>
<map_variables variable_2="V" variable_1="V"/>
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