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Fink, Slepchenko, Moraru, Watras, Schaff, Loew, 2000
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An image-based model of calcium waves in differentiated neuroblastoma cells
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Model Mathematics
Component based math viewer is available
Component: environment
Component: IP3_dynamics
j_IP3
=
J_IP3
ⅇ
-
k_0
time
d
d
time
time
=
-
k_degr
IP3
-
IP3_0
Component: ER
Component: Calcium_dynamics
d
d
time
time
=
alpha
J_channel
+
-
J_pump
+
J_leak
+
R_buffering
Component: Channel_kinetics
J_channel
=
J_max
IP3
IP3
+
K_IP3
Ca
Ca
+
K_act
h
3.0
1.0
-
Ca
Ca_ER
d
d
time
time
=
k_on
K_inh
-
h
Ca
+
K_inh
Component: SERCA_pump_kinetics
J_pump
=
V_max
Ca
2.0
Ca
2.0
+
K_p
2.0
Component: Leak
J_leak
=
L
1.0
-
Ca
Ca_ER
Component: Calcium_buffering
R_buffering
=
R1
+
R2
R1
=
-
k1_on
Ca
B1
+
k1_off
CaB1
R2
=
-
k2_on
Ca
B2
+
k2_off
CaB2
d
d
time
time
=
R1
d
d
time
time
=
-
R1
d
d
time
time
=
R2
d
d
time
time
=
-
R2
K1
=
k1_off
k1_on
K2
=
k2_off
k2_on
Component: Plasma_membrane_extrusion_mechanisms
gamma
=
gamma_s
if
soma_or_neurite
≦
0
gamma_n
otherwise
gamma_s
=
gamma_0
sigma
delta
sigma_neurite_2D
w_n
+
sigma_soma_2D
w_s
gamma_n
=
gamma_0
sigma
delta
delta
sigma_neurite_2D
w_n
+
sigma_soma_2D
w_s
j_Ca
=
gamma
Ca
-
Ca_c
if
Ca
>
Ca_c
0.0
otherwise
Source
Derived from workspace
Fink, Slepchenko, Moraru, Watras, Schaff, Loew, 2000
at changeset
62f9650b5ecb
.
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This work is licensed under a
Creative Commons Attribution 3.0 Unported License
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An image-based model of calcium waves in differentiated neuroblastoma cells