- Author:
- Catherine Lloyd <c.lloyd@auckland.ac.nz>
- Date:
- 2009-09-30 08:44:06+13:00
- Desc:
- Curated model.
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/karagiannis_popel_2004/rawfile/5f432985f9802b7b5b6d6c69cbacb1dd3ed95d3b/karagiannis_popel_2004.cellml
<?xml version='1.0' encoding='utf-8'?>
<!-- FILE : karagiannis_model_2004.xml
CREATED : 10th December 2007
LAST MODIFIED : 10th December 2007
AUTHOR : Catherine Lloyd
Bioengineering Institute
The University of Auckland
MODEL STATUS : This model conforms to the CellML 1.1 Specification.
DESCRIPTION : This file contains a CellML description of Karagiannis and Popel's 2004 mathematical model of collagen type I proteolysis by matrix metalloproteinase (MMP) 2 and membrane type I MMP during the migration of a tip endothelial cell.
CHANGES:
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" cmeta:id="karagiannis_model_2004" name="karagiannis_model_2004">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>A theoretical model of type I collagen proteolysis by matrix metalloproteinase (MMP) 2 and membrane type 1 MMP in the presence of tissue inhibitor of metalloproteinase 2</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This version of the model has been checked in COR and PCEnv and it runs to replicate the published results. The model is valid CellML and has consistent units.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
The formation of new biological vessels requires the coordinated assembly of a proliferating syncytium of endothelial cells (EC) at different developmental stages. Angiogenesis may also be an essential mechanism of blood vessel remodelling which occurs during a diverse range of physiological processes; including tissue regeneration following injury and new vessel formation during muscle exercise. It can also occur under pathological conditions such as atherosclerosis and the vascularisation of cancerous tumours.
</para>
<para>
Matrix metalloproteinases (MMPs) are a family of enzymes responsible for the proteolytic processing of extracellular matrix (ECM) structural proteins. During angiogenesis MMPs are expressed by a single endothelial cell at the tip of the new vessel. These enzymes manifest a proteolytic activity that allows the cells of the new vessle to penetrate the ECM. In the mathematical model presented here, Karagiannis and Popel investigate the proteolytic potential of such a tip endothelial cell. The model authors suggest this model provides a foundation for future quantitative studies of angiogenesis in ECMs of different compositions. The model is described in more detail in the figure below:
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
A theoretical model of type I collagen proteolysis by matrix metalloproteinase (MMP) 2 and membrane type 1 MMP in the presence of tissue inhibitor of metalloproteinase 2, Emmanouil D. Karagiannis and Aleksander S. Popel, 2004, <emphasis>The Journal of Biological Chemistry</emphasis>, 279, 39105-39114. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15252025&dopt=Abstract">PubMed ID: 15252025</ulink>
</para>
<informalfigure float="0" id="fig_pathway_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>model diagram</title>
</objectinfo>
<imagedata fileref="karagiannis_2006.png"/>
</imageobject>
</mediaobject>
<caption>A schematic diagram of the signalling pathway.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
<units name="molar">
<unit units="mole"/>
<unit units="litre" exponent="-1"/>
</units>
<units name="flux">
<unit units="molar"/>
<unit units="second" exponent="-1"/>
</units>
<units name="first_order_rate_constant">
<unit units="second" exponent="-1"/>
</units>
<units name="second_order_rate_constant">
<unit units="second" exponent="-1"/>
<unit units="molar" exponent="-1"/>
</units>
<component name="environment">
<variable name="time" units="second" public_interface="out"/>
</component>
<component name="main">
<variable name="time" units="second" public_interface="in"/>
<variable name="v1" units="flux"/>
<variable name="v2" units="flux"/>
<variable name="v3" units="flux"/>
<variable name="v4" units="flux"/>
<variable name="v5" units="flux"/>
<variable name="v6" units="flux"/>
<variable name="v7" units="flux"/>
<variable name="v8" units="flux"/>
<variable name="v9" units="flux"/>
<variable name="MT1" units="molar" initial_value="100e-9"/>
<variable name="MT1cat" units="molar" initial_value="0"/>
<variable name="MT1T2" units="molar" initial_value="0"/>
<variable name="MT1T2M2P" units="molar" initial_value="0"/>
<variable name="M2P" units="molar" initial_value="50e-9"/>
<variable name="M2" units="molar" initial_value="0"/>
<variable name="M2T2" units="molar" initial_value="0"/>
<variable name="M2T2star" units="molar" initial_value="0"/>
<variable name="M2C1" units="molar" initial_value="0"/>
<variable name="C1" units="molar" initial_value="1e-6"/>
<variable name="C1dmt1" units="molar" initial_value="0"/>
<variable name="C1dm2" units="molar" initial_value="0"/>
<variable name="T2" units="molar" initial_value="50e-9"/>
<variable name="kshed_eff" units="second_order_rate_constant" public_interface="in"/>
<variable name="kon_MT1T2" units="second_order_rate_constant" public_interface="in"/>
<variable name="ki_MT1T2" units="molar" public_interface="in"/>
<variable name="kon_MT1T2M2P" units="second_order_rate_constant" public_interface="in"/>
<variable name="koff_MT1T2M2P" units="first_order_rate_constant" public_interface="in"/>
<variable name="kact_eff_m2" units="second_order_rate_constant" public_interface="in"/>
<variable name="kon_M2T2" units="second_order_rate_constant" public_interface="in"/>
<variable name="ki_M2T2" units="molar" public_interface="in"/>
<variable name="kiso_M2T2" units="first_order_rate_constant" public_interface="in"/>
<variable name="k_iso_M2T2" units="first_order_rate_constant" public_interface="in"/>
<variable name="kon_M2C1" units="second_order_rate_constant" public_interface="in"/>
<variable name="koff_M2C1" units="first_order_rate_constant" public_interface="in"/>
<variable name="kcat_M2C1" units="first_order_rate_constant" public_interface="in"/>
<variable name="kcat_MT1C1" units="first_order_rate_constant" public_interface="in"/>
<variable name="km_MT1C1" units="molar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>v1</ci>
<apply>
<times/>
<ci>kshed_eff</ci>
<ci>MT1</ci>
<ci>MT1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v2</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_MT1T2</ci>
<ci>MT1</ci>
<ci>T2</ci>
</apply>
<apply>
<times/>
<ci>ki_MT1T2</ci>
<ci>kon_MT1T2</ci>
<ci>MT1T2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v3</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_MT1T2M2P</ci>
<ci>MT1T2</ci>
<ci>M2P</ci>
</apply>
<apply>
<times/>
<ci>koff_MT1T2M2P</ci>
<ci>MT1T2M2P</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v4</ci>
<apply>
<times/>
<ci>kact_eff_m2</ci>
<ci>MT1</ci>
<ci>MT1T2M2P</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v5</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_M2T2</ci>
<ci>M2</ci>
<ci>T2</ci>
</apply>
<apply>
<times/>
<ci>kon_M2T2</ci>
<ci>ki_M2T2</ci>
<ci>M2T2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v6</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kiso_M2T2</ci>
<ci>M2T2</ci>
</apply>
<apply>
<times/>
<ci>k_iso_M2T2</ci>
<ci>M2T2star</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v7</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_M2C1</ci>
<ci>M2</ci>
<ci>C1</ci>
</apply>
<apply>
<times/>
<ci>koff_M2C1</ci>
<ci>M2C1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v8</ci>
<apply>
<times/>
<ci>kcat_M2C1</ci>
<ci>M2C1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v9</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>kcat_MT1C1</ci>
<ci>km_MT1C1</ci>
</apply>
<ci>MT1</ci>
<ci>C1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>MT1</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<ci>v1</ci>
</apply>
<ci>v2</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>MT1cat</ci>
</apply>
<ci>v1</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>MT1T2</ci>
</apply>
<apply>
<minus/>
<ci>v2</ci>
<ci>v3</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>MT1T2M2P</ci>
</apply>
<apply>
<minus/>
<ci>v3</ci>
<ci>v4</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>M2P</ci>
</apply>
<apply>
<minus/>
<ci>v3</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>M2</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<ci>v4</ci>
<ci>v5</ci>
</apply>
<ci>v7</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>M2T2</ci>
</apply>
<apply>
<minus/>
<ci>v5</ci>
<ci>v6</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>M2T2star</ci>
</apply>
<ci>v6</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>M2C1</ci>
</apply>
<apply>
<minus/>
<ci>v7</ci>
<ci>v8</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<ci>v7</ci>
</apply>
<ci>v9</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1dmt1</ci>
</apply>
<ci>v9</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1dm2</ci>
</apply>
<ci>v8</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>T2</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<ci>v2</ci>
</apply>
<ci>v5</ci>
</apply>
</apply>
</math>
</component>
<component name="model_parameters">
<variable name="kshed_eff" units="second_order_rate_constant" initial_value="2.8e3" public_interface="out"/>
<variable name="kon_MT1T2" units="second_order_rate_constant" initial_value="3.54e6" public_interface="out"/>
<variable name="ki_MT1T2" units="molar" initial_value="4.9e-9" public_interface="out"/>
<variable name="kon_MT1T2M2P" units="second_order_rate_constant" initial_value="0.14e6" public_interface="out"/>
<variable name="koff_MT1T2M2P" units="first_order_rate_constant" initial_value="4.7e-3" public_interface="out"/>
<variable name="kact_eff_m2" units="second_order_rate_constant" initial_value="2.8e3" public_interface="out"/>
<variable name="kon_M2T2" units="second_order_rate_constant" initial_value="5.9e6" public_interface="out"/>
<variable name="ki_M2T2" units="molar" initial_value="1.07e-6" public_interface="out"/>
<variable name="kiso_M2T2" units="first_order_rate_constant" initial_value="33" public_interface="out"/>
<variable name="k_iso_M2T2" units="first_order_rate_constant" initial_value="2e-8" public_interface="out"/>
<variable name="kon_M2C1" units="second_order_rate_constant" initial_value="2.6e3" public_interface="out"/>
<variable name="koff_M2C1" units="first_order_rate_constant" initial_value="2.1e-3" public_interface="out"/>
<variable name="kcat_M2C1" units="first_order_rate_constant" initial_value="4.5e-3" public_interface="out"/>
<variable name="kcat_MT1C1" units="first_order_rate_constant" initial_value="1.97e-3" public_interface="out"/>
<variable name="km_MT1C1" units="molar" initial_value="2.9e-6" public_interface="out"/>
</component>
<connection>
<map_components component_1="main" component_2="model_parameters"/>
<map_variables variable_1="kshed_eff" variable_2="kshed_eff"/>
<map_variables variable_1="kon_MT1T2" variable_2="kon_MT1T2"/>
<map_variables variable_1="ki_MT1T2" variable_2="ki_MT1T2"/>
<map_variables variable_1="kon_MT1T2M2P" variable_2="kon_MT1T2M2P"/>
<map_variables variable_1="koff_MT1T2M2P" variable_2="koff_MT1T2M2P"/>
<map_variables variable_1="kact_eff_m2" variable_2="kact_eff_m2"/>
<map_variables variable_1="kon_M2T2" variable_2="kon_M2T2"/>
<map_variables variable_1="ki_M2T2" variable_2="ki_M2T2"/>
<map_variables variable_1="kiso_M2T2" variable_2="kiso_M2T2"/>
<map_variables variable_1="k_iso_M2T2" variable_2="k_iso_M2T2"/>
<map_variables variable_1="kon_M2C1" variable_2="kon_M2C1"/>
<map_variables variable_1="koff_M2C1" variable_2="koff_M2C1"/>
<map_variables variable_1="kcat_M2C1" variable_2="kcat_M2C1"/>
<map_variables variable_1="kcat_MT1C1" variable_2="kcat_MT1C1"/>
<map_variables variable_1="km_MT1C1" variable_2="km_MT1C1"/>
</connection>
<connection>
<map_components component_1="main" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<rdf:RDF xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Bag rdf:about="rdf:#19973935-340d-4b46-8263-8ddb4e920338">
<rdf:li>collagen</rdf:li>
<rdf:li>matrix metalloproteinase</rdf:li>
<rdf:li>signal transduction</rdf:li>
<rdf:li>cerebral aneurysm</rdf:li>
</rdf:Bag>
<rdf:Seq rdf:about="rdf:#9dc06318-1911-4ec4-9c7d-c21e7b34fe65">
<rdf:li rdf:resource="rdf:#85248546-ef36-4a18-8f4c-4ff89e58a8fa"/>
<rdf:li rdf:resource="rdf:#58215505-bf64-4f9e-bdf5-a5fcfab072e1"/>
</rdf:Seq>
<rdf:Description rdf:about="rdf:#178f621a-cfd5-4fd0-84a5-a3752b6ab61d">
<bqs:Pubmed_id>15252025</bqs:Pubmed_id>
<bqs:JournalArticle rdf:resource="rdf:#df6eeecd-a6f3-458e-a3d0-8803fbd202ab"/>
</rdf:Description>
<rdf:Description rdf:about="">
<dc:publisher>
The University of Auckland, Bioengineering Institute
</dc:publisher>
<dcterms:created rdf:resource="rdf:#923bc973-84fd-4654-8a0c-08a92dce9f33"/>
<dc:creator rdf:resource="rdf:#05c2a9a8-dc16-4266-91f3-aadf08f5656b"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#05c2a9a8-dc16-4266-91f3-aadf08f5656b">
<vCard:ORG rdf:resource="rdf:#3873f0de-7656-4ec9-8b53-378181e6cf9b"/>
<vCard:EMAIL rdf:resource="rdf:#4a783356-8793-4fc5-8679-0e1a95ffec68"/>
<vCard:N rdf:resource="rdf:#7181e1de-d053-4710-99ea-988e1001bac4"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#2f1ff8ed-a006-414d-8e01-cc76ac81f5f3">
<dc:title>
Journal of Biological Chemistry
</dc:title>
</rdf:Description>
<rdf:Description rdf:about="rdf:#3873f0de-7656-4ec9-8b53-378181e6cf9b">
<vCard:Orgname>The University of Auckland</vCard:Orgname>
<vCard:Orgunit>The Bioengineering Institute</vCard:Orgunit>
</rdf:Description>
<rdf:Description rdf:about="rdf:#4a783356-8793-4fc5-8679-0e1a95ffec68">
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
<rdf:value>c.lloyd@auckland.ac.nz</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#9ca35d9b-2c72-4859-a214-ada6643e3e8e">
<vCard:Given>Emmanouil</vCard:Given>
<vCard:Family>Karagiannis</vCard:Family>
<vCard:Other>D</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#7181e1de-d053-4710-99ea-988e1001bac4">
<vCard:Given>Catherine</vCard:Given>
<vCard:Family>Lloyd</vCard:Family>
<vCard:Other>May</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#ab647ae8-e28f-4e7a-9379-98b1418afd3b">
<dc:subject rdf:resource="rdf:#36c62bf3-20b0-4717-90cd-1ccb83710668"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#85248546-ef36-4a18-8f4c-4ff89e58a8fa">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#9ca35d9b-2c72-4859-a214-ada6643e3e8e"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#36c62bf3-20b0-4717-90cd-1ccb83710668">
<bqs:subject_type>keyword</bqs:subject_type>
<rdf:value rdf:resource="rdf:#19973935-340d-4b46-8263-8ddb4e920338"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#58215505-bf64-4f9e-bdf5-a5fcfab072e1">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#abacce14-8d6f-4a8b-9902-63e61e6a3d94"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#5060e338-f564-4668-bd27-87b51839e848">
<dc:creator rdf:resource="rdf:#cbd855ab-41f1-49cc-8060-948b587b7899"/>
<rdf:value>
This is a CellML description of Karagiannis and Popel's 2004 mathematical model of collagen type I proteolysis by matrix metalloproteinase (MMP) 2 and membrane type I MMP during the migration of a tip endothelial cell.
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#df6eeecd-a6f3-458e-a3d0-8803fbd202ab">
<dc:creator rdf:resource="rdf:#9dc06318-1911-4ec4-9c7d-c21e7b34fe65"/>
<dc:title>
A theoretical model of type I collagen proteolysis by matrix metalloproteinase (MMP) 2 and membrane type 1 MMP in the presence of tissue inhibitor of metalloproteinase 2
</dc:title>
<bqs:volume>279</bqs:volume>
<bqs:first_page>39105</bqs:first_page>
<bqs:Journal rdf:resource="rdf:#2f1ff8ed-a006-414d-8e01-cc76ac81f5f3"/>
<dcterms:issued rdf:resource="rdf:#e97829ad-8f93-4cd6-88ec-f3470751f4c7"/>
<bqs:last_page>39114</bqs:last_page>
</rdf:Description>
<rdf:Description rdf:about="rdf:#abacce14-8d6f-4a8b-9902-63e61e6a3d94">
<vCard:Given>Aleksander</vCard:Given>
<vCard:Family>Popel</vCard:Family>
<vCard:Other>S</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#e97829ad-8f93-4cd6-88ec-f3470751f4c7">
<dcterms:W3CDTF>2004-09-10</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="#karagiannis_model_2004">
<dc:title>
Karagiannis and Popel's 2004 mathematical model of collagen type I proteolysis by matrix metalloproteinase (MMP) 2 and membrane type I MMP during the migration of a tip endothelial cell.
</dc:title>
<cmeta:comment rdf:resource="rdf:#5060e338-f564-4668-bd27-87b51839e848"/>
<bqs:reference rdf:resource="rdf:#178f621a-cfd5-4fd0-84a5-a3752b6ab61d"/>
<bqs:reference rdf:resource="rdf:#ab647ae8-e28f-4e7a-9379-98b1418afd3b"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#923bc973-84fd-4654-8a0c-08a92dce9f33">
<dcterms:W3CDTF>2007-12-11</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#cbd855ab-41f1-49cc-8060-948b587b7899">
<vCard:FN>Catherine Lloyd</vCard:FN>
</rdf:Description>
<rdf:Description rdf:about="">
<cmeta:modification rdf:parseType="Resource">
<rdf:value>
The CellML model was curated to ensure the results it generates are the same as those generated by the original published model. A full desceription of the curation comments can be found in the associated file "Explanations".
</rdf:value>
<cmeta:modifier rdf:parseType="Resource">
<vCard:N rdf:parseType="Resource">
<vCard:Family>Gattepaille</vCard:Family>
<vCard:Given>Lucie</vCard:Given>
</vCard:N>
</cmeta:modifier>
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2009-09-30</dcterms:W3CDTF>
</dcterms:modified>
</cmeta:modification>
</rdf:Description>
</rdf:RDF>
</model>
