Location: Jelic, Cupic, Kolaranic, 2005 @ 0903bed4890d / jelic_cupic_kolaranic_2005_Fig4.cellml

Author:
Tommy Yu <tommy.yu@auckland.ac.nz>
Date:
2010-08-26 12:17:24+12:00
Desc:
xml:base fix
Permanent Source URI:
https://staging.physiomeproject.org/workspace/jelic_cupic_kolaranic_2005/rawfile/0903bed4890da99ed0cdbec8c0267b4999abaa21/jelic_cupic_kolaranic_2005_Fig4.cellml

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This CellML file was generated on 12/04/2010 at 11:26:20 at a.m. using:

COR (0.9.31.1371)
Copyright 2002-2010 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk

CellML 1.0 was used to generate this model
http://www.cellml.org/
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				<title>Mathematical modeling of the hypothalamic-pituitary-adrenal system activity</title>
				<author>
					<firstname>Catherine</firstname>
					<surname>Lloyd</surname>
					<affiliation>
						<shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
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				This CellML model runs in PCEnv and OpenCell, but not in COR because the free variable is dimensionless. The units are consistent throughout, and the mdeol runs to reproduce figure 4 from the paper. In order to reproduce figure 4, equation 7 was discarded and the variables were defined explicitly as described in the legend for figure 4. The model must be run for roughly 1 day before it stabilizes. 				 
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				<title>Model Structure</title>
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ABSTRACT: Mathematical modeling has proven to be valuable in understanding of the complex biological systems dynamics. In the present report we have developed an initial model of the hypothalamic-pituitary-adrenal system self-regulatory activity. A four-dimensional non-linear differential equation model of the hormone secretion was formulated and used to analyze plasma cortisol levels in humans. The aim of this work was to explore in greater detail the role of this system in normal, homeostatic, conditions, since it is the first and unavoidable step in further understanding of the role of this complex neuroendocrine system in pathophysiological conditions. Neither the underlying mechanisms nor the physiological significance of this system are fully understood yet.
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				<para>
The original paper reference is cited below:
</para>
				<para>
Mathematical modeling of the hypothalamic-pituitary-adrenal system activity, Smiljana Jelic, Zeljko Cupic, and Ljiljana Kolar-Anic, 2005, <emphasis>Mathematical Biosciences</emphasis>, 197, pp173-187.  <ulink url="http://www.ncbi.nlm.nih.gov/pubmed/16112688">PubMed ID: 16112688</ulink>
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					<caption>A schematic diagram of the hypothalamic-pituitary-adrenal system.  Corticotrophin-releasing hormone (CRH) and arginin-vasopressin (AVP) stimulate adrenocorticotropin (ACTH) secretion from the pituitary, followed by cortisol secretion from the adrenal cortex.  GR represents a glucocorticoid receptor and MR denotes a mineralocorticoid receptor.  + represents a postive feedback loop while - represents a negative feedback loop.</caption>
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			<dc:title>A Hypothalamic-Pituitary-Adrenal System Model: Figure 4</dc:title>
			<dc:publisher>The University of Auckland, Auckland Bioengineering Institute</dc:publisher>
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I've added initially values from the paper and have also made every varible (except time) dimensionless.</rdf:value>
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			<rdf:value>The model has now been checked in COR too.  I've added a complicated pulse stimulus equation to the model - but I'm not sure it's working properly!  Can PCEnv handle "sin"?
I've added initially values from the paper and have also made every varible (except time) dimensionless.</rdf:value>
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      <map_variables variable_1="C_1" variable_2="C_1"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="g" component_2="reaction_constants"/>
      <map_variables variable_1="alpha" variable_2="alpha"/>
      <map_variables variable_1="gamma" variable_2="gamma"/>
      <map_variables variable_1="L" variable_2="L"/>
      <map_variables variable_1="C_2" variable_2="C_2"/>
   </connection>
</model>