- Author:
- rcai987 <devnull@localhost>
- Date:
- 2014-12-08 16:12:22+13:00
- Desc:
- Added annotations to luo_ruddy_1994 model
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/luo_rudy_1994/rawfile/766c798887470862fe566a62f7a649a88d2370a0/luo_rudy_1994.cellml
<?xml version="1.0"?>
<!-- FILE : LR_II_model_1994.xml
CREATED : 28th March 2002
LAST MODIFIED : 30th July 2003
AUTHOR : Catherine Lloyd
The Bioengineering Institute
The University of Auckland
MODEL STATUS : This model conforms to the CellML 1.0 Specification released on
10th August 2001, and the CellML Metadata 1.0 Specification released on 16th
January, 2002.
DESCRIPTION : This file contains a CellML description of the mammalian
ventricular action potential based on the Luo-Rudy II model, 1994. This model
is a development of the LR-I model. In particular, the LR-II model describes
the processes which regulate [Ca]i (intracellular Calcium concentration), and
the movement of calcium ions through the cell and to and from the sarcoplasmic
reticulum.
CHANGES:
18/07/2002 - CML - Added more metadata.
09/04/2003 - AAC - Added publication date information.
05/06/2003 - CML - Fixed MathML in a few components.
30/07/2003 - CML - Fixed MathML in a few components.
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xml:base="file:///H:/luo_rudy_1994/luo_rudy_1994.cellml" cmeta:id="luo_rudy_1994" name="luo_rudy_1994">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This CellML model has been written to be compatible with CMISS. Alone it cannot be run and a new version will have to be created.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
ABSTRACT: A mathematical model of the cardiac ventricular action potential is presented. In our previous work, the membrane Na+ current and K+ currents were formulated. The present article focuses on processes that regulate intracellular Ca2+ and depend on its concentration. The model presented here for the mammalian ventricular action potential is based mostly on the guinea pig ventricular cell. However, it provides the framework for modeling other types of ventricular cells with appropriate modifications made to account for species differences. The following processes are formulated: Ca2+ current through the L-type channel (ICa), the Na(+)-Ca2+ exchanger, Ca2+ release and uptake by the sarcoplasmic reticulum (SR), buffering of Ca2+ in the SR and in the myoplasm, a Ca2+ pump in the sarcolemma, the Na(+)-K+ pump, and a nonspecific Ca(2+)-activated membrane current. Activation of ICa is an order of magnitude faster than in previous models. Inactivation of ICa depends on both the membrane voltage and [Ca2+]i. SR is divided into two subcompartments, a network SR (NSR) and a junctional SR (JSR). Functionally, Ca2+ enters the NSR and translocates to the JSR following a monoexponential function. Release of Ca2+ occurs at JSR and can be triggered by two different mechanisms, Ca(2+)-induced Ca2+ release and spontaneous release. The model provides the basis for the study of arrhythmogenic activity of the single myocyte including afterdepolarizations and triggered activity. It can simulate cellular responses under different degrees of Ca2+ overload. Such simulations are presented in our accompanying article in this issue of Circulation Research.</para>
<para>
The original paper reference is cited below:
</para>
<para>
A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes, Ching-hsing Luo and Yoram Rudy, 1994, <emphasis>Circulation Research</emphasis>, 74, 1071-1097. <ulink url="http://www.ncbi.nlm.nih.gov/pubmed/7514509">PubMed ID: 7514509</ulink>
</para>
<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>cell diagram of the LR-II model showing ionic currents, pumps and exchangers within the sarcolemma and the sarcoplasmic reticulum</title>
</objectinfo>
<imagedata fileref="luo_1994.png"/>
</imageobject>
</mediaobject>
<caption>A schematic diagram describing the ionic currents, pumps and exchangers that are captured in the LR-II model. The intracellular compartment is the sarcoplasmic reticulum (SR), which is divided into the two subcompartments, the network SR (NSR) and the junctional SR (JSR). Ca<superscript>2+</superscript> buffers are present in both the cytoplasm and the JSR.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
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<component cmeta:id="environment" name="environment">
<variable cmeta:id="environment_time" name="time" public_interface="out" units="ms"/>
</component>
<component cmeta:id="membrane" name="membrane">
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<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms"> 0.3 </cn>
<apply>
<exp/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV"> -0.0000002535 </cn>
<ci> V </ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<exp/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV"> -0.1 </cn>
<apply>
<plus/>
<ci> V </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV"> 32.0 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="dj_dt_eq">
<apply id="dj_dt">
<eq/>
<apply>
<diff/>
<bvar>
<ci> time </ci>
</bvar>
<ci> j </ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci> alpha_j </ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<ci> j </ci>
</apply>
</apply>
<apply>
<times/>
<ci> beta_j </ci>
<ci> j </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="L_type_Ca_channel" name="L_type_Ca_channel">
<variable cmeta:id="id_00012" name="i_Ca_L" public_interface="out" units="uA_per_mm2"/>
<variable cmeta:id="id_00013" name="i_CaCa" public_interface="out" units="uA_per_mm2"/>
<variable cmeta:id="id_00035" name="i_CaK" public_interface="out" units="uA_per_mm2"/>
<variable cmeta:id="id_00036" name="i_CaNa" public_interface="out" units="uA_per_mm2"/>
<variable initial_value="0.75" name="gamma_Nai" public_interface="out" units="dimensionless"/>
<variable initial_value="0.75" name="gamma_Nao" public_interface="out" units="dimensionless"/>
<variable initial_value="0.75" name="gamma_Ki" public_interface="out" units="dimensionless"/>
<variable initial_value="0.75" name="gamma_Ko" public_interface="out" units="dimensionless"/>
<variable cmeta:id="id_00014" name="I_CaCa" units="uA_per_mm2"/>
<variable cmeta:id="id_00037" name="I_CaK" units="uA_per_mm2"/>
<variable cmeta:id="id_00038" name="I_CaNa" units="uA_per_mm2"/>
<variable cmeta:id="id_00015" initial_value="5.4e-6" name="P_Ca" units="mm_per_ms"/>
<variable cmeta:id="id_00039" initial_value="6.75e-9" name="P_Na" units="mm_per_ms"/>
<variable cmeta:id="id_00040" initial_value="1.93e-9" name="P_K" units="mm_per_ms"/>
<variable initial_value="1.0" name="gamma_Cai" units="dimensionless"/>
<variable initial_value="0.34" name="gamma_Cao" units="dimensionless"/>
<variable name="time" private_interface="out" public_interface="in" units="ms"/>
<variable name="V" private_interface="out" public_interface="in" units="mV"/>
<variable cmeta:id="id_00041" name="Cai" private_interface="out" public_interface="in" units="mM"/>
<variable name="R" public_interface="in" units="gas_constant_units"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="faradays_constant_units"/>
<variable cmeta:id="id_00042" name="Cao" public_interface="in" units="mM"/>
<variable name="Nao" public_interface="in" units="mM"/>
<variable name="Ko" public_interface="in" units="mM"/>
<variable name="Nai" public_interface="in" units="mM"/>
<variable name="Ki" public_interface="in" units="mM"/>
<variable name="d" private_interface="in" units="dimensionless"/>
<variable name="f" private_interface="in" units="dimensionless"/>
<variable name="f_Ca" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="i_CaCa_calculation_eq">
<apply id="i_CaCa_calculation">
<eq/>
<ci> i_CaCa </ci>
<apply>
<times/>
<ci> d </ci>
<ci> f </ci>
<ci> f_Ca </ci>
<ci> I_CaCa </ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="i_CaNa_calculation_eq">
<apply id="i_CaNa_calculation">
<eq/>
<ci> i_CaNa </ci>
<apply>
<times/>
<ci> d </ci>
<ci> f </ci>
<ci> f_Ca </ci>
<ci> I_CaNa </ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="i_CaK_calculation_eq">
<apply id="i_CaK_calculation">
<eq/>
<ci> i_CaK </ci>
<apply>
<times/>
<ci> d </ci>
<ci> f </ci>
<ci> f_Ca </ci>
<ci> I_CaK </ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="I_CaCa_calculation_eq">
<apply id="I_CaCa_calculation">
<eq/>
<ci> I_CaCa </ci>
<apply>
<times/>
<ci> P_Ca </ci>
<apply>
<power/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> V </ci>
<apply>
<power/>
<ci> F </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
</apply>
</apply>
<apply>
<times/>
<ci> R </ci>
<ci> T </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci> gamma_Cai </ci>
<ci> Cai </ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
<ci> V </ci>
<ci> F </ci>
</apply>
<apply>
<times/>
<ci> R </ci>
<ci> T </ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci> gamma_Cao </ci>
<ci> Cao </ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
<ci> V </ci>
<ci> F </ci>
</apply>
<apply>
<times/>
<ci> R </ci>
<ci> T </ci>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="I_CaNa_calculation_eq">
<apply id="I_CaNa_calculation">
<eq/>
<ci> I_CaNa </ci>
<apply>
<times/>
<ci> P_Na </ci>
<apply>
<power/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> V </ci>
<apply>
<power/>
<ci> F </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
</apply>
</apply>
<apply>
<times/>
<ci> R </ci>
<ci> T </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci> gamma_Nai </ci>
<ci> Nai </ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<ci> V </ci>
<ci> F </ci>
</apply>
<apply>
<times/>
<ci> R </ci>
<ci> T </ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci> gamma_Nao </ci>
<ci> Nao </ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<ci> V </ci>
<ci> F </ci>
</apply>
<apply>
<times/>
<ci> R </ci>
<ci> T </ci>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="I_CaK_calculation_eq">
<apply id="I_CaK_calculation">
<eq/>
<ci> I_CaK </ci>
<apply>
<times/>
<ci> P_K </ci>
<apply>
<power/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> V </ci>
<apply>
<power/>
<ci> F </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
</apply>
</apply>
<apply>
<times/>
<ci> R </ci>
<ci> T </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci> gamma_Ki </ci>
<ci> Ki </ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<ci> V </ci>
<ci> F </ci>
</apply>
<apply>
<times/>
<ci> R </ci>
<ci> T </ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci> gamma_Ko </ci>
<ci> Ko </ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<ci> V </ci>
<ci> F </ci>
</apply>
<apply>
<times/>
<ci> R </ci>
<ci> T </ci>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="i_Ca_L_calculation_eq">
<apply id="i_Ca_L_calculation">
<eq/>
<ci> i_Ca_L </ci>
<apply> <plus/>
<ci> i_CaCa </ci>
<ci> i_CaK </ci>
<ci> i_CaNa </ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="L_type_Ca_channel_d_gate" name="L_type_Ca_channel_d_gate">
<variable initial_value="0.0" name="d" public_interface="out" units="dimensionless"/>
<variable name="alpha_d" units="per_ms"/>
<variable name="beta_d" units="per_ms"/>
<variable name="d_infinity" units="dimensionless"/>
<variable name="tau_d" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="alpha_d_calculation_eq">
<apply id="alpha_d_calculation">
<eq/>
<ci> alpha_d </ci>
<apply>
<divide/>
<ci> d_infinity </ci>
<ci> tau_d </ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="d_infinity_calculation_eq">
<apply id="d_infinity_calculation">
<eq/>
<ci> d_infinity </ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<plus/>
<ci> V </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV"> 10.0 </cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV"> 6.24 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="tau_d_calculation_eq">
<apply id="tau_d_calculation">
<eq/>
<ci> tau_d </ci>
<apply>
<times/>
<ci> d_infinity </ci>
<apply>
<divide/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<plus/>
<ci> V </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV"> 10.0 </cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV"> 6.24 </cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV_ms"> 0.035 </cn>
<apply>
<plus/>
<ci> V </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV"> 10.0 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="beta_d_calculation_eq">
<apply id="beta_d_calculation">
<eq/>
<ci> beta_d </ci>
<apply>
<divide/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<ci> d_infinity </ci>
</apply>
<ci> tau_d </ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="dd_dt_eq">
<apply id="dd_dt">
<eq/>
<apply>
<diff/>
<bvar>
<ci> time </ci>
</bvar>
<ci> d </ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci> alpha_d </ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<ci> d </ci>
</apply>
</apply>
<apply>
<times/>
<ci> beta_d </ci>
<ci> d </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="L_type_Ca_channel_f_gate" name="L_type_Ca_channel_f_gate">
<variable initial_value="1.0" name="f" public_interface="out" units="dimensionless"/>
<variable name="alpha_f" units="per_ms"/>
<variable name="beta_f" units="per_ms"/>
<variable name="f_infinity" units="dimensionless"/>
<variable name="tau_f" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="alpha_f_calculation_eq">
<apply id="alpha_f_calculation">
<eq/>
<ci> alpha_f </ci>
<apply>
<divide/>
<ci> f_infinity </ci>
<ci> tau_f </ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="f_infinity_calculation_eq">
<apply id="f_infinity_calculation">
<eq/>
<ci> f_infinity </ci>
<apply>
<plus/>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci> V </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV"> 35.06 </cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV"> 8.6 </cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 0.6 </cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV"> 50.0 </cn>
<ci> V </ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV"> 20.0 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="tau_f_calculation_eq">
<apply id="tau_f_calculation">
<eq/>
<ci> tau_f </ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms"> 1.0 </cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 0.0197 </cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV"> 0.0337 </cn>
<apply>
<plus/>
<ci> V </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV"> 10.0 </cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
</apply>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 0.02 </cn>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="beta_f_calculation_eq">
<apply id="beta_f_calculation">
<eq/>
<ci> beta_f </ci>
<apply>
<divide/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<ci> f_infinity </ci>
</apply>
<ci> tau_f </ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="df_dt_eq">
<apply id="df_dt">
<eq/>
<apply>
<diff/>
<bvar>
<ci> time </ci>
</bvar>
<ci> f </ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci> alpha_f </ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<ci> f </ci>
</apply>
</apply>
<apply>
<times/>
<ci> beta_f </ci>
<ci> f </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="L_type_Ca_channel_f_Ca_gate" name="L_type_Ca_channel_f_Ca_gate">
<variable name="f_Ca" public_interface="out" units="dimensionless"/>
<variable cmeta:id="id_00016" initial_value="0.6e-3" name="Km_Ca" units="mM"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<variable cmeta:id="id_00043" name="Cai" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="f_Ca_calculation_eq">
<apply id="f_Ca_calculation">
<eq/>
<ci> f_Ca </ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<power/>
<apply>
<divide/>
<ci> Cai </ci>
<ci> Km_Ca </ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="time_dependent_potassium_current" name="time_dependent_potassium_current">
<variable cmeta:id="id_00044" name="i_K" public_interface="out" units="uA_per_mm2"/>
<variable cmeta:id="id_00045" initial_value="2.82e-3" name="g_K_max" units="mS_per_mm2"/>
<variable cmeta:id="id_00046" name="g_K" units="mS_per_mm2"/>
<variable cmeta:id="id_00047" name="E_K" units="mV"/>
<variable initial_value="0.01833" name="PR_NaK" units="dimensionless"/>
<variable name="time" private_interface="out" public_interface="in" units="ms"/>
<variable name="V" private_interface="out" public_interface="in" units="mV"/>
<variable name="R" public_interface="in" units="gas_constant_units"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="faradays_constant_units"/>
<variable cmeta:id="id_00051" name="Ko" public_interface="in" units="mM"/>
<variable cmeta:id="id_00050" name="Ki" public_interface="in" units="mM"/>
<variable cmeta:id="id_00048" name="Nao" public_interface="in" units="mM"/>
<variable cmeta:id="id_00049" name="Nai" public_interface="in" units="mM"/>
<variable name="X" private_interface="in" units="dimensionless"/>
<variable name="Xi" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="g_K_calculation_eq">
<apply id="g_K_calculation">
<eq/>
<ci> g_K </ci>
<apply>
<times/>
<ci>g_K_max</ci>
<apply>
<root/>
<apply>
<divide/>
<ci> Ko </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM"> 5.4 </cn>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="E_K_calculation_eq">
<apply id="E_K_calculation">
<eq/>
<ci> E_K </ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci> R </ci>
<ci> T </ci>
</apply>
<ci> F </ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<plus/>
<ci> Ko </ci>
<apply>
<times/>
<ci> PR_NaK </ci>
<ci> Nao </ci>
</apply>
</apply>
<apply>
<plus/>
<ci> Ki </ci>
<apply>
<times/>
<ci> PR_NaK </ci>
<ci> Nai </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="i_K_calculation_eq">
<apply id="i_K_calculation">
<eq/>
<ci> i_K </ci>
<apply>
<times/>
<ci> g_K </ci>
<apply>
<power/>
<ci> X </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
</apply>
<ci> Xi </ci>
<apply>
<minus/>
<ci> V </ci>
<ci> E_K </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="time_dependent_potassium_current_X_gate" name="time_dependent_potassium_current_X_gate">
<variable initial_value="0.0" name="X" public_interface="out" units="dimensionless"/>
<variable name="alpha_X" units="per_ms"/>
<variable name="beta_X" units="per_ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="alpha_X_calculation_eq">
<apply id="alpha_X_calculation">
<eq/>
<ci> alpha_X </ci>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV_ms"> 0.0000719 </cn>
<apply>
<plus/>
<ci> V </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV"> 30.0 </cn>
</apply>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<exp/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> -0.148 </cn>
<apply>
<plus/>
<ci> V </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV"> 30.0 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="beta_X_calculation_eq">
<apply id="beta_X_calculation">
<eq/>
<ci> beta_X </ci>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV_ms"> 0.000131 </cn>
<apply>
<plus/>
<ci> V </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV"> 30.0 </cn>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> -1.0 </cn>
<apply>
<exp/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 0.0687 </cn>
<apply>
<plus/>
<ci> V </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV"> 30.0 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="dX_dt_eq">
<apply id="dX_dt">
<eq/>
<apply>
<diff/>
<bvar>
<ci> time </ci>
</bvar>
<ci> X </ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci> alpha_X </ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<ci> X </ci>
</apply>
</apply>
<apply>
<times/>
<ci> beta_X </ci>
<ci> X </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="time_dependent_potassium_current_Xi_gate" name="time_dependent_potassium_current_Xi_gate">
<variable name="Xi" public_interface="out" units="dimensionless"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="Xi_calculation_eq">
<apply id="Xi_calculation">
<eq/>
<ci> Xi </ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci> V </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV"> 56.26 </cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV"> 32.1 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="time_independent_potassium_current" name="time_independent_potassium_current">
<variable cmeta:id="id_00052" name="i_K1" public_interface="out" units="uA_per_mm2"/>
<variable cmeta:id="id_00053" name="E_K1" private_interface="out" public_interface="out" units="mV"/>
<variable cmeta:id="id_00054" initial_value="7.5e-3" name="g_K1_max" units="mS_per_mm2"/>
<variable cmeta:id="id_00055" name="g_K1" units="mS_per_mm2"/>
<variable name="time" private_interface="out" public_interface="in" units="ms"/>
<variable name="V" private_interface="out" public_interface="in" units="mV"/>
<variable name="Ko" public_interface="in" units="mM"/>
<variable name="Ki" public_interface="in" units="mM"/>
<variable name="R" public_interface="in" units="gas_constant_units"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="faradays_constant_units"/>
<variable name="K1_infinity" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="g_K1_calculation_eq">
<apply id="g_K1_calculation">
<eq/>
<ci> g_K1 </ci>
<apply>
<times/>
<ci>g_K1_max</ci>
<apply>
<root/>
<apply>
<divide/>
<ci> Ko </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM"> 5.4 </cn>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="E_K1_calculation_eq">
<apply id="E_K1_calculation">
<eq/>
<ci> E_K1 </ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci> R </ci>
<ci> T </ci>
</apply>
<ci> F </ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci> Ko </ci>
<ci> Ki </ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="i_K1_calculation_eq">
<apply id="i_K1_calculation">
<eq/>
<ci> i_K1 </ci>
<apply>
<times/>
<ci> g_K1 </ci>
<ci> K1_infinity </ci>
<apply>
<minus/>
<ci> V </ci>
<ci> E_K1 </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="time_independent_potassium_current_K1_gate" name="time_independent_potassium_current_K1_gate">
<variable name="K1_infinity" public_interface="out" units="dimensionless"/>
<variable name="alpha_K1" units="per_ms"/>
<variable name="beta_K1" units="per_ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<variable cmeta:id="id_00056" name="E_K1" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="alpha_K1_calculation_eq">
<apply id="alpha_K1_calculation">
<eq/>
<ci> alpha_K1 </ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms"> 1.02 </cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<exp/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV"> 0.2385 </cn>
<apply>
<minus/>
<apply>
<minus/>
<ci> V </ci>
<ci> E_K1 </ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV"> 59.215 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="beta_K1_calculation_eq">
<apply id="beta_K1_calculation">
<eq/>
<ci> beta_K1 </ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms"> 0.49124 </cn>
<apply>
<exp/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 0.08032 </cn>
<apply>
<minus/>
<apply>
<plus/>
<ci> V </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV"> 5.476 </cn>
</apply>
<ci> E_K1 </ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 0.06175 </cn>
<apply>
<minus/>
<ci> V </ci>
<apply>
<plus/>
<ci> E_K1 </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV"> 594.31 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<exp/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV"> -0.5143 </cn>
<apply>
<plus/>
<apply>
<minus/>
<ci> V </ci>
<ci> E_K1 </ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV"> 4.753 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="K1_infinity_calculation_eq">
<apply id="K1_infinity_calculation">
<eq/>
<ci> K1_infinity </ci>
<apply>
<divide/>
<ci> alpha_K1 </ci>
<apply>
<plus/>
<ci> alpha_K1 </ci>
<ci> beta_K1 </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="plateau_potassium_current" name="plateau_potassium_current">
<variable cmeta:id="id_00057" name="i_Kp" public_interface="out" units="uA_per_mm2"/>
<variable cmeta:id="id_00058" name="E_Kp" units="mV"/>
<variable cmeta:id="id_00059" initial_value="1.83e-4" name="g_Kp" units="mS_per_mm2"/>
<variable cmeta:id="id_00060" name="Kp" units="dimensionless"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable cmeta:id="id_00061" name="E_K1" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="E_Kp_calculation_eq">
<apply id="E_Kp_calculation">
<eq/>
<ci> E_Kp </ci>
<ci> E_K1 </ci>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="Kp_calculation_eq">
<apply id="Kp_calculation">
<eq/>
<ci> Kp </ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV"> 7.488 </cn>
<ci> V </ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV"> 5.98 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="i_Kp_calculation_eq">
<apply id="i_Kp_calculation">
<eq/>
<ci> i_Kp </ci>
<apply>
<times/>
<ci> g_Kp </ci>
<ci> Kp </ci>
<apply>
<minus/>
<ci> V </ci>
<ci> E_Kp </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="sarcolemmal_calcium_pump" name="sarcolemmal_calcium_pump">
<variable cmeta:id="id_00017" name="i_p_Ca" public_interface="out" units="uA_per_mm2"/>
<variable cmeta:id="id_00018" initial_value="0.5e-3" name="K_mpCa" units="mM"/>
<variable cmeta:id="id_00019" initial_value="1.15e-2" name="I_pCa" units="uA_per_mm2"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="Cai" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="i_p_Ca_calculation_eq">
<apply id="i_p_Ca_calculation">
<eq/>
<ci> i_p_Ca </ci>
<apply>
<times/>
<ci> I_pCa </ci>
<apply>
<divide/>
<ci> Cai </ci>
<apply>
<plus/>
<ci> K_mpCa </ci>
<ci> Cai </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="sodium_background_current" name="sodium_background_current">
<variable cmeta:id="id_00005" name="i_Na_b" public_interface="out" units="uA_per_mm2"/>
<variable cmeta:id="id_00006" initial_value="1.41e-5" name="g_Nab" units="mS_per_mm2"/>
<variable cmeta:id="id_00008" name="E_NaN" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable cmeta:id="id_00007" name="E_Na" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="E_NaN_calculation_eq">
<apply id="E_NaN_calculation">
<eq/>
<ci> E_NaN </ci>
<ci> E_Na </ci>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="i_Na_b_calculation_eq">
<apply id="i_Na_b_calculation">
<eq/>
<ci> i_Na_b </ci>
<apply>
<times/>
<ci> g_Nab </ci>
<apply>
<minus/>
<ci> V </ci>
<ci> E_NaN </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="calcium_background_current" name="calcium_background_current">
<variable cmeta:id="id_00020" name="i_Ca_b" public_interface="out" units="uA_per_mm2"/>
<variable cmeta:id="id_00021" initial_value="3.016e-5" name="g_Cab" units="mS_per_mm2"/>
<variable cmeta:id="id_00022" name="E_CaN" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="R" public_interface="in" units="gas_constant_units"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="faradays_constant_units"/>
<variable cmeta:id="id_00063" name="Cai" public_interface="in" units="mM"/>
<variable cmeta:id="id_00062" name="Cao" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="E_CaN_calculation_eq">
<apply id="E_CaN_calculation">
<eq/>
<ci> E_CaN </ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci> R </ci>
<ci> T </ci>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
<ci> F </ci>
</apply>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci> Cao </ci>
<ci> Cai </ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="i_Ca_b_calculation_eq">
<apply id="i_Ca_b_calculation">
<eq/>
<ci> i_Ca_b </ci>
<apply>
<times/>
<ci> g_Cab </ci>
<apply>
<minus/>
<ci> V </ci>
<ci> E_CaN </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="sodium_potassium_pump" name="sodium_potassium_pump">
<variable cmeta:id="id_00064" name="i_NaK" public_interface="out" units="uA_per_mm2"/>
<variable cmeta:id="id_00065" initial_value="1.5e-2" name="I_NaK" units="uA_per_mm2"/>
<variable cmeta:id="id_00066" name="f_NaK" units="dimensionless"/>
<variable initial_value="10.0" name="K_mNai" units="mM"/>
<variable initial_value="1.5" name="K_mKo" units="mM"/>
<variable name="sigma" units="dimensionless"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="R" public_interface="in" units="gas_constant_units"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="faradays_constant_units"/>
<variable name="Nai" public_interface="in" units="mM"/>
<variable name="Nao" public_interface="in" units="mM"/>
<variable name="Ko" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="f_NaK_calculation">
<eq/>
<ci> f_NaK </ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<plus/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 0.1245 </cn>
<apply>
<exp/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> -0.1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> V </ci>
<ci> F </ci>
</apply>
<apply>
<times/>
<ci> R </ci>
<ci> T </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 0.0365 </cn>
<ci> sigma </ci>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci> V </ci>
<ci> F </ci>
</apply>
<apply>
<times/>
<ci> R </ci>
<ci> T </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="sigma_calculation">
<eq/>
<ci> sigma </ci>
<apply>
<times/>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 7.0 </cn>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci> Nao </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 67.3 </cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="i_NaK_calculation_eq">
<apply id="i_NaK_calculation">
<eq/>
<ci> i_NaK </ci>
<apply>
<times/>
<ci> I_NaK </ci>
<ci> f_NaK </ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<power/>
<apply>
<divide/>
<ci> K_mNai </ci>
<ci> Nai </ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.5 </cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<ci> Ko </ci>
<apply>
<plus/>
<ci> Ko </ci>
<ci> K_mKo </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="non_specific_calcium_activated_current" name="non_specific_calcium_activated_current">
<variable cmeta:id="id_00023" name="i_ns_Ca" public_interface="out" units="uA_per_mm2"/>
<variable cmeta:id="id_00067" name="i_ns_Na" public_interface="out" units="uA_per_mm2"/>
<variable cmeta:id="id_00068" name="i_ns_K" public_interface="out" units="uA_per_mm2"/>
<variable cmeta:id="id_00069" initial_value="1.75e-9" name="P_ns_Ca" units="mm_per_ms"/>
<variable name="gamma_Nai" public_interface="in" units="dimensionless"/>
<variable name="gamma_Nao" public_interface="in" units="dimensionless"/>
<variable name="gamma_Ki" public_interface="in" units="dimensionless"/>
<variable name="gamma_Ko" public_interface="in" units="dimensionless"/>
<variable name="R" public_interface="in" units="gas_constant_units"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="faradays_constant_units"/>
<variable cmeta:id="id_00070" name="Cao" public_interface="in" units="mM"/>
<variable cmeta:id="id_00075" name="Nao" public_interface="in" units="mM"/>
<variable cmeta:id="id_00081" name="Ko" public_interface="in" units="mM"/>
<variable cmeta:id="id_00076" name="Nai" public_interface="in" units="mM"/>
<variable cmeta:id="id_00082" name="Ki" public_interface="in" units="mM"/>
<variable cmeta:id="id_00083" name="I_ns_Na" units="uA_per_mm2"/>
<variable cmeta:id="id_00084" name="I_ns_K" units="uA_per_mm2"/>
<variable initial_value="1.2e-3" name="K_m_ns_Ca" units="mM"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="Cai" public_interface="in" units="mM"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="Vns" units="mV"/>
<variable name="EnsCa" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="EnsCa_calculation_eq">
<apply id="EnsCa_calculation">
<eq/>
<ci> EnsCa </ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci> R </ci>
<ci> T </ci>
</apply>
<ci> F </ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Ko</ci>
<ci>Nao</ci>
</apply>
<apply>
<plus/>
<ci>Ki</ci>
<ci>Nai</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="Vns_calculation_eq">
<apply id="Vns_calculation">
<eq/>
<ci>Vns</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>EnsCa</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="i_ns_Na_calculation_eq">
<apply id="i_ns_Na_calculation">
<eq/>
<ci> i_ns_Na </ci>
<apply>
<times/>
<ci> I_ns_Na </ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<power/>
<apply>
<divide/>
<ci> K_m_ns_Ca </ci>
<ci> Cai </ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 3.0 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="i_ns_K_calculation_eq">
<apply id="i_ns_K_calculation">
<eq/>
<ci> i_ns_K </ci>
<apply>
<times/>
<ci> I_ns_K </ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<power/>
<apply>
<divide/>
<ci> K_m_ns_Ca </ci>
<ci> Cai </ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 3.0 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="i_ns_Ca_calculation_eq">
<apply id="i_ns_Ca_calculation">
<eq/>
<ci> i_ns_Ca </ci>
<apply>
<plus/>
<ci> i_ns_Na </ci>
<ci> i_ns_K </ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="I_ns_Na_calculation_eq">
<apply id="I_ns_Na_calculation">
<eq/>
<ci> I_ns_Na </ci>
<apply>
<times/>
<ci> P_ns_Ca </ci>
<apply>
<power/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> Vns </ci>
<apply>
<power/>
<ci> F </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
</apply>
</apply>
<apply>
<times/>
<ci> R </ci>
<ci> T </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci> gamma_Nai </ci>
<ci> Nai </ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<ci> Vns </ci>
<ci> F </ci>
</apply>
<apply>
<times/>
<ci> R </ci>
<ci> T </ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci> gamma_Nao </ci>
<ci> Nao </ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<ci> Vns </ci>
<ci> F </ci>
</apply>
<apply>
<times/>
<ci> R </ci>
<ci> T </ci>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="I_ns_K_calculation_eq">
<apply id="I_ns_K_calculation">
<eq/>
<ci> I_ns_K </ci>
<apply>
<times/>
<ci> P_ns_Ca </ci>
<apply>
<power/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> Vns </ci>
<apply>
<power/>
<ci> F </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
</apply>
</apply>
<apply>
<times/>
<ci> R </ci>
<ci> T </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci> gamma_Ki </ci>
<ci> Ki </ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<ci> Vns </ci>
<ci> F </ci>
</apply>
<apply>
<times/>
<ci> R </ci>
<ci> T </ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci> gamma_Ko </ci>
<ci> Ko </ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<ci> Vns </ci>
<ci> F </ci>
</apply>
<apply>
<times/>
<ci> R </ci>
<ci> T </ci>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="Na_Ca_exchanger" name="Na_Ca_exchanger">
<variable cmeta:id="id_00090" name="i_NaCa" public_interface="out" units="uA_per_mm2"/>
<variable cmeta:id="id_00091" initial_value="20.0" name="K_NaCa" units="uA_per_mm2"/>
<variable initial_value="87.5" name="K_mNa" units="mM"/>
<variable initial_value="1.38" name="K_mCa" units="mM"/>
<variable initial_value="0.1" name="K_sat" units="dimensionless"/>
<variable initial_value="0.35" name="eta" units="dimensionless"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="R" public_interface="in" units="gas_constant_units"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="faradays_constant_units"/>
<variable cmeta:id="id_00077" name="Nai" public_interface="in" units="mM"/>
<variable cmeta:id="id_00078" name="Nao" public_interface="in" units="mM"/>
<variable cmeta:id="id_00071" name="Cai" public_interface="in" units="mM"/>
<variable cmeta:id="id_00072" name="Cao" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="Na_Ca_exchanger_eq">
<apply id="Na_Ca_exchanger">
<eq/>
<ci> i_NaCa </ci>
<apply>
<times/>
<ci> K_NaCa </ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<plus/>
<apply>
<power/>
<ci> K_mNa </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 3.0 </cn>
</apply>
<apply>
<power/>
<ci> Nao </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 3.0 </cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<plus/>
<ci> K_mCa </ci>
<ci> Cao </ci>
</apply>
</apply>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<times/>
<ci> K_sat </ci>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci> eta </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
</apply>
<ci> V </ci>
<apply>
<divide/>
<ci> F </ci>
<apply>
<times/>
<ci> R </ci>
<ci> T </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<times/>
<ci> eta </ci>
<ci> V </ci>
<apply>
<divide/>
<ci> F </ci>
<apply>
<times/>
<ci> R </ci>
<ci> T </ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci> Nai </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 3.0 </cn>
</apply>
<ci> Cao </ci>
</apply>
<apply>
<times/>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci> eta </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
</apply>
<ci> V </ci>
<apply>
<divide/>
<ci> F </ci>
<apply>
<times/>
<ci> R </ci>
<ci> T </ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci> Nao </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 3.0 </cn>
</apply>
<ci> Cai </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="calcium_fluxes_in_the_SR" name="calcium_fluxes_in_the_SR">
<variable name="i_rel" public_interface="out" units="mM_per_ms"/>
<variable name="i_up" public_interface="out" units="mM_per_ms"/>
<variable name="i_leak" public_interface="out" units="mM_per_ms"/>
<variable name="i_tr" public_interface="out" units="mM_per_ms"/>
<variable name="G_rel" units="per_ms"/>
<variable name="G_rel_peak" units="per_ms"/>
<variable initial_value="60.0" name="G_rel_max" units="per_ms"/>
<variable initial_value="2.0" name="tau_on" units="ms"/>
<variable initial_value="2.0" name="tau_off" units="ms"/>
<variable initial_value="0.0" name="t_CICR" units="ms"/>
<variable initial_value="180.0" name="tau_tr" units="ms"/>
<variable initial_value="0.8e-3" name="K_mrel" units="mM"/>
<variable initial_value="0.92e-3" name="K_mup" units="mM"/>
<variable cmeta:id="id_00088" name="K_leak" units="per_ms"/>
<variable initial_value="0.005" name="I_up" units="mM_per_ms"/>
<variable cmeta:id="id_00087" initial_value="15.0" name="Ca_NSR_max" units="mM"/>
<variable initial_value="0.0" name="delta_Ca_i2" units="mM"/>
<variable initial_value="0.18e-3" name="delta_Ca_ith" units="mM"/>
<variable name="time" public_interface="in" units="ms"/>
<variable cmeta:id="id_00089" name="Cai" public_interface="in" units="mM"/>
<variable cmeta:id="id_00085" name="Ca_JSR" public_interface="in" units="mM"/>
<variable cmeta:id="id_00086" name="Ca_NSR" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="i_rel_calculation_eq">
<apply id="i_rel_calculation">
<eq/>
<ci> i_rel </ci>
<apply>
<times/>
<ci> G_rel </ci>
<apply>
<minus/>
<ci> Ca_JSR </ci>
<ci> Cai </ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="G_rel_calculation_eq">
<apply id="G_rel_calculation">
<eq/>
<ci> G_rel </ci>
<apply>
<times/>
<ci> G_rel_peak </ci>
<apply>
<divide/>
<apply>
<minus/>
<ci> delta_Ca_i2 </ci>
<ci> delta_Ca_ith </ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci> K_mrel </ci>
<ci> delta_Ca_i2 </ci>
</apply>
<ci> delta_Ca_ith </ci>
</apply>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<divide/>
<ci> t_CICR </ci>
<ci> tau_on </ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<divide/>
<ci> t_CICR </ci>
<ci> tau_off </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="G_rel_peak_calculation_eq">
<apply id="G_rel_peak_calculation">
<eq/>
<ci> G_rel_peak </ci>
<piecewise>
<piece>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms"> 0.0 </cn>
<apply>
<lt/>
<ci> delta_Ca_i2 </ci>
<ci> delta_Ca_ith </ci>
</apply>
</piece>
<otherwise>
<ci> G_rel_max </ci>
</otherwise>
</piecewise>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="i_up_calculation_eq">
<apply id="i_up_calculation">
<eq/>
<ci> i_up </ci>
<apply>
<times/>
<ci> I_up </ci>
<apply>
<divide/>
<ci> Cai </ci>
<apply>
<plus/>
<ci> Cai </ci>
<ci> K_mup </ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="i_leak_calculation_eq">
<apply id="i_leak_calcualtion">
<eq/>
<ci> i_leak </ci>
<apply>
<times/>
<ci> K_leak </ci>
<ci> Ca_NSR </ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="K_leak_calculation_eq">
<apply id="K_leak_calculation">
<eq/>
<ci> K_leak </ci>
<apply>
<divide/>
<ci> I_up </ci>
<ci> Ca_NSR_max </ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="i_tr_calculation_eq">
<apply id="i_tr_calculation">
<eq/>
<ci> i_tr </ci>
<apply>
<divide/>
<apply>
<minus/>
<ci> Ca_NSR </ci>
<ci> Ca_JSR </ci>
</apply>
<ci> tau_tr </ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="ionic_concentrations" name="ionic_concentrations">
<variable cmeta:id="id_00079" initial_value="10.0" name="Nai" public_interface="out" units="mM"/>
<variable cmeta:id="id_00080" initial_value="140.0" name="Nao" public_interface="out" units="mM"/>
<variable cmeta:id="id_00074" initial_value="0.12e-3" name="Cai" public_interface="out" units="mM"/>
<variable cmeta:id="id_00073" initial_value="1.8" name="Cao" public_interface="out" units="mM"/>
<variable cmeta:id="id_00092" initial_value="145.0" name="Ki" public_interface="out" units="mM"/>
<variable cmeta:id="id_00093" initial_value="5.4" name="Ko" public_interface="out" units="mM"/>
<variable initial_value="1.8" name="Ca_JSR" public_interface="out" units="mM"/>
<variable initial_value="1.8" name="Ca_NSR" public_interface="out" units="mM"/>
<variable initial_value="200" name="Am" units="per_mm"/>
<variable initial_value="0.68" name="V_myo" units="dimensionless"/>
<variable initial_value="0.0048" name="V_JSR" units="dimensionless"/>
<variable initial_value="0.0552" name="V_NSR" units="dimensionless"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="F" public_interface="in" units="faradays_constant_units"/>
<variable cmeta:id="id_00094" name="i_Na" public_interface="in" units="uA_per_mm2"/>
<variable cmeta:id="id_00095" name="i_CaNa" public_interface="in" units="uA_per_mm2"/>
<variable cmeta:id="id_00096" name="i_Na_b" public_interface="in" units="uA_per_mm2"/>
<variable cmeta:id="id_00097" name="i_ns_Na" public_interface="in" units="uA_per_mm2"/>
<variable cmeta:id="id_00098" name="i_NaCa" public_interface="in" units="uA_per_mm2"/>
<variable cmeta:id="id_00099" name="i_NaK" public_interface="in" units="uA_per_mm2"/>
<variable cmeta:id="id_00024" name="i_CaCa" public_interface="in" units="uA_per_mm2"/>
<variable cmeta:id="id_00100" name="i_CaK" public_interface="in" units="uA_per_mm2"/>
<variable cmeta:id="id_00025" name="i_p_Ca" public_interface="in" units="uA_per_mm2"/>
<variable cmeta:id="id_00101" name="i_Ca_b" public_interface="in" units="uA_per_mm2"/>
<variable cmeta:id="id_00102" name="i_K" public_interface="in" units="uA_per_mm2"/>
<variable cmeta:id="id_00103" name="i_K1" public_interface="in" units="uA_per_mm2"/>
<variable cmeta:id="id_00104" name="i_Kp" public_interface="in" units="uA_per_mm2"/>
<variable cmeta:id="id_00105" name="i_ns_K" public_interface="in" units="uA_per_mm2"/>
<variable name="i_tr" public_interface="in" units="mM_per_ms"/>
<variable name="i_rel" public_interface="in" units="mM_per_ms"/>
<variable cmeta:id="id_00106" name="i_leak" public_interface="in" units="mM_per_ms"/>
<variable name="i_up" public_interface="in" units="mM_per_ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="sodium_diff_eq">
<apply id="sodium_diff_eq">
<eq/>
<apply>
<diff/>
<bvar>
<ci> time </ci>
</bvar>
<ci> Nai </ci>
</apply>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci> i_Na </ci>
<ci> i_CaNa </ci>
<ci> i_Na_b </ci>
<ci> i_ns_Na </ci>
<apply>
<times/>
<ci> i_NaCa </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 3.0 </cn>
</apply>
<apply>
<times/>
<ci> i_NaK </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 3.0 </cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<ci> Am </ci>
<apply>
<times/>
<ci> V_myo </ci>
<ci> F </ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="calcium_internal_diff_eq">
<apply id="calcium_internal_diff_eq">
<eq/>
<apply>
<diff/>
<bvar>
<ci> time </ci>
</bvar>
<ci> Cai </ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci> i_CaCa </ci>
<ci> i_p_Ca </ci>
<ci> i_Ca_b </ci>
</apply>
<ci> i_NaCa </ci>
</apply>
</apply>
<apply>
<divide/>
<ci> Am </ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
<ci> V_myo </ci>
<ci> F </ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci> i_rel </ci>
<apply>
<divide/>
<ci> V_JSR </ci>
<ci> V_myo </ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<minus/>
<ci> i_leak </ci>
<ci> i_up </ci>
</apply>
<apply>
<divide/>
<ci> V_NSR </ci>
<ci> V_myo </ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="potassium_internal_diff_eq">
<apply id="potassium_internal_diff_eq">
<eq/>
<apply>
<diff/>
<bvar>
<ci> time </ci>
</bvar>
<ci> Ki </ci>
</apply>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci> i_CaK </ci>
<ci> i_K </ci>
<ci> i_K1 </ci>
<ci> i_Kp </ci>
<ci> i_ns_K </ci>
<apply>
<minus/>
<apply>
<times/>
<ci> i_NaK </ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<ci> Am </ci>
<apply>
<times/>
<ci> V_myo </ci>
<ci> F </ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="calcium_JSR_diff_eq">
<apply id="calcium_JSR_diff_eq">
<eq/>
<apply>
<diff/>
<bvar>
<ci> time </ci>
</bvar>
<ci> Ca_JSR </ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<ci> i_rel </ci>
<apply>
<times/>
<ci> i_tr </ci>
<apply>
<divide/>
<ci> V_NSR </ci>
<ci> V_JSR </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="calcium_NSR_diff_eq">
<apply id="calcium_NSR_diff_eq">
<eq/>
<apply>
<diff/>
<bvar>
<ci> time </ci>
</bvar>
<ci> Ca_NSR </ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci> i_leak </ci>
<ci> i_tr </ci>
</apply>
<ci> i_up </ci>
</apply>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="fast_sodium_current">
<component_ref component="fast_sodium_current_m_gate"/>
<component_ref component="fast_sodium_current_h_gate"/>
<component_ref component="fast_sodium_current_j_gate"/>
</component_ref>
<component_ref component="L_type_Ca_channel">
<component_ref component="L_type_Ca_channel_d_gate"/>
<component_ref component="L_type_Ca_channel_f_gate"/>
<component_ref component="L_type_Ca_channel_f_Ca_gate"/>
</component_ref>
<component_ref component="time_dependent_potassium_current">
<component_ref component="time_dependent_potassium_current_X_gate"/>
<component_ref component="time_dependent_potassium_current_Xi_gate"/>
</component_ref>
<component_ref component="time_independent_potassium_current">
<component_ref component="time_independent_potassium_current_K1_gate"/>
</component_ref>
</group>
<connection>
<map_components component_1="membrane" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="time_dependent_potassium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Na_Ca_exchanger" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="plateau_potassium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="sarcolemmal_calcium_pump" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="sodium_background_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="calcium_background_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="non_specific_calcium_activated_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="ionic_concentrations" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="calcium_fluxes_in_the_SR" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="fast_sodium_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="L_type_Ca_channel"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="time_dependent_potassium_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_K" variable_2="i_K"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="Na_Ca_exchanger"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="time_independent_potassium_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="plateau_potassium_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Kp" variable_2="i_Kp"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sarcolemmal_calcium_pump"/>
<map_variables variable_1="i_p_Ca" variable_2="i_p_Ca"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_background_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Na_b" variable_2="i_Na_b"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="calcium_background_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Ca_b" variable_2="i_Ca_b"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_potassium_pump"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="non_specific_calcium_activated_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="i_ns_Ca" variable_2="i_ns_Ca"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="ionic_concentrations"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="ionic_concentrations"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="sodium_background_current"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="ionic_concentrations"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="i_CaCa" variable_2="i_CaCa"/>
<map_variables variable_1="i_CaNa" variable_2="i_CaNa"/>
<map_variables variable_1="i_CaK" variable_2="i_CaK"/>
</connection>
<connection>
<map_components component_1="time_dependent_potassium_current" component_2="ionic_concentrations"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="i_K" variable_2="i_K"/>
</connection>
<connection>
<map_components component_1="Na_Ca_exchanger" component_2="ionic_concentrations"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="ionic_concentrations"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
</connection>
<connection>
<map_components component_1="plateau_potassium_current" component_2="time_independent_potassium_current"/>
<map_variables variable_1="E_K1" variable_2="E_K1"/>
</connection>
<connection>
<map_components component_1="plateau_potassium_current" component_2="ionic_concentrations"/>
<map_variables variable_1="i_Kp" variable_2="i_Kp"/>
</connection>
<connection>
<map_components component_1="sarcolemmal_calcium_pump" component_2="ionic_concentrations"/>
<map_variables variable_1="i_p_Ca" variable_2="i_p_Ca"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection>
<map_components component_1="sodium_background_current" component_2="ionic_concentrations"/>
<map_variables variable_1="i_Na_b" variable_2="i_Na_b"/>
</connection>
<connection>
<map_components component_1="calcium_background_current" component_2="ionic_concentrations"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="i_Ca_b" variable_2="i_Ca_b"/>
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="ionic_concentrations"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
</connection>
<connection>
<map_components component_1="non_specific_calcium_activated_current" component_2="ionic_concentrations"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="i_ns_Na" variable_2="i_ns_Na"/>
<map_variables variable_1="i_ns_K" variable_2="i_ns_K"/>
</connection>
<connection>
<map_components component_1="calcium_fluxes_in_the_SR" component_2="ionic_concentrations"/>
<map_variables variable_1="i_rel" variable_2="i_rel"/>
<map_variables variable_1="i_tr" variable_2="i_tr"/>
<map_variables variable_1="i_leak" variable_2="i_leak"/>
<map_variables variable_1="i_up" variable_2="i_up"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Ca_JSR" variable_2="Ca_JSR"/>
<map_variables variable_1="Ca_NSR" variable_2="Ca_NSR"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="non_specific_calcium_activated_current"/>
<map_variables variable_1="gamma_Nao" variable_2="gamma_Nao"/>
<map_variables variable_1="gamma_Nai" variable_2="gamma_Nai"/>
<map_variables variable_1="gamma_Ko" variable_2="gamma_Ko"/>
<map_variables variable_1="gamma_Ki" variable_2="gamma_Ki"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="fast_sodium_current_m_gate"/>
<map_variables variable_1="m" variable_2="m"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="fast_sodium_current_h_gate"/>
<map_variables variable_1="h" variable_2="h"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="fast_sodium_current_j_gate"/>
<map_variables variable_1="j" variable_2="j"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_d_gate"/>
<map_variables variable_1="d" variable_2="d"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_f_gate"/>
<map_variables variable_1="f" variable_2="f"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_f_Ca_gate"/>
<map_variables variable_1="f_Ca" variable_2="f_Ca"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="time_dependent_potassium_current" component_2="time_dependent_potassium_current_X_gate"/>
<map_variables variable_1="X" variable_2="X"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="time_dependent_potassium_current" component_2="time_dependent_potassium_current_Xi_gate"/>
<map_variables variable_1="Xi" variable_2="Xi"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="time_independent_potassium_current_K1_gate"/>
<map_variables variable_1="K1_infinity" variable_2="K1_infinity"/>
<map_variables variable_1="E_K1" variable_2="E_K1"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"><rdf:Description rdf:about="rdf:#06b56481-8a0b-44e4-b51e-becc5946d0ae"><rdf:value xml:lang="en">
The opening rate of the d gate.
</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#b24b01df-79b2-4688-9b1a-6afaf16c3f68"><rdf:value xml:lang="en">
The kinetics of the m gate.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#beta_d_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#7e3e20b1-2812-44d7-af86-cc1b02c8dc88"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#7e3e20b1-2812-44d7-af86-cc1b02c8dc88"><rdf:value xml:lang="en">
The closing rate of the d gate.
</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#eca238c5-1bac-4ef4-ba1b-1957814fb5a0"><rdf:value xml:lang="en">
The reversal potential for the channel.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#i_rel_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#cfed257d-2438-487f-bb26-32007b0a0c0a"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#cfed257d-2438-487f-bb26-32007b0a0c0a"><rdf:value xml:lang="en">
The release flux from the junctional sarcoplasmic reticulum into the
cytosol.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#i_CaCa_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#47d79ba7-612b-4607-a02b-d25d3431bfb0"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#47d79ba7-612b-4607-a02b-d25d3431bfb0"><rdf:value xml:lang="en">
The calcium component of the total L-type channel current.
</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#e3b59417-3a58-4c54-8ac2-4f3ace00863b"><rdf:value xml:lang="en">
The opening rate for the K1 gate.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#i_ns_K_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#3a6533b9-0f33-426a-8db1-098aa4ad0b57"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#3a6533b9-0f33-426a-8db1-098aa4ad0b57"><rdf:value xml:lang="en">
The potassium component of the channel's current.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#alpha_f_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#0ee202ac-d501-4afd-a075-c903938bbb09"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#0ee202ac-d501-4afd-a075-c903938bbb09"><rdf:value xml:lang="en">
The opening rate of the f gate.
</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#2cf60e99-7a37-4381-8053-6ce89db98df3"><rdf:value xml:lang="en">
We need to use dV/dt in the calulation of calcium-induced
calcium-release, so we make it accessible here.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#alpha_K1_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#e3b59417-3a58-4c54-8ac2-4f3ace00863b"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#5e0e2c60-77e0-4562-b96f-ac1c98a7a28e"><rdf:value xml:lang="en">
The maximum calcium component of the total L-type channel current.
</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#b5770b23-e0d6-4651-b301-346789ff2487"><rdf:value xml:lang="en">
Calculation of the exchanger current.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#I_ns_Na_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#11db82ba-aadc-4708-a32a-3af86fd666a9"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#11db82ba-aadc-4708-a32a-3af86fd666a9"><rdf:value xml:lang="en">
The maximum sodium component of the channel's current.
</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#c1a52631-c294-44d6-ac5a-874857131743"><rdf:value xml:lang="en">
The gating kinetics for the channel.
</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#06477d3e-368a-4468-b526-75ec896e4d78"><rdf:value xml:lang="en">
The kinetics of for the j gate.
</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#2b24949f-d4c5-42a8-b723-5eb181fad921"><rdf:value xml:lang="en">
The reversal potential of the channel.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#I_ns_K_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#bfe4cc97-227f-48d2-8200-a737a815dde8"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#bfe4cc97-227f-48d2-8200-a737a815dde8"><rdf:value xml:lang="en">
The maximum potassium component of the channel's current.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#I_CaCa_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#5e0e2c60-77e0-4562-b96f-ac1c98a7a28e"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#8905761e-5adb-4bad-bde8-40ac702a9e82"><rdf:value xml:lang="en">
The kinetics of the h gate.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#IStim_for_cmiss_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#acea15f8-7896-42b4-a9c8-1424fe3a72e5"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#acea15f8-7896-42b4-a9c8-1424fe3a72e5"><rdf:value xml:lang="en">
This is a dummy equation that we simply use to make grabbing the
value in CMISS much easier.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#K1_infinity_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#1c98d94a-c7a7-4075-99c8-b40d62dc9c71"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#1c98d94a-c7a7-4075-99c8-b40d62dc9c71"><rdf:value xml:lang="en">
The steady-state kinetics of the K1 gate.
</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#5bfd99b6-78b5-41cc-8e53-5a1b9c86e9a6"><rdf:value xml:lang="en">
Assign the rate of change of potential for the differential
equation.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#i_Na_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#4e27dc9d-a4bb-4bbd-9917-7710f97fb88e"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#4e27dc9d-a4bb-4bbd-9917-7710f97fb88e"><rdf:value xml:lang="en">
Calculation of the fast sodium current.
</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#3d8953ae-2ae0-4a86-80d5-f65c1d6ae520"><rdf:value xml:lang="en">
The change in calcium concentration in the junctional sarcoplasmic
reticulum.
</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#9845ea23-14d8-4e82-93a4-d57bad1885df"><rdf:value xml:lang="en">
The change in intracellular calcium concentration.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#i_leak_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#f37d3616-ad4a-40e4-84a1-b51164d3c645"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#f37d3616-ad4a-40e4-84a1-b51164d3c645"><rdf:value xml:lang="en">
Calcium leak flux from the network sarcoplasmic reticulum into the
cytosol.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#df_dt_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#dcf4b094-5f49-4f18-844a-6542dc314118"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#dcf4b094-5f49-4f18-844a-6542dc314118"><rdf:value xml:lang="en">
The kinetics of the f gate.
</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#8710373c-3c70-4e66-8de9-b935dad3d7a2"><rdf:value xml:lang="en">
The total current through the channel.
</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#47f37758-7bc6-485f-8a2f-3b30c2b18ad5"><rdf:value xml:lang="en">
Calculation of the channel conductance.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#beta_h_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#47017c89-3625-4d2c-83a0-4beb85a60991"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#47017c89-3625-4d2c-83a0-4beb85a60991"><rdf:value xml:lang="en">
The closing rate for the h gate.
</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#11405b4e-4614-4f56-aaf9-b2bf0029ad2b"><rdf:value xml:lang="en">
The change in intracellular potassium concentration.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#E_NaN_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#eca238c5-1bac-4ef4-ba1b-1957814fb5a0"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="cellml://cellml#potassium_internal_diff_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#11405b4e-4614-4f56-aaf9-b2bf0029ad2b"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="cellml://cellml#dV_dt_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#2cf60e99-7a37-4381-8053-6ce89db98df3"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="cellml://cellml#alpha_j_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#6cbb0fc7-8bd7-4acf-be74-070f925d4c43"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#6cbb0fc7-8bd7-4acf-be74-070f925d4c43"><rdf:value xml:lang="en">
The opening rate for the j gate.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#i_CaNa_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#ecc0192c-13e9-45f9-850c-28d1cd1259ea"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#ecc0192c-13e9-45f9-850c-28d1cd1259ea"><rdf:value xml:lang="en">
The sodium component of the total L-type channel current.
</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#fda547bd-f935-468c-b90e-b8411713034c"><rdf:value xml:lang="en">
Calculation of the release channel conductance. This is incorrect as
there is no CICR induced via the accumulation of calcium in the
cytosol in the period following max(dV/dt)
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#i_K1_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#f2d1ca1a-68f8-4f41-9d64-9292a0f53b14"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#f2d1ca1a-68f8-4f41-9d64-9292a0f53b14"><rdf:value xml:lang="en">
Calculation of the channel current.
</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#9795c58e-41a2-48e6-8c6f-c48c07c0e3f8"><rdf:value xml:lang="en">
Calculation of the current.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#E_Kp_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#43d60ff4-386d-4018-b017-9ec441a88a83"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#43d60ff4-386d-4018-b017-9ec441a88a83"><rdf:value xml:lang="en">
The reversal potential for the channel.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#i_Ca_b_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#ef1a7209-efdd-4c03-a2db-afc401ad754e"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#ef1a7209-efdd-4c03-a2db-afc401ad754e"><rdf:value xml:lang="en">
Calculation of the current.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#beta_X_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#1e3f89aa-bd17-4569-875f-82d9f7fd4bab"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#1e3f89aa-bd17-4569-875f-82d9f7fd4bab"><rdf:value xml:lang="en">
The closing rate for the X gate.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#Xi_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#d82cd9a6-2d48-4037-9b4e-0a28b67a6a5e"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#d82cd9a6-2d48-4037-9b4e-0a28b67a6a5e"><rdf:value xml:lang="en">
The kinetics of the Xi gate.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#i_Kp_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#9795c58e-41a2-48e6-8c6f-c48c07c0e3f8"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#6114ba02-ae30-4208-993c-f7c95eb48ad0"><rdf:value xml:lang="en">
The sodium component of the channel's current.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#Na_Ca_exchanger_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#4c6309a7-a8b2-41d4-b393-142d4c7cead2"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#4c6309a7-a8b2-41d4-b393-142d4c7cead2"><rdf:value xml:lang="en">
Calculation of the exchanger current.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#membrane_voltage_diff_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#5bfd99b6-78b5-41cc-8e53-5a1b9c86e9a6"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="cellml://cellml#E_K_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#2b24949f-d4c5-42a8-b723-5eb181fad921"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#80947412-cef4-45d5-8e08-03e24effedb5"><rdf:value xml:lang="en">
Translocation flux from the network to the junctional sarcoplasmic
reticulum.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#G_rel_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#fda547bd-f935-468c-b90e-b8411713034c"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="cellml://cellml#alpha_h_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#31113158-c092-4a36-af97-8db775f63e7d"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#31113158-c092-4a36-af97-8db775f63e7d"><rdf:value xml:lang="en">
The opening rate for the h gate.
</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#c3ab0860-e7bc-4272-99bb-27831d3c5872"><rdf:value xml:lang="en">
The closing rate for the j gate.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#I_CaNa_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#91a35310-b6b0-4b4d-9975-6ab1107690a0"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#91a35310-b6b0-4b4d-9975-6ab1107690a0"><rdf:value xml:lang="en">
The maximum sodium component of the total L-type channel current.
</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#df428f1e-3520-4930-bbca-bcb82223dcd1"><rdf:value xml:lang="en">
The closing rate for the K1 gate.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#i_NaK_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#b5770b23-e0d6-4651-b301-346789ff2487"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="cellml://cellml#i_ns_Ca_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#8710373c-3c70-4e66-8de9-b935dad3d7a2"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#e70eab76-ebf0-472c-b3f7-586ca26f6190"><rdf:value xml:lang="en">
The opening rate for the X gate.
</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#b9af0253-a338-41b1-9897-c03504cb1f54"><rdf:value xml:lang="en">
Calculation of the current.
</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#90659886-14c8-4ca0-9ae9-ad99d85d57b8"><rdf:value xml:lang="en">
The total current of the L-type channel current.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#alpha_d_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#06b56481-8a0b-44e4-b51e-becc5946d0ae"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#60f5de3b-a543-42b2-b867-a60ca08189d7"><rdf:value xml:lang="en">
The change in intracellular sodium concentration.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#beta_f_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#31486372-d1dc-4d54-972c-c71117a32e52"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#31486372-d1dc-4d54-972c-c71117a32e52"><rdf:value xml:lang="en">
The closing rate of the f gate.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#alpha_m_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#4b682ab7-cdbc-47fb-8a9c-2f475ac2039e"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#4b682ab7-cdbc-47fb-8a9c-2f475ac2039e"><rdf:value xml:lang="en">
The opening rate for the m gate.
</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#eeea0bfd-f962-49f4-90aa-560d9b2ff5aa"><rdf:value xml:lang="en">
The conductance for the channel.
</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#74c8f184-9256-4be1-beab-ac8b7276f635"><rdf:value xml:lang="en">
The kinetics of the fCa gate.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#g_K1_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#47f37758-7bc6-485f-8a2f-3b30c2b18ad5"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="cellml://cellml#i_p_Ca_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#13c03188-2ea0-42e6-b3c0-facf6d220ace"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#13c03188-2ea0-42e6-b3c0-facf6d220ace"><rdf:value xml:lang="en">
The calcium pump current.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#EnsCa_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#860e71ac-2d5e-45cc-a9e8-40a1ebc340fe"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#860e71ac-2d5e-45cc-a9e8-40a1ebc340fe"><rdf:value xml:lang="en">
The channel reversal potential.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#ionic_concentrations"><cmeta:comment><rdf:Description rdf:about="rdf:#286fd670-6f28-4e62-8fa3-4951ff063dc9"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#286fd670-6f28-4e62-8fa3-4951ff063dc9"><rdf:value xml:lang="en">
Component grouping together the differential equations for the
various ionic concentrations that the model tracks.
</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#6ed40cfe-2830-4c4d-b6ff-2ab75608d720"><rdf:value xml:lang="en">
The change in calcium concentration in the network sarcoplasmic
reticulum.
</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#53493837-f9f6-4536-b2e1-bf2ea45f0690"><rdf:value xml:lang="en">
The kinetics of the d gate.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#dd_dt_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#53493837-f9f6-4536-b2e1-bf2ea45f0690"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="cellml://cellml#i_CaK_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#976183a8-493e-450f-be70-79434284c49e"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#976183a8-493e-450f-be70-79434284c49e"><rdf:value xml:lang="en">
The potassium component of the total L-type channel current.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#i_tr_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#80947412-cef4-45d5-8e08-03e24effedb5"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#1150b3fc-c6e2-4389-9c48-c566f671553c"><rdf:value xml:lang="en">
Calculation of reversal potential for the fast sodium channel.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#f_Ca_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#74c8f184-9256-4be1-beab-ac8b7276f635"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="cellml://cellml#alpha_X_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#e70eab76-ebf0-472c-b3f7-586ca26f6190"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="cellml://cellml#i_up_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#cb9693bc-2647-453b-9ab2-5c083422a712"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#cb9693bc-2647-453b-9ab2-5c083422a712"><rdf:value xml:lang="en">
The uptake flux into the sarcoplasmic reticulum from the cytosol.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#dh_dt_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#8905761e-5adb-4bad-bde8-40ac702a9e82"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="cellml://cellml#g_K_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#eeea0bfd-f962-49f4-90aa-560d9b2ff5aa"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#6f57b22d-9d38-4fd7-a2e3-c020dd11ee72"><rdf:value xml:lang="en">
The closing rate for the m gate.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#calcium_internal_diff_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#9845ea23-14d8-4e82-93a4-d57bad1885df"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#5883b036-a136-49be-908e-0035c14c9d3e"><rdf:value xml:lang="en">
Calculation of the channel reversal potential.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#i_Ca_L_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#90659886-14c8-4ca0-9ae9-ad99d85d57b8"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#a0fb41c6-024b-4adb-9bb9-9a86fcfbe740"><rdf:value xml:lang="en">
Calculation of the current.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#sodium_diff_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#60f5de3b-a543-42b2-b867-a60ca08189d7"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="cellml://cellml#beta_m_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#6f57b22d-9d38-4fd7-a2e3-c020dd11ee72"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="cellml://cellml#i_Na_b_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#b9af0253-a338-41b1-9897-c03504cb1f54"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="cellml://cellml#i_K_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#a0fb41c6-024b-4adb-9bb9-9a86fcfbe740"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#8da7daa7-8b4f-4d33-a5d5-0a2c1c2cd177"><rdf:value xml:lang="en">
The kinetics of the X gate.
</rdf:value></rdf:Description><rdf:Description rdf:about="cellml://cellml#E_K1_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#5883b036-a136-49be-908e-0035c14c9d3e"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="cellml://cellml#E_Na_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#1150b3fc-c6e2-4389-9c48-c566f671553c"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#87a92d7c-0058-4baf-b791-0450ebf7b58a"><rdf:value xml:lang="en">
The reversal potential for the channel.
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The maximum potassium component of the total L-type channel current.
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