# NHE3 Model - Figure 2

#### Figure 2

This is the general mathematical model for the NHE3 model with modifications to enable simulations which are capable of reproducing Figure 2 in the original paper. The simulation experiment for this model can be obtained by loading the corresponding SED-ML document into OpenCOR and executing the simulation. The results of which are shown below. A rendering of the mathematical model itself is available here.

In Figure 2, the Na^{+} influx is computed for a range of external pH when NH_{4}^{+} is not present. Internal and external Na^{+} concentrations are fixed at 0.0 and 0.1 mM; internal pH is 6; and external pH is varied from 6 to 8. (*top*) Na^{+} flux is shown as a function of the external pH. (*bottom*) Reciprocal flux is shown as a function of the external H^{+} concentration.

A screenshot illustrating the results when the associated SED-ML document is loaded into OpenCOR and the simulation executed.

This can be reproduced directly from the repository by choosing the **Launch with OpenCOR** link from the *Views Available*.