- Author:
- Hanne <Hanne@hanne-nielsens-macbook.local>
- Date:
- 2009-12-14 16:24:57+13:00
- Desc:
- Added images in ai and svg format, removed non pub med references
- Permanent Source URI:
- https://staging.physiomeproject.org/workspace/sneyd_tsaneva-atanasova_yule_thompson_shuttleworth_2004/rawfile/eda1db86340ab1ca122e2f5a1c8c098896fc3acb/sneyd_tsaneva-atanasova_yule_thompson_shuttleworth_2004.cellml
<?xml version='1.0' encoding='utf-8'?>
<!-- FILE : sneyd_model_2004.xml
CREATED : 13th June 2004
LAST MODIFIED : 21st April 2005
AUTHOR : Catherine Lloyd
The Bioengineering Institute
The University of Auckland
MODEL STATUS : This model conforms to the CellML 1.0 Specification released on
10th August 2001, and the 16/01/2002 CellML Metadata 1.0 Specification.
DESCRIPTION : This file contains a CellML description of Sneyd et al.'s 2004 mathematical model for Ca2+ oscillations and their control by membrane fluxes.
CHANGES:
21/04/2005 - PJV - Changed unit dimensions to correct inconsistancy
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" cmeta:id="sneyd_tsaneva-atanasova_yule_thompson_shuttleworth_2004_version01" name="sneyd_tsaneva-atanasova_yule_thompson_shuttleworth_2004_version01">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Modelling the Control of Calcium Oscillations by Membrane Fluxes</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This is the original unchecked version of the model imported from the previous
CellML model repository, 24-Jan-2006.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
In reponse to an increased concentration of inositol trisphoshate (IP<subscript>3</subscript>), oscillations in the concentration of intracellular Ca<superscript>2+</superscript> occur in many different cell types where they play important regulatory roles of many cellular functions. Transmembrane Ca<superscript>2+</superscript> transport is known to have a pronounced effect on these Ca<superscript>2+</superscript> oscillations, however, controversy over the mechanisms underlying these effects exists. To further complicate the issue, the consequences of blocking membrane transport or inhibiting Ca<superscript>2+</superscript> entry vary between different cell types. For example, in some cell types Ca<superscript>2+</superscript> oscillations persist in the absence of Ca<superscript>2+</superscript> entry, while in others oscillations depend on Ca<superscript>2+</superscript> entry.
</para>
<para>
Using a combination of theoretical and experimental work, Sneyd <emphasis>et al.</emphasis> study these differences between cell types. They conclude that small changes in the total amount of Ca<superscript>2+</superscript> in a cell have have a large effect on Ca<superscript>2+</superscript> oscillations. The mathematical model which the authors develop (see the figure below) is based on a dynamic model of the IP<subscript>3</subscript> receptor (also see <ulink url="${HTML_EXMPL_SNEYD_MODEL}">A Dynamic Model of the Type-2 Inositol Triphosphate Receptor, 2002</ulink>). The model predicts that the cell can be balanced at a point where small changes in the total amount of Ca<superscript>2+</superscript> can move the cellinto or out of oscillatory regions, resulting in the appearance or disappearance of oscillations. Sneyd <emphasis>et al.</emphasis> make the conclusion that the role of Ca<superscript>2+</superscript> entry during an oscillation is to replenish the total amount of Ca<superscript>2+</superscript> in the cell.
</para>
<para>
The model has been described here in CellML (the raw CellML description of the Sneyd <emphasis>et al.</emphasis> 2004 model can be downloaded in various formats as described in <xref linkend="sec_download_this_model"/>).
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
Control of calcium oscillations by membrane fluxes</ulink>, J. Sneyd, K. Tsaneva-Atanasova, D. I. Yule, J. L. Thompson, and T. J. Shuttleworth, 2004, <emphasis>PNAS</emphasis>, 101, 1392-1396. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14734814&dopt=Abstract">PubMed ID: 14734814</ulink>
</para>
<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
<imageobject>
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<title>cell diagram</title>
</objectinfo>
<imagedata fileref="sneyd_2004.png"/>
</imageobject>
</mediaobject>
<caption>Schematic diagram of the calcium fluxes described by the mathematical model.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
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Control of calcium oscillations by membrane fluxes
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The University of Auckland, Bioengineering Institute
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Sneyd et al.'s 2004 mathematical model for Ca2+ oscillations and their control by membrane fluxes.
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