- Author:
- pmr2.import <nobody@models.cellml.org>
- Date:
- 2008-07-02 21:53:12+12:00
- Desc:
- committing version01 of reidl_borowski_sensse_starke_zapotocky_eiswirth_2006
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/reidl_borowski_sensse_starke_zapotocky_eiswirth_2006/rawfile/9891a385dad4c71829a70182e9d623e16d616ac5/reidl_borowski_sensse_starke_zapotocky_eiswirth_2006.cellml
<?xml version='1.0' encoding='utf-8'?>
<!--
This CellML file was generated on 3/07/2008 at 9:14:13 at a.m. using:
COR (0.9.31.979)
Copyright 2002-2008 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk
CellML 1.0 was used to generate this model
http://www.CellML.org/
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" name="reidl_borowski_sensse_starke_zapotocky_eiswirth_2006" cmeta:id="reidl_borowski_sensse_starke_zapotocky_eiswirth_2006">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Model of Calcium Oscillations Due to Negative Feedback in Olfactory Cilia</title>
<author>
<firstname>Geoffrey</firstname>
<surname>Nunns</surname>
<affiliation>
<shortaffil>Bioengineering Institute, The University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This model is known to run in both PCEnv and COR. It recreates the published results, and is currently set up for a dual pulse experiment, with duration of 100 milliseconds. The model is relatively stiff, so maximum step size and number of steps might have to be adjusted to obtain discernible changes.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
Abstract: We present a mathematical model for calcium oscillations in the cilia of olfactory sensory neurons. The underlying mechanism is based on direct negative regulation of cyclic nucleotide-gated channels by calcium/calmodulin and does not require any autocatalysis such as calcium-induced calcium release. The model is in quantitative agreement with available experimental data, both with respect to oscillations and to fast adaptation. We give predictions for the ranges of parameters in which oscillations should be observable. Relevance of the model to calcium oscillations in other systems is discussed.
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
<ulink url="http://www.biophysj.org/cgi/content/abstract/90/4/1147">Model of Calcium Oscillations Due to Negative Feedback in Olfactory Cilia</ulink>, J. Reidl, P. Borowski, A. Sensse, J. Starke, M. Zapotocky, and M. Eiswirth, 2006, <ulink url="http://www.biophysj.org/">
<emphasis>Biophysical Journal</emphasis>
</ulink>, 90, 1147-1155. (<ulink url="http://www.biophysj.org/cgi/reprint/90/4/1147">PDF</ulink> versions of the article are available for Journal Members on the Biophys. J website.) <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16326896&dopt=Abstract">PubMed ID: 16326896 </ulink>
</para>
</sect1>
</article>
</documentation>
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