https://staging.physiomeproject.org/workspace/lockwood_ewy_hermann_holford_2006 en-us Lockwood, Ewy, Hermann, Holford, 2006 Application of Clinical Trial Simulation to Compare Proof-of-Concept Study Designs for Drugs with a Slow Onset of Effect; An Example in Alzheimer’s Disease Removed link to image after realising there is no obvious schematic diagram for this model. https://staging.physiomeproject.org/workspace/lockwood_ewy_hermann_holford_2006/@@file/5781efa9e2ddf73c30b2e63e549a1c0aed43def5 Removed link to image after realising there is no obvious schematic diagram for this model. Catherine Lloyd 2009-12-07 Added fianl curation comment before exposing the model. https://staging.physiomeproject.org/workspace/lockwood_ewy_hermann_holford_2006/@@file/559ec899d7b22ce059382210e8d7f9c510fa47c7 Added fianl curation comment before exposing the model. Catherine Lloyd 2009-12-07 Added documentation to the model to explain where (and why) there are some differences between the published model and the CellML translation. https://staging.physiomeproject.org/workspace/lockwood_ewy_hermann_holford_2006/@@file/26f5001c6d610a618dbffa622468345eccc16e49 Added documentation to the model to explain where (and why) there are some differences between the published model and the CellML translation. Catherine Lloyd 2009-12-03 Added equations for drug clearance based on the parameters in table III. https://staging.physiomeproject.org/workspace/lockwood_ewy_hermann_holford_2006/@@file/7b2b23a44b8ae8cd99ff2e070b71fd00ecb30477 Added equations for drug clearance based on the parameters in table III. Catherine Lloyd 2009-12-03 Corrected units, corrected some equations, had to add a dummy ode to get the model to run in COR because it's purely algebraic. Also added documentation and metadata. Model now runs to almost match the paper but we need to add an equation describing drug input and clearance. This is not explicitly defined in an equation in the paper but it can hopefully be constructed from what is written in the text. https://staging.physiomeproject.org/workspace/lockwood_ewy_hermann_holford_2006/@@file/c5bc10cf7952125929be52fc37a0a1eca256ba7c Corrected units, corrected some equations, had to add a dummy ode to get the model to run in COR because it's purely algebraic. Also added documentation and metadata. Model now runs to almost match the paper but we need to add an equation describing drug input and clearance. This is not explicitly defined in an equation in the paper but it can hopefully be constructed from what is written in the text. Catherine Lloyd 2009-12-02 initial commit https://staging.physiomeproject.org/workspace/lockwood_ewy_hermann_holford_2006/@@file/ae5c521c0bc279371a97b1b1fed15f47cb625cfb initial commit James Lawson 2009-11-30