- Author:
- pmr2.import <nobody@models.cellml.org>
- Date:
- 2009-06-17 15:04:12+12:00
- Desc:
- committing version02 of macgregor_leng_2005
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/macgregor_leng_2005/rawfile/24e52a3f7eabf7bd727c15aba57e5c4102ef0968/macgregor_leng_2005_a.cellml
<?xml version='1.0' encoding='utf-8'?>
<!-- FILE : macgregor_model_2005.xml
CREATED : 19th June 2007
LAST MODIFIED : 19th June 2007
AUTHOR : Catherine Lloyd
Bioengineering Institute
The University of Auckland
MODEL STATUS : This model conforms to the CellML 1.1 Specification.
DESCRIPTION : This file contains a CellML description of MacGregor and Leng's 2005 mathematical model of hypothalamic control of growth hormone secretion.
CHANGES:
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<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Modelling the Hypothalamic Control of Growth Hormone Secretion</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This particular CellML model describes the pituitary model of the published article. The units have been checked and are consistent and the model runs in PCEnv to replicate the published results (as shown in figure 3B of the paper)..
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
In most mammals, including humans, growth hormone (GH) is secreted in a pulsatile pattern, which is regulated by two hypothalamic peptides; growth hormone-releasing hormone (GHRH) and somatostatin. The former stimulates GH secretion while the latter inhibits it. The activity of the hypothalamic neuroendocrine neurones is affected by feedback from GH and somatomedins, including activation of somatostatin release and possibly inhibition of GHRH release. Furthermore, there is evidence that somatostatin neurones may inhibit the activity of GHRH neurones.
</para>
<para>
In their 2005 model, MacGregor and Lend use mathematical equations to describe these biological features and present a model of the hypothalamic network that controls GH secretion (see <xref linkend="fig_reaction_diagram"/> below).
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
<ulink url="http://www.blackwell-synergy.com/doi/abs/10.1111/j.1365-2826.2005.01370.x">Modelling the hypothalamic control of growth hormone secretion</ulink>, D. J. MacGregor and G. Leng, 2005, <ulink url="http://www.blackwell-synergy.com/toc/jne/17/12">
<emphasis>Journal of Neuroendocrinology</emphasis>
</ulink>, volume 17, 788-803. (<ulink url="http://www.blackwell-synergy.com/doi/full/10.1111/j.1365-2826.2005.01370.x">Full text (HTML)</ulink> and PDF versions of the article are available to subscribers on the <emphasis>Journal of Neuroendocrinology</emphasis> website.) <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16280026&query_hl=1&itool=pubmed_docsum">PubMed ID: 16280026</ulink>
</para>
<informalfigure float="0" id="fig_reaction_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>model diagram</title>
</objectinfo>
<imagedata fileref="macgregor_2005.png"/>
</imageobject>
</mediaobject>
<caption>A schematic diagram of the different components and connections in the growth hormone secretory system. Somatostatin (SOS) inhibits the secretion of both growth hormone-releasing hormone (GHRH) and growth hormone (GH). After a delay, GH feeds back to prime the pool of releasable somatostatin, resulting in the bulk release of somatostatin, which in turn allows further GHRH release and and another burst of GH.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
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<rdf:RDF>
<rdf:Bag rdf:about="rdf:#e934ccce-66bd-4ec4-bfd1-bae7066a355b">
<rdf:li>endocrine</rdf:li>
<rdf:li>somatostatin</rdf:li>
<rdf:li>hypothalamus</rdf:li>
<rdf:li>growth hormone releasing hormone</rdf:li>
<rdf:li>growth hormone</rdf:li>
</rdf:Bag>
<rdf:Seq rdf:about="rdf:#3bf615c8-8e2c-4cfc-be30-4a5292e696a1">
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<rdf:li rdf:resource="rdf:#8f070586-19f9-4d6d-820b-b50bad39355a"/>
</rdf:Seq>
<rdf:Description rdf:about="">
<dc:publisher>The University of Auckland, Bioengineering Institute</dc:publisher>
<cmeta:comment rdf:resource="rdf:#580f1f38-27da-4e6e-9311-5a8dd7a07bf3"/>
<dcterms:created rdf:resource="rdf:#8ed9d161-151a-491f-87ee-627e5b74d21c"/>
<dc:creator rdf:resource="rdf:#04a9cae3-1b65-490e-9864-8b1cec2b9082"/>
<cmeta:modification rdf:resource="rdf:#96dc0f6c-66ef-412f-aac8-0e55b9a3f23a"/>
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<rdf:Description rdf:about="rdf:#0c78cb72-74d0-4763-9098-4dd25c0e992e">
<vCard:Orgname>The University of Auckland</vCard:Orgname>
<vCard:Orgunit>The Bioengineering Institute</vCard:Orgunit>
</rdf:Description>
<rdf:Description rdf:about="rdf:#e548e51a-8a50-4c30-99ac-1d602784711e">
<dc:title>Journal of Neuroendocrinology</dc:title>
</rdf:Description>
<rdf:Description rdf:about="rdf:#580f1f38-27da-4e6e-9311-5a8dd7a07bf3">
<dc:creator rdf:resource="rdf:#09eae02c-27dd-4330-9526-e054b73ac94b"/>
<rdf:value>The model runs in PCEnv to replicate the results in the published paper. In particular the initial conditions have been set to the same as those which generate the results for figure 3B in the published paper.</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#854fa0cf-23ca-4f40-89ca-5f27bf8efc4e">
<dcterms:W3CDTF>2005-00-00 00:00</dcterms:W3CDTF>
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MacGregor and Leng's 2005 mathematical model of hypothalamic control of growth hormone secretion.
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<dc:title>Modelling the hypothalamic control of growth hormone secretion.</dc:title>
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<rdf:value>Checked the model in COR and made all the units consistent. I also reduced the model back to its foundation form (the pituitary part only), and added two complex piecewise equations to simulate the injection of the hormones.</rdf:value>
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