Model Status
This model is known to run in OpenCell and COR to reproduce the output shown in the publication.
Model Structure
ABSTRACT: Calcium (Ca2+)-induced Ca2+ release (CICR) in cardiac myocytes exhibits high gain and is graded. These properties result from local control of Ca2+ release. Existing local control models of Ca2+ release in which interactions between L-Type Ca2+ channels (LCCs) and ryanodine-sensitive Ca2+ release channels (RyRs) are simulated stochastically are able to reconstruct these properties, but only at high computational cost. Here we present a general analytical approach for deriving simplified models of local control of CICR, consisting of low-dimensional systems of coupled ordinary differential equations, from these more complex local control models in which LCC-RyR interactions are simulated stochastically. The resulting model, referred to as the coupled LCC-RyR gating model, successfully reproduces a range of experimental data, including L-Type Ca2+ current in response to voltage-clamp stimuli, inactivation of LCC current with and without Ca2+ release from the sarcoplasmic reticulum, voltage-dependence of excitation-contraction coupling gain, graded release, and the force-frequency relationship. The model does so with low computational cost.
The original publication reference is cited below:
A Simplified Local Control Model of Calcium-Induced Calcium Release in Cardiac Ventricular Myocytes, R. Hinch, J.R. Greenstein, A.J. Tanskanen, L. Xu, R.L. Winslow, 2004 Biophysical Journal, 87, 3723-3736, PubMed ID: 15465866
state diagram
Schematic diagram of the currents and the ion exchanges described by the cardiac ventricular myocyte model.
state diagram
The nine-state Markov model of the calcium release unit (CaRU). In state yij, the LCC is in the state i and the RyR is in the state j.
L
Xu
A Simplified Local Control Model of Calcium-Induced Calcium Release in Cardiac Ventricular Myocytes
87(6)
3723
3736
This model runs in both COR and PCEnv.
A
Tanskanen
J
added cmeta:ids to some variables
2008-08-04T15:07:01+12:00
R
Winslow
L
Biophysical Journal
j.terkildsen@auckland.ac.nz
keyword
ventricular myocyte
calcium dynamics
calcium
electrophysiology
cardiac
myocyte
15465866
500
10000
James
Lawson
Richard
Jonna
Terkildsen
2004-12-01 00:00
Robert
Hinch
Jonna
Terkildsen
University of Auckland
2007-12-20T00:00:00+00:00
J
Greenstein
L
2007-12-20T15:28:34+13:00
Auckland Bioengineering Institute
Systems Biology Group